{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:43:44Z","timestamp":1790343824288,"version":"4.1.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":41,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82374315"],"award-info":[{"award-number":["82374315"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82204628"],"award-info":[{"award-number":["82204628"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Key Research and Development Program of China","award":["2024YFC2310902"],"award-info":[{"award-number":["2024YFC2310902"]}]},{"name":"Special Projects in Key Areas of Colleges and Universities in Guangdong Province","award":["2022ZDZX2015"],"award-info":[{"award-number":["2022ZDZX2015"]}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["2022A1515011312"],"award-info":[{"award-number":["2022A1515011312"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Program of Guangzhou","award":["2024A04J4899"],"award-info":[{"award-number":["2024A04J4899"]}]},{"name":"Young Talent Project of Guangzhou University of Chinese Medicine","award":["A1-2601-24-414-110Z76"],"award-info":[{"award-number":["A1-2601-24-414-110Z76"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"DOI":"10.1186\/s12951-026-04381-7","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T01:55:32Z","timestamp":1776477332000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["MnUA\u2013DOX\u2013artesunate hydrogel remodels immunosuppressive tumor microenvironment and prevents postoperative recurrence in triple-negative breast cancer"],"prefix":"10.1186","volume":"24","author":[{"given":"Keneng","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Run","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weichi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjia","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengli","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinhuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changsheng","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,18]]},"reference":[{"issue":"3","key":"4381_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229\u201363. https:\/\/doi.org\/10.3322\/caac.21834. From NLM.","journal-title":"CA Cancer J Clin"},{"issue":"4","key":"4381_CR2","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1038\/s41591-025-03502-3","volume":"31","author":"J Kim","year":"2025","unstructured":"Kim J, Harper A, McCormack V, Sung H, Houssami N, Morgan E, Mutebi M, Garvey G, Soerjomataram I, Fidler-Benaoudia MM. Global patterns and trends in breast cancer incidence and mortality across 185 countries. Nat Med. 2025;31(4):1154\u201362. https:\/\/doi.org\/10.1038\/s41591-025-03502-3. From NLM.","journal-title":"Nat Med"},{"issue":"6797","key":"4381_CR3","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/35021093","volume":"406","author":"CM Perou","year":"2000","unstructured":"Perou CM, S\u00f8rlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al. Molecular portraits of human breast tumours. Nature. 2000;406(6797):747\u201352. https:\/\/doi.org\/10.1038\/35021093. From NLM.","journal-title":"Nature"},{"issue":"3","key":"4381_CR4","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s10549-012-2315-y","volume":"136","author":"L Malorni","year":"2012","unstructured":"Malorni L, Shetty PB, De Angelis C, Hilsenbeck S, Rimawi MF, Elledge R, Osborne CK, De Placido S, Arpino G. Clinical and biologic features of triple-negative breast cancers in a large cohort of patients with long-term follow-up. Breast Cancer Res Treat. 