{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T03:20:23Z","timestamp":1794280823452,"version":"4.9.0"},"reference-count":159,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":41,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82573074"],"award-info":[{"award-number":["82573074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82372905"],"award-info":[{"award-number":["82372905"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Program of Guangzhou","award":["No.2025A04J3464"],"award-info":[{"award-number":["No.2025A04J3464"]}]},{"name":"Guangdong Provincial Science and Technology Project Foundation","award":["2022A0505050038"],"award-info":[{"award-number":["2022A0505050038"]}]},{"name":"Young Top-notch Talent of Pearl River Talent Plan","award":["0920220228"],"award-info":[{"award-number":["0920220228"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"DOI":"10.1186\/s12951-026-04438-7","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T06:25:00Z","timestamp":1776147900000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lysosome-centered nanomedicine for cancer therapy: mechanisms, materials, and modalities"],"prefix":"10.1186","volume":"24","author":[{"given":"Rongwei","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyan","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuguang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"4438_CR1","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1016\/S0140-6736(25)01635-6","volume":"406","author":"GBD Cancer Collaborators","year":"2025","unstructured":"Cancer Collaborators GBD. The global, regional, and national burden of cancer, 1990\u20132023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023. Lancet. 2025;406:1565\u201386. https:\/\/doi.org\/10.1016\/S0140-6736(25)01635-6.","journal-title":"Lancet"},{"key":"4438_CR2","doi-asserted-by":"publisher","first-page":"9663","DOI":"10.1007\/s11033-023-08809-3","volume":"50","author":"R Kaur","year":"2023","unstructured":"Kaur R, Bhardwaj A, Gupta S. Cancer treatment therapies: traditional to modern approaches to combat cancers. Mol Biol Rep. 2023;50:9663\u201376. https:\/\/doi.org\/10.1007\/s11033-023-08809-3.","journal-title":"Mol Biol Rep"},{"key":"4438_CR3","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/s41586-019-1730-1","volume":"575","author":"N Vasan","year":"2019","unstructured":"Vasan N, Baselga J, Hyman DM. A view on drug resistance in cancer. Nature. 2019;575:299\u2013309. https:\/\/doi.org\/10.1038\/s41586-019-1730-1.","journal-title":"Nature"},{"key":"4438_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-01967-3","volume":"23","author":"L Wang","year":"2024","unstructured":"Wang L, Wang X, Zhu X, Zhong L, Jiang Q, Wang Y, et al. Drug resistance in ovarian cancer: from mechanism to clinical trial. Mol Cancer. 2024;23:66. https:\/\/doi.org\/10.1186\/s12943-024-01967-3.","journal-title":"Mol Cancer"},{"key":"4438_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1394816","volume":"15","author":"SF Liu","year":"2024","unstructured":"Liu SF, Li MJ, Liang B, Sun W, Shao Y, Hu X, et al. Breaking the barrier: nanoparticle-enhanced radiotherapy as the new vanguard in brain tumor treatment. Front Pharmacol. 2024;15:1394816. https:\/\/doi.org\/10.3389\/fphar.2024.1394816.","journal-title":"Front Pharmacol"},{"key":"4438_CR6","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202415296","volume":"12","author":"H Aliouat","year":"2025","unstructured":"Aliouat H, Zhang D, Peng L, Huang J, Cheng H, Zhu J, et al. Targeted DNA nanomachine enables specific miRNA-responsive singlet oxygen amplification for precise cutaneous squamous cancer therapy. Adv Sci (Weinh). 2025;12:e2415296. https:\/\/doi.org\/10.1002\/advs.202415296.","journal-title":"Adv Sci (Weinh)"},{"key":"4438_CR7","doi-asserted-by":"publisher","first-page":"18051","DOI":"10.1021\/acs.nanolett.5c04783","volume":"25","author":"F Wu","year":"2025","unstructured":"Wu F, Sun Y, He Y, Wen N, Zhang Q, Wu H, et al. Membrane-anchored pH-responsive DNA nanodevice enhances natural-killer-cell interaction specificity toward tumor cells. Nano Lett. 2025;25:18051\u20138. https:\/\/doi.org\/10.1021\/acs.nanolett.5c04783.","journal-title":"Nano Lett"},{"key":"4438_CR8","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c18781","author":"X Wan","year":"2025","unstructured":"Wan X, Tao Y, Ge Y, Pan W, Miao P, Li N, et al. Dual-cascade activated DNAzyme nanoreactor within a Zn-based MOF for mitochondrial gene regulation. ACS Appl Mater Interfaces. 2025. https:\/\/doi.org\/10.1021\/acsami.5c18781.","journal-title":"ACS Appl Mater Interfaces"},{"key":"4438_CR9","doi-asserted-by":"publisher","first-page":"44072","DOI":"10.1021\/jacs.5c10972","volume":"147","author":"X Yu","year":"2025","unstructured":"Yu X, Qi S, Zhang W, Li H, Cao F, Wang Y, Peng K, Lin X, Chen X, Yu G. Lipid Nanoparticle Chaperone with Redox-Adaptive Intracellular Microenvironment Modulation Potentiates the Potency of mRNA Vaccines. J Am Chem Soc. 2025;147:44072\u201386. https:\/\/doi.org\/10.1021\/jacs.5c10972.","journal-title":"J Am Chem Soc"},{"key":"4438_CR10","doi-asserted-by":"publisher","first-page":"123950","DOI":"10.1016\/j.biomaterials.2025.123950","volume":"329","author":"R Yang","year":"2025","unstructured":"Yang R, You Z, Xie B, Liu M, Santiago EY, Besteiro LV, Wang Y, Ma B, Liu H, Ma D. Plasmon-boosted titanium nitride-based nanoplatform for synergistic photothermal-chemodynamic cancer therapy with smart degradability. Biomaterials. 2025;329:123950. https:\/\/doi.org\/10.1016\/j.biomaterials.2025.123950.","journal-title":"Biomaterials"},{"key":"4438_CR11","doi-asserted-by":"publisher","DOI":"10.1039\/d5nr04209g","author":"Y Wang","year":"2026","unstructured":"Wang Y, Qu H, Zhang G, Geng W, Hang L, Zhang T, Li Y. Engineering a CeO(2) layer on gold nanopyramids for enhanced near-infrared photothermal conversion. Nanoscale. 2026. https:\/\/doi.org\/10.1039\/d5nr04209g.","journal-title":"Nanoscale"},{"key":"4438_CR12","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.actbio.2023.12.030","volume":"175","author":"Y Yu","year":"2024","unstructured":"Yu Y, Zhang J, Huang W, Luo L, Han L, Sun T. Spatiotemporally controlled AuNPs@ZIF-8 based nanocarriers for synergistic photothermal\/chemodynamic therapy. Acta Biomater. 2024;175:317\u201328. https:\/\/doi.org\/10.1016\/j.actbio.2023.12.030.","journal-title":"Acta Biomater"},{"key":"4438_CR13","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1146\/annurev-physiol-021014-071649","volume":"77","author":"H Xu","year":"2015","unstructured":"Xu H, Ren D. Lysosomal physiology. Annu Rev Physiol. 2015;77:57\u201380. https:\/\/doi.org\/10.1146\/annurev-physiol-021014-071649.","journal-title":"Annu Rev Physiol"},{"key":"4438_CR14","doi-asserted-by":"publisher","first-page":"2460","DOI":"10.1021\/acscentsci.5c01647","volume":"11","author":"D Zhang","year":"2025","unstructured":"Zhang D, Zhou X, Cai J, Tan W, Liu Y, Zhao Z. Molecularly Built Ligands Degrade Membrane Receptors via Enhancing Their Accumulation in Lysosomes. ACS Cent Sci. 2025;11:2460\u201373. https:\/\/doi.org\/10.1021\/acscentsci.5c01647.","journal-title":"ACS Cent Sci"},{"key":"4438_CR15","doi-asserted-by":"publisher","DOI":"10.1039\/d5nr03792a","author":"D Liu","year":"2026","unstructured":"Liu D, Mao J, Dai Y, Li K, Tian Q, Xue F, Yang S, An L. Dual modulation of lysosomal integrity via alkalization and lipid peroxidation: a promising strategy for tumor inhibition. Nanoscale. 2026. https:\/\/doi.org\/10.1039\/d5nr03792a.","journal-title":"Nanoscale"},{"key":"4438_CR16","doi-asserted-by":"publisher","first-page":"34527","DOI":"10.1021\/acsnano.5c01922","volume":"19","author":"P Zhang","year":"2025","unstructured":"Zhang P, Yao Q, Zhang X, Yi X, Xiao C, Chen X. Fenton Reaction-Mediated Endolysosomal Disruption for Efficient Cytosolic Protein Delivery. ACS Nano. 2025;19:34527\u201339. https:\/\/doi.org\/10.1021\/acsnano.5c01922.","journal-title":"ACS Nano"},{"key":"4438_CR17","doi-asserted-by":"publisher","first-page":"3622","DOI":"10.1039\/d4mh01781a","volume":"12","author":"Y Wang","year":"2025","unstructured":"Wang Y, Ukwattage V, Xiong Y, Such GK. Advancing endosomal escape of polymeric nanoparticles: towards improved intracellular delivery. Mater Horiz. 