{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:30:05Z","timestamp":1788838205526,"version":"build-2803163510"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["22475156"],"award-info":[{"award-number":["22475156"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["52422307"],"award-info":[{"award-number":["52422307"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["52293383"],"award-info":[{"award-number":["52293383"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82305249"],"award-info":[{"award-number":["82305249"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"DOI":"10.1186\/s12951-025-04014-5","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T07:54:57Z","timestamp":1767772497000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cocrystal-inspired glycyrrhizic acid\u2013azole nanoassemblies for synergistic biofilm disruption and immune modulation in fungal infections"],"prefix":"10.1186","volume":"24","author":[{"given":"Chen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linna","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunsong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenpin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiansheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linqi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"4014_CR1","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/s41579-024-01062-w","volume":"22","author":"GD Brown","year":"2024","unstructured":"Brown GD, Ballou ER, Bates S, Bignell EM, Borman AM, Brand AC, et al. The pathobiology of human fungal infections. Nat Rev Microbiol. 2024;22:687\u2013704. https:\/\/doi.org\/10.1038\/s41579-024-01062-w.","journal-title":"Nat Rev Microbiol"},{"key":"4014_CR2","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1038\/s41579-023-00960-9","volume":"21","author":"SR Lockhart","year":"2023","unstructured":"Lockhart SR, Chowdhary A, Gold JAW. The rapid emergence of antifungal-resistant human-pathogenic fungi. Nat Rev Microbiol. 2023;21:818. https:\/\/doi.org\/10.1038\/s41579-023-00960-9.","journal-title":"Nat Rev Microbiol"},{"key":"4014_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-01800-x","volume":"21","author":"M Yang","year":"2023","unstructured":"Yang M, Cao Y, Zhang Z, Guo J, Hu C, Wang Z, et al. Low intensity ultrasound-mediated drug-loaded nanoparticles intravaginal drug delivery: an effective synergistic therapy scheme for treatment of vulvovaginal candidiasis. J Nanobiotechnology. 2023;21:53. https:\/\/doi.org\/10.1186\/s12951-023-01800-x.","journal-title":"J Nanobiotechnology"},{"key":"4014_CR4","doi-asserted-by":"crossref","unstructured":"Piao Y-Z, Su L, Hu X, He W, Hu X, Omolo CA et al. One-component lipidic bicontinuous nanospheres as a smart drug loading platform to eradicate candida biofilms in oral and vaginal infection. Nano Today. 2024;54:102123.","DOI":"10.1016\/j.nantod.2023.102123"},{"key":"4014_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202000537","volume":"30","author":"L Su","year":"2020","unstructured":"Su L, Li Y, Liu Y, Ma R, Liu Y, Huang F, et al. Antifungal-inbuilt metal\u2013organic-frameworks eradicate candida albicans biofilms. Adv Funct Mater. 2020;30:2000537.","journal-title":"Adv Funct Mater"},{"key":"4014_CR6","doi-asserted-by":"crossref","unstructured":"Kaur J, Nobile CJ. Antifungal drug-resistance mechanisms in Candida biofilms. Curr Opin Microbiol. 2023;71:102237.","DOI":"10.1016\/j.mib.2022.102237"},{"key":"4014_CR7","doi-asserted-by":"crossref","unstructured":"Odds FC, Brown AJP, Gow NAR. Antifungal agents: mechanisms of action. Trends Microbiol. 