2012;136(3):795\u2013804. https:\/\/doi.org\/10.1007\/s10549-012-2315-y. From NLM.","journal-title":"Breast Cancer Res Treat"},{"issue":"5","key":"4381_CR5","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1177\/0897190014546108","volume":"27","author":"JN Barreto","year":"2014","unstructured":"Barreto JN, McCullough KB, Ice LL, Smith JA. Antineoplastic agents and the associated myelosuppressive effects: a review. J Pharm Pract. 2014;27(5):440\u20136. 10.1177\/0897190014546108 From NLM.","journal-title":"J Pharm Pract"},{"issue":"6","key":"4381_CR6","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1634\/theoncologist.10-6-427","volume":"10","author":"GH Lyman","year":"2005","unstructured":"Lyman GH, Lyman CH, Agboola O. Risk models for predicting chemotherapy-induced neutropenia. Oncologist. 2005;10(6):427\u201337. https:\/\/doi.org\/10.1634\/theoncologist.10-6-427. From NLM.","journal-title":"Oncologist"},{"issue":"1","key":"4381_CR7","doi-asserted-by":"publisher","first-page":"6973","DOI":"10.1038\/s41467-023-42509-7","volume":"14","author":"Y Li","year":"2023","unstructured":"Li Y, Chen W, Kang Y, Zhen X, Zhou Z, Liu C, Chen S, Huang X, Liu HJ, Koo S, et al. Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity. Nat Commun. 2023;14(1):6973. https:\/\/doi.org\/10.1038\/s41467-023-42509-7. From NLM.","journal-title":"Nat Commun"},{"issue":"8","key":"4381_CR8","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1093\/intimm\/dxw014","volume":"28","author":"S Spranger","year":"2016","unstructured":"Spranger S. Mechanisms of tumor escape in the context of the T-cell-inflamed and the non-T-cell-inflamed tumor microenvironment. Int Immunol. 2016;28(8):383\u201391. https:\/\/doi.org\/10.1093\/intimm\/dxw014. From NLM.","journal-title":"Int Immunol"},{"issue":"8","key":"4381_CR9","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1200\/jco.2007.14.4147","volume":"26","author":"C Liedtke","year":"2008","unstructured":"Liedtke C, Mazouni C, Hess KR, Andr\u00e9 F, Tordai A, Mejia JA, Symmans WF, Gonzalez-Angulo AM, Hennessy B, Green M, et al. Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer. J Clin Oncol. 2008;26(8):1275\u201381. https:\/\/doi.org\/10.1200\/jco.2007.14.4147. From NLM.","journal-title":"J Clin Oncol"},{"key":"4381_CR10","doi-asserted-by":"publisher","unstructured":"Krall JA, Reinhardt F, Mercury OA, Pattabiraman DR, Brooks MW, Dougan M, Lambert AW, Bierie B, Ploegh HL, Dougan SK, et al. The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy. Sci Transl Med. 2018;10(436). https:\/\/doi.org\/10.1126\/scitranslmed.aan3464. From NLM.","DOI":"10.1126\/scitranslmed.aan3464"},{"issue":"26","key":"4381_CR11","doi-asserted-by":"publisher","first-page":"2402127","DOI":"10.1002\/adhm.202402127","volume":"14","author":"Z Li","year":"2025","unstructured":"Li Z, Chen Z, Shi K, Huang P, Zeng W, Huang Q, Peng J, Yang L, Chen H, Zhao Y, et al. Polyphenol-Based Self-Assembled Nanomedicine for a Three-Pronged Approach to Reversing Tumor Immunosuppression. Adv Healthc Mater. 2025;14(26):2402127. https:\/\/doi.org\/10.1002\/adhm.202402127.","journal-title":"Adv Healthc Mater"},{"key":"4381_CR12","doi-asserted-by":"publisher","first-page":"119932","DOI":"10.1016\/j.biomaterials.2020.119932","volume":"242","author":"H Ye","year":"2020","unstructured":"Ye H, Wang K, Lu Q, Zhao J, Wang M, Kan Q, Zhang H, Wang Y, He Z, Sun J. Nanosponges of circulating tumor-derived exosomes for breast cancer metastasis inhibition. Biomaterials. 2020;242:119932. https:\/\/doi.org\/10.1016\/j.biomaterials.2020.119932. From NLM.","journal-title":"Biomaterials"},{"key":"4381_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biomaterials.2019.03.024","volume":"206","author":"H Ye","year":"2019","unstructured":"Ye H, Wang K, Wang M, Liu R, Song H, Li N, Lu Q, Zhang W, Du Y, Yang W, et al. Bioinspired nanoplatelets for chemo-photothermal therapy of breast cancer metastasis inhibition. Biomaterials. 