{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:40:01Z","timestamp":1792788001547,"version":"4.5.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":82,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Chongqing medical scientific research project"},{"name":"Research grant from Jinfeng Laboratory","id":[{"id":"https:\/\/ror.org\/04amdcz96","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Natural Science Foundation of Chongqing, China"},{"name":"Chongqing Technological Innovation and Application Development Major Projects"},{"name":"The Special Funding Project of Chongqing Municipality"},{"name":"Chongqing Medical Young Talents Project"},{"name":"Science and Technology Research Project of Chongqing Education Commission"},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Young Top Talent Project of the First Affiliated Hospital of Chongqing Medical University","id":[{"id":"https:\/\/ror.org\/033vnzz93","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"DOI":"10.1186\/s12951-026-04782-8","type":"journal-article","created":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T13:14:16Z","timestamp":1783257256000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In situ imaging of proximal biomolecules via Proximity Anchored Modules Assembly"],"prefix":"10.1186","volume":"24","author":[{"given":"Yuting","family":"Zou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijia","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1921-9761","authenticated-orcid":false,"given":"Wei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,5]]},"reference":[{"key":"4782_CR1","doi-asserted-by":"publisher","unstructured":"Kuna RS, Kumar A, Wessendorf-Rodriguez KA, Galvez H, Green CR, McGregor GH, Cordes T, Shaw RJ, Svensson RU, Metallo CM. Inter-Organelle Cross-Talk Supports Acetyl-Coenzyme A Homeostasis and Lipogenesis under Metabolic Stress. Sci Adv. 2023;9(18). https:\/\/doi.org\/10.1126\/sciadv.adf0138.","DOI":"10.1126\/sciadv.adf0138"},{"issue":"6","key":"4782_CR2","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s11892-020-01300-4","volume":"20","author":"SN Keenan","year":"2020","unstructured":"Keenan SN, Watt MJ, Montgomery MK. Inter-Organelle Communication in the Pathogenesis of Mitochondrial Dysfunction and Insulin Resistance. Curr Diab Rep. 2020;20(6):20. https:\/\/doi.org\/10.1007\/s11892-020-01300-4.","journal-title":"Curr Diab Rep"},{"issue":"5","key":"4782_CR3","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.trecan.2024.01.009","volume":"10","author":"A Gkountakos","year":"2024","unstructured":"Gkountakos A, Singhi AD, Westphalen CB, Scarpa A, Luchini C. Fusion Genes in Pancreatic Tumors. Trends Cancer. 2024;10(5):430\u201343. https:\/\/doi.org\/10.1016\/j.trecan.2024.01.009.","journal-title":"Trends Cancer"},{"issue":"1","key":"4782_CR4","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1002\/cac2.12120","volume":"41","author":"J Wang","year":"2021","unstructured":"Wang J, Ma H-L, Liu W-R, Peng Y, Zhou J-K, Yang J-L. CircBA1 Derived from BCR-ABL Fusion Gene Inhibits Cell Proliferation in Chronic Myeloid Leukemia. Cancer Commun. 