{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:44:27Z","timestamp":1792788267477,"version":"4.5.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":83,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Natural Science Foundation of Hunan Province","award":["No.2022JJ40393"],"award-info":[{"award-number":["No.2022JJ40393"]}]},{"name":"Natural Science Foundation of Hunan Province","award":["No.2023JJ40588"],"award-info":[{"award-number":["No.2023JJ40588"]}]},{"name":"Natural\u00a0Science\u00a0Foundation\u00a0of\u00a0China","award":["No.82404928"],"award-info":[{"award-number":["No.82404928"]}]},{"name":"Hunan\u00a0Provincial\u00a0Health\u00a0Commission","award":["No. D202303109450"],"award-info":[{"award-number":["No. D202303109450"]}]},{"name":"Hunan\u00a0Provincial\u00a0Health\u00a0Commission","award":["No.B202303109577"],"award-info":[{"award-number":["No.B202303109577"]}]},{"name":"Interdisciplinary Research Program in Medicine and Engineering, the First Affiliated Hospital of University of South China","award":["IRP-M&E-2025-05"],"award-info":[{"award-number":["IRP-M&E-2025-05"]}],"id":[{"id":"https:\/\/ror.org\/049z3cb60","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Clinical Medical Research \u201c4310\u201d Program of the University of South China","award":["No.20224310NHYCG07"],"award-info":[{"award-number":["No.20224310NHYCG07"]}],"id":[{"id":"https:\/\/ror.org\/03mqfn238","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"DOI":"10.1186\/s12951-026-04671-0","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:34:24Z","timestamp":1782930864000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["ISL@mTOMV nanoparticles: a promising approach for VM-targeted therapy in breast cancer"],"prefix":"10.1186","volume":"24","author":[{"given":"Chengxiao","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxiang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziliang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"4671_CR1","doi-asserted-by":"publisher","first-page":"470","DOI":"10.3390\/diagnostics13030470","volume":"13","author":"B El Hejjioui","year":"2023","unstructured":"El Hejjioui B, Bouguenouch L, Melhouf MA, El Mouhi H, Bennis S. Clinical Evidence of Circulating Tumor DNA Application in Aggressive Breast Cancer. Diagnostics. 2023;13:470. https:\/\/doi.org\/10.3390\/diagnostics13030470.","journal-title":"Diagnostics"},{"key":"4671_CR2","doi-asserted-by":"publisher","unstructured":"Tong L, Yu X, Wang S, Chen L, Wu Y. Research Progress on Molecular Subtyping and Modern Treatment of Triple-Negative Breast Cancer. Breast Cancer: Targets Therapy 2023;Volume 15:647\u201358. https:\/\/doi.org\/10.2147\/bctt.s426121","DOI":"10.2147\/bctt.s426121"},{"key":"4671_CR3","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.bbadis.2018.01.002","volume":"1864","author":"M Guha","year":"2018","unstructured":"Guha M, Srinivasan S, Raman P, Jiang Y, Kaufman BA, Taylor D, et al. Aggressive triple negative breast cancers have unique molecular signature on the basis of mitochondrial genetic and functional defects. Biochim et Biophys Acta (BBA) - Mol Basis Disease. 