2019;206:1\u201312. https:\/\/doi.org\/10.1016\/j.biomaterials.2019.03.024. From NLM.","journal-title":"Biomaterials"},{"issue":"1","key":"4381_CR14","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1038\/s41467-025-56407-7","volume":"16","author":"K Li","year":"2025","unstructured":"Li K, Yu X, Xu Y, Wang H, Liu Z, Wu C, Luo X, Xu J, Fang Y, Ju E, et al. Cascaded immunotherapy with implantable dual-drug depots sequentially releasing STING agonists and apoptosis inducers. Nat Commun. 2025;16(1):1629. https:\/\/doi.org\/10.1038\/s41467-025-56407-7. From NLM.","journal-title":"Nat Commun"},{"issue":"11","key":"4381_CR15","doi-asserted-by":"publisher","first-page":"10637","DOI":"10.1021\/acsnano.3c01733","volume":"17","author":"H Ye","year":"2023","unstructured":"Ye H, Wang K, Zhao J, Lu Q, Wang M, Sun B, Shen Y, Liu H, Pan\u00e9 S, Chen XZ, et al. In Situ Sprayed Nanovaccine Suppressing Exosomal PD-L1 by Golgi Apparatus Disorganization for Postsurgical Melanoma Immunotherapy. ACS Nano. 2023;17(11):10637\u201350. https:\/\/doi.org\/10.1021\/acsnano.3c01733. From NLM.","journal-title":"ACS Nano"},{"issue":"1","key":"4381_CR16","doi-asserted-by":"publisher","first-page":"108343","DOI":"10.1016\/j.cclet.2023.108343","volume":"35","author":"R Tian","year":"2024","unstructured":"Tian R, Qiu X, Mu W, Cai B, Liu Z, Liu S, Chen X. Self-adaptive hydrogel for breast cancer therapy via accurate tumor elimination and on-demand adipose tissue regeneration. Chin Chem Lett. 2024;35(1):108343. https:\/\/doi.org\/10.1016\/j.cclet.2023.108343.","journal-title":"Chin Chem Lett"},{"key":"4381_CR17","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1016\/j.jcis.2023.07.154","volume":"650 Pt B","author":"Z Li","year":"2023","unstructured":"Li Z, Yang L, Zhang D, Wang W, Huang Q, Liu Q, Shi K, Yu Y, Gao N, Chen H, et al. Mussel-inspired plug-and-play hydrogel glue for postoperative tumor recurrence and wound infection inhibition. J Colloid Interface Sci. 2023;650 Pt B:1907\u201317. https:\/\/doi.org\/10.1016\/j.jcis.2023.07.154. From NLM.","journal-title":"J Colloid Interface Sci"},{"issue":"4","key":"4381_CR18","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.immuni.2018.03.017","volume":"48","author":"C Wang","year":"2018","unstructured":"Wang C, Guan Y, Lv M, Zhang R, Guo Z, Wei X, Du X, Yang J, Li T, Wan Y, et al. Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses. Immunity. 2018;48(4):675\u2013e687677. https:\/\/doi.org\/10.1016\/j.immuni.2018.03.017. From NLM.","journal-title":"Immunity"},{"issue":"7","key":"4381_CR19","doi-asserted-by":"publisher","first-page":"108053","DOI":"10.1016\/j.celrep.2020.108053","volume":"32","author":"Z Zhao","year":"2020","unstructured":"Zhao Z, Ma Z, Wang B, Guan Y, Su XD, Jiang Z. Mn(2+) Directly Activates cGAS and Structural Analysis Suggests Mn(2+) Induces a Noncanonical Catalytic Synthesis of 2\u20193\u2019-cGAMP. Cell Rep. 2020;32(7):108053. https:\/\/doi.org\/10.1016\/j.celrep.2020.108053. From NLM.","journal-title":"Cell Rep"},{"issue":"50","key":"4381_CR20","doi-asserted-by":"publisher","first-page":"15408","DOI":"10.1073\/pnas.1512832112","volume":"112","author":"O Demaria","year":"2015","unstructured":"Demaria O, De Gassart A, Coso S, Gestermann N, Di Domizio J, Flatz L, Gaide O, Michielin O, Hwu P, Petrova TV, et al. STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity. Proc Natl Acad Sci U S A. 2015;112(50):15408\u201313. https:\/\/doi.org\/10.1073\/pnas.1512832112. From NLM.