2003;11:272\u20139.","DOI":"10.1016\/S0966-842X(03)00117-3"},{"key":"4014_CR8","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1358\/dot.2015.51.12.2421058","volume":"51","author":"LR Peyton","year":"2015","unstructured":"Peyton LR, Gallagher S, Hashemzadeh M. Triazole antifungals: a review. Drugs Today. 2015;51:705\u201318.","journal-title":"Drugs Today"},{"key":"4014_CR9","doi-asserted-by":"crossref","unstructured":"Cong Z, Yan Z, Xiao X, Liu L, Luo Z, Zou J et al. Peptide-mimicking poly(2-oxazoline) displaying potent antibacterial and antibiofilm activities against multidrug-resistant Gram-positive pathogenic bacteria. J Mater Sci Technol. 2025;214:233\u201344.","DOI":"10.1016\/j.jmst.2024.06.041"},{"key":"4014_CR10","doi-asserted-by":"crossref","unstructured":"Jia D, Zhang H, Yang W, Zheng X, Xu H, Zhang Y et al. Enhanced chemodynamic therapy for biofilm eradication: A self-supplied H2O2 nanoplatform with integrated photothermal property. J Mater Sci Technol. 2025;225:203\u201311.","DOI":"10.1016\/j.jmst.2024.11.040"},{"key":"4014_CR11","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02841-6","volume":"22","author":"Y Gao","year":"2024","unstructured":"Gao Y, Cao Q, Xiao Y, Wu Y, Ding L, Huang H, et al. The progress and future of the treatment of Candida albicans infections based on nanotechnology. J Nanobiotechnology. 2024;22:568. https:\/\/doi.org\/10.1186\/s12951-024-02841-6.","journal-title":"J Nanobiotechnology"},{"key":"4014_CR12","doi-asserted-by":"publisher","first-page":"3943","DOI":"10.1021\/acsnano.1c09391","volume":"16","author":"R Wang","year":"2022","unstructured":"Wang R, Zhao Y, Huang Z, Zhou Y, Wang W, Xuan Y, et al. Self-assembly of podophyllotoxin-loaded lipid bilayer nanoparticles for highly effective chemotherapy and immunotherapy via downregulation of programmed cell death ligand 1 production. ACS Nano. 2022;16:3943\u201354. https:\/\/doi.org\/10.1021\/acsnano.1c09391.","journal-title":"ACS Nano"},{"key":"4014_CR13","doi-asserted-by":"publisher","first-page":"27557","DOI":"10.1021\/acsnano.4c08508","volume":"18","author":"Y Hu","year":"2024","unstructured":"Hu Y, Miao Y, Zhang Y, Wang X, Liu X, Zhang W, et al. Co-assembled binary polyphenol natural products for the prevention and treatment of radiation-induced skin injury. ACS Nano. 2024;18:27557\u201369. https:\/\/doi.org\/10.1021\/acsnano.4c08508.","journal-title":"ACS Nano"},{"key":"4014_CR14","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03146-y","volume":"23","author":"Y Yao","year":"2025","unstructured":"Yao Y, Xu Z, Ding H, Yang S, Chen B, Zhou M, et al. Carrier-free nanoparticles\u2014new strategy of improving druggability of natural products. J Nanobiotechnology. 2025;23:108. https:\/\/doi.org\/10.1186\/s12951-025-03146-y.","journal-title":"J Nanobiotechnology"},{"key":"4014_CR15","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202200521","volume":"34","author":"Y Qian","year":"2022","unstructured":"Qian Y, Zheng Y, Jin J, Wu X, Xu K, Dai M, et al. Immunoregulation in diabetic wound repair with a photoenhanced glycyrrhizic acid hydrogel scaffold. Adv Mater. 2022;34:2200521.","journal-title":"Adv Mater"},{"key":"4014_CR16","doi-asserted-by":"publisher","DOI":"10.34133\/research.0496","volume":"7","author":"L Zhang","year":"2025","unstructured":"Zhang L, Luo Z, Chen H, Wu X, Zhao Y. Glycyrrhizic acid hydrogel microparticles encapsulated with mesenchymal stem cell exosomes for wound healing. Research. 2025;7:496. https:\/\/doi.org\/10.34133\/research.0496.","journal-title":"Research"},{"key":"4014_CR17","doi-asserted-by":"crossref","unstructured":"Jiang H, Lu Q, Huang X, Zhang H, Zeng J, Wang M et al. Sinomenine-glycyrrhizic acid self-assembly enhanced the anti-inflammatory effect of sinomenine in the treatment of rheumatoid arthritis. J Control Release. 