2025;12:3622\u201332. https:\/\/doi.org\/10.1039\/d4mh01781a.","journal-title":"Mater Horiz"},{"key":"4438_CR18","doi-asserted-by":"publisher","first-page":"9582","DOI":"10.1039\/d4cs00411f","volume":"53","author":"Y Chen","year":"2024","unstructured":"Chen Y, Liu F, Pal S, Hu Q. Proteolysis-targeting drug delivery system (ProDDS): integrating targeted protein degradation concepts into formulation design. Chem Soc Rev. 2024;53:9582\u2013608. https:\/\/doi.org\/10.1039\/d4cs00411f.","journal-title":"Chem Soc Rev"},{"key":"4438_CR19","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1016\/j.apsb.2023.09.007","volume":"14","author":"Y Lee","year":"2024","unstructured":"Lee Y, Song S, Yang S, Kim J, Moon Y, Shim N, Yoon HY, Kim S, Shim MK, Kim K. Photo-induced crosslinked and anti-PD-L1 peptide incorporated liposomes to promote PD-L1 multivalent binding for effective immune checkpoint blockade therapy. Acta Pharm Sin B. 2024;14:1428\u201340. https:\/\/doi.org\/10.1016\/j.apsb.2023.09.007.","journal-title":"Acta Pharm Sin B"},{"key":"4438_CR20","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03508-6","volume":"23","author":"J Zhang","year":"2025","unstructured":"Zhang J, Zhang YP, Sun Q, Wang Y, Mei D, Wang X, et al. Cancer cell membrane-camouflaged pH-responsive nanoparticles for enhancing siRNA effect and synergistic anti-tumor therapy. J Nanobiotechnology. 2025;23:471. https:\/\/doi.org\/10.1186\/s12951-025-03508-6.","journal-title":"J Nanobiotechnology"},{"key":"4438_CR21","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1002\/asia.201403115","volume":"10","author":"C Zhou","year":"2015","unstructured":"Zhou C, Chen T, Wu C, Zhu G, Qiu L, Cui C, Hou W, Tan W. Aptamer CaCO3 nanostructures: a facile, pH-responsive, specific platform for targeted anticancer theranostics. Chem Asian J. 2015;10:166\u201371. https:\/\/doi.org\/10.1002\/asia.201403115.","journal-title":"Chem Asian J"},{"key":"4438_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41592-0","volume":"14","author":"M Tang","year":"2023","unstructured":"Tang M, Chen B, Xia H, Pan M, Zhao R, Zhou J, et al. pH-gated nanoparticles selectively regulate lysosomal function of tumour-associated macrophages for cancer immunotherapy. Nat Commun. 2023;14:5888. https:\/\/doi.org\/10.1038\/s41467-023-41592-0.","journal-title":"Nat Commun"},{"key":"4438_CR23","doi-asserted-by":"publisher","first-page":"S297","DOI":"10.1080\/21691401.2018.1492418","volume":"46","author":"JH Jiang","year":"2018","unstructured":"Jiang JH, Pi J, Jin H, Cai JY. Functional graphene oxide as cancer-targeted drug delivery system to selectively induce oesophageal cancer cell apoptosis. Artif Cells Nanomed Biotechnol. 2018;46:S297\u2013307. https:\/\/doi.org\/10.1080\/21691401.2018.1492418.","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"4438_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202306230","volume":"11","author":"X Song","year":"2024","unstructured":"Song X, Cai H, Shi Z, Li Z, Zheng X, Yang K, et al. Enzyme-responsive branched glycopolymer-based nanoassembly for co-delivery of paclitaxel and Akt inhibitor toward synergistic therapy of gastric cancer. Adv Sci. 2024;11:e2306230. https:\/\/doi.org\/10.1002\/advs.202306230.","journal-title":"Adv Sci"},{"key":"4438_CR25","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1021\/acsnano.6b05541","volume":"11","author":"H Han","year":"2017","unstructured":"Han H, Valdeperez D, Jin Q, Yang B, Li Z, Wu Y, et al. Dual enzymatic reaction-assisted gemcitabine delivery systems for programmed pancreatic cancer therapy. ACS Nano. 2017;11:1281\u201391. https:\/\/doi.org\/10.1021\/acsnano.6b05541.","journal-title":"ACS Nano"},{"key":"4438_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2023.108103","volume":"63","author":"E Volta-Duran","year":"2023","unstructured":"Volta-Duran E, Parlade E, Serna N, Villaverde A, Vazquez E, Unzueta U. Endosomal escape for cell-targeted proteins. Going out after going in. Biotechnol Adv. 2023;63:108103. https:\/\/doi.org\/10.1016\/j.biotechadv.2023.108103.","journal-title":"Biotechnol Adv"},{"key":"4438_CR27","doi-asserted-by":"publisher","first-page":"112588","DOI":"10.1016\/j.colsurfb.2022.112588","volume":"216","author":"QY Wang","year":"2022","unstructured":"Wang QY, Xiang Yali QH, Hu SH, Huang J, Lin QH, Zhou. Surface charge switchable nano-micelle for pH\/redox-triggered and endosomal escape mediated co-delivery of doxorubicin and paclitaxel in treatment of lung adenocarcinoma. Colloids Surf B Biointerfaces. 2022;216:112588. https:\/\/doi.org\/10.1016\/j.colsurfb.2022.112588.","journal-title":"Colloids Surf B Biointerfaces"},{"key":"4438_CR28","doi-asserted-by":"publisher","first-page":"17405","DOI":"10.1021\/acsnano.0c07610","volume":"14","author":"M Wang","year":"2020","unstructured":"Wang M, Zhang L, Cai Y, Yang Y, Qiu L, Shen Y, et al. Bioengineered human serum albumin fusion protein as target\/enzyme\/pH three-stage propulsive drug vehicle for tumor therapy. ACS Nano. 2020;14:17405\u201318. https:\/\/doi.org\/10.1021\/acsnano.0c07610.","journal-title":"ACS Nano"},{"key":"4438_CR29","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/EXP.20210008","volume":"1","author":"S Guo","year":"2021","unstructured":"Guo S, Li K, Hu B, Li C, Zhang M, Hussain A, Wang X, Cheng Q, Yang F, Ge K, Zhang J, Chang J, Liang XJ, Weng Y, Huang Y. Membrane-destabilizing ionizable lipid empowered imaging-guided siRNA delivery and cancer treatment. Explor (Beijing). 2021;1:35\u201349. https:\/\/doi.org\/10.1002\/EXP.20210008.","journal-title":"Explor (Beijing)"},{"key":"4438_CR30","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1093\/abbs\/gmab073","volume":"53","author":"W Yao","year":"2021","unstructured":"Yao W, Yao J, Qian F, Que Z, Yu P, Luo T, Zheng D, Zhang Z, Tian J. Paclitaxel-loaded and folic acid-modified PLGA nanomedicine with glutathione response for the treatment of lung cancer. Acta Biochim Biophys Sin (Shanghai). 2021;53:1027\u201336. https:\/\/doi.org\/10.1093\/abbs\/gmab073.","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"4438_CR31","doi-asserted-by":"publisher","first-page":"3398","DOI":"10.1021\/acsbiomaterials.9b00436","volume":"5","author":"C Zhang","year":"2019","unstructured":"Zhang C, Li S, Yu A, Wang Y. Nano CaCO(3) lysosomal bombs enhance chemotherapy drug efficacy via rebalancing tumor intracellular pH. ACS Biomater Sci Eng. 2019;5:3398\u2013408. https:\/\/doi.org\/10.1021\/acsbiomaterials.9b00436.","journal-title":"ACS Biomater Sci Eng"},{"key":"4438_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111069","volume":"114","author":"XS Sun","year":"2020","unstructured":"Sun XS, Jang MS, Fu Y, Lee JH, Lee DS, Li Y, et al. Intracellular delivery of cytochrome C using hypoxia-responsive polypeptide micelles for efficient cancer therapy. Mater Sci Eng C Mater Biol Appl. 2020;114:111069. https:\/\/doi.org\/10.1016\/j.msec.2020.111069.","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"4438_CR33","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1016\/j.apsb.2023.11.019","volume":"14","author":"H Zhang","year":"2024","unstructured":"Zhang H, Xuan X, Wang Y, Qi Z, Cao K, Tian Y, Wang C, Chang J, Zhang Z, Hou L. In situ autophagy regulation in synergy with phototherapy for breast cancer treatment. Acta Pharm Sin B. 2024;14:2317\u201332. https:\/\/doi.org\/10.1016\/j.apsb.2023.11.019.","journal-title":"Acta Pharm Sin B"},{"key":"4438_CR34","doi-asserted-by":"publisher","first-page":"7989","DOI":"10.1021\/acs.nanolett.5c01609","volume":"25","author":"G Wang","year":"2025","unstructured":"Wang G, Guo H, Wei M, Wang Y, Jin Z, Zhou J, et al. A hybrid-targeting nanoparticle for penetrable delivery of temozolomide to enhance glioblastoma therapy. Nano Lett. 2025;25:7989\u201397. https:\/\/doi.org\/10.1021\/acs.nanolett.5c01609.","journal-title":"Nano Lett"},{"key":"4438_CR35","doi-asserted-by":"publisher","first-page":"6468","DOI":"10.1021\/acsnano.4c17285","volume":"19","author":"J Ding","year":"2025","unstructured":"Ding J, Zhao X, Long S, Sun W, Du J, Fan J, et al. A dual stimuli-responsive nanoimmunomodulator for antitumor synergy of macrophages and T cells. ACS Nano. 2025;19:6468\u201378. https:\/\/doi.org\/10.1021\/acsnano.4c17285.","journal-title":"ACS Nano"},{"key":"4438_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122056","volume":"295","author":"L Wang","year":"2023","unstructured":"Wang L, Liu C, Wang X, Ma S, Liu F, Zhang Y, et al. Tumor-specific activated nano-domino-CRISPR to amplify intrinsic oxidative and activate endogenous apoptosis for spatiotemporally specific therapy. Biomaterials. 2023;295:122056. https:\/\/doi.org\/10.1016\/j.biomaterials.2023.122056.","journal-title":"Biomaterials"},{"key":"4438_CR37","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1166\/jnn.2021.18677","volume":"21","author":"Y Chen","year":"2021","unstructured":"Chen Y, Xiang M, Wang Z. Application of novel hollow carbon nanosphere drug-loading system in chemotherapy of esophageal squamous cell carcinoma. J Nanosci Nanotechnol. 