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"4381_CR21","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.immuni.2014.10.019","volume":"41","author":"L Deng","year":"2014","unstructured":"Deng L, Liang H, Xu M, Yang X, Burnette B, Arina A, Li XD, Mauceri H, Beckett M, Darga T, et al. STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors. Immunity. 2014;41(5):843\u201352. https:\/\/doi.org\/10.1016\/j.immuni.2014.10.019. From NLM.","journal-title":"Immunity"},{"issue":"11","key":"4381_CR22","doi-asserted-by":"publisher","first-page":"3074","DOI":"10.1016\/j.celrep.2018.11.047","volume":"25","author":"KE Sivick","year":"2018","unstructured":"Sivick KE, Desbien AL, Glickman LH, Reiner GL, Corrales L, Surh NH, Hudson TE, Vu UT, Francica BJ, Banda T, et al. Magnitude of Therapeutic STING Activation Determines CD8(+) T Cell-Mediated Anti-tumor Immunity. Cell Rep. 2018;25(11):3074\u2013e30853075. https:\/\/doi.org\/10.1016\/j.celrep.2018.11.047. From NLM.","journal-title":"Cell Rep"},{"issue":"3","key":"4381_CR23","doi-asserted-by":"publisher","first-page":"112185","DOI":"10.1016\/j.celrep.2023.112185","volume":"42","author":"L Zhang","year":"2023","unstructured":"Zhang L, Wei X, Wang Z, Liu P, Hou Y, Xu Y, Su H, Koci MD, Yin H, Zhang C. NF-\u03baB activation enhances STING signaling by altering microtubule-mediated STING trafficking. Cell Rep. 2023;42(3):112185. https:\/\/doi.org\/10.1016\/j.celrep.2023.112185. From NLM.","journal-title":"Cell Rep"},{"issue":"11","key":"4381_CR24","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/nrrheum.2017.155","volume":"13","author":"AK So","year":"2017","unstructured":"So AK, Martinon F. Inflammation in gout: mechanisms and therapeutic targets. Nat Rev Rheumatol. 2017;13(11):639\u201347. https:\/\/doi.org\/10.1038\/nrrheum.2017.155. From NLM.","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"4381_CR25","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/s41568-018-0090-8","volume":"19","author":"J Huynh","year":"2019","unstructured":"Huynh J, Chand A, Gough D, Ernst M. Therapeutically exploiting STAT3 activity in cancer - using tissue repair as a road map. Nat Rev Cancer. 2019;19(2):82\u201396. https:\/\/doi.org\/10.1038\/s41568-018-0090-8. From NLM.","journal-title":"Nat Rev Cancer"},{"issue":"4","key":"4381_CR26","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1038\/nrclinonc.2018.8","volume":"15","author":"DE Johnson","year":"2018","unstructured":"Johnson DE, O\u2019Keefe RA, Grandis JR. Targeting the IL-6\/JAK\/STAT3 signalling axis in cancer. Nat Rev Clin Oncol. 2018;15(4):234\u201348. https:\/\/doi.org\/10.1038\/nrclinonc.2018.8. From NLM.","journal-title":"Nat Rev Clin Oncol"},{"issue":"22","key":"4381_CR27","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.2174\/1568026616666160212122820","volume":"16","author":"M Ilamathi","year":"2016","unstructured":"Ilamathi M, Santhosh S, Sivaramakrishnan V. Artesunate as an Anti-Cancer Agent Targets Stat-3 and Favorably Suppresses Hepatocellular Carcinoma. Curr Top Med Chem. 2016;16(22):2453\u201363. 10.2174\/1568026616666160212122820 From NLM.","journal-title":"Curr Top Med Chem"},{"issue":"2","key":"4381_CR28","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1039\/d4cb00114a","volume":"6","author":"D Deng","year":"2025","unstructured":"Deng D, Xu N, Wang M, Zhang G, Su Y, Fang H, Su Z. An artesunate-modified half-sandwich iridium(iii) complex inhibits colon cancer cell proliferation and metastasis through the STAT3 pathway. RSC Chem Biol. 2025;6(2):218\u201326. https:\/\/doi.org\/10.1039\/d4cb00114a. From NLM.","journal-title":"RSC Chem Biol"},{"key":"4381_CR29","doi-asserted-by":"publisher","first-page":"107526","DOI":"10.1016\/j.phrs.2024.107526","volume":"210","author":"X