{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:34:39Z","timestamp":1787020479044,"version":"build-2736575974"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":49,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["22575150"],"award-info":[{"award-number":["22575150"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["22375126"],"award-info":[{"award-number":["22375126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82272674"],"award-info":[{"award-number":["82272674"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medicine Engineering joint foundation of Shanghai Jiao Tong University","award":["YG2024ZD15"],"award-info":[{"award-number":["YG2024ZD15"]}]},{"name":"Outstanding Youth Foundation of Heilongjiang Provincial Natural Science Foundation","award":["YQ2023H010"],"award-info":[{"award-number":["YQ2023H010"]}]},{"name":"Research Project of the First Affiliated Hospital of Harbin Medical University","award":["2021J04"],"award-info":[{"award-number":["2021J04"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"DOI":"10.1186\/s12951-026-04469-0","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:35:37Z","timestamp":1777455337000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biomimetic PD-1 macrophage nanoplatform for Cip2a silencing and immune activation in oral squamous cell carcinoma"],"prefix":"10.1186","volume":"24","author":[{"given":"Chenyu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizhu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dali","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"4469_CR1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.70048","author":"H Rumgay","year":"2026","unstructured":"Rumgay H, Colombet M, Ramos da Cunha A, et al. Global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2022. CA Cancer J Clin. 2026. https:\/\/doi.org\/10.3322\/caac.70048.","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"4469_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-023-00532-4","volume":"9","author":"L Sun","year":"2023","unstructured":"Sun L, Kang X, Wang C, et al. Single-cell and spatial dissection of precancerous lesions underlying the initiation process of oral squamous cell carcinoma. Cell Discov. 2023;9(1):28. https:\/\/doi.org\/10.1038\/s41421-023-00532-4.","journal-title":"Cell Discov"},{"key":"4469_CR3","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.semcancer.2019.09.011","volume":"61","author":"AWY Chai","year":"2020","unstructured":"Chai AWY, Lim KP, Cheong SC. Translational genomics and recent advances in oral squamous cell carcinoma. Semin Cancer Biol. 2020;61:71\u201383. https:\/\/doi.org\/10.1016\/j.semcancer.2019.09.011.","journal-title":"Semin Cancer Biol"},{"issue":"1","key":"4469_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-025-02487-4","volume":"24","author":"B Zhang","year":"2025","unstructured":"Zhang B, Tan H, Kuang J, et al. Neoadjuvant immunotherapy in squamous cell carcinoma of the head and neck: current evidence and future perspectives. Mol Cancer. 2025;24(1):284. https:\/\/doi.org\/10.1186\/s12943-025-02487-4.","journal-title":"Mol Cancer"},{"issue":"1","key":"4469_CR5","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/s41577-019-0218-4","volume":"20","author":"A Kalbasi","year":"2020","unstructured":"Kalbasi A, Ribas A. Tumour-intrinsic resistance to immune checkpoint blockade. Nat Rev Immunol. 2020;20(1):25\u201339. https:\/\/doi.org\/10.1038\/s41577-019-0218-4.","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"4469_CR6","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.semcancer.2018.01.008","volume":"52","author":"B Solomon","year":"2018","unstructured":"Solomon B, Young RJ, Rischin D. Head and neck squamous cell carcinoma: genomics and emerging biomarkers for immunomodulatory cancer treatments. Semin Cancer Biol. 2018;52(2):228\u201340. https:\/\/doi.org\/10.1016\/j.semcancer.2018.01.008.","journal-title":"Semin Cancer Biol"},{"issue":"1","key":"4469_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-021-01489-2","volume":"21","author":"M Yi","year":"2022","unstructured":"Yi M, Zheng X, Niu M, et al. Combination strategies with PD-1\/PD-L1 blockade: current advances and future directions. Mol Cancer. 