2021;21:814\u201323. https:\/\/doi.org\/10.1166\/jnn.2021.18677.","journal-title":"J Nanosci Nanotechnol"},{"key":"4438_CR38","doi-asserted-by":"publisher","first-page":"22129","DOI":"10.1021\/acsnano.3c09581","volume":"17","author":"R Jiang","year":"2023","unstructured":"Jiang R, Li L, Li M. Biomimetic construction of degradable DNAzyme-loaded nanocapsules for self-sufficient gene therapy of pulmonary metastatic breast cancer. ACS Nano. 2023;17:22129\u201344. https:\/\/doi.org\/10.1021\/acsnano.3c09581.","journal-title":"ACS Nano"},{"key":"4438_CR39","doi-asserted-by":"publisher","first-page":"5807","DOI":"10.1021\/acsnano.1c10921","volume":"16","author":"L Hou","year":"2022","unstructured":"Hou L, Pu L, Chen Y, Bai Y, Zhou Y, Chen M, et al. Targeted intervention of NF2-YAP signaling axis in CD24-overexpressing cells contributes to encouraging therapeutic effects in TNBC. ACS Nano. 2022;16:5807\u201319. https:\/\/doi.org\/10.1021\/acsnano.1c10921.","journal-title":"ACS Nano"},{"key":"4438_CR40","doi-asserted-by":"publisher","first-page":"28793","DOI":"10.1021\/acsnano.4c08468","volume":"18","author":"Y Fu","year":"2024","unstructured":"Fu Y, He Y, Wei X, Zhang X, Tu W, Xue W, et al. Sonocatalysis regulates tumor autophagy for enhanced immunotherapy. ACS Nano. 2024;18:28793\u2013809. https:\/\/doi.org\/10.1021\/acsnano.4c08468.","journal-title":"ACS Nano"},{"key":"4438_CR41","doi-asserted-by":"publisher","first-page":"4049","DOI":"10.1021\/acsnano.8b08246","volume":"13","author":"C Kong","year":"2019","unstructured":"Kong C, Li Y, Liu Z, Ye J, Wang Z, Zhang L, et al. Targeting the oncogene KRAS mutant pancreatic cancer by synergistic blocking of lysosomal acidification and rapid drug release. ACS Nano. 2019;13:4049\u201363. https:\/\/doi.org\/10.1021\/acsnano.8b08246.","journal-title":"ACS Nano"},{"key":"4438_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.122297","volume":"628","author":"H Zhang","year":"2022","unstructured":"Zhang H, Meng L, Yin L, Fan T, Yu L, Han S, et al. ClC-3 silencing mediates lysosomal acidification arrest and autophagy inhibition to sensitize chemo-photothermal therapy. Int J Pharm. 2022;628:122297. https:\/\/doi.org\/10.1016\/j.ijpharm.2022.122297.","journal-title":"Int J Pharm"},{"key":"4438_CR43","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1039\/d0na00990c","volume":"3","author":"N Li","year":"2021","unstructured":"Li N, Han S, Ma B, Huang X, Xu L, Cao J, et al. Chemosensitivity enhanced by autophagy inhibition based on a polycationic nano-drug carrier. Nanoscale Adv. 2021;3:1656\u201373. https:\/\/doi.org\/10.1039\/d0na00990c.","journal-title":"Nanoscale Adv"},{"key":"4438_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.155633","author":"P Elblova","year":"2024","unstructured":"Elblova P, Lunova M, Henry SJW, Tu X, Cale A, Dejneka A, et al. Peptide-coated DNA nanostructures as a platform for control of lysosomal function in cells. Chem Eng J. 2024. https:\/\/doi.org\/10.1016\/j.cej.2024.155633.","journal-title":"Chem Eng J"},{"key":"4438_CR45","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201700585","volume":"5","author":"HY Wan","year":"2018","unstructured":"Wan HY, Chen JL, Zhu X, Liu L, Wang J, Zhu XM. Titania-coated gold nano-bipyramids for blocking autophagy flux and sensitizing cancer cells to proteasome inhibitor-induced death. Adv Sci Weinh. 2018;5:1700585. https:\/\/doi.org\/10.1002\/advs.201700585.","journal-title":"Adv Sci Weinh"},{"key":"4438_CR46","doi-asserted-by":"publisher","first-page":"6790","DOI":"10.1021\/acs.nanolett.7b03021","volume":"17","author":"L Ding","year":"2017","unstructured":"Ding L, Zhu X, Wang Y, Shi B, Ling X, Chen H, et al. Intracellular fate of nanoparticles with polydopamine surface engineering and a novel strategy for exocytosis-inhibiting, lysosome impairment-based cancer therapy. Nano Lett. 2017;17:6790\u2013801. https:\/\/doi.org\/10.1021\/acs.nanolett.7b03021.","journal-title":"Nano Lett"},{"key":"4438_CR47","doi-asserted-by":"publisher","first-page":"12208","DOI":"10.1021\/acsnano.5c00268","volume":"19","author":"S Zhang","year":"2025","unstructured":"Zhang S, Lv J, Cheng X, Chen K, Wei Q, Gong X, et al. Provoking lysosome disruption via in situ engineered double-network assemblies for targeted cancer cell death. ACS Nano. 2025;19:12208\u201321. https:\/\/doi.org\/10.1021\/acsnano.5c00268.","journal-title":"ACS Nano"},{"key":"4438_CR48","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202204567","volume":"61","author":"Z Ma","year":"2022","unstructured":"Ma Z, Lin K, Tang M, Ramachandran M, Qiu R, Li J, et al. A pH-driven small-molecule nanotransformer hijacks lysosomes and overcomes autophagy-induced resistance in cancer. Angew Chem Int Ed Engl. 2022;61:e202204567. https:\/\/doi.org\/10.1002\/anie.202204567.","journal-title":"Angew Chem Int Ed Engl"},{"key":"4438_CR49","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.7150\/thno.18352","volume":"7","author":"Y Shen","year":"2017","unstructured":"Shen Y, Wu C, Uyeda TQP, Plaza GR, Liu B, Han Y, et al. Elongated nanoparticle aggregates in cancer cells for mechanical destruction with low frequency rotating magnetic field. Theranostics. 2017;7:1735\u201348. https:\/\/doi.org\/10.7150\/thno.18352.","journal-title":"Theranostics"},{"key":"4438_CR50","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1039\/d1na00474c","volume":"4","author":"S Lopez","year":"2022","unstructured":"Lopez S, Hallali N, Lalatonne Y, Hillion A, Antunes JC, Serhan N, et al. Magneto-mechanical destruction of cancer-associated fibroblasts using ultra-small iron oxide nanoparticles and low frequency rotating magnetic fields. Nanoscale. 2022;4:421\u201336. https:\/\/doi.org\/10.1039\/d1na00474c.","journal-title":"Nanoscale"},{"key":"4438_CR51","doi-asserted-by":"publisher","first-page":"50926","DOI":"10.1021\/acsami.3c12599","volume":"15","author":"Q Tang","year":"2023","unstructured":"Tang Q, Zhang F, Luo L, Duan Y, Zhu T, Ni Y, et al. Ultrasound-induced gold nanoparticle united with acoustic reprogramming of macrophages for enhanced cancer therapy. ACS Appl Mater Interfaces. 2023;15:50926\u201339. https:\/\/doi.org\/10.1021\/acsami.3c12599.","journal-title":"ACS Appl Mater Interfaces"},{"key":"4438_CR52","doi-asserted-by":"publisher","first-page":"28659","DOI":"10.1021\/acsnano.4c05938","volume":"18","author":"Z Shi","year":"2024","unstructured":"Shi Z, Zeng Y, Luo J, Wang X, Ma G, Zhang T, et al. Endogenous magnetic lipid droplet-mediated cascade-targeted sonodynamic therapy as an approach to reversing breast cancer multidrug resistance. ACS Nano. 2024;18:28659\u201374. https:\/\/doi.org\/10.1021\/acsnano.4c05938.","journal-title":"ACS Nano"},{"key":"4438_CR53","doi-asserted-by":"publisher","first-page":"3983","DOI":"10.1021\/acs.nanolett.2c00540","volume":"22","author":"DY Hou","year":"2022","unstructured":"Hou DY, Wang MD, Zhang NY, Xu S, Wang ZJ, Hu XJ, et al. A lysosome-targeting self-condensation prodrug-nanoplatform system for addressing drug resistance of cancer. Nano Lett. 2022;22:3983\u201392. https:\/\/doi.org\/10.1021\/acs.nanolett.2c00540.","journal-title":"Nano Lett"},{"key":"4438_CR54","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202504798","volume":"37","author":"L Kong","year":"2025","unstructured":"Kong L, Xu K, Bao X, Ye K, Fan D, Wang N, et al. mTORC1 selective nano-inhibitor by disrupting the lysosomal arginine-SLC38A9- mTORC1-CDKs axis for precision bladder cancer therapy. Adv Mater. 2025;37:e2504798. https:\/\/doi.org\/10.1002\/adma.202504798.","journal-title":"Adv Mater"},{"key":"4438_CR55","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1021\/acsnano.3c09536","volume":"18","author":"H Song","year":"2024","unstructured":"Song H, Huang W, Jia F, Wang Z, Zhang J, Qian R, et al. Targeted degradation of signal transduction and activator of transcription 3 by chaperone-mediated autophagy targeting chimeric nanoplatform. ACS Nano. 2024;18:1599\u2013610. https:\/\/doi.org\/10.1021\/acsnano.3c09536.","journal-title":"ACS Nano"},{"key":"4438_CR56","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-025-01765-4","volume":"19","author":"S Li","year":"2025","unstructured":"Li S, Jin Y, Wu H, Yuan H, Zhao J. Recent advances in targeting protein degradation for tumor immunotherapy. J Hematol Oncol. 2025;19:5. https:\/\/doi.org\/10.1186\/s13045-025-01765-4.","journal-title":"J Hematol Oncol"},{"key":"4438_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41401-024-01364-y","volume":"46","author":"YY Li","year":"2025","unstructured":"Li YY, Yang Y, Zhang RS, Ge RX, Xie SB. Targeted degradation of membrane and extracellular proteins with LYTACs. Acta Pharmacol Sin. 2025;46:1\u20137. https:\/\/doi.org\/10.1038\/s41401-024-01364-y.","journal-title":"Acta Pharmacol Sin"},{"key":"4438_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2025.109426","volume":"552","author":"Y Zhang","year":"2025","unstructured":"Zhang Y, Liu H, Zhen W, Jiang T, Cui J. Advancement of drugs conjugated with GalNAc in the targeted delivery to hepatocytes based on asialoglycoprotein receptor. Carbohydr Res. 2025;552:109426. https:\/\/doi.org\/10.1016\/j.carres.2025.109426.","journal-title":"Carbohydr Res"},{"key":"4438_CR59","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.jconrel.2015.02.022","volume":"203","author":"AA D'Souza","year":"2015","unstructured":"D\u2019Souza AA, Devarajan PV. Asialoglycoprotein receptor mediated hepatocyte targeting - strategies and applications. J Control Release. 