Liu","year":"2024","unstructured":"Liu X, Cai Y, Zhang Y, Zhang H, Tian S, Gong Y, Song Q, Chen X, Ma X, Wen Y, et al. Artesunate: A potential drug for the prevention and treatment from hepatitis to hepatocellular carcinoma. Pharmacol Res. 2024;210:107526. https:\/\/doi.org\/10.1016\/j.phrs.2024.107526. From NLM.","journal-title":"Pharmacol Res"},{"issue":"3","key":"4381_CR30","first-page":"691","volume":"11","author":"Z Jiang","year":"2021","unstructured":"Jiang Z, Wang Z, Chen L, Zhang C, Liao F, Wang Y, Wang Y, Luo P, Luo M, Shi C. Artesunate induces ER-derived-ROS-mediated cell death by disrupting labile iron pool and iron redistribution in hepatocellular carcinoma cells. Am J Cancer Res. 2021;11(3):691\u2013711. From NLM.","journal-title":"Am J Cancer Res"},{"key":"4381_CR31","doi-asserted-by":"publisher","DOI":"10.26599\/NR.2025.94907663","author":"Z He","year":"2025","unstructured":"He Z, chen F, Liu H, Liu T, He D, Wang Y, Li J, Chen D, Tian Z, Li M, et al. Dual-targeted self-delivery micelle co-loading doxorubicin and artesunate for enhanced AML treatment via mitochondrial damage induction. Nano Res. 2025. https:\/\/doi.org\/10.26599\/NR.2025.94907663.","journal-title":"Nano Res"},{"issue":"5","key":"4381_CR32","doi-asserted-by":"publisher","first-page":"e2416796122","DOI":"10.1073\/pnas.2416796122","volume":"122","author":"L Lei","year":"2025","unstructured":"Lei L, Song Y, Yang L, Wang Y, Xia X, Zhang Y, Zhang X, Zhang X, Duggal I, He B, et al. Triethylamine-mediated protonation-deprotonation unlocks dual-drug self assembly to suppress breast cancer progression and metastasis. Proc Natl Acad Sci U S A. 2025;122(5):e2416796122. https:\/\/doi.org\/10.1073\/pnas.2416796122. From NLM.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"18","key":"4381_CR33","doi-asserted-by":"publisher","first-page":"6830","DOI":"10.1039\/d2nr00783e","volume":"14","author":"S Tiburcius","year":"2022","unstructured":"Tiburcius S, Krishnan K, Jose L, Patel V, Ghosh A, Sathish CI, Weidenhofer J, Yang JH, Verrills NM, Karakoti A, et al. Egg-yolk core-shell mesoporous silica nanoparticles for high doxorubicin loading and delivery to prostate cancer cells. Nanoscale. 2022;14(18):6830\u201345. https:\/\/doi.org\/10.1039\/d2nr00783e. From NLM.","journal-title":"Nanoscale"},{"key":"4381_CR34","doi-asserted-by":"publisher","first-page":"3483","DOI":"10.2147\/ijn.S372851","volume":"17","author":"H Wei","year":"2022","unstructured":"Wei H, Chen F, Chen J, Lin H, Wang S, Wang Y, Wu C, Lin J, Zhong G. Mesenchymal Stem Cell Derived Exosomes as Nanodrug Carrier of Doxorubicin for Targeted Osteosarcoma Therapy via SDF1-CXCR4 Axis. Int J Nanomed. 2022;17:3483\u201395. https:\/\/doi.org\/10.2147\/ijn.S372851. From NLM.","journal-title":"Int J Nanomed"},{"issue":"1","key":"4381_CR35","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1080\/10717544.2018.1501120","volume":"25","author":"Y Yan","year":"2018","unstructured":"Yan Y, Wang R, Hu Y, Sun R, Song T, Shi X, Yin S. Stacking of doxorubicin on folic acid-targeted multiwalled carbon nanotubes for in vivo chemotherapy of tumors. Drug Deliv. 2018;25(1):1607\u201316. https:\/\/doi.org\/10.1080\/10717544.2018.1501120. From NLM.","journal-title":"Drug Deliv"},{"key":"4381_CR36","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jcis.2019.12.096","volume":"565","author":"B Shriky","year":"2020","unstructured":"Shriky B, Kelly A, Isreb M, Babenko M, Mahmoudi N, Rogers S, Shebanova O, Snow T, Gough T. Pluronic F127 thermosensitive injectable smart hydrogels for controlled drug delivery system development. J Colloid Interface Sci. 2020;565:119\u201330. https:\/\/doi.org\/10.1016\/j.jcis.2019.12.096. From NLM.","journal-title":"J Colloid Interface Sci"},{"key":"4381_CR37","doi-asserted-by":"publisher","unstructured":"Kciuk M, Gieleci\u0144ska A, Mujwar S, Ko\u0142at D, Ka\u0142uzi\u0144ska-Ko\u0142at \u017b, Celik I, Kontek R. Doxorubicin-An Agent with Multiple Mechanisms of Anticancer Activity. Cells. 