2022;21(1):28. https:\/\/doi.org\/10.1186\/s12943-021-01489-2.","journal-title":"Mol Cancer"},{"issue":"1","key":"4469_CR8","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.cell.2007.04.044","volume":"130","author":"MR Junttila","year":"2007","unstructured":"Junttila MR, Puustinen P, Niemel\u00e4 M, et al. CIP2A inhibits PP2A in human malignancies. Cell. 2007;130(1):51\u201362. https:\/\/doi.org\/10.1016\/j.cell.2007.04.044.","journal-title":"Cell"},{"issue":"7","key":"4469_CR9","doi-asserted-by":"publisher","first-page":"694","DOI":"10.4161\/cbt.10.7.12895","volume":"10","author":"J Katz","year":"2010","unstructured":"Katz J, Jakymiw A, Ducksworth MK, et al. CIP2A expression and localization in oral carcinoma and dysplasia. Cancer Biol Ther. 2010;10(7):694\u20139. https:\/\/doi.org\/10.4161\/cbt.10.7.12895.","journal-title":"Cancer Biol Ther"},{"issue":"7967","key":"4469_CR10","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1038\/s41586-023-06216-z","volume":"618","author":"P Trivedi","year":"2023","unstructured":"Trivedi P, Steele CD, Au FKC, et al. Mitotic tethering enables inheritance of shattered micronuclear chromosomes. Nature. 2023;618(7967):1049\u201356. https:\/\/doi.org\/10.1038\/s41586-023-06216-z.","journal-title":"Nature"},{"issue":"1","key":"4469_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36693-9","volume":"14","author":"K Pavic","year":"2023","unstructured":"Pavic K, Gupta N, Omella JD, et al. Structural mechanism for inhibition of PP2A-B56\u03b1 and oncogenicity by CIP2A. Nat Commun. 2023;14(1):1143. https:\/\/doi.org\/10.1038\/s41467-023-36693-9.","journal-title":"Nat Commun"},{"issue":"12","key":"4469_CR12","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1038\/bjc.2011.167","volume":"104","author":"C B\u00f6ckelman","year":"2011","unstructured":"B\u00f6ckelman C, Hagstr\u00f6m J, M\u00e4kinen LK, et al. High CIP2A immunoreactivity is an independent prognostic indicator in early-stage tongue cancer. Br J Cancer. 2011;104(12):1890\u20135. https:\/\/doi.org\/10.1038\/bjc.2011.167.","journal-title":"Br J Cancer"},{"issue":"15","key":"4469_CR13","doi-asserted-by":"publisher","first-page":"4092","DOI":"10.1158\/1078-0432.Ccr-12-3439","volume":"19","author":"WW Sung","year":"2013","unstructured":"Sung WW, Wang YC, Lin PL, et al. IL-10 promotes tumor aggressiveness via upregulation of CIP2A transcription in lung adenocarcinoma. Clin Cancer Res. 2013;19(15):4092\u2013103. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-12-3439.","journal-title":"Clin Cancer Res"},{"issue":"12","key":"4469_CR14","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1038\/s43018-021-00266-w","volume":"2","author":"S Adam","year":"2021","unstructured":"Adam S, Rossi SE, Moatti N, et al. The CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer. Nat Cancer. 2021;2(12):1357\u201371. https:\/\/doi.org\/10.1038\/s43018-021-00266-w.","journal-title":"Nat Cancer"},{"issue":"22","key":"4469_CR15","doi-asserted-by":"publisher","first-page":"6548","DOI":"10.1158\/0008-5472.CAN-13-1994","volume":"73","author":"A Khanna","year":"2013","unstructured":"Khanna A, Pimanda JE, Westermarck J. Cancerous inhibitor of protein phosphatase 2A, an emerging human oncoprotein and a potential cancer therapy target. Cancer Res. 2013;73(22):6548-53. https:\/\/doi.org\/10.1158\/0008-5472.CAN-13-1994","journal-title":"Cancer Res."