2025;382:113718.","DOI":"10.1016\/j.jconrel.2025.113718"},{"key":"4014_CR18","doi-asserted-by":"crossref","unstructured":"Zhan M, Zhou D, Lei L, Zhu J, Khan MZH, Liu X et al. Glycyrrhizic acid and glycyrrhetinic acid loaded cyclodextrin MOFs with enhanced antibacterial and anti-inflammatory effects for accelerating diabetic wound healing. Colloids Surfaces B Biointerfaces. 2025;245:114200.","DOI":"10.1016\/j.colsurfb.2024.114200"},{"key":"4014_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2024.114345","volume":"245","author":"S Qin","year":"2025","unstructured":"Qin S, Li H, Liu X, Zheng X, Zhao X, Wen S, et al. Supramolecular nanofiber network hydrogel dressing for promoting wound healing with low swelling and mechanical stability properties. Colloids Surf B Biointerfaces. 2025;245:114345.","journal-title":"Colloids Surf B Biointerfaces"},{"key":"4014_CR20","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02165-x","volume":"21","author":"C Qiu","year":"2023","unstructured":"Qiu C, Zhang JZ, Wu B, Xu CC, Pang HH, Tu QC, et al. Advanced application of nanotechnology in active constituents of traditional Chinese medicines. J Nanobiotechnology. 2023;21:456. https:\/\/doi.org\/10.1186\/s12951-023-02165-x.","journal-title":"J Nanobiotechnology"},{"key":"4014_CR21","doi-asserted-by":"crossref","unstructured":"Zhao Z, Cai M, Wang P, Wang D, Liu Y, Chen Y. Application of glycyrrhizic acid and glycyrrhetinic acid in the drug delivery system. J Drug Deliv Sci Technol. 2024;97:105754.","DOI":"10.1016\/j.jddst.2024.105754"},{"key":"4014_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.162677","volume":"512","author":"Q Li","year":"2025","unstructured":"Li Q, Liu Y, Liu S, Zhang S, Yu X, Wan Z, et al. All-natural aggregation-induced emission-active glycyrrhizic acid hydrogels for drug-resistant bacteria-infected wound healing. Chem Eng J. 2025;512:162677.","journal-title":"Chem Eng J"},{"key":"4014_CR23","doi-asserted-by":"crossref","unstructured":"Li Q, Wan Z, Yang X. Glycyrrhizic acid: self-assembly and applications in multiphase food systems. Curr Opin Food Sci. 2022;43:107\u201313.","DOI":"10.1016\/j.cofs.2021.11.008"},{"key":"4014_CR24","doi-asserted-by":"crossref","unstructured":"Becker A. API co-crystals \u2013 Trends in CMC-related aspects of pharmaceutical development beyond solubility. Drug Discov Today. 2023;28:103527.","DOI":"10.1016\/j.drudis.2023.103527"},{"key":"4014_CR25","doi-asserted-by":"crossref","unstructured":"Thipparaboina R, Kumar D, Chavan RB, Shastri NR. Multidrug co-crystals: towards the development of effective therapeutic hybrids. Drug Discov Today. 2016;21:481\u201390.","DOI":"10.1016\/j.drudis.2016.02.001"},{"key":"4014_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jpp\/rgad097","volume":"76","author":"A Chettri","year":"2024","unstructured":"Chettri A, Subba A, Singh GP, Bag PP. Pharmaceutical co-crystals: a green way to enhance drug stability and solubility for improved therapeutic efficacy. J Pharm Pharmacol. 2024;76:1\u201312.","journal-title":"J Pharm Pharmacol"},{"key":"4014_CR27","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1016\/j.jconrel.2022.12.042","volume":"353","author":"P Kumbhar","year":"2023","unstructured":"Kumbhar P, Kolekar K, Khot C, Dabhole S, Salawi A, Sabei FY, et al. Co-crystal nanoarchitectonics as an emerging strategy in attenuating cancer: fundamentals and applications. J Control Release. 2023;353:1150\u201370.","journal-title":"J Control Release"},{"issue":"43","key":"4014_CR28","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202510382","volume":"37","author":"Y Liu","year":"2025","unstructured":"Liu Y, Gao C, Zhang X, Li W, Huang Y, Zhou T, et al. Lipidic prodrug co-crystals: a platform for combination therapy targeting fungal biofilms. Adv Mater. 