{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T01:50:23Z","timestamp":1793757023503,"version":"4.6.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Zhejiang Province Traditional Chinese Medicine Science and Technology Project","award":["2026ZL1003"],"award-info":[{"award-number":["2026ZL1003"]}]},{"name":"the Natural Science Foundation of Hangzhou","award":["2024SZRZDC200001"],"award-info":[{"award-number":["2024SZRZDC200001"]}]},{"name":"the National Natural Science Foundation of Zhejiang Province","award":["LZ26H290001"],"award-info":[{"award-number":["LZ26H290001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"DOI":"10.1186\/s12951-026-04769-5","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:33:00Z","timestamp":1783506780000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeting mitochondrial-ER homeostasis via autophagy inhibition with celastrol-based nanotherapy for triple-negative breast cancer"],"prefix":"10.1186","volume":"24","author":[{"given":"Yuhao","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanming","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiqin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jigang","family":"Piao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"4769_CR1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.pharmthera.2019.02.006","volume":"199","author":"SY Hwang","year":"2019","unstructured":"Hwang SY, Park S, Kwon Y. Recent therapeutic trends and promising targets in triple negative breast cancer. Pharmacol Ther. 2019;199:30\u201357. https:\/\/doi.org\/10.1016\/j.pharmthera.2019.02.006. ,05.","journal-title":"Pharmacol Ther"},{"key":"4769_CR2","doi-asserted-by":"publisher","unstructured":"Perou CM, S\u00f8rlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, Williams C, Zhu SX, L\u00f8nning PE, B\u00f8rresen-Dale AL, Brown PO, Botstein D. Molecular portraits of human breast tumours. Nature. 2000;406(6797). https:\/\/doi.org\/10.1038\/35021093. 747\u2009\u2013\u200952,05.","DOI":"10.1038\/35021093"},{"key":"4769_CR3","doi-asserted-by":"publisher","unstructured":"Bartsch R, Ziebermayr R, Zielinski CC, Steger GG. Triple-negative breast cancer, Wiener medizinische Wochenschrift (1946) 160(7\u20138) (2010) 174\u2009\u2013\u200981,05. https:\/\/doi.org\/10.1007\/s10354-010-0773-6","DOI":"10.1007\/s10354-010-0773-6"},{"issue":"7751","key":"4769_CR4","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/s41586-019-1005-x","volume":"568","author":"J Lee","year":"2019","unstructured":"Lee J, Yesilkanal AE, Wynne JP, Frankenberger C, Liu J, Yan J, Elbaz M, Rabe DC, Rustandy FD, Tiwari P, Grossman EA, Hart PC, Kang C, Sanderson SM, Andrade J, Nomura DK, Bonini MG, Locasale JW, Rosner MR. Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism. Nature. 2019;568(7751):254\u201325805. https:\/\/doi.org\/10.1038\/s41586-019-1005-x.","journal-title":"Nature"},{"issue":"1","key":"4769_CR5","doi-asserted-by":"publisher","first-page":"5905","DOI":"10.1186\/s40779-024-00556-1","volume":"11","author":"WL Hong","year":"2024","unstructured":"Hong WL, Huang H, Zeng X, Duan CY. Targeting mitochondrial quality control: new therapeutic strategies for major diseases. Mil Med Res. 2024;11(1):5905. https:\/\/doi.org\/10.1186\/s40779-024-00556-1.","journal-title":"Mil Med Res"},{"issue":"9","key":"4769_CR6","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1158\/0008-5472.Can-20-1628","volume":"81","author":"C Sandoval-Acu\u00f1a","year":"2021","unstructured":"Sandoval-Acu\u00f1a C, Torrealba N, Tomkova V, Jadhav SB, Blazkova K, Merta L, Lettlova S, Adamcov\u00e1 MK, Rosel D, Br\u00e1bek J, Neuzil J, Stursa J, Werner L, Truksa J. Targeting Mitochondrial Iron Metabolism Suppresses Tumor Growth and Metastasis by Inducing Mitochondrial Dysfunction and Mitophagy. Cancer Res. 