},{"issue":"1","key":"4469_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0207-x","volume":"5","author":"B Hu","year":"2020","unstructured":"Hu B, Zhong L, Weng Y, et al. Therapeutic siRNA: state of the art. Signal Transduct Target Ther. 2020;5(1):101. https:\/\/doi.org\/10.1038\/s41392-020-0207-x.","journal-title":"Signal Transduct Target Ther"},{"issue":"2","key":"4469_CR17","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aav9322","volume":"5","author":"D Wang","year":"2019","unstructured":"Wang D, Lin J, Jia F, et al. Bottlebrush-architectured poly(ethylene glycol) as an efficient vector for RNA interference in vivo. Sci Adv. 2019;5(2):eaav9322. https:\/\/doi.org\/10.1126\/sciadv.aav9322.","journal-title":"Sci Adv"},{"issue":"1","key":"4469_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-02035-4","volume":"9","author":"X Sun","year":"2024","unstructured":"Sun X, Setrerrahmane S, Li C, et al. Nucleic acid drugs: recent progress and future perspectives. Signal Transduct Target Ther. 2024;9(1):316. https:\/\/doi.org\/10.1038\/s41392-024-02035-4.","journal-title":"Signal Transduct Target Ther"},{"issue":"3","key":"4469_CR19","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1021\/polymscitech.5c00010","volume":"1","author":"Y Xu","year":"2025","unstructured":"Xu Y, Chen J, Ding J, et al. Synthetic polymers for drug, gene, and vaccine delivery. Polymer Science & Technology. 2025;1(3):171\u2013220. https:\/\/doi.org\/10.1021\/polymscitech.5c00010.","journal-title":"Polymer Science & Technology"},{"issue":"1","key":"4469_CR20","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41571-022-00699-x","volume":"20","author":"RH Fang","year":"2023","unstructured":"Fang RH, Gao W, Zhang L. Targeting drugs to tumours using cell membrane-coated nanoparticles. Nat Rev Clin Oncol. 2023;20(1):33\u201348. https:\/\/doi.org\/10.1038\/s41571-022-00699-x.","journal-title":"Nat Rev Clin Oncol"},{"issue":"23","key":"4469_CR21","doi-asserted-by":"publisher","first-page":"23746","DOI":"10.1021\/acsnano.3c07555","volume":"17","author":"Z Cao","year":"2023","unstructured":"Cao Z, Liu X, Zhang W, et al. Biomimetic macrophage membrane-camouflaged nanoparticles induce ferroptosis by promoting mitochondrial damage in glioblastoma. ACS Nano. 2023;17(23):23746\u201360. https:\/\/doi.org\/10.1021\/acsnano.3c07555.","journal-title":"ACS Nano"},{"issue":"40","key":"4469_CR22","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202002054","volume":"32","author":"Y Xia","year":"2020","unstructured":"Xia Y, Rao L, Yao H, et al. Engineering macrophages for cancer immunotherapy and drug delivery. Adv Mater. 2020;32(40):e2002054. https:\/\/doi.org\/10.1002\/adma.202002054.","journal-title":"Adv Mater"},{"key":"4469_CR23","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.bioactmat.2022.06.013","volume":"20","author":"K Ying","year":"2023","unstructured":"Ying K, Zhu Y, Wan J, et al. Macrophage membrane-biomimetic adhesive polycaprolactone nanocamptothecin for improving cancer-targeting efficiency and impairing metastasis. Bioact Mater. 2023;20:449\u201362. https:\/\/doi.org\/10.1016\/j.bioactmat.2022.06.013.","journal-title":"Bioact Mater"},{"issue":"10","key":"4469_CR24","doi-asserted-by":"publisher","first-page":"4823","DOI":"10.7150\/thno.108875","volume":"15","author":"M Khan","year":"2025","unstructured":"Khan M, Ullah R, Wang G, et al. Macrophage membrane-functionalized nanotherapeutics for tumor targeted therapy. Theranostics. 