2021;41(1):79\u201382. https:\/\/doi.org\/10.1002\/cac2.12120.","journal-title":"Cancer Commun"},{"issue":"4","key":"4782_CR5","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/s41551-018-0212-3","volume":"2","author":"H-W Lee","year":"2018","unstructured":"Lee H-W, Choi B, Kang HN, Kim H, Min A, Cha M, Ryu JY, Park S, Sohn J, Shin K, Yun MR, Han JY, Shon MJ, Jeong C, Chung J, Lee S-H, Im S-A, Cho BC, Yoon T-Y. Profiling of Protein\u2013Protein Interactions via Single-Molecule Techniques Predicts the Dependence of Cancers on Growth-Factor Receptors. Nat Biomed Eng. 2018;2(4):239\u201353. https:\/\/doi.org\/10.1038\/s41551-018-0212-3.","journal-title":"Nat Biomed Eng"},{"issue":"5","key":"4782_CR6","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/s41587-025-02592-1","volume":"43","author":"NA Till","year":"2025","unstructured":"Till NA, Ramanathan M, Bertozzi CR. Induced Proximity at the Cell Surface. Nat Biotechnol. 2025;43(5):702\u201311. https:\/\/doi.org\/10.1038\/s41587-025-02592-1.","journal-title":"Nat Biotechnol"},{"issue":"4","key":"4782_CR7","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1038\/s41571-024-00869-z","volume":"21","author":"M Katoh","year":"2024","unstructured":"Katoh M, Loriot Y, Brandi G, Tavolari S, Wainberg ZA, Katoh MFGFR-T, Therapeutics. Clinical Activity, Mechanisms of Resistance and New Directions. Nat Rev Clin Oncol. 2024;21(4):312\u201329. https:\/\/doi.org\/10.1038\/s41571-024-00869-z.","journal-title":"Nat Rev Clin Oncol"},{"issue":"13","key":"4782_CR8","doi-asserted-by":"publisher","first-page":"11477","DOI":"10.1021\/jacs.5c01559","volume":"147","author":"M Wakano","year":"2025","unstructured":"Wakano M, Tsunoda M, Murayama K, Morimoto J, Ueki R, Aoyama-Ishiwatari S, Hirabayashi Y, Asanuma H, Sando S. Reversible Optical Control of Receptor Tyrosine Kinase Activity and ERK Dynamics Using Azobenzene-Carrying DNA Aptamer Agonist. J Am Chem Soc. 2025;147(13):11477\u201384. https:\/\/doi.org\/10.1021\/jacs.5c01559.","journal-title":"J Am Chem Soc"},{"issue":"11","key":"4782_CR9","doi-asserted-by":"publisher","first-page":"12840","DOI":"10.1021\/acsnano.9b05082","volume":"13","author":"H Shi","year":"2019","unstructured":"Shi H, Wang Y, Zheng J, Ning L, Huang Y, Sheng A, Chen T, Xiang Y, Zhu X, Li G. Dual-Responsive DNA Nanodevice for the Available Imaging of an Apoptotic Signaling Pathway in Situ. ACS Nano. 2019;13(11):12840\u201350. https:\/\/doi.org\/10.1021\/acsnano.9b05082.","journal-title":"ACS Nano"},{"issue":"46","key":"4782_CR10","doi-asserted-by":"publisher","first-page":"2508992","DOI":"10.1002\/adfm.202508992","volume":"35","author":"M Yu","year":"2025","unstructured":"Yu M, Shang J, Xie C, Jiang Y, Wang Y, Liu X, Wang F. An Integrated Sequential-Activated DNA Circuit for Reliable Imaging of Intracellular miRNA and Remote Control of Cellular Function. Adv Funct Mater. 2025;35(46):2508992. https:\/\/doi.org\/10.1002\/adfm.202508992.","journal-title":"Adv Funct Mater"},{"issue":"7","key":"4782_CR11","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/s41551-024-01225-3","volume":"8","author":"Y Liu","year":"2024","unstructured":"Liu Y, Sundah NR, Ho NRY, Shen WX, Xu Y, Natalia A, Yu Z, Seet JE, Chan CW, Loh TP, Lim BY, Shao H. Bidirectional Linkage of DNA Barcodes for the Multiplexed Mapping of Higher-Order Protein Interactions in Cells. Nat Biomed Eng. 2024;8(7):909\u201323. https:\/\/doi.org\/10.1038\/s41551-024-01225-3.","journal-title":"Nat Biomed Eng"},{"issue":"7","key":"4782_CR12","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1016\/j.cell.2024.02.041","volume":"187","author":"A Passaro","year":"2024","unstructured":"Passaro A, Bakir MA, Hamilton EG, Diehn M, Andr\u00e9 F, Roy-Chowdhuri S, Mountzios G, Wistuba II, Swanton C, Peters S. Cancer Biomarkers: Emerging Trends and Clinical Implications for Personalized Treatment. Cell. 