2021;81(9):2289\u2013303. https:\/\/doi.org\/10.1158\/0008-5472.Can-20-1628.","journal-title":"Cancer Res"},{"issue":"1","key":"4769_CR7","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.tcb.2024.08.007","volume":"35","author":"A Larra\u00f1aga-SanMiguel","year":"2025","unstructured":"Larra\u00f1aga-SanMiguel A, Bengoa-Vergniory N, Flores-Romero H. Crosstalk between mitochondria-ER contact sites and the apoptotic machinery as a novel health meter. Trends Cell Biol. 2025;35(1):33\u201345. https:\/\/doi.org\/10.1016\/j.tcb.2024.08.007.","journal-title":"Trends Cell Biol"},{"issue":"2","key":"4769_CR8","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/s41401-024-01359-9","volume":"46","author":"WB Zhao","year":"2025","unstructured":"Zhao WB, Sheng R. The correlation between mitochondria-associated endoplasmic reticulum membranes (MAMs) and Ca(2+) transport in the pathogenesis of diseases. Acta Pharmacol Sin. 2025;46(2):271\u201391. https:\/\/doi.org\/10.1038\/s41401-024-01359-9. ,05.","journal-title":"Acta Pharmacol Sin"},{"issue":"4","key":"4769_CR9","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.cell.2019.04.010","volume":"177","author":"MI Hern\u00e1ndez-Alvarez","year":"2019","unstructured":"Hern\u00e1ndez-Alvarez MI, Sebasti\u00e1n D, Vives S, Ivanova S, Bartoccioni P, Kakimoto P, Plana N, Veiga SR, Hern\u00e1ndez V, Vasconcelos N, Peddinti G, Adrover A, Jov\u00e9 M, Pamplona R, Gordaliza-Alaguero I, Calvo E, Cabr\u00e9 N, Castro R, Kuzmanic A, Boutant M, Sala D, Hyotylainen T, Ore\u0161i\u010d M, Fort J, Errasti-Murugarren E, Rodr\u00edgues CMP, Orozco M, Joven J, Cant\u00f3 C, Palacin M, Fern\u00e1ndez-Veledo S, Vendrell J, Zorzano A. Transf Causes Liver Disease Cell. 2019;177(4):881\u201395. https:\/\/doi.org\/10.1016\/j.cell.2019.04.010. e17,05. Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine.","journal-title":"Transf Causes Liver Disease Cell"},{"issue":"3","key":"4769_CR10","doi-asserted-by":"publisher","first-page":"05","DOI":"10.3390\/cells10030657","volume":"10","author":"N Wang","year":"2021","unstructured":"Wang N, Wang C, Zhao H, He Y, Lan B, Sun L, Gao Y. The MAMs Structure and Its Role in Cell Death. Cells. 2021;10(3):05. https:\/\/doi.org\/10.3390\/cells10030657.","journal-title":"Cells"},{"issue":"2","key":"4769_CR11","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.3892\/mmr.2018.9704","volume":"19","author":"Q Liang","year":"2019","unstructured":"Liang Q, Zhang Y, Huang M, Xiao Y, Xiao F. Role of mitochondrial damage in Cr(VI)\u2013induced endoplasmic reticulum stress in L\u201302 hepatocytes. Mol Med Rep. 2019;19(2):1256\u2013126505. https:\/\/doi.org\/10.3892\/mmr.2018.9704.","journal-title":"Mol Med Rep"},{"issue":"1","key":"4769_CR12","doi-asserted-by":"publisher","first-page":"70105","DOI":"10.1186\/s12967-023-04560-2","volume":"21","author":"M Yan","year":"2023","unstructured":"Yan M, Wang J, Wang H, Zhou J, Qi H, Naji Y, Zhao L, Tang Y, Dai Y. Knockdown of NR3C1 inhibits the proliferation and migration of clear cell renal cell carcinoma through activating endoplasmic reticulum stress-mitophagy. J Transl Med. 2023;21(1):70105. https:\/\/doi.org\/10.1186\/s12967-023-04560-2.","journal-title":"J Transl Med"},{"issue":"6","key":"4769_CR13","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1002\/tox.23115","volume":"36","author":"MB Dlamini","year":"2021","unstructured":"Dlamini MB, Gao Z, Hasenbilige L, Jiang C, Geng Q, Li X, Shi Y, Liu J, Cao. The crosstalk between mitochondrial dysfunction and endoplasmic reticulum stress promoted ATF4-mediated mitophagy induced by hexavalent chromium. Environ Toxicol. 