2015;203:126\u201339. https:\/\/doi.org\/10.1016\/j.jconrel.2015.02.022.","journal-title":"J Control Release"},{"key":"4438_CR60","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300288","volume":"10","author":"K Wang","year":"2023","unstructured":"Wang K, Yu A, Liu K, Feng C, Hou Y, Chen J, et al. Nano-LYTACs for degradation of membrane proteins and inhibition of CD24\/Siglec-10 signaling pathway. Adv Sci. 2023;10:e2300288. https:\/\/doi.org\/10.1002\/advs.202300288.","journal-title":"Adv Sci"},{"key":"4438_CR61","doi-asserted-by":"publisher","first-page":"3559","DOI":"10.1007\/s00259-024-06804-9","volume":"51","author":"J Du","year":"2024","unstructured":"Du J, Han S, Zhou H, Wang J, Wang F, Zhao M, Song R, Li K, Zhu H, Zhang W, Yang Z, Liu Z. Targeted protein degradation combined with PET imaging reveals the role of host PD-L1 in determining anti-PD-1 therapy efficacy. Eur J Nucl Med Mol Imaging. 2024;51:3559\u201371. https:\/\/doi.org\/10.1007\/s00259-024-06804-9.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"4438_CR62","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1038\/s41589-021-00770-1","volume":"17","author":"G Ahn","year":"2021","unstructured":"Ahn G, Banik SM, Miller CL, Riley NM, Cochran JR, Bertozzi CR. LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation. Nat Chem Biol. 2021;17:937\u201346. https:\/\/doi.org\/10.1038\/s41589-021-00770-1.","journal-title":"Nat Chem Biol"},{"key":"4438_CR63","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1396192","volume":"15","author":"NM Elemam","year":"2024","unstructured":"Elemam NM, Hotait HY, Saleh MA, El-Huneidi W, Talaat IM. Insulin-like growth factor family and prostate cancer: new insights and emerging opportunities. Front Endocrinol (Lausanne). 2024;15:1396192. https:\/\/doi.org\/10.3389\/fendo.2024.1396192.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"4438_CR64","doi-asserted-by":"publisher","first-page":"11573","DOI":"10.1021\/acs.nanolett.4c03102","volume":"24","author":"S Yu","year":"2024","unstructured":"Yu S, Shi T, Li C, Xie C, Wang F, Liu X. Programming DNA nanoassemblies into polyvalent lysosomal degraders for potent degradation of pathogenic membrane proteins. Nano Lett. 2024;24:11573\u201380. https:\/\/doi.org\/10.1021\/acs.nanolett.4c03102.","journal-title":"Nano Lett"},{"key":"4438_CR65","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.117871","volume":"296","author":"Y Li","year":"2025","unstructured":"Li Y, Song J, Ge R, Luo X, Zhou P, Lei H, et al. Targeting both wild-type EGFR and its drug-resistant mutants with erlotinib-aptamer conjugates. Eur J Med Chem. 2025;296:117871. https:\/\/doi.org\/10.1016\/j.ejmech.2025.117871.","journal-title":"Eur J Med Chem"},{"key":"4438_CR66","doi-asserted-by":"publisher","first-page":"9154","DOI":"10.1021\/acs.nanolett.2c03890","volume":"22","author":"R Qian","year":"2022","unstructured":"Qian R, Cao G, Su W, Zhang J, Jiang Y, Song H, et al. Enhanced sensitivity of tumor cells to autophagy inhibitors using fasting-mimicking diet and targeted lysosomal delivery nanoplatform. Nano Lett. 2022;22:9154\u201362. https:\/\/doi.org\/10.1021\/acs.nanolett.2c03890.","journal-title":"Nano Lett"},{"key":"4438_CR67","doi-asserted-by":"publisher","DOI":"10.1002\/pro.70051","volume":"34","author":"Y Pan","year":"2025","unstructured":"Pan Y, Xiang Q, Deng K, Anwar MI, Wang L, Wang Y, et al. Engineering IGF2 for lysosome-targeting chimeras development to target drug-resistant membrane proteins in tumor therapy. Protein Sci. 2025;34:e70051. https:\/\/doi.org\/10.1002\/pro.70051.","journal-title":"Protein Sci"},{"key":"4438_CR68","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1038\/s41589-025-01924-1","volume":"21","author":"D Xiao","year":"2025","unstructured":"Xiao D, Dong J, Xie F, Feng X, Wang J, Xu X, et al. Polyvalent folate receptor-targeting chimeras for degradation of membrane proteins. Nat Chem Biol. 2025;21:1731\u201341. https:\/\/doi.org\/10.1038\/s41589-025-01924-1.","journal-title":"Nat Chem Biol"},{"key":"4438_CR69","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1016\/j.apsb.2025.02.037","volume":"15","author":"Y Fang","year":"2025","unstructured":"Fang Y, Zhu Y, Wang W, Xia Z, He S, Dong G, Sheng C. GPC3-mediated lysosome-targeting chimeras (GLTACs) for targeted degradation of membrane proteins. Acta Pharm Sin B. 2025;15:2156\u201369. https:\/\/doi.org\/10.1016\/j.apsb.2025.02.037.","journal-title":"Acta Pharm Sin B"},{"key":"4438_CR70","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202511467","volume":"64","author":"S He","year":"2025","unstructured":"He S, Huang W, Zhu Y, Gao F, Fang Y, Zhu J, et al. HerTACs enable tumor-selective lysosomal degradation of membrane and extracellular proteins via HER2 trafficking. Angew Chem Int Ed. 2025;64:e202511467. https:\/\/doi.org\/10.1002\/anie.202511467.","journal-title":"Angew Chem Int Ed"},{"key":"4438_CR71","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202501222","volume":"12","author":"X Chang","year":"2025","unstructured":"Chang X, Qiu X, Tong X, Gan S, Yi W, Xie S, et al. Sortilin-mediated rapid, precise and sustained degradation of membrane proteins via mRNA-encoded lysosome-targeting chimera. Adv Sci (Weinh). 2025;12:e2501222. https:\/\/doi.org\/10.1002\/advs.202501222.","journal-title":"Adv Sci (Weinh)"},{"key":"4438_CR72","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202503134","volume":"12","author":"D Kim","year":"2025","unstructured":"Kim D, Yang G, Lim C, Park G, Lee J, Sim Y, et al. Cancer specific CAIX-targeting supramolecular lysosome-targeting chimeras (Supra-LYTAC) for targeted protein degradation. Adv Sci. 2025;12:e2503134. https:\/\/doi.org\/10.1002\/advs.202503134.","journal-title":"Adv Sci"},{"key":"4438_CR73","doi-asserted-by":"publisher","first-page":"17728","DOI":"10.1021\/jacs.4c02463","volume":"146","author":"J Luo","year":"2024","unstructured":"Luo J, Gao Q, Tan K, Zhang S, Shi W, Luo L, et al. Lysosome targeting chimaeras for Glut1-facilitated targeted protein degradation. J Am Chem Soc. 2024;146:17728\u201337. https:\/\/doi.org\/10.1021\/jacs.4c02463.","journal-title":"J Am Chem Soc"},{"key":"4438_CR74","doi-asserted-by":"publisher","first-page":"25490","DOI":"10.1021\/jacs.4c04794","volume":"146","author":"W Sun","year":"2024","unstructured":"Sun W, Zhang H, Xie W, Ma L, Dang Y, Liu Y, et al. Development of integrin-facilitated bispecific aptamer chimeras for membrane protein degradation. J Am Chem Soc. 2024;146:25490\u2013500. https:\/\/doi.org\/10.1021\/jacs.4c04794.","journal-title":"J Am Chem Soc"},{"key":"4438_CR75","doi-asserted-by":"publisher","first-page":"6864","DOI":"10.1021\/acs.nanolett.4c06279","volume":"25","author":"C Shi","year":"2025","unstructured":"Shi C, Su LY, Xu W, Wang S, Cao Y, Yao M, et al. Smartphone-manipulated mild-temperature photothermal control of the TfR-LYTAC platform for tumor treatment. Nano Lett. 2025;25:6864\u201371. https:\/\/doi.org\/10.1021\/acs.nanolett.4c06279.","journal-title":"Nano Lett"},{"key":"4438_CR76","doi-asserted-by":"publisher","first-page":"23553","DOI":"10.1021\/acsnano.4c07416","volume":"18","author":"H Lu","year":"2024","unstructured":"Lu H, Guan P, Xu S, Han Y, Liu Z. Boosting cancer immunotherapy via reversing PD-L1-mediated immunosuppression with a molecularly imprinted lysosomal nanodegrader. ACS Nano. 2024;18:23553\u201365. https:\/\/doi.org\/10.1021\/acsnano.4c07416.","journal-title":"ACS Nano"},{"key":"4438_CR77","doi-asserted-by":"publisher","first-page":"45951","DOI":"10.1021\/jacs.5c11823","volume":"147","author":"Z Zhang","year":"2025","unstructured":"Zhang Z, Qian H, Xu R, Duan Q, Wang Y, Fu T, et al. Chemical evolution of double covalent aptamers for sustained protein degradation and improved cytotoxicity in NK-cell-mediated tumor therapy. J Am Chem Soc. 2025;147:45951\u201365. https:\/\/doi.org\/10.1021\/jacs.5c11823.","journal-title":"J Am Chem Soc"},{"key":"4438_CR78","doi-asserted-by":"publisher","first-page":"46667","DOI":"10.1021\/acsami.5c09287","volume":"17","author":"Y Xu","year":"2025","unstructured":"Xu Y, Zhang Y, Song B, Liu Y, Hao Y, Duan Z, et al. A tumor-specific membrane protein degradation platform via covalent reaction-induced aggregation. ACS Appl Mater Interfaces. 2025;17:46667\u201379. https:\/\/doi.org\/10.1021\/acsami.5c09287.","journal-title":"ACS Appl Mater Interfaces"},{"key":"4438_CR79","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-56648-6","volume":"16","author":"Y Xiao","year":"2025","unstructured":"Xiao Y, He Z, Li W, Chen D, Niu X, Yang X, et al. A covalent peptide-based lysosome-targeting protein degradation platform for cancer immunotherapy. Nat Commun. 