2025;37:e10382. https:\/\/doi.org\/10.1002\/adma.202510382","journal-title":"Adv Mater"},{"key":"4014_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.102209","volume":"61","author":"S Narala","year":"2021","unstructured":"Narala S, Nyavanandi D, Srinivasan P, Mandati P, Bandari S, Repka MA. Pharmaceutical co-crystals, salts, and co-amorphous systems: a novel opportunity of hot-melt extrusion. J Drug Deliv Sci Technol. 2021;61:102209.","journal-title":"J Drug Deliv Sci Technol"},{"key":"4014_CR30","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1021\/acs.cgd.1c01408","volume":"22","author":"R Rathi","year":"2022","unstructured":"Rathi R, Kaur S, Singh I. A review on co-crystals of herbal bioactives for solubility enhancement: preparation methods and characterization techniques. Cryst Growth Des. 2022;22:2023\u201342.","journal-title":"Cryst Growth Des"},{"key":"4014_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2024.104050","volume":"29","author":"K Rode","year":"2024","unstructured":"Rode K, Maji I, Mahajan S, Singh PK. Unlocking the potential of flavonoid-based co-crystal and co-amorphous systems. Drug Discov Today. 2024;29:104050.","journal-title":"Drug Discov Today"},{"key":"4014_CR32","doi-asserted-by":"crossref","unstructured":"Jia X, Hao H, Zhang Q, Yang M, Wang N, Sun S et al. The bioavailability enhancement and insight into the action mechanism of poorly soluble natural compounds from co-crystals preparation: Oridonin as an example. Phytomedicine. 2024;122:155179.","DOI":"10.1016\/j.phymed.2023.155179"},{"key":"4014_CR33","doi-asserted-by":"publisher","first-page":"34884","DOI":"10.1021\/acsnano.4c12580","volume":"18","author":"H Wu","year":"2024","unstructured":"Wu H, Liu Y, Wang Y, Piao Y, Meng Z, Hu X, et al. Dynamic covalent prodrug nanonetworks via reaction-induced self-assembly for periodontitis treatment. ACS Nano. 2024;18:34884\u2013901. https:\/\/doi.org\/10.1021\/acsnano.4c12580.","journal-title":"ACS Nano"},{"issue":"1","key":"4014_CR34","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s12951-022-01260-9","volume":"20","author":"X Jia","year":"2022","unstructured":"Jia X, Yuan Z, Yang Y, Huang X, Han N, Liu X, et al. Multi-functional self-assembly nanoparticles originating from small molecule natural product for oral insulin delivery through modulating tight junctions. J Nanobiotechnol. 2022;20:116. https:\/\/doi.org\/10.1186\/s12951-022-01260-9.","journal-title":"J Nanobiotechnol"},{"key":"4014_CR35","doi-asserted-by":"publisher","first-page":"10816","DOI":"10.1021\/acsnano.4c12348","volume":"19","author":"F Wu","year":"2025","unstructured":"Wu F, Wang Y, Li Y, Shi L, Yuan L, Ren Y, et al. Single-atom Cu anchored on carbon nitride as a bifunctional glucose oxidase and peroxidase nanozyme for antibacterial therapy. ACS Nano. 2025;19:10816\u201328. https:\/\/doi.org\/10.1021\/acsnano.4c12348.","journal-title":"ACS Nano"},{"key":"4014_CR36","volume":"8","author":"LJ Ming","year":"2013","unstructured":"Ming LJ, Yin ACY. Therapeutic effects of glycyrrhizic acid. Nat Prod Commun. 2013;8:1934578X1300800335.","journal-title":"Nat Prod Commun"},{"key":"4014_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2025.1514170","volume":"16","author":"H Xiao","year":"2025","unstructured":"Xiao H, Zhang Y, Li Q. 2-hydroxy-4-methoxybenzaldehyde (HMB) disrupts ergosterol biosynthesis, redox metabolism, and DON biosynthesis of fusarium graminearum revealed by transcriptome analysis. Front Microbiol. 