2025;15(10):4823\u201347. https:\/\/doi.org\/10.7150\/thno.108875.","journal-title":"Theranostics"},{"issue":"29","key":"4469_CR25","doi-asserted-by":"publisher","first-page":"26296","DOI":"10.1021\/acsnano.5c04463","volume":"19","author":"X Su","year":"2025","unstructured":"Su X, Su M, Guo E, et al. Tissue-resident macrophage membrane-coated nanomedicine for targeted tumor therapy. ACS Nano. 2025;19(29):26296\u2013319. https:\/\/doi.org\/10.1021\/acsnano.5c04463.","journal-title":"ACS Nano"},{"issue":"1","key":"4469_CR26","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/imr.13255","volume":"320","author":"Y Li","year":"2023","unstructured":"Li Y, Rezvani K, Rafei H. Next-generation chimeric antigen receptors for T- and natural killer-cell therapies against cancer. Immunol Rev. 2023;320(1):217\u201335. https:\/\/doi.org\/10.1111\/imr.13255.","journal-title":"Immunol Rev"},{"issue":"16","key":"4469_CR27","doi-asserted-by":"publisher","first-page":"6606","DOI":"10.1021\/acs.nanolett.2c01863","volume":"22","author":"T Yin","year":"2022","unstructured":"Yin T, Fan Q, Hu F, et al. Engineered macrophage-membrane-coated nanoparticles with enhanced PD-1 expression induce immunomodulation for a synergistic and targeted antiglioblastoma activity. Nano Lett. 2022;22(16):6606\u201314. https:\/\/doi.org\/10.1021\/acs.nanolett.2c01863.","journal-title":"Nano Lett"},{"key":"4469_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116482","volume":"174","author":"N Hu","year":"2024","unstructured":"Hu N, Xue H, Zhang T, et al. Harnessing PD-1 cell membrane-coated paclitaxel dimer nanoparticles for potentiated chemoimmunotherapy. Biomed Pharmacother. 2024;174:116482. https:\/\/doi.org\/10.1016\/j.biopha.2024.116482.","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"4469_CR29","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-024-00586-9","volume":"11","author":"Y Godiyal","year":"2024","unstructured":"Godiyal Y, Maheshwari D, Taniguchi H, et al. Role of PD-1\/PD-L1 signaling axis in oncogenesis and its targeting by bioactive natural compounds for cancer immunotherapy. Mil Med Res. 2024;11(1):82. https:\/\/doi.org\/10.1186\/s40779-024-00586-9.","journal-title":"Mil Med Res"},{"issue":"1","key":"4469_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01979-x","volume":"9","author":"B Wu","year":"2024","unstructured":"Wu B, Zhang B, Li B, et al. Cold and hot tumors: from molecular mechanisms to targeted therapy. Signal Transduct Target Ther. 2024;9(1):274. https:\/\/doi.org\/10.1038\/s41392-024-01979-x.","journal-title":"Signal Transduct Target Ther"},{"issue":"12","key":"4469_CR31","doi-asserted-by":"publisher","first-page":"10430","DOI":"10.1021\/jacs.4c18308","volume":"147","author":"Y Mo","year":"2025","unstructured":"Mo Y, Keszei AFA, Kothari S, et al. Lipid-siRNA organization modulates the intracellular dynamics of lipid nanoparticles. J Am Chem Soc. 2025;147(12):10430\u201345. https:\/\/doi.org\/10.1021\/jacs.4c18308.","journal-title":"J Am Chem Soc"},{"issue":"4592","key":"4469_CR32","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1126\/science.6828875","volume":"220","author":"RM Hochmuth","year":"1983","unstructured":"Hochmuth RM, Evans CA, Wiles HC, et al. Mechanical measurement of red cell membrane thickness. Science. 1983;220(4592):101\u20132. https:\/\/doi.org\/10.1126\/science.6828875.","journal-title":"Science"},{"issue":"50","key":"4469_CR33","doi-asserted-by":"publisher","first-page":"34063","DOI":"10.1021\/acsnano.4c09653","volume":"18","author":"W Wang","year":"2024","unstructured":"Wang W, Zou C, Liu X, et al. Biomimetic dendritic cell-based nanovaccines for reprogramming the immune microenvironment to boost tumor immunotherapy. ACS Nano. 2024;18(50):34063\u201376. https:\/\/doi.org\/10.1021\/acsnano.4c09653.","journal-title":"ACS Nano"},{"key":"4469_CR34","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.bioactmat.2025.01.012","volume":"47","author":"X Ji","year":"2025","unstructured":"Ji X, Qian X, Luo G, et al. Engineered macrophage nanoparticles enhance microwave ablation efficacy in osteosarcoma via targeting the CD47-SIRP\u03b1 axis: a novel biomimetic immunotherapeutic approach. Bioact Mater. 