2025;16:1388. https:\/\/doi.org\/10.1038\/s41467-025-56648-6.","journal-title":"Nat Commun"},{"key":"4438_CR80","doi-asserted-by":"publisher","first-page":"20989","DOI":"10.1021\/jacs.5c05456","volume":"147","author":"R Zhang","year":"2025","unstructured":"Zhang R, Yang C, Gao X, He Z, Ji DK, Tan W. Phototriggered LYTAC: photoactive bispecific aptamer chimera enhances targeted degradation of membrane protein through regulating cell autophagy. J Am Chem Soc. 2025;147:20989\u20131002. https:\/\/doi.org\/10.1021\/jacs.5c05456.","journal-title":"J Am Chem Soc"},{"key":"4438_CR81","doi-asserted-by":"publisher","first-page":"7954","DOI":"10.1039\/d1cc02629a","volume":"57","author":"WY Li","year":"2021","unstructured":"Li WY, Zhao CW, Zhang YF, Guan Q, Wan JJ, Ma JP, et al. A metal-organic cage-based nanoagent for enhanced photodynamic antitumor therapy. Chem Commun (Camb). 2021;57:7954\u20137. https:\/\/doi.org\/10.1039\/d1cc02629a.","journal-title":"Chem Commun (Camb)"},{"key":"4438_CR82","doi-asserted-by":"publisher","first-page":"18164","DOI":"10.1021\/acsnano.4c16628","volume":"19","author":"Y Liu","year":"2025","unstructured":"Liu Y, Ran X, Zhou G, Liu Y, Tan W. Multivalent aptamer assembly enhances tumor-specific degradation of transforming growth factor-beta to remodel the stromal and immunosuppressive cancer microenvironment. ACS Nano. 2025;19:18164\u201375. https:\/\/doi.org\/10.1021\/acsnano.4c16628.","journal-title":"ACS Nano"},{"key":"4438_CR83","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2424500122","volume":"122","author":"W Xie","year":"2025","unstructured":"Xie W, Sun W, Li Q, Dang Y, Ma L, Liu Y, et al. Click-constructed modular signal aptamer chimeras enable receptor-independent degradation of membrane proteins. Proc Natl Acad Sci U S A. 2025;122:e2424500122. https:\/\/doi.org\/10.1073\/pnas.2424500122.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4438_CR84","doi-asserted-by":"publisher","first-page":"19107","DOI":"10.1021\/jacs.3c07687","volume":"145","author":"J Yu","year":"2023","unstructured":"Yu J, Li H, Fang T, Yun C, Liu X, Xu J, et al. Harnessing the lysosomal sorting signals of the cation-independent mannose-6-phosphate receptor for targeted degradation of membrane proteins. J Am Chem Soc. 2023;145:19107\u201319. https:\/\/doi.org\/10.1021\/jacs.3c07687.","journal-title":"J Am Chem Soc"},{"key":"4438_CR85","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1038\/s41586-024-07948-2","volume":"638","author":"B Huang","year":"2025","unstructured":"Huang B, Abedi M, Ahn G, Coventry B, Sappington I, Tang C, Wang R, Schlichthaerle T, Zhang JZ, Wang Y, Goreshnik I, Chiu CW, Chazin-Gray A, Chan S, Gerben S, Murray A, Wang S, O\u2019Neill J, Yi L, Yeh R, Misquith A, Wolf A, Tomasovic LM, Piraner DI, Duran Gonzalez MJ, Bennett NR, Venkatesh P, Ahlrichs M, Dobbins C, Yang W, Wang X, Sahtoe DD, Vafeados D, Mout R, Shivaei S, Cao L, Carter L, Stewart L, Spangler JB, Roybal KT, Greisen PJ, Li X, Bernardes GJL, Bertozzi CR, Baker D. Designed endocytosis-inducing proteins degrade targets and amplify signals. Nature. 2025;638:796\u2013804. https:\/\/doi.org\/10.1038\/s41586-024-07948-2.","journal-title":"Nature"},{"key":"4438_CR86","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202310039","volume":"20","author":"Y Fang","year":"2024","unstructured":"Fang Y, Zhang Y, Bi S, Peng B, Wang C, Ju H, et al. Securing LYTAC with logic-identification system for cancer cell-selective membrane protein degradation. Small. 2024;20:e2310039. https:\/\/doi.org\/10.1002\/smll.202310039.","journal-title":"Small"},{"key":"4438_CR87","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202520774","volume":"65","author":"H Dong","year":"2026","unstructured":"Dong H, Chu C, Ullah I, Xu Q, Pan Z, Yuan Y. Split-deliver-click: tumor-specific protein degradation via \u201cAND\u201d logic-gated in-cell bioorthogonal clicking of PROTACs. Angew Chem Int Ed Engl. 2026;65:e20774. https:\/\/doi.org\/10.1002\/anie.202520774.","journal-title":"Angew Chem Int Ed Engl"},{"key":"4438_CR88","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202423004","volume":"64","author":"Q Wang","year":"2025","unstructured":"Wang Q, Chang R, Li X, Zhang Y, Fan X, Shi L, et al. Logic-gated DNA intelligent nanorobots for cellular lysosome interference and enhanced therapeutics. Angew Chem Int Ed Engl. 2025;64:e202423004. https:\/\/doi.org\/10.1002\/anie.202423004.","journal-title":"Angew Chem Int Ed Engl"},{"key":"4438_CR89","doi-asserted-by":"publisher","first-page":"29609","DOI":"10.1021\/jacs.4c10010","volume":"146","author":"M Cui","year":"2024","unstructured":"Cui M, Zhang D, Zheng X, Zhai H, Xie M, Fan Q, et al. Intelligent modular DNA lysosome-targeting chimera nanodevice for precision tumor therapy. J Am Chem Soc. 2024;146:29609\u201320. https:\/\/doi.org\/10.1021\/jacs.4c10010.","journal-title":"J Am Chem Soc"},{"key":"4438_CR90","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202407986","volume":"63","author":"S Jiang","year":"2024","unstructured":"Jiang S, Lv X, Ouyang Z, Chi H, Zeng Y, Wang Y, et al. Programmable circular multivalent nanobody-targeting chimeras (mNbTACs) for multireceptor-mediated protein degradation and targeted drug delivery. Angew Chem Int Ed Engl. 2024;63:e202407986. https:\/\/doi.org\/10.1002\/anie.202407986.","journal-title":"Angew Chem Int Ed Engl"},{"key":"4438_CR91","doi-asserted-by":"publisher","first-page":"3118","DOI":"10.1039\/d3cc00168g","volume":"59","author":"W Lu","year":"2023","unstructured":"Lu W, Chen J, Guo Z, Ma Y, Gu Z, Liu Z. Targeted degradation of ABCG2 for reversing multidrug resistance by hypervalent bispecific gold nanoparticle-anchored aptamer chimeras. Chem Commun (Camb). 2023;59:3118\u201321. https:\/\/doi.org\/10.1039\/d3cc00168g.","journal-title":"Chem Commun (Camb)"},{"key":"4438_CR92","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202417942","volume":"37","author":"Y Xing","year":"2025","unstructured":"Xing Y, Li J, Wang L, Zhu Z, Yan J, Liu Y, et al. A bifunctional lysosome-targeting chimera nanoplatform for tumor-selective protein degradation and enhanced cancer immunotherapy. Adv Mater. 2025;37:e2417942. https:\/\/doi.org\/10.1002\/adma.202417942.","journal-title":"Adv Mater"},{"key":"4438_CR93","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116958","volume":"280","author":"K Wang","year":"2024","unstructured":"Wang K, Qi Z, Guo J, Shen G, Ni X, Jiang S, et al. Discovery of small molecules for autophagy-lysosome degradation of immune checkpoint proteins. Eur J Med Chem. 2024;280:116958. https:\/\/doi.org\/10.1016\/j.ejmech.2024.116958.","journal-title":"Eur J Med Chem"},{"key":"4438_CR94","doi-asserted-by":"publisher","first-page":"3644","DOI":"10.1016\/j.ymthe.2025.05.002","volume":"33","author":"Y Wang","year":"2025","unstructured":"Wang Y, Zhang G, Rong P, Guo P, Huang S, Hang Y, Wang P, Tang L, Li X, Tang X, Ding S, Huang X, Liu J, Sun L. Intrinsic\/proximal cell surface marker logic-gated extracellular targeted protein degradation in specific cell population. Mol Ther. 2025;33:3644\u201361. https:\/\/doi.org\/10.1016\/j.ymthe.2025.05.002.","journal-title":"Mol Ther"},{"key":"4438_CR95","doi-asserted-by":"publisher","first-page":"3253","DOI":"10.1039\/d3cs00344b","volume":"53","author":"J Kim","year":"2024","unstructured":"Kim J, Byun I, Kim DY, Joh H, Kim HJ, Lee MJ. Targeted protein degradation directly engaging lysosomes or proteasomes. Chem Soc Rev. 2024;53:3253\u201372. https:\/\/doi.org\/10.1039\/d3cs00344b.","journal-title":"Chem Soc Rev"},{"key":"4438_CR96","doi-asserted-by":"publisher","first-page":"4094","DOI":"10.1016\/j.msec.2013.05.056","volume":"33","author":"MC DeBrosse","year":"2013","unstructured":"DeBrosse MC, Comfort KK, Untener EA, Comfort DA, Hussain SM. High aspect ratio gold nanorods displayed augmented cellular internalization and surface chemistry mediated cytotoxicity. Mater Sci Eng C Mater Biol Appl. 2013;33:4094\u2013100. https:\/\/doi.org\/10.1016\/j.msec.2013.05.056.","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"4438_CR97","doi-asserted-by":"publisher","first-page":"9571","DOI":"10.1021\/acs.nanolett.3c03148","volume":"23","author":"T Wang","year":"2023","unstructured":"Wang T, Sun L, Ren T, Hou M, Long Y, Jiang JH, et al. Targeted protein degradation mediated by genetically engineered lysosome-targeting exosomes. Nano Lett. 2023;23:9571\u20138. https:\/\/doi.org\/10.1021\/acs.nanolett.3c03148.","journal-title":"Nano Lett"},{"key":"4438_CR98","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/s41565-024-01801-3","volume":"20","author":"Y Liu","year":"2025","unstructured":"Liu Y, Liu R, Dong J, Xia X, Yang H, Wei S, Fan L, Fang M, Zou Y, Zheng M, Leong KW, Shi B. Targeted protein degradation via cellular trafficking of nanoparticles. Nat Nanotechnol. 