2018;1864:1060\u201371. https:\/\/doi.org\/10.1016\/j.bbadis.2018.01.002.","journal-title":"Biochim et Biophys Acta (BBA) - Mol Basis Disease"},{"key":"4671_CR4","doi-asserted-by":"publisher","unstructured":"Wang C, Chen Z, Zhou Y, Huang W, Zhu H, Mao F, et al. T1a triple negative breast cancer has the worst prognosis among all the small tumor (<1\u00a0cm) of TNBC and HER2-rich subtypes. Gland Surgery. 2021;10:943\u201352. https:\/\/doi.org\/10.21037\/gs-20-762.","DOI":"10.21037\/gs-20-762."},{"key":"4671_CR5","doi-asserted-by":"publisher","first-page":"4474","DOI":"10.7150\/jca.44313","volume":"11","author":"CO Madu","year":"2020","unstructured":"Madu CO, Wang S, Madu CO, Lu Y. Angiogenesis in Breast Cancer Progression, Diagnosis, and Treatment. J Cancer. 2020;11:4474\u201394. https:\/\/doi.org\/10.7150\/jca.44313.","journal-title":"J Cancer"},{"key":"4671_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-024-01446-5","author":"G Elayat","year":"2024","unstructured":"Elayat G, Selim A. Angiogenesis in breast cancer: insights and innovations. Clin Experimental Med. 2024. https:\/\/doi.org\/10.1007\/s10238-024-01446-5. 24.","journal-title":"Clin Experimental Med"},{"key":"4671_CR7","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.3390\/cells10071758","volume":"10","author":"G Morales-Guadarrama","year":"2021","unstructured":"Morales-Guadarrama G, Garc\u00eda-Becerra R, M\u00e9ndez-P\u00e9rez EA, Garc\u00eda-Quiroz J, Avila E, D\u00edaz L. Vasculogenic Mimicry in Breast Cancer: Clinical Relevance and Drivers. Cells. 2021;10:1758. https:\/\/doi.org\/10.3390\/cells10071758.","journal-title":"Cells"},{"key":"4671_CR8","doi-asserted-by":"publisher","unstructured":"Andonegui-Elguera MA, Alfaro-Mora Y, C\u00e1ceres-Guti\u00e9rrez R, Caro-S\u00e1nchez CHS, Herrera LA, D\u00edaz-Ch\u00e1vez J. An Overview of Vasculogenic Mimicry in Breast Cancer. Front Oncol. 2020;10. https:\/\/doi.org\/10.3389\/fonc.2020.00220.","DOI":"10.3389\/fonc.2020.00220"},{"key":"4671_CR9","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1080\/01635581.2020.1733624","volume":"73","author":"A-A Sicard","year":"2020","unstructured":"Sicard A-A, Dao T, Suarez NG, Annabi B. Diet-Derived Gallated Catechins Prevent TGF-\u03b2-Mediated Epithelial-Mesenchymal Transition, Cell Migration and Vasculogenic Mimicry in Chemosensitive ES-2 Ovarian Cancer Cells. Nutr Cancer. 2020;73:169\u201380. https:\/\/doi.org\/10.1080\/01635581.2020.1733624.","journal-title":"Nutr Cancer"},{"key":"4671_CR10","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1093\/jpp\/rgae065","volume":"76","author":"H Li","year":"2024","unstructured":"Li H, Hou M, Zhang P, Ren L, Guo Y, Zou L, et al. Wedelolactone suppresses breast cancer growth and metastasis via regulating TGF-\u03b21\/Smad signaling pathway. J Pharm Pharmacol. 2024;76:1038\u201350. https:\/\/doi.org\/10.1093\/jpp\/rgae065.","journal-title":"J Pharm Pharmacol"},{"key":"4671_CR11","doi-asserted-by":"publisher","unstructured":"Xu J, Yang X, Deng Q, Yang C, Wang D, Jiang G, et al. TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer. Nat Commun. 2021;12. https:\/\/doi.org\/10.1038\/s41467-021-24703-7.","DOI":"10.1038\/s41467-021-24703-7"},{"key":"4671_CR12","doi-asserted-by":"publisher","first-page":"156","DOI":"10.2174\/1389450115666141224125117","volume":"16","author":"A Khwairakpam","year":"2015","unstructured":"Khwairakpam A, Shyamananda M, Sailo B, Rathnakaram S, Padmavathi G, Kotoky J, et al. ATP Citrate Lyase (ACLY): A Promising Target for Cancer Prevention and Treatment. Curr Drug Targets. 