2025;47:248\u201365. https:\/\/doi.org\/10.1016\/j.bioactmat.2025.01.012.","journal-title":"Bioact Mater"},{"issue":"6","key":"4469_CR35","doi-asserted-by":"publisher","first-page":"5295","DOI":"10.1007\/s12274-022-4182-0","volume":"15","author":"TY Xue","year":"2022","unstructured":"Xue TY, Zhang ZR, Fang TL, et al. Cellular vesicles expressing PD-1-blocking scFv reinvigorate T cell immunity against cancer. Nano Res. 2022;15(6):5295\u2013304. https:\/\/doi.org\/10.1007\/s12274-022-4182-0.","journal-title":"Nano Res"},{"issue":"29","key":"4469_CR36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2113180119","volume":"119","author":"D Wang","year":"2022","unstructured":"Wang D, Wang Q, Wang Y, et al. Targeting oncogenic KRAS with molecular brush-conjugated antisense oligonucleotides. Proc Natl Acad Sci U S A. 2022;119(29):e2113180119. https:\/\/doi.org\/10.1073\/pnas.2113180119.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4469_CR37","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.actbio.2023.03.002","volume":"161","author":"B Li","year":"2023","unstructured":"Li B, Yang T, Liu J, et al. Genetically engineered PD-1 displaying nanovesicles for synergistic checkpoint blockades and chemo-metabolic therapy against non-small cell lung cancer. Acta Biomater. 2023;161:184\u2013200. https:\/\/doi.org\/10.1016\/j.actbio.2023.03.002.","journal-title":"Acta Biomater"},{"key":"4469_CR38","doi-asserted-by":"crossref","unstructured":"38. Kong, H.; Wang, S.; Zhuo, C.; et al. Nanovescicles integrating PD-1-mediated targeting and CRISPR\/Cas9-based CD47 editing for dual immune checkpoint blockade. J. Control. Release 2025, 114480, DOI: 10.1016\/j.jconrel.2025.114480.","DOI":"10.1016\/j.jconrel.2025.114480"},{"issue":"41","key":"4469_CR39","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202400702","volume":"11","author":"X Li","year":"2024","unstructured":"Li X, Liu Y, Gui J, et al. Cell identity and spatial distribution of PD-1\/PD-L1 blockade responders. Adv Sci. 2024;11(41):e2400702. https:\/\/doi.org\/10.1002\/advs.202400702.","journal-title":"Adv Sci"},{"issue":"1","key":"4469_CR40","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02023-w","volume":"23","author":"X Lin","year":"2024","unstructured":"Lin X, Kang K, Chen P, et al. Regulatory mechanisms of PD-1\/PD-L1 in cancers. Mol Cancer. 2024;23(1):108. https:\/\/doi.org\/10.1186\/s12943-024-02023-w.","journal-title":"Mol Cancer"},{"key":"4469_CR41","doi-asserted-by":"publisher","DOI":"10.34133\/research.0148","volume":"6","author":"C Qiu","year":"2023","unstructured":"Qiu C, Xia F, Zhang J, et al. Advanced strategies for overcoming endosomal\/lysosomal barrier in nanodrug delivery. Research. 2023;6:0148. https:\/\/doi.org\/10.34133\/research.0148.","journal-title":"Research"},{"key":"4469_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.145516","volume":"474","author":"JY Zhou","year":"2023","unstructured":"Zhou JY, Shen QH, Hong XJ, et al. Synergization of an endoplasmic reticulum-targeted iridium(III) photosensitizer with PD-L1 inhibitor for oral squamous cell carcinoma immunotherapy. Chem Eng J. 2023;474:145516. https:\/\/doi.org\/10.1016\/j.cej.2023.145516.","journal-title":"Chem Eng J"},{"key":"4469_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123433","volume":"323","author":"H Guo","year":"2025","unstructured":"Guo H, Huang G, Long H, et al. Harnessing PD-1-overexpressing macrophage membrane for preparation of lenvatinib-loaded vesicles to boost immunotherapy against HCC recurrence after radiofrequency ablation. Biomaterials. 2025;323:123433. https:\/\/doi.org\/10.1016\/j.biomaterials.2025.123433.","journal-title":"Biomaterials"},{"issue":"4","key":"4469_CR44","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/s41568-024-00787-3","volume":"25","author":"CY Moon","year":"2025","unstructured":"Moon CY, Belabed M, Park MD, et al. Dendritic cell maturation in cancer. Nat Rev Cancer. 