2021;36(6):1162\u201372. https:\/\/doi.org\/10.1002\/tox.23115.","journal-title":"Environ Toxicol"},{"key":"4769_CR14","doi-asserted-by":"publisher","first-page":"84821405","DOI":"10.3389\/fcell.2022.848214","volume":"10","author":"S Wang","year":"2022","unstructured":"Wang S, Tan J, Miao Y, Zhang Q. Mitochondrial Dynamics, Mitophagy, and Mitochondria-Endoplasmic Reticulum Contact Sites Crosstalk Under Hypoxia. Front Cell Dev Biol. 2022;10:84821405. https:\/\/doi.org\/10.3389\/fcell.2022.848214.","journal-title":"Front Cell Dev Biol"},{"issue":"16","key":"4769_CR15","doi-asserted-by":"publisher","first-page":"6816","DOI":"10.18632\/oncotarget.2256","volume":"5","author":"MJ Yoon","year":"2014","unstructured":"Yoon MJ, Lee AR, Jeong SA, Kim YS, Kim JY, Kwon YJ, Choi KS. Release of Ca2\u2009+\u2009from the endoplasmic reticulum and its subsequent influx into mitochondria trigger celastrol-induced paraptosis in cancer cells. Oncotarget. 2014;5(16):6816. https:\/\/doi.org\/10.18632\/oncotarget.2256. -31,05.","journal-title":"Oncotarget"},{"key":"4769_CR16","doi-asserted-by":"publisher","unstructured":"Liu M, Fan Y, Li D, Han B, Meng Y, Chen F, Liu T, Song Z, Han Y, Huang L, Chang Y, Cao P, Nakai A, Tan K. Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS-mitochondrial fission-mitophagy axis. Mol Oncol. 2021;15(8). https:\/\/doi.org\/10.1002\/1878-0261.12936. 2084\u20132105,05.","DOI":"10.1002\/1878-0261.12936"},{"issue":"11","key":"4769_CR17","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.1080\/15548627.2022.2039535","volume":"18","author":"J Xu","year":"2022","unstructured":"Xu J, Yang KC, Go NE, Colborne S, Ho CJ, Hosseini-Beheshti E, Lystad AH, Simonsen A, Guns ET, Morin GB, Gorski SM. Chloroquine treatment induces secretion of autophagy-related proteins and inclusion of Atg8-family proteins in distinct extracellular vesicle populations. Autophagy. 2022;18(11):2547\u2013256005. https:\/\/doi.org\/10.1080\/15548627.2022.2039535.","journal-title":"Autophagy"},{"issue":"1","key":"4769_CR18","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1021\/acs.jmedchem.1c01690","volume":"65","author":"Y Guo","year":"2022","unstructured":"Guo Y, Jin S, Yuan H, Yang T, Wang K, Guo Z, Wang X. DNA-Unresponsive Platinum(II) Complex Induces ERS-Mediated Mitophagy in Cancer Cells. J Med Chem. 2022;65(1):520\u201353005. https:\/\/doi.org\/10.1021\/acs.jmedchem.1c01690.","journal-title":"J Med Chem"},{"issue":"7","key":"4769_CR19","doi-asserted-by":"publisher","first-page":"05","DOI":"10.3390\/molecules28073185","volume":"28","author":"N Lei","year":"2023","unstructured":"Lei N, Song H, Zeng L, Ji S, Meng X, Zhu X, Li X, Feng Q, Liu J, Mu J. Persistent Lipid Accumulation Leads to Persistent Exacerbation of Endoplasmic Reticulum Stress and Inflammation in Progressive NASH via the IRE1\u03b1\/TRAF2 Complex. Molecules. 2023;28(7):05. https:\/\/doi.org\/10.3390\/molecules28073185.","journal-title":"Molecules"},{"issue":"9","key":"4769_CR20","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1038\/s41401-020-00572-6","volume":"42","author":"CJ Zhang","year":"2021","unstructured":"Zhang CJ, Zhu N, Long J, Wu HT, Wang YX, Liu BY, Liao DF, Qin L. Celastrol induces lipophagy via the LXR\u03b1\/ABCA1 pathway in clear cell renal cell carcinoma. Acta Pharmacol Sin. 2021;42(9):1472\u201385. https:\/\/doi.org\/10.1038\/s41401-020-00572-6.","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"4769_CR21","doi-asserted-by":"publisher","first-page":"598905","DOI":"10.1038\/s41467-021-26295-8","volume":"12","author":"SZ Peng","year":"2021","unstructured":"Peng SZ, Chen XH, Chen SJ, Zhang J, Wang CY, Liu WR, Zhang D, Su Y, Zhang XK. Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62\/SQSTM1 condensates. Nat Commun. 2021;12(1):598905. https:\/\/doi.org\/10.1038\/s41467-021-26295-8.","journal-title":"Nat Commun"},{"key":"4769_CR22","doi-asserted-by":"publisher","unstructured":"Oroojalian F, Beygi M, Baradaran B, Mokhtarzadeh A, Shahbazi MA. Immune Cell Membrane-Coated Biomimetic Nanoparticles for Targeted Cancer Therapy. Small. 