2015;16:156\u201363. https:\/\/doi.org\/10.2174\/1389450115666141224125117.","journal-title":"Curr Drug Targets"},{"key":"4671_CR13","doi-asserted-by":"publisher","first-page":"115015","DOI":"10.1016\/j.celrep.2024.115015","volume":"43","author":"H Wang","year":"2024","unstructured":"Wang H, Yi X, Wang X, Yang Y, Zhang H, Wang H, et al. Nucleo-cytosolic acetyl-CoA drives tumor immune evasion by regulating PD-L1 in melanoma. Cell Rep. 2024;43:115015. https:\/\/doi.org\/10.1016\/j.celrep.2024.115015.","journal-title":"Cell Rep"},{"key":"4671_CR14","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1039\/d4nr02757d","volume":"17","author":"J He","year":"2025","unstructured":"He J, Li J, Li M, He Z, Ye Y, Li J, et al. Platelet backpacking nanoparticles based on bacterial outer membrane vesicles enhanced photothermal-immune anti-tumor therapy. Nanoscale. 2025;17:1510\u201323. https:\/\/doi.org\/10.1039\/d4nr02757d.","journal-title":"Nanoscale"},{"key":"4671_CR15","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.bioactmat.2022.05.037","volume":"20","author":"Y Li","year":"2023","unstructured":"Li Y, Wu J, Qiu X, Dong S, He J, Liu J, et al. Bacterial outer membrane vesicles-based therapeutic platform eradicates triple-negative breast tumor by combinational photodynamic\/chemo-\/immunotherapy. Bioactive Mater. 2023;20:548\u201360. https:\/\/doi.org\/10.1016\/j.bioactmat.2022.05.037.","journal-title":"Bioactive Mater"},{"key":"4671_CR16","doi-asserted-by":"publisher","first-page":"19585","DOI":"10.1021\/acs.analchem.4c04449","volume":"96","author":"N Li","year":"2024","unstructured":"Li N, Wang M, Liu F, Wu P, Wu F, Xiao H, et al. Bioorthogonal Engineering of Bacterial Outer Membrane Vesicles for NIR-II Fluorescence Imaging-Guided Synergistic Enhanced Immunotherapy. Anal Chem. 2024;96:19585\u201396. https:\/\/doi.org\/10.1021\/acs.analchem.4c04449.","journal-title":"Anal Chem"},{"key":"4671_CR17","doi-asserted-by":"publisher","first-page":"26296","DOI":"10.1021\/jacs.3c09472","volume":"145","author":"X Liu","year":"2023","unstructured":"Liu X, Sun M, Pu F, Ren J, Qu X. Transforming Intratumor Bacteria into Immunopotentiators to Reverse Cold Tumors for Enhanced Immuno-chemodynamic Therapy of Triple-Negative Breast Cancer. J Am Chem Soc. 2023;145:26296\u2013307. https:\/\/doi.org\/10.1021\/jacs.3c09472.","journal-title":"J Am Chem Soc"},{"key":"4671_CR18","doi-asserted-by":"publisher","first-page":"30332","DOI":"10.1021\/acsnano.4c07364","volume":"18","author":"J Sun","year":"2024","unstructured":"Sun J, Tan L, Ye B-C, Bi X. Engineered Outer Membrane Vesicles as Nanosized Immune Cell Engagers for Enhanced Solid Tumor Immunotherapy. ACS Nano. 2024;18:30332\u201344. https:\/\/doi.org\/10.1021\/acsnano.4c07364.","journal-title":"ACS Nano"},{"key":"4671_CR19","doi-asserted-by":"publisher","unstructured":"Wang D, Liu C, You S, Zhang K, Li M, Cao Y, et al. Bacterial Vesicle-Cancer Cell Hybrid Membrane-Coated Nanoparticles for Tumor Specific Immune Activation and Photothermal Therapy. ACS Applied Materials & Interfaces. 2020;12:41138\u201347. https:\/\/doi.org\/10.1021\/acsami.0c13169.","DOI":"10.1021\/acsami.0c13169."