2025;20:296\u2013302. https:\/\/doi.org\/10.1038\/s41565-024-01801-3.","journal-title":"Nat Nanotechnol"},{"key":"4438_CR99","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202411061","volume":"37","author":"X Wang","year":"2025","unstructured":"Wang X, Chen S, Xia X, Du Y, Wei Y, Yang W, et al. Lysosome-targeting protein degradation through endocytosis pathway triggered by polyvalent nano-chimera for AD therapy. Adv Mater. 2025;37:e2411061. https:\/\/doi.org\/10.1002\/adma.202411061.","journal-title":"Adv Mater"},{"key":"4438_CR100","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1021\/acs.biochem.2c00310","volume":"62","author":"RR Paudel","year":"2023","unstructured":"Paudel RR, Lu D, Roy Chowdhury S, Monroy EY, Wang J. Targeted protein degradation via lysosomes. Biochemistry. 2023;62:564\u201379. https:\/\/doi.org\/10.1021\/acs.biochem.2c00310.","journal-title":"Biochemistry"},{"key":"4438_CR101","doi-asserted-by":"publisher","DOI":"10.1038\/srep24567","volume":"6","author":"X Liu","year":"2016","unstructured":"Liu X, Wu F, Tian Y, Wu M, Zhou Q, Jiang S, et al. Size dependent cellular uptake of rod-like bionanoparticles with different aspect ratios. Sci Rep. 2016;6:24567. https:\/\/doi.org\/10.1038\/srep24567.","journal-title":"Sci Rep"},{"key":"4438_CR102","doi-asserted-by":"publisher","first-page":"5483","DOI":"10.1002\/smll.201501284","volume":"11","author":"RH Fang","year":"2015","unstructured":"Fang RH, Kroll AV, Zhang L. Nanoparticle-based manipulation of antigen-presenting cells for cancer immunotherapy. Small. 2015;11:5483\u201396. https:\/\/doi.org\/10.1002\/smll.201501284.","journal-title":"Small"},{"key":"4438_CR103","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11121836","author":"JC Harris","year":"2019","unstructured":"Harris JC, Scully MA, Day ES. Cancer cell membrane-coated nanoparticles for cancer management. Cancers (Basel). 2019. https:\/\/doi.org\/10.3390\/cancers11121836.","journal-title":"Cancers (Basel)."},{"key":"4438_CR104","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1038\/s41401-024-01266-z","volume":"45","author":"ZF Zou","year":"2024","unstructured":"Zou ZF, Yang L, Nie HJ, Gao J, Lei SM, Lai Y, Zhang F, Wagner E, Yu HJ, Chen XH, Xu ZA. Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy. Acta Pharmacol Sin. 2024;45:1740\u201351. https:\/\/doi.org\/10.1038\/s41401-024-01266-z.","journal-title":"Acta Pharmacol Sin"},{"key":"4438_CR105","doi-asserted-by":"publisher","unstructured":"Zhao Y, Liao Y, Li P, de Gonzalez R. S., Chen X., Nieto N. S., Brunel F. M., Cox N., Stock J., McHenry M., Fu G., Huang P., Wu W., Cai D., Li L., Zaykov A. N., Tang W. Potent and Selective IGF-IIR-Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins. Adv Sci (Weinheim Baden-Wurttemberg Germany). 2026;e18793. https:\/\/doi.org\/10.1002\/advs.202518793.","DOI":"10.1002\/advs.202518793"},{"key":"4438_CR106","doi-asserted-by":"publisher","first-page":"8832","DOI":"10.1039\/d2cs00624c","volume":"51","author":"Y Ding","year":"2022","unstructured":"Ding Y, Xing D, Fei Y, Lu B. Emerging degrader technologies engaging lysosomal pathways. Chem Soc Rev. 2022;51:8832\u201376. https:\/\/doi.org\/10.1039\/d2cs00624c.","journal-title":"Chem Soc Rev"},{"key":"4438_CR107","doi-asserted-by":"publisher","first-page":"16573","DOI":"10.1039\/d5sc03783b","volume":"16","author":"S Dutta","year":"2025","unstructured":"Dutta S, Tripathy S, Bej S, Parvin S, Jana B, Patra CR, Das A. Esterase-induced release of a theranostic prodrug in lysosomes for improved therapeutic efficacy and lower systemic toxicity. Chem Sci. 2025;16:16573\u201383. https:\/\/doi.org\/10.1039\/d5sc03783b.","journal-title":"Chem Sci"},{"key":"4438_CR108","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114624","volume":"192","author":"Y Sun","year":"2023","unstructured":"Sun Y, Sha Y, Cui G, Meng F, Zhong Z. Lysosomal-mediated drug release and activation for cancer therapy and immunotherapy. Adv Drug Deliv Rev. 2023;192:114624. https:\/\/doi.org\/10.1016\/j.addr.2022.114624.","journal-title":"Adv Drug Deliv Rev"},{"key":"4438_CR109","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17070803","author":"J Wang","year":"2025","unstructured":"Wang J, Chen R, Xie Y, Qin X, Zhou Y, Xu C. Endo\/lysosomal-escapable lipid nanoparticle platforms for enhancing mRNA delivery in cancer therapy. Pharmaceutics. 2025. https:\/\/doi.org\/10.3390\/pharmaceutics17070803.","journal-title":"Pharmaceutics."},{"key":"4438_CR110","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2024.104070","volume":"29","author":"A Ahmad","year":"2024","unstructured":"Ahmad A, Khan JM, Paray BA, Rashid K, Parvez A. Endolysosomal trapping of therapeutics and endosomal escape strategies. Drug Discov Today. 2024;29:104070. https:\/\/doi.org\/10.1016\/j.drudis.2024.104070.","journal-title":"Drug Discov Today"},{"key":"4438_CR111","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.216728","volume":"587","author":"J Feng","year":"2024","unstructured":"Feng J, Wang ZX, Bin JL, Chen YX, Ma J, Deng JH, et al. Pharmacological approaches for targeting lysosomes to induce ferroptotic cell death in cancer. Cancer Lett. 2024;587:216728. https:\/\/doi.org\/10.1016\/j.canlet.2024.216728.","journal-title":"Cancer Lett"},{"key":"4438_CR112","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1549792","volume":"15","author":"MS Manivannan","year":"2025","unstructured":"Manivannan MS, Peters A, Gibson SB. Lysosome targeted therapies in hematological malignancies. Front Oncol. 2025;15:1549792. https:\/\/doi.org\/10.3389\/fonc.2025.1549792.","journal-title":"Front Oncol"},{"issue":"11","key":"4438_CR113","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202513649","volume":"22","author":"Q Xiang","year":"2026","unstructured":"Xiang Q, Zhang Y, Ren Y, Luo F, Wu Y, Ran H, et al. Unleashing the potent antitumor force: a reactive oxygen species (ROS) storm formation by ultrasound-activatable metal nanosonosensitizers. Small. 2026;e13649. https:\/\/doi.org\/10.1002\/smll.202513649.","journal-title":"Small"},{"key":"4438_CR114","doi-asserted-by":"publisher","first-page":"6123","DOI":"10.1039\/d3tb00236e","volume":"11","author":"E Pang","year":"2023","unstructured":"Pang E, Xing X, Zhao S, Tan Q, Pan T, Yu T, Gan Y, Wang B, Tan S, Zhang Y, Yin P, Song X, Lan M. Lysosome- and plasma membrane-accumulative and tumor-targetable polythiophene nanoparticles for enhanced sonodynamic therapy. J Mater Chem B. 2023;11:6123\u201330. https:\/\/doi.org\/10.1039\/d3tb00236e.","journal-title":"J Mater Chem B"},{"key":"4438_CR115","doi-asserted-by":"publisher","first-page":"5261","DOI":"10.7150\/thno.33183","volume":"9","author":"Y Liu","year":"2019","unstructured":"Liu Y, Bai L, Guo K, Jia Y, Zhang K, Liu Q, Wang P, Wang X. Focused ultrasound-augmented targeting delivery of nanosonosensitizers from homogenous exosomes for enhanced sonodynamic cancer therapy. Theranostics. 2019;9:5261\u201381. https:\/\/doi.org\/10.7150\/thno.33183.","journal-title":"Theranostics"},{"key":"4438_CR116","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101666","volume":"32","author":"M Yang","year":"2025","unstructured":"Yang M, Hu Y, Hao X, Chen Q, Cao Y, Ran H, et al. Ultrasound-actuated ion homeostasis perturbator for oxidative damage-augmented Ca(2+) interference therapy and combined immunotherapy. Mater Today Bio. 2025;32:101666. https:\/\/doi.org\/10.1016\/j.mtbio.2025.101666.","journal-title":"Mater Today Bio"},{"key":"4438_CR117","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1667812","volume":"16","author":"J Tao","year":"2025","unstructured":"Tao J, Yuan Z, Zhou M. Targeted photodynamic therapy: enhancing efficacy through specific organelle engagement. Front Pharmacol. 2025;16:1667812. https:\/\/doi.org\/10.3389\/fphar.2025.1667812.","journal-title":"Front Pharmacol"},{"key":"4438_CR118","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300752","volume":"12","author":"M He","year":"2023","unstructured":"He M, Cheng Z, Wang Z, Li M, Liang H, Liu H, et al. Controllable regulation of Ag(2) S quantum-dot-mediated protein nanoassemblies for imaging-guided synergistic PDT\/PTT\/chemotherapy against hypoxic tumor. Adv Healthc Mater. 2023;12:e2300752. https:\/\/doi.org\/10.1002\/adhm.202300752.","journal-title":"Adv Healthc Mater"},{"key":"4438_CR119","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202203309","volume":"34","author":"J Qi","year":"2022","unstructured":"Qi J, Jia S, Kang X, Wu X, Hong Y, Shan K, et al. Semiconducting polymer nanoparticles with surface-mimicking protein secondary structure as lysosome-targeting chimaeras for self-synergistic cancer immunotherapy. Adv Mater. 