2025;16:1\u201312.","journal-title":"Front Microbiol"},{"key":"4014_CR38","doi-asserted-by":"publisher","first-page":"3391","DOI":"10.1073\/pnas.83.10.3391","volume":"83","author":"AL Greenleaf","year":"1986","unstructured":"Greenleaf AL, Kelly JL, Lehman IR. Yeast RP041 gene product is required for transcription and maintenance of the mitochondrial genome. Proc Natl Acad Sci U S A. 1986;83:3391\u20134.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4014_CR39","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1002\/yea.3700","volume":"39","author":"N Fukuda","year":"2022","unstructured":"Fukuda N, Takeuchi M. Complete dominant inheritance of intracellular leucine accumulation traits in polyploid yeasts. Yeast. 2022;39:272\u201382.","journal-title":"Yeast"},{"key":"4014_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12864-016-2853-5","volume":"17","author":"G Degani","year":"2016","unstructured":"Degani G, Ragni E, Botias P, Ravasio D, Calderon J, Pianezzola E, et al. Genomic and functional analyses unveil the response to hyphal wall stress in Candida albicans cells lacking \u03b2(1,3)-glucan remodeling. BMC Genomics. 2016;17:1\u201324.","journal-title":"BMC Genomics"},{"issue":"3","key":"4014_CR41","doi-asserted-by":"publisher","first-page":"S63","DOI":"10.1053\/j.gastro.2021.12.131","volume":"162","author":"K Blunt","year":"2022","unstructured":"Blunt K, Jacobse J, Allaman M, Washington M, Goettel J, Wilson K, et al. Gpx3 is required to mediate protective effects of Gpx1 loss in colitis. Gastroenterology. 2022;162:S63.","journal-title":"Gastroenterology"},{"key":"4014_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40209-w","volume":"14","author":"Z Liu","year":"2023","unstructured":"Liu Z, Basso P, Hossain S, Liston SD, Robbins N, Whitesell L, et al. Multifactor transcriptional control of alternative oxidase induction integrates diverse environmental inputs to enable fungal virulence. Nat Commun. 2023;14:4528.","journal-title":"Nat Commun"},{"key":"4014_CR43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39398-1","author":"R Song","year":"2023","unstructured":"Song R, McAlpine W, Fond AM, Nair-Gill E, Choi JH, Nystr\u00f6m EEL, et al. Trans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation. Nat Commun. 2023; 14:3652 https:\/\/doi.org\/10.1038\/s41467-023-39398-1","journal-title":"Nat Commun"},{"key":"4014_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/g3journal\/jkad151","volume":"13","author":"A Sharma","year":"2023","unstructured":"Sharma A, Mitchell AP. Strain variation in gene expression impact of hyphal cyclin Hgc1 in Candida albicans. G3: Genes, Genomes, Genetics. 2023;13:1\u20135.","journal-title":"G3: Genes, Genomes, Genetics"},{"key":"4014_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/jof8050522","volume":"8","author":"A Imre","year":"2022","unstructured":"Imre A, Kov\u00e1cs R, T\u00f3th Z, Majoros L, Benk\u0151 Z, Pfliegler WP, et al. Heme Oxygenase-1 (HMX1) loss of function increases the In-Host fitness of the Saccharomyces \u2018boulardii\u2019 probiotic yeast in a mouse fungemia model. J Fungi. 2022;8:1\u201321.","journal-title":"J Fungi"},{"key":"4014_CR46","doi-asserted-by":"publisher","first-page":"17588","DOI":"10.1073\/pnas.1310644110","volume":"110","author":"S Zhang","year":"2013","unstructured":"Zhang S, Xie M, Ren G, Yu B. CDC5, a DNA binding protein, positively regulates posttranscriptional processing and\/or transcription of primary microRNA transcripts. Proc Natl Acad Sci U S A. 2013;110:17588\u201393.