2023;12(4). https:\/\/doi.org\/10.3390\/cells12040659. From NLM.","DOI":"10.3390\/cells12040659"},{"key":"4381_CR38","doi-asserted-by":"publisher","unstructured":"Huang Z, Gan S, Zhuang X, Chen Y, Lu L, Wang Y, Qi X, Feng Q, Huang Q, Du B, et al. Artesunate Inhibits the Cell Growth in Colorectal Cancer by Promoting ROS-Dependent Cell Senescence and Autophagy. Cells. 2022;11(16). https:\/\/doi.org\/10.3390\/cells11162472. From NLM.","DOI":"10.3390\/cells11162472"},{"issue":"4","key":"4381_CR39","doi-asserted-by":"publisher","first-page":"eaao1736","DOI":"10.1126\/sciadv.aao1736","volume":"4","author":"R Kuai","year":"2018","unstructured":"Kuai R, Yuan W, Son S, Nam J, Xu Y, Fan Y, Schwendeman A, Moon JJ. Elimination of established tumors with nanodisc-based combination chemoimmunotherapy. Sci Adv. 2018;4(4):eaao1736. https:\/\/doi.org\/10.1126\/sciadv.aao1736. From NLM.","journal-title":"Sci Adv"},{"key":"4381_CR40","doi-asserted-by":"publisher","unstructured":"Garg AD, Agostinis P. ER stress, autophagy and immunogenic cell death in photodynamic therapy-induced anti-cancer immune responses. Photochem Photobiol Sci 2014, 13 (3), 474\u2013487. https:\/\/doi.org\/10.1039\/c3pp50333j From NLM.","DOI":"10.1039\/c3pp50333j"},{"issue":"4","key":"4381_CR41","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.cytogfr.2013.05.001","volume":"24","author":"O Kepp","year":"2013","unstructured":"Kepp O, Menger L, Vacchelli E, Locher C, Adjemian S, Yamazaki T, Martins I, Sukkurwala AQ, Michaud M, Senovilla L, et al. Crosstalk between ER stress and immunogenic cell death. Cytokine Growth Factor Rev. 2013;24(4):311\u20138. https:\/\/doi.org\/10.1016\/j.cytogfr.2013.05.001. From NLM.","journal-title":"Cytokine Growth Factor Rev"},{"issue":"14","key":"4381_CR42","doi-asserted-by":"publisher","first-page":"4385","DOI":"10.1158\/1078-0432.Ccr-07-4804","volume":"14","author":"J Begley","year":"2008","unstructured":"Begley J, Ribas A. Targeted therapies to improve tumor immunotherapy. Clin Cancer Res. 2008;14(14):4385\u201391. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-07-4804. From NLM.","journal-title":"Clin Cancer Res"},{"issue":"5","key":"4381_CR43","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/nrc3498","volume":"13","author":"M H\u00f6lzel","year":"2013","unstructured":"H\u00f6lzel M, Bovier A, T\u00fcting T. Plasticity of tumour and immune cells: a source of heterogeneity and a cause for therapy resistance? Nat Rev Cancer. 2013;13(5):365\u201376. https:\/\/doi.org\/10.1038\/nrc3498. From NLM.","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"4381_CR44","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1186\/s13046-018-0987-9","volume":"37","author":"W Chen","year":"2018","unstructured":"Chen W, Li P, Liu Y, Yang Y, Ye X, Zhang F, Huang H. Isoalantolactone induces apoptosis through ROS-mediated ER stress and inhibition of STAT3 in prostate cancer cells. J Exp Clin Cancer Res. 2018;37(1):309. https:\/\/doi.org\/10.1186\/s13046-018-0987-9. From NLM.","journal-title":"J Exp Clin Cancer Res"},{"key":"4381_CR45","doi-asserted-by":"publisher","unstructured":"Lei S, Su W, Xia ZY, Wang Y, Zhou L, Qiao S, Zhao B, Xia Z, Irwin MG. Hyperglycemia-Induced Oxidative Stress Abrogates Remifentanil Preconditioning-Mediated Cardioprotection