2022;34:e2203309. https:\/\/doi.org\/10.1002\/adma.202203309.","journal-title":"Adv Mater"},{"key":"4438_CR120","doi-asserted-by":"publisher","first-page":"14709","DOI":"10.1021\/acs.nanolett.4c03913","volume":"24","author":"T Chen","year":"2024","unstructured":"Chen T, Liang K, Wang J, Li J, Xue X, Hao Y, et al. An aged tree with a new bloom: a simple spatiotemporal programming strategy enables carbon dot photosensitizers to regulate cell pyroptosis for enhanced tumor photodynamic-immunotherapy. Nano Lett. 2024;24:14709\u201319. https:\/\/doi.org\/10.1021\/acs.nanolett.4c03913.","journal-title":"Nano Lett"},{"key":"4438_CR121","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.4c03937","author":"Y Chen","year":"2024","unstructured":"Chen Y, Liu X, Guo Y, Liu S, Wang J, He X, et al. Tiny pH-resolved DNA nanospheres for cellular pyroptosis or apoptosis regulation. Nano Lett. 2024. https:\/\/doi.org\/10.1021\/acs.nanolett.4c03937.","journal-title":"Nano Lett"},{"key":"4438_CR122","doi-asserted-by":"publisher","first-page":"7438","DOI":"10.1021\/acsnano.5c14676","volume":"20","author":"P Jiang","year":"2026","unstructured":"Jiang P, Wang L, Jiang R, Zeng R, Huang W, Mao G, et al. A type I\/II photosensitizer with lysosome-targeting capabilities induces immunogenic cell death in cancer cells to enhance tumor immunotherapy. ACS Nano. 2026;20:7438\u201353. https:\/\/doi.org\/10.1021\/acsnano.5c14676.","journal-title":"ACS Nano"},{"key":"4438_CR123","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.jconrel.2017.11.050","volume":"270","author":"P Clerc","year":"2018","unstructured":"Clerc P, Jeanjean P, Hallali N, Gougeon M, Pipy B, Carrey J, et al. Targeted magnetic intra-lysosomal hyperthermia produces lysosomal reactive oxygen species and causes Caspase-1 dependent cell death. J Control Release. 2018;270:120\u201334. https:\/\/doi.org\/10.1016\/j.jconrel.2017.11.050.","journal-title":"J Control Release"},{"key":"4438_CR124","doi-asserted-by":"publisher","DOI":"10.3390\/nano8070468","author":"D El Hajj Diab","year":"2018","unstructured":"El Hajj Diab D, Clerc P, Serhan N, Fourmy D, Gigoux V. Combined treatments of magnetic intra-lysosomal hyperthermia with doxorubicin promotes synergistic anti-tumoral activity. Nanomaterials. 2018. https:\/\/doi.org\/10.3390\/nano8070468.","journal-title":"Nanomaterials"},{"key":"4438_CR125","doi-asserted-by":"publisher","first-page":"8790","DOI":"10.1039\/d1nr01547h","volume":"13","author":"H Wang","year":"2021","unstructured":"Wang H, Zhang H, Xiang Y, Pan W, Li N, Tang B. An efficient strategy for cancer therapy using a tumor- and lysosome-targeted organic photothermal agent. Nanoscale. 2021;13:8790\u20134. https:\/\/doi.org\/10.1039\/d1nr01547h.","journal-title":"Nanoscale"},{"key":"4438_CR126","doi-asserted-by":"publisher","first-page":"9859","DOI":"10.1021\/acsnano.5b05138","volume":"9","author":"H Lee","year":"2015","unstructured":"Lee H, Dam DH, Ha JW, Yue J, Odom TW. Enhanced human epidermal growth factor receptor 2 degradation in breast cancer cells by lysosome-targeting gold nanoconstructs. ACS Nano. 2015;9:9859\u201367. https:\/\/doi.org\/10.1021\/acsnano.5b05138.","journal-title":"ACS Nano"},{"key":"4438_CR127","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202410841","author":"W Xiong","year":"2024","unstructured":"Xiong W, Cheng Z, Chen H, Liang H, Wang M, Chen Y, et al. Biomimetic tumor cell membrane-encapsulated nanoparticles combine NIR\u2010II photothermal therapy and chemotherapy for enhanced immunotherapy in triple\u2010negative breast cancer. Adv Funct Mater. 2024. https:\/\/doi.org\/10.1002\/adfm.202410841.","journal-title":"Adv Funct Mater"},{"key":"4438_CR128","doi-asserted-by":"publisher","first-page":"4863","DOI":"10.2147\/IJN.S511655","volume":"20","author":"M Baldan","year":"2025","unstructured":"Baldan M, Zhang S, Sun Q, Su Y, Mei D, Sun R, et al. NIR-triggered siRNA release and lysosomal escape for synergistic photothermal tumor therapy. Int J Nanomed. 2025;20:4863\u201382. https:\/\/doi.org\/10.2147\/IJN.S511655.","journal-title":"Int J Nanomed"},{"key":"4438_CR129","doi-asserted-by":"publisher","first-page":"2661","DOI":"10.1021\/acs.nanolett.4c00347","volume":"24","author":"Z Wang","year":"2024","unstructured":"Wang Z, Ge Y, Liu J, Shi P, Xue R, Hao B, et al. Integrating a biomineralized nanocluster for H(2)S-sensitized ROS bomb against breast cancer. Nano Lett. 2024;24:2661\u201370. https:\/\/doi.org\/10.1021\/acs.nanolett.4c00347.","journal-title":"Nano Lett"},{"key":"4438_CR130","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202412227","volume":"36","author":"Z Hu","year":"2024","unstructured":"Hu Z, Tan H, Ye Y, Xu W, Gao J, Liu L, et al. NIR-actuated ferroptosis nanomotor for enhanced tumor penetration and therapy. Adv Mater. 2024;36:e2412227. https:\/\/doi.org\/10.1002\/adma.202412227.","journal-title":"Adv Mater"},{"key":"4438_CR131","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-025-02400-z","volume":"24","author":"K Mandal","year":"2025","unstructured":"Mandal K, Barik GK, Santra MK. Overcoming resistance to anti-PD-L1 immunotherapy: mechanisms, combination strategies, and future directions. Mol Cancer. 2025;24:246. https:\/\/doi.org\/10.1186\/s12943-025-02400-z.","journal-title":"Mol Cancer"},{"key":"4438_CR132","doi-asserted-by":"publisher","DOI":"10.3390\/nano10040679","author":"BM Strauch","year":"2020","unstructured":"Strauch BM, Hubele W, Hartwig A. Impact of endocytosis and lysosomal acidification on the toxicity of copper oxide nano- and microsized particles: uptake and gene expression related to oxidative stress and the DNA damage response. Nanomaterials. 2020. https:\/\/doi.org\/10.3390\/nano10040679.","journal-title":"Nanomaterials"},{"key":"4438_CR133","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.actbio.2021.05.010","volume":"132","author":"A Hirota","year":"2021","unstructured":"Hirota A, AlMusawi S, Nateri AS, Ordonez-Moran P, Imajo M. Biomaterials for intestinal organoid technology and personalized disease modeling. Acta Biomater. 2021;132:272\u201387. https:\/\/doi.org\/10.1016\/j.actbio.2021.05.010.","journal-title":"Acta Biomater"},{"key":"4438_CR134","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.tcb.2023.01.001","volume":"33","author":"H Yang","year":"2023","unstructured":"Yang H, Tan JX. Lysosomal quality control: molecular mechanisms and therapeutic implications. Trends Cell Biol. 2023;33:749\u201364. https:\/\/doi.org\/10.1016\/j.tcb.2023.01.001.","journal-title":"Trends Cell Biol"},{"key":"4438_CR135","doi-asserted-by":"publisher","first-page":"3740","DOI":"10.1080\/15548627.2021.1896906","volume":"17","author":"SJ Jeong","year":"2021","unstructured":"Jeong SJ, Stitham J, Evans TD, Zhang X, Rodriguez-Velez A, Yeh YS, Tao J, Takabatake K, Epelman S, Lodhi IJ, Schilling JD, DeBosch BJ, Diwan A, Razani B. Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response. Autophagy. 2021;17:3740\u201352. https:\/\/doi.org\/10.1080\/15548627.2021.1896906.","journal-title":"Autophagy"},{"key":"4438_CR136","doi-asserted-by":"publisher","DOI":"10.3390\/cells11193153","author":"B Franco-Ju\u00e1rez","year":"2022","unstructured":"Franco-Ju\u00e1rez B, Coronel-Cruz C, Hern\u00e1ndez-Ochoa B, G\u00f3mez-Manzo S, C\u00e1rdenas-Rodr\u00edguez N, Arreguin-Espinosa R, et al. TFEB; beyond its role as an autophagy and lysosomes regulator. Cells. 2022. https:\/\/doi.org\/10.3390\/cells11193153.","journal-title":"Cells."},{"key":"4438_CR137","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115698","volume":"215","author":"L Zhang","year":"2023","unstructured":"Zhang L, Li Z, Zhang L, Qin Y, Yu D. Dissecting the multifaced function of transcription factor EB (TFEB) in human diseases: from molecular mechanism to pharmacological modulation. Biochem Pharmacol. 2023;215:115698. https:\/\/doi.org\/10.1016\/j.bcp.2023.115698.","journal-title":"Biochem Pharmacol"},{"key":"4438_CR138","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16060795","author":"Y Moon","year":"2024","unstructured":"Moon Y, Cho H, Kim K. Nano-delivery of immunogenic cell death inducers and immune checkpoint blockade agents: single-nanostructure strategies for enhancing immunotherapy. Pharmaceutics. 2024. https:\/\/doi.org\/10.3390\/pharmaceutics16060795.","journal-title":"Pharmaceutics"},{"key":"4438_CR139","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1016\/j.cmet.2024.06.014","volume":"36","author":"C Vernieri","year":"2024","unstructured":"Vernieri C, Ligorio F, Tripathy D, Longo VD. Cyclic fasting-mimicking diet in cancer treatment: preclinical and clinical evidence. Cell Metab. 2024;36:1644\u201367. https:\/\/doi.org\/10.1016\/j.cmet.2024.06.014.","journal-title":"Cell Metab"},{"key":"4438_CR140","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/nrm2217","volume":"8","author":"JP Luzio","year":"2007","unstructured":"Luzio JP, Pryor PR, Bright NA. Lysosomes: fusion and function. Nat Rev Mol Cell Biol. 2007;8:622\u201332. https:\/\/doi.org\/10.1038\/nrm2217.