},{"key":"4671_CR20","doi-asserted-by":"publisher","first-page":"19756","DOI":"10.1021\/acsnano.1c07180","volume":"15","author":"J Xiong","year":"2021","unstructured":"Xiong J, Wu M, Chen J, Liu Y, Chen Y, Fan G, et al. Cancer-Erythrocyte Hybrid Membrane-Camouflaged Magnetic Nanoparticles with Enhanced Photothermal-Immunotherapy for Ovarian Cancer. ACS Nano. 2021;15:19756\u201370. https:\/\/doi.org\/10.1021\/acsnano.1c07180.","journal-title":"ACS Nano"},{"key":"4671_CR21","doi-asserted-by":"publisher","first-page":"8609","DOI":"10.1021\/acs.nanolett.1c02482","volume":"21","author":"M-Z Zou","year":"2021","unstructured":"Zou M-Z, Li Z-H, Bai X-F, Liu C-J, Zhang X-Z. Hybrid Vesicles Based on Autologous Tumor Cell Membrane and Bacterial Outer Membrane To Enhance Innate Immune Response and Personalized Tumor Immunotherapy. Nano Lett. 2021;21:8609\u201318. https:\/\/doi.org\/10.1021\/acs.nanolett.1c02482.","journal-title":"Nano Lett"},{"key":"4671_CR22","doi-asserted-by":"publisher","unstructured":"Liu XZ, Wen ZJ, Li YM, Sun WR, Hu XQ, Zhu JZ, et al. Bioengineered Bacterial Membrane Vesicles with Multifunctional Nanoparticles as a Versatile Platform for Cancer Immunotherapy. ACS Applied Materials & Interfaces. 2023;15:3744\u201359. https:\/\/doi.org\/10.1021\/acsami.2c18244.","DOI":"10.1021\/acsami.2c18244."},{"key":"4671_CR23","doi-asserted-by":"publisher","unstructured":"Liu A, Jiang B, Song C, Zhong Q, Mo Y, Yang R, et al. Isoliquiritigenin inhibits circ0030018 to suppress glioma tumorigenesis via the miR-1236\/HER2 signaling pathway. MedComm. 2023;4. https:\/\/doi.org\/10.1002\/mco2.282.","DOI":"10.1002\/mco2.282"},{"key":"4671_CR24","doi-asserted-by":"publisher","first-page":"e68566","DOI":"10.1371\/journal.pone.0068566","volume":"8","author":"Z Wang","year":"2013","unstructured":"Wang Z, Wang N, Han S, Wang D, Mo S, Yu L, et al. Dietary Compound Isoliquiritigenin Inhibits Breast Cancer Neoangiogenesis via VEGF\/VEGFR-2 Signaling Pathway. PLoS ONE. 2013;8:e68566. https:\/\/doi.org\/10.1371\/journal.pone.0068566.","journal-title":"PLoS ONE"},{"key":"4671_CR25","doi-asserted-by":"publisher","unstructured":"Ferreira NN, Leite CM, Moreno NS, Miranda RR, Pincela Lins PM, Rodero CF, et al. Nose-to-Brain Delivery of Biomimetic Nanoparticles for Glioblastoma Targeted Therapy. ACS Appl Mater Interfaces. 2024;17:484\u201399. https:\/\/doi.org\/10.1021\/acsami.4c16837.","DOI":"10.1021\/acsami.4c16837"},{"key":"4671_CR26","doi-asserted-by":"publisher","first-page":"19065","DOI":"10.1039\/d3ra01876h","volume":"13","author":"X Ou","year":"2023","unstructured":"Ou X, Zhang Z, Lin L, Du Y, Tang Y, Wang Y, et al. Tumor-homing bacterium-adsorbed liposomes encapsulating perfluorohexane\/doxorubicin enhance pulsed-focused ultrasound for tumor therapy. RSC Adv. 2023;13:19065\u201378. https:\/\/doi.org\/10.1039\/d3ra01876h.","journal-title":"RSC Adv"},{"key":"4671_CR27","doi-asserted-by":"publisher","first-page":"e34693","DOI":"10.1371\/journal.pone.0034693","volume":"7","author":"B Kim","year":"2012","unstructured":"Kim B, Yang M-S, Choi D, Kim J-H, Kim H-S, Seol W, et al. Impaired Inflammatory Responses in Murine Lrrk2-Knockdown Brain Microglia. PLoS ONE. 2012;7:e34693. https:\/\/doi.org\/10.1371\/journal.pone.0034693.","journal-title":"PLoS ONE"},{"key":"4671_CR28","doi-asserted-by":"publisher","unstructured":"Martinez R, Finocchiaro C, Delhaye L, Gysens F, Anckaert J, Trypsteen W, et al. A co-culture model to study modulators of tumor immune evasion through scalable arrayed CRISPR-interference screens. Front Immunol. 