2025;25(4):225\u201348. https:\/\/doi.org\/10.1038\/s41568-024-00787-3.","journal-title":"Nat Rev Cancer"},{"issue":"5","key":"4469_CR45","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/s41568-021-00339-z","volume":"21","author":"S Jhunjhunwala","year":"2021","unstructured":"Jhunjhunwala S, Hammer C, Delamarre L. Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion. Nat Rev Cancer. 2021;21(5):298\u2013312. https:\/\/doi.org\/10.1038\/s41568-021-00339-z.","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"4469_CR46","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s41577-019-0210-z","volume":"20","author":"SK Wculek","year":"2020","unstructured":"Wculek SK, Cueto FJ, Mujal AM, et al. Dendritic cells in cancer immunology and immunotherapy. Nat Rev Immunol. 2020;20(1):7\u201324. https:\/\/doi.org\/10.1038\/s41577-019-0210-z.","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"4469_CR47","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.cell.2023.12.011","volume":"187","author":"Y Shapir Itai","year":"2024","unstructured":"Shapir Itai Y, Barboy O, Salomon R, et al. Bispecific dendritic-T cell engager potentiates anti-tumor immunity. Cell. 2024;187(2):375-389.e18. https:\/\/doi.org\/10.1016\/j.cell.2023.12.011.","journal-title":"Cell"},{"issue":"4","key":"4469_CR48","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/s41571-024-00859-1","volume":"21","author":"I Heras-Murillo","year":"2024","unstructured":"Heras-Murillo I, Ad\u00e1n-Barrientos I, Gal\u00e1n M, et al. Dendritic cells as orchestrators of anticancer immunity and immunotherapy. Nat Rev Clin Oncol. 2024;21(4):257\u201377. https:\/\/doi.org\/10.1038\/s41571-024-00859-1.","journal-title":"Nat Rev Clin Oncol"},{"issue":"1","key":"4469_CR49","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ccell.2024.11.011","volume":"43","author":"CT Kureshi","year":"2025","unstructured":"Kureshi CT, Dougan SK. Cytokines in cancer. Cancer Cell. 2025;43(1):15\u201335. https:\/\/doi.org\/10.1016\/j.ccell.2024.11.011.","journal-title":"Cancer Cell"},{"issue":"4","key":"4469_CR50","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1038\/nrclinonc.2018.8","volume":"15","author":"DE Johnson","year":"2018","unstructured":"Johnson DE, O\u2019Keefe RA, Grandis JR. Targeting the IL-6\/JAK\/STAT3 signalling axis in cancer. Nat Rev Clin Oncol. 2018;15(4):234\u201348. https:\/\/doi.org\/10.1038\/nrclinonc.2018.8.","journal-title":"Nat Rev Clin Oncol"},{"issue":"3","key":"4469_CR51","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.immuni.2018.03.014","volume":"48","author":"C Sun","year":"2018","unstructured":"Sun C, Mezzadra R, Schumacher TN. Regulation and function of the PD-L1 checkpoint. Immunity. 2018;48(3):434\u201352. https:\/\/doi.org\/10.1016\/j.immuni.2018.03.014.","journal-title":"Immunity"},{"issue":"1","key":"4469_CR52","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01746-6","volume":"20","author":"Y Wu","year":"2022","unstructured":"Wu Y, Wan S, Yang S, et al. Macrophage cell membrane-based nanoparticles: a new promising biomimetic platform for targeted delivery and treatment. J Nanobiotechnol. 2022;20(1):542. https:\/\/doi.org\/10.1186\/s12951-022-01746-6.","journal-title":"J Nanobiotechnol"},{"issue":"11","key":"4469_CR53","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1038\/s41565-021-00972-7","volume":"16","author":"Y Zhai","year":"2021","unstructured":"Zhai Y, Wang J, Lang T, et al. T lymphocyte membrane-decorated epigenetic nanoinducer of interferons for cancer immunotherapy. Nat Nanotechnol. 