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4438_CR141","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1038\/nrm1985","volume":"7","author":"JS Bonifacino","year":"2006","unstructured":"Bonifacino JS, Rojas R. Retrograde transport from endosomes to the trans-Golgi network. Nat Rev Mol Cell Biol. 2006;7:568\u201379. https:\/\/doi.org\/10.1038\/nrm1985.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4438_CR142","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s41580-019-0180-9","volume":"21","author":"WA Prinz","year":"2020","unstructured":"Prinz WA, Toulmay A, Balla T. The functional universe of membrane contact sites. Nat Rev Mol Cell Biol. 2020;21:7\u201324. https:\/\/doi.org\/10.1038\/s41580-019-0180-9.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4438_CR143","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/nature25486","volume":"554","author":"YC Wong","year":"2018","unstructured":"Wong YC, Ysselstein D, Krainc D. Mitochondria-lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis. Nature. 2018;554:382\u20136. https:\/\/doi.org\/10.1038\/nature25486.","journal-title":"Nature"},{"key":"4438_CR144","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/nbt.3330","volume":"33","author":"E Blanco","year":"2015","unstructured":"Blanco E, Shen H, Ferrari M. Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat Biotechnol. 2015;33:941\u201351. https:\/\/doi.org\/10.1038\/nbt.3330.","journal-title":"Nat Biotechnol"},{"key":"4438_CR145","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.ejpb.2021.02.010","volume":"161","author":"S Patnaik","year":"2021","unstructured":"Patnaik S, Gorain B, Padhi S, Choudhury H, Gabr GA, Md S, et al. Recent update of toxicity aspects of nanoparticulate systems for drug delivery. Eur J Pharm Biopharm. 2021;161:100\u201319. https:\/\/doi.org\/10.1016\/j.ejpb.2021.02.010.","journal-title":"Eur J Pharm Biopharm"},{"key":"4438_CR146","doi-asserted-by":"publisher","first-page":"7062","DOI":"10.1021\/acsabm.4c00913","volume":"7","author":"R Ghosh","year":"2024","unstructured":"Ghosh R, Pathan S, Jayakannan M. Structural engineering of cationic block copolymer architectures for selective breaching of prokaryotic and eukaryotic biological species. ACS Appl Bio Mater. 2024;7:7062\u201375. https:\/\/doi.org\/10.1021\/acsabm.4c00913.","journal-title":"ACS Appl Bio Mater"},{"key":"4438_CR147","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1038\/nnano.2017.233","volume":"12","author":"A Tropsha","year":"2017","unstructured":"Tropsha A, Mills KC, Hickey AJ. Reproducibility, sharing and progress in nanomaterial databases. Nat Nanotechnol. 2017;12:1111\u20134. https:\/\/doi.org\/10.1038\/nnano.2017.233.","journal-title":"Nat Nanotechnol"},{"key":"4438_CR148","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14091940","author":"K Osouli-Bostanabad","year":"2022","unstructured":"Osouli-Bostanabad K, Puliga S, Serrano DR, Bucchi A, Halbert G, Lalatsa A. Microfluidic manufacture of lipid-based nanomedicines. Pharmaceutics. 2022. https:\/\/doi.org\/10.3390\/pharmaceutics14091940.","journal-title":"Pharmaceutics"},{"key":"4438_CR149","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2026.124001","volume":"330","author":"L Li","year":"2026","unstructured":"Li L, Liu A, Wang Z, Liang H, Whittake AK, Guo H, et al. Biomimetic cascade \u201cfour-in-one\u201d nanozyme for remodeling the redox tumor microenvironment and disrupting energy homeostasis to enhance ferroptosis against triple-negative breast cancer. Biomaterials. 2026;330:124001. https:\/\/doi.org\/10.1016\/j.biomaterials.2026.124001.","journal-title":"Biomaterials"},{"key":"4438_CR150","doi-asserted-by":"publisher","first-page":"20167","DOI":"10.1021\/acsnano.3c05872","volume":"17","author":"M Dolci","year":"2023","unstructured":"Dolci M, Wang Y, Nooteboom SW, Soto Rodriguez PED, Sanchez S, Albertazzi L, et al. Real-time optical tracking of protein corona formation on single nanoparticles in serum. ACS Nano. 2023;17:20167\u201378. https:\/\/doi.org\/10.1021\/acsnano.3c05872.","journal-title":"ACS Nano"},{"key":"4438_CR151","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202308924","volume":"11","author":"Q Duan","year":"2024","unstructured":"Duan Q, Jia HR, Chen W, Qin C, Zhang K, Jia F, et al. Multivalent aptamer-based lysosome-targeting chimeras (LYTACs) platform for mono- or dual-targeted proteins degradation on cell surface. Adv Sci (Weinh). 2024;11:e2308924. https:\/\/doi.org\/10.1002\/advs.202308924.","journal-title":"Adv Sci (Weinh)"},{"key":"4438_CR152","doi-asserted-by":"publisher","first-page":"24895","DOI":"10.1021\/acsnano.5c03556","volume":"19","author":"H Zhu","year":"2025","unstructured":"Zhu H, Zhang G, Ning Y, Zhang Y, Wu Y, Li J, et al. Tetrahedral deoxyribonucleic acid-engineered multivalent lysosome-targeting chimera for enhanced and dual membrane protein degradation. ACS Nano. 2025;19:24895\u2013903. https:\/\/doi.org\/10.1021\/acsnano.5c03556.","journal-title":"ACS Nano"},{"key":"4438_CR153","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202425051","volume":"64","author":"T Xie","year":"2025","unstructured":"Xie T, Zhang Y, Ling N, Yuan Y, Liu W, Guo J, et al. Aptamer as a molecular tethering agent induces PrP(C) aggregation and degradation to inhibit melanoma proliferation. Angew Chem Int Ed Engl. 2025;64:e202425051. https:\/\/doi.org\/10.1002\/anie.202425051.","journal-title":"Angew Chem Int Ed Engl"},{"key":"4438_CR154","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124231","volume":"658","author":"Z Xu","year":"2024","unstructured":"Xu Z, Lin H, Dai J, Wen X, Yu X, Xu C, et al. Protein-nanoparticle co-assembly supraparticles for drug delivery: ultrahigh drug loading and colloidal stability, and instant and complete lysosomal drug release. Int J Pharm. 2024;658:124231. https:\/\/doi.org\/10.1016\/j.ijpharm.2024.124231.","journal-title":"Int J Pharm"},{"issue":"8","key":"4438_CR155","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202518041","volume":"38","author":"S Chen","year":"2025","unstructured":"Chen S, Wu C, Wang D, Zhuang J, Li Z, Li B, et al. Lock-and-shield strategy enables stable and stimuli-responsive tumor-targeted gene delivery. Adv Mater. 2025;e18041. https:\/\/doi.org\/10.1002\/adma.202518041.","journal-title":"Adv Mater"},{"key":"4438_CR156","doi-asserted-by":"publisher","first-page":"4862","DOI":"10.1021\/acsami.1c19022","volume":"14","author":"B Roy","year":"2022","unstructured":"Roy B, Mengji R, Roy S, Pal B, Jana A, Singh NDP. Lysosomotropic phototrigger: an AIE\u2009+\u2009ESIPT active naphthalene-based single-component photoresponsive nanocarrier with two-photon uncaging and real-time monitoring ability. ACS Appl Mater Interfaces. 2022;14:4862\u201370. https:\/\/doi.org\/10.1021\/acsami.1c19022.","journal-title":"ACS Appl Mater Interfaces"},{"key":"4438_CR157","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1039\/d4cs01095g","volume":"54","author":"A Cumberworth","year":"2025","unstructured":"Cumberworth A, Reinhardt A. Models and simulations of structural DNA nanotechnology reveal fundamental principles of self-assembly. Chem Soc Rev. 2025;54:2344\u201368. https:\/\/doi.org\/10.1039\/d4cs01095g.","journal-title":"Chem Soc Rev"},{"key":"4438_CR158","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2023.103045","volume":"85","author":"F Tong","year":"2024","unstructured":"Tong F, Wang Y, Gao H. Progress and challenges in the translation of cancer nanomedicines. Curr Opin Biotechnol. 2024;85:103045. https:\/\/doi.org\/10.1016\/j.copbio.2023.103045.","journal-title":"Curr Opin Biotechnol"},{"key":"4438_CR159","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.125202","volume":"671","author":"X Zhang","year":"2025","unstructured":"Zhang X, Chan HW, Shao Z, Wang Q, Chow S, Chow SF. Navigating translational research in nanomedicine: a strategic guide to formulation and manufacturing. Int J Pharm. 2025;671:125202. https:\/\/doi.org\/10.1016\/j.ijpharm.2025.125202.","journal-title":"Int J Pharm"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-026-04438-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-026-04438-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-026-04438-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:41:53Z","timestamp":1779669713000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12951-026-04438-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,14]]},"references-count":159,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4438"],"URL":"https:\/\/doi.org\/10.1186\/s12951-026-04438-7","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,14]]},"assertion":[{"value":"2 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"471"}}