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4014_CR47","doi-asserted-by":"publisher","first-page":"2979","DOI":"10.1007\/s00253-017-8101-3","volume":"101","author":"YH Kim","year":"2017","unstructured":"Kim YH, Kang JY, Gil JY, Kim SY, Shin KK, Kang HA, et al. Abolishment of N-glycan mannosylphosphorylation in glyco-engineered Saccharomyces cerevisiae by double disruption of MNN4 and MNN14 genes. Appl Microbiol Biotechnol. 2017;101:2979\u201389.","journal-title":"Appl Microbiol Biotechnol"},{"key":"4014_CR48","doi-asserted-by":"publisher","first-page":"5895","DOI":"10.1007\/s00253-021-11440-6","volume":"105","author":"K Inokuma","year":"2021","unstructured":"Inokuma K, Kitada Y, Bamba T, Kobayashi Y, Yukawa T, den Haan R, et al. Improving the functionality of surface-engineered yeast cells by altering the cell wall morphology of the host strain. Appl Microbiol Biotechnol. 2021;105:5895\u2013904.","journal-title":"Appl Microbiol Biotechnol"},{"key":"4014_CR49","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/s00580-013-1713-9","volume":"23","author":"A Rashki","year":"2014","unstructured":"Rashki A, Rashki Ghalehnoo Z, Rashki Ghalehnoo M. Functional analysis of genes involved in beta-1, 2-mannosylation of glycans and putative cell wall proteins in Candida albicans during hyphae transition. Comp Clin Path. 2014;23:917\u201321.","journal-title":"Comp Clin Path"},{"key":"4014_CR50","doi-asserted-by":"publisher","first-page":"33939","DOI":"10.1074\/jbc.M113.505735","volume":"288","author":"AC Bishop","year":"2013","unstructured":"Bishop AC, Ganguly S, Solis NV, Cooley BM, Jensen-Seaman MI, Filler SG, et al. Glycerophosphocholine utilization by candida albicans: role of the git3 transporter in virulence. J Biol Chem. 2013;288:33939\u201352.","journal-title":"J Biol Chem"},{"key":"4014_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/jof7070542","volume":"7","author":"T Yamada","year":"2021","unstructured":"Yamada T, Yaguchi T, Salamin K, Guenova E, Feuermann M, Monod M. Mfs1, a pleiotropic transporter in dermatophytes that plays a key role in their intrinsic resistance to Chloramphenicol and fluconazole. J Fungi. 2021;7:1\u201314.","journal-title":"J Fungi"},{"key":"4014_CR52","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1080\/09674845.2016.1155269","volume":"73","author":"E Khajeh","year":"2016","unstructured":"Khajeh E, Shokouh SJH, Rajabibazl M, Roudbary M, Rafiei S, Aslani P, et al. Antifungal effect of Echinophora platyloba on expression of CDR1 and CDR2 genes in fluconazole-resistant Candida albicans. Br J Biomed Sci. 2016;73:44\u20138.","journal-title":"Br J Biomed Sci"},{"key":"4014_CR53","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1042\/BSR20090151","volume":"30","author":"M Sharma","year":"2010","unstructured":"Sharma M, Manoharlal R, Puri N, Prasad R. Antifungal curcumin induces reactive oxygen species and triggers an early apoptosis but prevents hyphae development by targeting the global repressor TUP1 in Candida albicans. Biosci Rep. 2010;30:391\u2013404.","journal-title":"Biosci Rep"},{"key":"4014_CR54","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.plaphy.2018.05.007","volume":"128","author":"S Lubna, Asaf","year":"2018","unstructured":"Lubna, Asaf S, Hamayun M, Khan AL, Waqas M, Khan MA, et al. Salt tolerance of Glycine max.L induced by endophytic fungus Aspergillus flavus CSH1, via regulating its endogenous hormones and antioxidative system. Plant Physiol Biochem. 2018;128:13\u201323.","journal-title":"Plant Physiol Biochem"},{"key":"4014_CR55","doi-asserted-by":"publisher","first-page":"2917","DOI":"10.1042\/BST20211030","volume":"49","author":"C Bonifer","year":"2021","unstructured":"Bonifer C, Glaubitz C. MsbA: an ABC transporter paradigm. Biochem Soc Trans. 