in Diabetic Rats by Impairing Caveolin-3-Modulated PI3K\/Akt and JAK2\/STAT3 Signaling. Oxid Med Cell Longev 2019, 2019, 9836302. https:\/\/doi.org\/10.1155\/2019\/9836302 From NLM.","DOI":"10.1155\/2019\/9836302"},{"issue":"13","key":"4381_CR46","doi-asserted-by":"publisher","first-page":"5943","DOI":"10.7150\/thno.41498","volume":"10","author":"L Tong","year":"2020","unstructured":"Tong L, Li J, Li Q, Wang X, Medikonda R, Zhao T, Li T, Ma H, Yi L, Liu P, et al. ACT001 reduces the expression of PD-L1 by inhibiting the phosphorylation of STAT3 in glioblastoma. Theranostics. 2020;10(13):5943\u201356. https:\/\/doi.org\/10.7150\/thno.41498. From NLM.","journal-title":"Theranostics"},{"issue":"5","key":"4381_CR47","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/nrc2628","volume":"9","author":"F Balkwill","year":"2009","unstructured":"Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer. 2009;9(5):361\u201371. https:\/\/doi.org\/10.1038\/nrc2628. From NLM.","journal-title":"Nat Rev Cancer"},{"issue":"9","key":"4381_CR48","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/s41577-018-0029-z","volume":"18","author":"LB Ivashkiv","year":"2018","unstructured":"Ivashkiv LB. IFN\u03b3: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy. Nat Rev Immunol. 2018;18(9):545\u201358. https:\/\/doi.org\/10.1038\/s41577-018-0029-z. From NLM.","journal-title":"Nat Rev Immunol"},{"key":"4381_CR49","doi-asserted-by":"publisher","unstructured":"Kang S, Narazaki M, Metwally H, Kishimoto T. Historical overview of the interleukin-6 family cytokine. J Exp Med. 2020;217(5). https:\/\/doi.org\/10.1084\/jem.20190347. From NLM.","DOI":"10.1084\/jem.20190347"},{"key":"4381_CR50","doi-asserted-by":"publisher","unstructured":"Yang C, Wang Z, Li L, Zhang Z, Jin X, Wu P, Sun S, Pan J, Su K, Jia F, et al. Aged neutrophils form mitochondria-dependent vital NETs to promote breast cancer lung metastasis. J Immunother Cancer. 2021;9(10). https:\/\/doi.org\/10.1136\/jitc-2021-002875. From NLM.","DOI":"10.1136\/jitc-2021-002875"},{"issue":"D1","key":"4381_CR51","doi-asserted-by":"publisher","first-page":"D1670","DOI":"10.1093\/nar\/gkae973","volume":"53","author":"S Jiang","year":"2025","unstructured":"Jiang S, Li H, Zhang L, Mu W, Zhang Y, Chen T, Wu J, Tang H, Zheng S, Liu Y, et al. Generic Diagramming Platform (GDP): a comprehensive database of high-quality biomedical graphics. Nucleic Acids Res. 2025;53(D1):D1670\u20136. https:\/\/doi.org\/10.1093\/nar\/gkae973. From NLM.","journal-title":"Nucleic Acids Res"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-026-04381-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-026-04381-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-026-04381-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T23:12:50Z","timestamp":1780009970000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12951-026-04381-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,18]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4381"],"URL":"https:\/\/doi.org\/10.1186\/s12951-026-04381-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7975044\/v1","asserted-by":"object"}]},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,18]]},"assertion":[{"value":"29 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were approved by the Ethics Committee of Science and Technology Industrial Park, Guangzhou University of Chinese Medicine (PZ24115). All applicable institutional guidelines for the care and use of animals were followed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors agree with the submission and publication of this paper.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"511"}}