2024;15. https:\/\/doi.org\/10.3389\/fimmu.2024.1444886.","DOI":"10.3389\/fimmu.2024.1444886"},{"key":"4671_CR29","doi-asserted-by":"publisher","first-page":"112899","DOI":"10.1016\/j.jim.2020.112899","volume":"487","author":"V Olivo Pimentel","year":"2020","unstructured":"Olivo Pimentel V, Yaromina A, Marcus D, Dubois LJ, Lambin P. A novel co-culture assay to assess anti-tumor CD8 + T cell cytotoxicity via luminescence and multicolor flow cytometry. J Immunol Methods. 2020;487:112899. https:\/\/doi.org\/10.1016\/j.jim.2020.112899.","journal-title":"J Immunol Methods"},{"key":"4671_CR30","doi-asserted-by":"publisher","first-page":"23437","DOI":"10.1021\/acsami.6b04179","volume":"8","author":"S Pulakkat","year":"2016","unstructured":"Pulakkat S, Balaji SA, Rangarajan A, Raichur AM. Surface Engineered Protein Nanoparticles With Hyaluronic Acid Based Multilayers For Targeted Delivery Of Anticancer Agents. ACS Appl Mater Interfaces. 2016;8:23437\u201349. https:\/\/doi.org\/10.1021\/acsami.6b04179.","journal-title":"ACS Appl Mater Interfaces"},{"key":"4671_CR31","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1158\/2159-8290.cd-18-0567","volume":"9","author":"A Carrer","year":"2019","unstructured":"Carrer A, Trefely S, Zhao S, Campbell SL, Norgard RJ, Schultz KC, et al. Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis. Cancer Discov. 2019;9:416\u201335. https:\/\/doi.org\/10.1158\/2159-8290.cd-18-0567.","journal-title":"Cancer Discov"},{"key":"4671_CR32","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.cmet.2022.02.015","volume":"34","author":"SM Hochrein","year":"2022","unstructured":"Hochrein SM, Wu H, Eckstein M, Arrigoni L, Herman JS, Schumacher F, et al. The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming. Cell Metabol. 2022;34:516\u2013e53211. https:\/\/doi.org\/10.1016\/j.cmet.2022.02.015.","journal-title":"Cell Metabol"},{"key":"4671_CR33","doi-asserted-by":"publisher","first-page":"2904","DOI":"10.3390\/cells10112904","volume":"10","author":"S-U Shin","year":"2021","unstructured":"Shin S-U, Cho H-M, Das R, Gil-Henn H, Ramakrishnan S, Al Bayati A, et al. Inhibition of Vasculogenic Mimicry and Angiogenesis by an Anti-EGFR IgG1-Human Endostatin-P125A Fusion Protein Reduces Triple Negative Breast Cancer Metastases. Cells. 2021;10:2904. https:\/\/doi.org\/10.3390\/cells10112904.","journal-title":"Cells"},{"key":"4671_CR34","doi-asserted-by":"publisher","first-page":"173282","DOI":"10.1016\/j.ejphar.2020.173282","volume":"881","author":"NF Maroufi","year":"2020","unstructured":"Maroufi NF, Amiri M, Dizaji BF, Vahedian V, Akbarzadeh M, Roshanravan N, et al. Inhibitory effect of melatonin on hypoxia-induced vasculogenic mimicry via suppressing epithelial-mesenchymal transition (EMT) in breast cancer stem cells. Eur J Pharmacol. 