2021;17(12). https:\/\/doi.org\/10.1002\/smll.202006484. e2006484,05.","DOI":"10.1002\/smll.202006484"},{"issue":"1","key":"4769_CR23","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41571-022-00699-x","volume":"20","author":"RH Fang","year":"2023","unstructured":"Fang RH, Gao W, Zhang L. Targeting drugs to tumours using cell membrane-coated nanoparticles. Nat Rev Clin Oncol. 2023;20(1):33\u201348. https:\/\/doi.org\/10.1038\/s41571-022-00699-x. ,05.","journal-title":"Nat Rev Clin Oncol"},{"issue":"3","key":"4769_CR24","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1007\/s13346-022-01252-0","volume":"13","author":"H Liu","year":"2023","unstructured":"Liu H, Su YY, Jiang XC, Gao JQ. Cell membrane-coated nanoparticles: a novel multifunctional biomimetic drug delivery system. Drug Deliv Transl Res. 2023;13(3):716\u201337. https:\/\/doi.org\/10.1007\/s13346-022-01252-0. ,05.","journal-title":"Drug Deliv Transl Res"},{"issue":"8","key":"4769_CR25","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.1016\/j.apsb.2022.02.023","volume":"12","author":"Y Zeng","year":"2022","unstructured":"Zeng Y, Li S, Zhang S, Wang L, Yuan H, Hu F. Cell membrane coated-nanoparticles for cancer immunotherapy. Acta Pharm Sin B. 2022;12(8):3233\u201354. https:\/\/doi.org\/10.1016\/j.apsb.2022.02.023.","journal-title":"Acta Pharm Sin B"},{"issue":"23","key":"4769_CR26","doi-asserted-by":"publisher","first-page":"05","DOI":"10.1002\/adma.201706759","volume":"30","author":"RH Fang","year":"2018","unstructured":"Fang RH, Kroll AV, Gao W, Zhang L. Cell Membrane Coating Nanotechnology, Advanced materials (Deerfield Beach. Fla). 2018;30(23):05. https:\/\/doi.org\/10.1002\/adma.201706759. e1706759,.","journal-title":"Fla)"},{"issue":"46","key":"4769_CR27","doi-asserted-by":"publisher","first-page":"E9863","DOI":"10.1073\/pnas.1708782114","volume":"114","author":"X Huang","year":"2017","unstructured":"Huang X, Zhou X, Hu X, Joshi AS, Guo X, Zhu Y, Chen Q, Prinz WA, Hu J. Sequences flanking the transmembrane segments facilitate mitochondrial localization and membrane fusion by mitofusin. Proc Natl Acad Sci USA. 2017;114(46):E9863. https:\/\/doi.org\/10.1073\/pnas.1708782114. e9872,05.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"4769_CR28","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1159\/000486222","volume":"45","author":"F Wang","year":"2018","unstructured":"Wang F, Tang J, Li P, Si S, Yu H, Yang X, Tao J, Lv Q, Gu M, Yang H, Wang Z. Chloroquine Enhances the Radiosensitivity of Bladder Cancer Cells by Inhibiting Autophagy and Activating Apoptosis. Cell Physiol biochemistry: Int J experimental Cell Physiol Biochem Pharmacol. 2018;45(1):54\u201366. https:\/\/doi.org\/10.1159\/000486222.","journal-title":"Cell Physiol biochemistry: Int J experimental Cell Physiol Biochem Pharmacol"},{"key":"4769_CR29","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1186\/s12935-018-0705-x","volume":"19","author":"H Wang","year":"2019","unstructured":"Wang H, Zhao Z, Lei S, Li S, Xiang Z, Wang X, Huang X, Xia G, Huang X. Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species. Cancer Cell Int. 2019;19:705. https:\/\/doi.org\/10.1186\/s12935-018-0705-x.","journal-title":"Cancer Cell Int"},{"issue":"22","key":"4769_CR30","doi-asserted-by":"publisher","first-page":"10290","DOI":"10.7150\/thno.46728","volume":"10","author":"X Chen","year":"2020","unstructured":"Chen X, Zhao Y, Luo W, Chen S, Lin F, Zhang X, Fan S, Shen X, Wang Y, Liang G. Celastrol induces ROS-mediated apoptosis via directly targeting peroxiredoxin-2 in gastric cancer cells. Theranostics. 