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Our findings reveal the significant impact of these sub-10\u00a0nm carbon-based quantum dots, specifically carbon quantum dots (CQD), graphene quantum dots (GQD), and graphitic oxide quantum dots (GOQDs), on migrasome formation, mitochondrial integrity, and platelet function. We establish a clear correlation between the application of these nanoparticles and the induction of migrasomes. Furthermore, our results indicate that CQD, GQD, and GOQDs enhance migrasome formation by upregulating phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), cholesterol, and GTP-RhoA. Additionally, these nanoparticles provide mitochondrial protection through a process called mitocytosis and promote increased platelet aggregation. This study represents a pioneering effort to connect various types of nanoscale graphene materials with the dynamic behavior of migrasomes, thereby advancing our understanding of nanoscale materials and their biological implications.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical Abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1186\/s12951-025-04010-9","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T11:04:24Z","timestamp":1768647864000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Carbon-based quantum dots enhance platelets aggregation through migrasomes biogenesis"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4051-8395","authenticated-orcid":false,"given":"Ang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7015-9661","authenticated-orcid":false,"given":"Leiliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,17]]},"reference":[{"key":"4010_CR1","doi-asserted-by":"publisher","first-page":"e1904362","DOI":"10.1002\/adma.201904362","volume":"33","author":"S Chung","year":"2021","unstructured":"Chung S, Revia RA, Zhang M. 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