2021;49:2917\u201327.","journal-title":"Biochem Soc Trans"},{"key":"4014_CR56","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.riam.2017.02.006","volume":"34","author":"D Mart\u00ednez-Soto","year":"2017","unstructured":"Mart\u00ednez-Soto D, Ruiz-Herrera J. Functional analysis of the MAPK pathways in fungi. Rev Iberoam Micol. 2017;34:192\u2013202.","journal-title":"Rev Iberoam Micol"},{"key":"4014_CR57","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-60570-2","volume":"16","author":"Y Li","year":"2025","unstructured":"Li Y, He W, Piao Y, Wang Y, Peng M, Li H, et al. Bacterial membrane nanovesicles encapsulating prodrug assemblies combine chemical and immunological therapies for chronic bacterial infection. Nat Commun. 2025;16:5246. https:\/\/doi.org\/10.1038\/s41467-025-60570-2.","journal-title":"Nat Commun"},{"key":"4014_CR58","doi-asserted-by":"crossref","unstructured":"Feng W, Liu N, Gao L, Zhou Q, Yu L, Ye X et al. Rapid inactivation of multidrug-resistant bacteria and enhancement of osteoinduction via titania nanotubes grafted with polyguanidines. J Mater Sci Technol. 2021;69:188\u201399.","DOI":"10.1016\/j.jmst.2020.08.021"},{"key":"4014_CR59","doi-asserted-by":"crossref","unstructured":"Zhang H, Zou Y, Lu K, Wu Y, Lin Y, Cheng J et al. A nanoplatform with oxygen self-supplying and heat-sensitizing capabilities enhances the efficacy of photodynamic therapy in eradicating multidrug-resistant biofilms. J Mater Sci Technol. 2024;169:209\u201319.","DOI":"10.1016\/j.jmst.2023.07.001"},{"key":"4014_CR60","doi-asserted-by":"crossref","unstructured":"Li Y, Chi J, Xu P, Dong X, Le A-T, Shi K et al. Supramolecular G-quadruplex hydrogels: Bridging fabrication to biomedical application. J Mater Sci Technol. 2023;155:238\u201352.","DOI":"10.1016\/j.jmst.2023.01.034"},{"key":"4014_CR61","doi-asserted-by":"crossref","unstructured":"Xu F, Cui Y-Z, Yang X-Y, Zheng Y-X, Chen X-B, Zhou H et al. CXCL10 secreted by SPRY1-deficient epidermal keratinocytes fuels joint inflammation in psoriatic arthritis via CD14 signaling. J Clin Invest. 2025;135:1\u201349.","DOI":"10.1172\/JCI186135"},{"key":"4014_CR62","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.mucimm.2025.01.003","volume":"18","author":"L Erkert","year":"2025","unstructured":"Erkert L, Ruder B, Kabisch M, Gamez Belmonte R, Patankar JV, Gonzalez Acera M, et al. TIFA renders intestinal epithelial cells responsive to microbial ADP-heptose and drives colonic inflammation in mice. Mucosal Immunol. 2025;18:453\u201366.","journal-title":"Mucosal Immunol"},{"key":"4014_CR63","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/s41584-023-01002-7","volume":"19","author":"D Siegmund","year":"2023","unstructured":"Siegmund D, Wajant H. TNF and TNF receptors as therapeutic targets for rheumatic diseases and beyond. Nat Rev Rheumatol. 2023;19:576\u201391.","journal-title":"Nat Rev Rheumatol"},{"key":"4014_CR64","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1007\/s40265-018-0942-2","volume":"78","author":"B Afsar","year":"2018","unstructured":"Afsar B, Covic A, Ortiz A, Afsar RE, Kanbay M. The future of IL-1 targeting in kidney disease. Drugs. 2018;78:1073\u201383.","journal-title":"Drugs"},{"key":"4014_CR65","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1021\/acscombsci.8b00133","volume":"21","author":"KRK Reddy","year":"2019","unstructured":"Reddy KRK, Dasari C, Vandavasi S, Natani S, Supriya B, Jadav SS, et al. Novel cellularly active inhibitor regresses DDAH1 induced prostate tumor growth by restraining tumor angiogenesis through targeting DDAH1\/ADMA\/NOS pathway. ACS Comb Sci. 2019;21:241\u201356.","journal-title":"ACS Comb Sci"},{"key":"4014_CR66","doi-asserted-by":"publisher","DOI":"10.1172\/JCI145734","author":"YJ Jin","year":"2021","unstructured":"Jin YJ, Chennupati R, Li R, Liang G, Wang SP, Iring A, et al. Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation. J Clin Invest. 2021;131:e145734. https:\/\/doi.org\/10.1172\/JCI145734","journal-title":"J Clin Invest"},{"key":"4014_CR67","doi-asserted-by":"publisher","first-page":"4376","DOI":"10.1073\/pnas.1010647108","volume":"108","author":"A Bas","year":"2011","unstructured":"Bas A, Swamy M, Abeler-D\u00f6rner L, Williams G, Pang DJ, Barbee SD, et al. Butyrophilin-like 1 encodes an enterocyte protein that selectively regulates functional interactions with T lymphocytes. Proc Natl Acad Sci U S A. 2011;108:4376\u201381.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4014_CR68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep31524","volume":"6","author":"C Lebrero-Fern\u00e1ndez","year":"2016","unstructured":"Lebrero-Fern\u00e1ndez C, Bas-Forsberg A. The ontogeny of butyrophilin-like (Btnl) 1 and Btnl6 in murine small intestine. Sci Rep. 2016;6:1\u20138.","journal-title":"Sci Rep"},{"key":"4014_CR69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12967-019-1857-8","volume":"17","author":"Z Geng","year":"2019","unstructured":"Geng Z, Fan WY, Zhou B, Ye C, Tong Y, Zhou YB, et al. FNDC5 attenuates obesity-induced cardiac hypertrophy by inactivating JAK2\/STAT3-associated inflammation and oxidative stress. J Transl Med. 2019;17:1\u201313.","journal-title":"J Transl Med"},{"key":"4014_CR70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s11658-019-0162-0","volume":"24","author":"Y Bao","year":"2019","unstructured":"Bao Y, Wang L, Shi L, Yun F, Liu X, Chen Y, et al. Transcriptome profiling revealed multiple genes and ECM-receptor interaction pathways that may be associated with breast cancer. Cell Mol Biol Lett. 2019;24:1\u201320.","journal-title":"Cell Mol Biol Lett"},{"key":"4014_CR71","doi-asserted-by":"publisher","first-page":"23827","DOI":"10.1021\/acsnano.4c09027","volume":"18","author":"F Fang","year":"2024","unstructured":"Fang F, Chen X. Carrier-free nanodrugs: from bench to bedside. ACS Nano. 2024;18:23827. https:\/\/doi.org\/10.1021\/acsnano.4c09027.","journal-title":"ACS Nano"},{"key":"4014_CR72","doi-asserted-by":"publisher","first-page":"114765","DOI":"10.1016\/j.jep.2021.114765","volume":"284","author":"I Kusumawati","year":"2022","unstructured":"Kusumawati I, Rullyansyah S, Rohmania, Rizka AF, Hestianah EP, Matsunami K. Histomorphometric study of ethanolic extract of Graptophyllum pictum (L.) Griff. Leaves on Croton oil-induced hemorrhoid mice: A Javanese traditional anti-hemorrhoid herb. J Ethnopharmacol. 2022;284:114765.","journal-title":"J Ethnopharmacol"},{"key":"4014_CR73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-023-48677-2","volume":"13","author":"M Ke","year":"2023","unstructured":"Ke M, Huang S, Lin H, Xu Z, Li X, Li Z, et al. Establishment and study of a rat internal haemorrhoid model. Sci Rep. 2023;13:1\u201310.","journal-title":"Sci Rep"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-025-04014-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-025-04014-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-025-04014-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T10:51:28Z","timestamp":1770202288000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12951-025-04014-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,7]]},"references-count":73,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4014"],"URL":"https:\/\/doi.org\/10.1186\/s12951-025-04014-5","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,7]]},"assertion":[{"value":"16 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"115"}}