2021;16(11):1271\u201380. https:\/\/doi.org\/10.1038\/s41565-021-00972-7.","journal-title":"Nat Nanotechnol"},{"issue":"4","key":"4469_CR54","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12441","volume":"51","author":"J Shen","year":"2018","unstructured":"Shen J, Xiao Z, Zhao Q, et al. Anti-cancer therapy with TNF\u03b1 and IFN\u03b3: a comprehensive review. Cell Prolif. 2018;51(4):e12441. https:\/\/doi.org\/10.1111\/cpr.12441.","journal-title":"Cell Prolif"},{"issue":"3","key":"4469_CR55","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.molcel.2019.09.030","volume":"76","author":"JH Cha","year":"2019","unstructured":"Cha JH, Chan LC, Li CW, et al. Mechanisms controlling PD-L1 expression in cancer. Mol Cell. 2019;76(3):359\u201370. https:\/\/doi.org\/10.1016\/j.molcel.2019.09.030.","journal-title":"Mol Cell"},{"issue":"3","key":"4469_CR56","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/s41577-021-00566-3","volume":"22","author":"AM Gocher","year":"2022","unstructured":"Gocher AM, Workman CJ, Vignali DAA. Interferon-\u03b3: teammate or opponent in the tumour microenvironment? Nat Rev Immunol. 2022;22(3):158\u201372. https:\/\/doi.org\/10.1038\/s41577-021-00566-3.","journal-title":"Nat Rev Immunol"},{"issue":"8","key":"4469_CR57","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/s41584-022-00797-1","volume":"18","author":"L Broderick","year":"2022","unstructured":"Broderick L, Hoffman HM. IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting. Nat Rev Rheumatol. 2022;18(8):448\u201363. https:\/\/doi.org\/10.1038\/s41584-022-00797-1.","journal-title":"Nat Rev Rheumatol"},{"issue":"12","key":"4469_CR58","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/s41577-022-00707-2","volume":"22","author":"N Pishesha","year":"2022","unstructured":"Pishesha N, Harmand TJ, Ploegh HL. A guide to antigen processing and presentation. Nat Rev Immunol. 2022;22(12):751\u201364. https:\/\/doi.org\/10.1038\/s41577-022-00707-2.","journal-title":"Nat Rev Immunol"},{"key":"4469_CR59","doi-asserted-by":"publisher","unstructured":"Raavi, Koehler AN Vegas A J At the interface: small-moleculeinhibitors of soluble cytokines. Chem. Rev. 2025;125(9):4528\u201368. https:\/\/doi.org\/10.1021\/acs.chemrev.4c00469","DOI":"10.1021\/acs.chemrev.4c00469"},{"key":"4469_CR60","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.omtm.2023.06.005","volume":"30","author":"N Chander","year":"2023","unstructured":"Chander N, Basha G, Yan Cheng MH, et al. Lipid nanoparticle mRNA systems containing high levels of sphingomyelin engender higher protein expression in hepatic and extra-hepatic tissues. Mol Ther Methods Clin Dev. 2023;30:235\u201345. https:\/\/doi.org\/10.1016\/j.omtm.2023.06.005.","journal-title":"Mol Ther Methods Clin Dev"},{"issue":"8","key":"4469_CR61","doi-asserted-by":"publisher","first-page":"7928","DOI":"10.1021\/acsnano.4c14969","volume":"19","author":"J Wu","year":"2025","unstructured":"Wu J, Cheng Y, Qian K, et al. siRNA-encapsulated biomimetic liposomes effectively inhibit tumor cells\u2019 hexosamine biosynthesis pathway for attenuating hyaluronan barriers to pancreatic cancer chemotherapy. ACS Nano. 2025;19(8):7928\u201347. https:\/\/doi.org\/10.1021\/acsnano.4c14969.","journal-title":"ACS Nano"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-026-04469-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-026-04469-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-026-04469-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:59:05Z","timestamp":1781650745000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12951-026-04469-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":61,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4469"],"URL":"https:\/\/doi.org\/10.1186\/s12951-026-04469-0","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,29]]},"assertion":[{"value":"23 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"573"}}