2020;10(22):10290\u2013308. https:\/\/doi.org\/10.7150\/thno.46728.","journal-title":"Theranostics"},{"issue":"12","key":"4769_CR31","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.tips.2018.10.004","volume":"39","author":"AS Limpert","year":"2018","unstructured":"Limpert AS, Lambert LJ, Bakas NA, Bata N, Brun SN, Shaw RJ, Cosford NDP. Autophagy in Cancer: Regulation by Small Molecules. Trends Pharmacol Sci. 2018;39(12):1021\u2013103205. https:\/\/doi.org\/10.1016\/j.tips.2018.10.004.","journal-title":"Trends Pharmacol Sci"},{"key":"4769_CR32","doi-asserted-by":"publisher","unstructured":"Bj\u00f8rk\u00f8y G, Lamark T, Pankiv S, \u00d8vervatn A, Brech A, Johansen T. Monitoring autophagic degradation of p62\/SQSTM1, Methods in enzymology 452 (2009) 181\u2009\u2013\u200997,05. https:\/\/doi.org\/10.1016\/s0076-6879(08)03612-4","DOI":"10.1016\/s0076-6879(08)03612-4"},{"issue":"2","key":"4769_CR33","doi-asserted-by":"publisher","first-page":"248105","DOI":"10.4081\/ejh.2015.2481","volume":"59","author":"AM Schl\u00e4fli","year":"2015","unstructured":"Schl\u00e4fli AM, Berezowska S, Adams O, Langer R, Tschan MP. Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry. Eur J histochemistry: EJH. 2015;59(2):248105. https:\/\/doi.org\/10.4081\/ejh.2015.2481.","journal-title":"Eur J histochemistry: EJH"},{"key":"4769_CR34","doi-asserted-by":"publisher","unstructured":"Golden EB, Cho HY, Jahanian A, Hofman FM, Louie SG, Sch\u00f6nthal AH, Chen TC. Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy. NeuroSurg Focus. 2014;37(6). https:\/\/doi.org\/10.3171\/2014.9.Focus14504. E12,05.","DOI":"10.3171\/2014.9.Focus14504"},{"key":"4769_CR35","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.mito.2021.03.008","volume":"58","author":"S Panda","year":"2021","unstructured":"Panda S, Behera S, Alam MF, Syed GH. Endoplasmic reticulum & mitochondrial calcium homeostasis: The interplay with viruses. Mitochondrion. 2021;58:227\u201342. https:\/\/doi.org\/10.1016\/j.mito.2021.03.008. ,05.","journal-title":"Mitochondrion"},{"key":"4769_CR36","doi-asserted-by":"publisher","first-page":"43105","DOI":"10.3389\/fcell.2020.00431","volume":"8","author":"Y Xie","year":"2020","unstructured":"Xie Y, Li J, Kang R, Tang D. Interplay Between Lipid Metabolism and Autophagy. Front cell Dev biology. 2020;8:43105. https:\/\/doi.org\/10.3389\/fcell.2020.00431.","journal-title":"Front cell Dev biology"},{"key":"4769_CR37","doi-asserted-by":"publisher","unstructured":"Bezawork-Geleta A, Devereux CJ, Keenan SN, Lou J, Cho E, Nie S, De Souza DP, Narayana VK, Siddall NA, Rodrigues CHM, Portelli S, Zheng T, Nim HT, Ramialison M, Hime GR, Dodd GT, Hinde E, Ascher DB, Stroud DA, Watt MJ. Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites. Nat Commun. 2025;16(1). https:\/\/doi.org\/10.1038\/s41467-025-57405-5. 2135,05.","DOI":"10.1038\/s41467-025-57405-5"},{"key":"4769_CR38","doi-asserted-by":"publisher","unstructured":"Tian H, Sun S, Qiu X, Wang J, Gao Y, Chen J, Han X, Bao Z, Guo X, Sun Y, Lin Y, Hu M, Zhang F, Zhang Z, Wang F, Zheng S, Shao J. Diallyl Trisulfide From Garlic Regulates RAB18 Phase Separation to Inhibit Lipophagy and Induce Cuproptosis in Hepatic Stellate Cells for Antifibrotic Effects. Adv Sci (Weinh). 2025;12(21). https:\/\/doi.org\/10.1002\/advs.202415325. e2415325,05.","DOI":"10.1002\/advs.202415325"},{"issue":"6","key":"4769_CR39","doi-asserted-by":"publisher","first-page":"6707","DOI":"10.18632\/oncotarget.24158","volume":"9","author":"GP Collett","year":"2018","unstructured":"Collett GP, Redman CW, Sargent IL, Vatish M. Endoplasmic reticulum stress stimulates the release of extracellular vesicles carrying danger-associated molecular pattern (DAMP) molecules. Oncotarget. 