2020;881:173282. https:\/\/doi.org\/10.1016\/j.ejphar.2020.173282.","journal-title":"Eur J Pharmacol"},{"key":"4671_CR35","doi-asserted-by":"publisher","first-page":"13770","DOI":"10.3390\/ijms241813770","volume":"24","author":"G Morales-Guadarrama","year":"2023","unstructured":"Morales-Guadarrama G, M\u00e9ndez-P\u00e9rez EA, Garc\u00eda-Quiroz J, Avila E, Ibarra-S\u00e1nchez MJ, Esparza-L\u00f3pez J, et al. The Inhibition of the FGFR\/PI3K\/Akt Axis by AZD4547 Disrupts the Proangiogenic Microenvironment and Vasculogenic Mimicry Arising from the Interplay between Endothelial and Triple-Negative Breast Cancer Cells. Int J Mol Sci. 2023;24:13770. https:\/\/doi.org\/10.3390\/ijms241813770.","journal-title":"Int J Mol Sci"},{"key":"4671_CR36","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1267\/ahc.18041","volume":"51","author":"Y Izawa","year":"2018","unstructured":"Izawa Y, Kashii-Magaribuchi K, Yoshida K, Nosaka M, Tsuji N, Yamamoto A, et al. Stem-like Human Breast Cancer Cells Initiate Vasculogenic Mimicry on Matrigel. Acta Histochem Cytochem. 2018;51:173\u201383. https:\/\/doi.org\/10.1267\/ahc.18041.","journal-title":"Acta Histochem Cytochem"},{"key":"4671_CR37","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1615\/critreveukaryotgeneexpr.2015014042","volume":"25","author":"S Kotiyal","year":"2015","unstructured":"Kotiyal S, Bhattacharya S. Epithelial Mesenchymal Transition and Vascular Mimicry in Breast Cancer Stem Cells. Crit Rev Eukaryot Gene Expr. 2015;25:269\u201380. https:\/\/doi.org\/10.1615\/critreveukaryotgeneexpr.2015014042.","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"4671_CR38","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.abb.2008.11.016","volume":"482","author":"D Lopez","year":"2009","unstructured":"Lopez D, Niu G, Huber P, Carter WB. Tumor-induced upregulation of Twist, Snail, and Slug represses the activity of the human VE-cadherin promoter. Arch Biochem Biophys. 2009;482:77\u201382. https:\/\/doi.org\/10.1016\/j.abb.2008.11.016.","journal-title":"Arch Biochem Biophys"},{"key":"4671_CR39","doi-asserted-by":"publisher","first-page":"47801","DOI":"10.18632\/oncotarget.17999","volume":"8","author":"J Yang","year":"2017","unstructured":"Yang J, Zhu D-M, Zhou X-G, Yin N, Zhang Y, Zhang Z-X, et al. HIF-2\u03b1 promotes the formation of vasculogenic mimicry in pancreatic cancer by regulating the binding of Twist1 to the VE-cadherin promoter. Oncotarget. 2017;8:47801\u201315. https:\/\/doi.org\/10.18632\/oncotarget.17999.","journal-title":"Oncotarget"},{"key":"4671_CR40","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.3390\/genes12091460","volume":"12","author":"W Zheng","year":"2021","unstructured":"Zheng W, Tasselli L, Li T, Chua KF. Mammalian SIRT6 Represses Invasive Cancer Cell Phenotypes through ATP Citrate Lyase (ACLY)-Dependent Histone Acetylation. Genes. 2021;12:1460. https:\/\/doi.org\/10.3390\/genes12091460.","journal-title":"Genes"},{"key":"4671_CR41","doi-asserted-by":"publisher","first-page":"115741","DOI":"10.1016\/j.biopha.2023.115741","volume":"168","author":"G Chen","year":"2023","unstructured":"Chen G, Bao B, Cheng Y, Tian M, Song J, Zheng L, et al. Acetyl-CoA metabolism as a therapeutic target for cancer. Biomed Pharmacother. 