2018;9(6):6707\u201317. https:\/\/doi.org\/10.18632\/oncotarget.24158.","journal-title":"Oncotarget"},{"key":"4769_CR40","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.jconrel.2021.07.038","volume":"337","author":"A Banstola","year":"2021","unstructured":"Banstola A, Poudel K, Kim JO, Jeong JH, Yook S. Recent progress in stimuli-responsive nanosystems for inducing immunogenic cell death. J controlled release: official J Controlled Release Soc. 2021;337:505\u201352005. https:\/\/doi.org\/10.1016\/j.jconrel.2021.07.038.","journal-title":"J controlled release: official J Controlled Release Soc"},{"key":"4769_CR41","doi-asserted-by":"publisher","first-page":"11011005","DOI":"10.1016\/j.abb.2024.110110","volume":"759","author":"S Ghosh","year":"2024","unstructured":"Ghosh S, Ghatak D, Dutta R, Goswami D, De R. PINK1 insufficiency can be exploited as a specific target for drug combinations inducing mitochondrial pathology-mediated cell death in gastric adenocarcinoma. Arch Biochem Biophys. 2024;759:11011005. https:\/\/doi.org\/10.1016\/j.abb.2024.110110.","journal-title":"Arch Biochem Biophys"},{"key":"4769_CR42","doi-asserted-by":"publisher","first-page":"15026805","DOI":"10.1016\/j.bbrc.2024.150268","volume":"726","author":"S Ghosh","year":"2024","unstructured":"Ghosh S, Dutta R, Ghatak D, Goswami D, De R. Immunometabolic characteristics of Dendritic Cells and its significant modulation by mitochondria-associated signaling in the tumor microenvironment influence cancer progression. Biochem Biophys Res Commun. 2024;726:15026805. https:\/\/doi.org\/10.1016\/j.bbrc.2024.150268.","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"4769_CR43","doi-asserted-by":"publisher","first-page":"18947105","DOI":"10.1016\/j.bbcan.2025.189471","volume":"1880","author":"S Ghosh","year":"2025","unstructured":"Ghosh S, Dutta R, Goswami D, Ghatak D, De R. Mitochondrial dynamics and metabolic attributes regulate function of natural killer cell and infiltration in tumor microenvironment modulating disease progression. Biochim Biophys Acta Rev Cancer. 2025;1880(6):18947105. https:\/\/doi.org\/10.1016\/j.bbcan.2025.189471.","journal-title":"Biochim Biophys Acta Rev Cancer"},{"issue":"3","key":"4769_CR44","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1007\/s12013-024-01366-x","volume":"82","author":"S Ghosh","year":"2024","unstructured":"Ghosh S, Goswami D, Dutta R, Ghatak D, De R. Pan-Cancer Analysis of Cytochrome C Oxidase Assembly Factor 1 (COA1) Reveals Instrumental Role of Mitochondrial Protein Assembly in Cancer that Modulates Disease Progression and Prognostic Outcome. Cell Biochem Biophys. 2024;82(3):2533\u201355. https:\/\/doi.org\/10.1007\/s12013-024-01366-x.","journal-title":"Cell Biochem Biophys"},{"key":"4769_CR45","doi-asserted-by":"publisher","first-page":"11536905","DOI":"10.1016\/j.bcp.2022.115369","volume":"208","author":"S Dubey","year":"2023","unstructured":"Dubey S, Ghosh S, Goswami D, Ghatak D, De R. Immunometabolic attributes and mitochondria-associated signaling of Tumor-Associated Macrophages in tumor microenvironment modulate cancer progression. Biochem Pharmacol. 2023;208:11536905. https:\/\/doi.org\/10.1016\/j.bcp.2022.115369.","journal-title":"Biochem Pharmacol"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-026-04769-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-026-04769-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-026-04769-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:34:55Z","timestamp":1785774895000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12951-026-04769-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,8]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4769"],"URL":"https:\/\/doi.org\/10.1186\/s12951-026-04769-5","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,8]]},"assertion":[{"value":"17 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All experimental procedures strictly complied with the guidelines approved by the Animal Care and Use Committee of Zhejiang Chinese Medical University, in accordance with ethical permit No. IACUC-20230821-09.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"707"}}