2023;168:115741. https:\/\/doi.org\/10.1016\/j.biopha.2023.115741.","journal-title":"Biomed Pharmacother"},{"key":"4671_CR42","doi-asserted-by":"publisher","first-page":"7619","DOI":"10.1021\/acsbiomaterials.4c01251","volume":"10","author":"J Zhao","year":"2024","unstructured":"Zhao J, Yu B, Li L, Guo S, Sha X, Ru W, et al. Outer Membrane Vesicle-Cancer Hybrid Membrane Coating Indocyanine Green Nanoparticles for Enhancing Photothermal Therapy Efficacy in Tumors. ACS Biomater Sci Eng. 2024;10:7619\u201331. https:\/\/doi.org\/10.1021\/acsbiomaterials.4c01251.","journal-title":"ACS Biomater Sci Eng"},{"key":"4671_CR43","doi-asserted-by":"publisher","first-page":"102585","DOI":"10.1016\/j.nano.2022.102585","volume":"45","author":"C Cui","year":"2022","unstructured":"Cui C, Guo T, Zhang S, Yang M, Cheng J, Wang J, et al. Bacteria-derived outer membrane vesicles engineered with over-expressed pre-miRNA as delivery nanocarriers for cancer therapy. Nanomed Nanotechnol Biol Med. 2022;45:102585. https:\/\/doi.org\/10.1016\/j.nano.2022.102585.","journal-title":"Nanomed Nanotechnol Biol Med"},{"key":"4671_CR44","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.taap.2013.05.031","volume":"272","author":"Y Li","year":"2013","unstructured":"Li Y, Zhao H, Wang Y, Zheng H, Yu W, Chai H, et al. Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K\/Akt in human breast cancer. Toxicol Appl Pharmcol. 2013;272:37\u201348. https:\/\/doi.org\/10.1016\/j.taap.2013.05.031.","journal-title":"Toxicol Appl Pharmcol"},{"key":"4671_CR45","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1517\/14728222.2013.756869","volume":"17","author":"K-L Wang","year":"2013","unstructured":"Wang K-L, Hsia S-M, Chan C-J, Chang F-Y, Huang C-Y, Bau D-T, et al. Inhibitory effects of isoliquiritigenin on the migration and invasion of human breast cancer cells. Expert Opin Ther Targets. 2013;17:337\u201349. https:\/\/doi.org\/10.1517\/14728222.2013.756869.","journal-title":"Expert Opin Ther Targets"},{"key":"4671_CR46","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.2174\/0109298673259973231023110945","volume":"32","author":"C Xu","year":"2025","unstructured":"Xu C, Zhang C, Ganesan K, Qui C, Tang H, Gao F, et al. Anti-migratory Properties of Cryoprotective Isoliquiritigenin-zein Phosphatidylcholine Nanoparticles Prevent Triple-negative Breast Cancer through PI3K-mTOR and MMP2\/9 Pathways. Curr Med Chem. 2025;32:1770\u201388. https:\/\/doi.org\/10.2174\/0109298673259973231023110945.","journal-title":"Curr Med Chem"},{"key":"4671_CR47","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1517\/14728222.2013.773312","volume":"17","author":"V Lorusso","year":"2013","unstructured":"Lorusso V, Marech I. Novel plant-derived target drugs: a step forward from licorice? Expert Opin Ther Targets. 2013;17:333\u20135. https:\/\/doi.org\/10.1517\/14728222.2013.773312.","journal-title":"Expert Opin Ther Targets"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-026-04671-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-026-04671-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-026-04671-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:04:11Z","timestamp":1790075051000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12951-026-04671-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4671"],"URL":"https:\/\/doi.org\/10.1186\/s12951-026-04671-0","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"assertion":[{"value":"7 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal experiments were approved by the Animal Ethics Committee of University of South China.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"884"}}