2024;187(7):1617\u201335. https:\/\/doi.org\/10.1016\/j.cell.2024.02.041.","journal-title":"Cell"},{"issue":"3","key":"4782_CR13","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jtho.2018.12.005","volume":"14","author":"Y Yatabe","year":"2019","unstructured":"Yatabe Y, Dacic S, Borczuk AC, Warth A, Russell PA, Lantuejoul S, Beasley MB, Thunnissen E, Pelosi G, Rekhtman N, Bubendorf L, Mino-Kenudson M, Yoshida A, Geisinger KR, Noguchi M, Chirieac LR, Bolting J, Chung J-H, Chou T-Y, Chen G, Poleri C, Lopez-Rios F, Papotti M, Sholl LM, Roden AC, Travis WD, Hirsch FR, Kerr KM, Tsao M-S, Nicholson AG, Wistuba I, Moreira AL. Best Practices Recommendations for Diagnostic Immunohistochemistry in Lung Cancer. J Thorac Oncol. 2019;14(3):377\u2013407. https:\/\/doi.org\/10.1016\/j.jtho.2018.12.005.","journal-title":"J Thorac Oncol"},{"issue":"1","key":"4782_CR14","doi-asserted-by":"publisher","first-page":"5102","DOI":"10.1038\/s41467-020-18789-8","volume":"11","author":"M Dos Santos","year":"2020","unstructured":"Dos Santos M, Backer S, Saintpierre B, Izac B, Andrieu M, Letourneur F, Relaix F, Sotiropoulos A, Maire P. Single-Nucleus RNA-Seq and FISH Identify Coordinated Transcriptional Activity in Mammalian Myofibers. Nat Commun. 2020;11(1):5102. https:\/\/doi.org\/10.1038\/s41467-020-18789-8.","journal-title":"Nat Commun"},{"issue":"7","key":"4782_CR15","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41592-020-0858-0","volume":"17","author":"JJL Goh","year":"2020","unstructured":"Goh JJL, Chou N, Seow WY, Ha N, Cheng CPP, Chang Y-C, Zhao ZW, Chen KH. Highly Specific Multiplexed RNA Imaging in Tissues with Split-FISH. Nat Methods. 2020;17(7):689\u201393. https:\/\/doi.org\/10.1038\/s41592-020-0858-0.","journal-title":"Nat Methods"},{"key":"4782_CR16","doi-asserted-by":"publisher","unstructured":"Shi L, Yang C, Zhang M, Li K, Wang K, Jiao L, Liu R, Wang Y, Li M, Wang Y, Ma L, Hu S, Bian X. Dissecting the Mechanism of Atlastin-Mediated Homotypic Membrane Fusion at the Single-Molecule Level. Nat Commun. 2024;15(1). https:\/\/doi.org\/10.1038\/s41467-024-46919-z.","DOI":"10.1038\/s41467-024-46919-z"},{"issue":"2","key":"4782_CR17","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/s41592-020-01010-5","volume":"18","author":"W Qin","year":"2021","unstructured":"Qin W, Cho KF, Cavanagh PE, Ting AY. Deciphering Molecular Interactions by Proximity Labeling. Nat Methods. 2021;18(2):133\u201343. https:\/\/doi.org\/10.1038\/s41592-020-01010-5.","journal-title":"Nat Methods"},{"issue":"30","key":"4782_CR18","doi-asserted-by":"publisher","first-page":"16458","DOI":"10.1021\/jacs.3c02752","volume":"145","author":"S Albright","year":"2023","unstructured":"Albright S, Cacace M, Tivon Y, Deiters A. Cell Surface Labeling and Detection of Protein Tyrosine Kinase 7 via Covalent Aptamers. J Am Chem Soc. 2023;145(30):16458\u201363. https:\/\/doi.org\/10.1021\/jacs.3c02752.","journal-title":"J Am Chem Soc"},{"issue":"6","key":"4782_CR19","doi-asserted-by":"publisher","first-page":"e64","DOI":"10.1093\/nar\/gni063","volume":"33","author":"DA Di Giusto","year":"2005","unstructured":"Di Giusto DA, Wlassoff WA, Gooding JJ, Messerle BA, King GC. Proximity Extension of Circular DNA Aptamers with Real-Time Protein Detection. Nucleic Acids Res. 2005;33(6):e64. https:\/\/doi.org\/10.1093\/nar\/gni063.","journal-title":"Nucleic Acids Res"},{"issue":"15","key":"4782_CR20","doi-asserted-by":"publisher","first-page":"e102","DOI":"10.1093\/nar\/gkr424","volume":"39","author":"M Lundberg","year":"2011","unstructured":"Lundberg M, Eriksson A, Tran B, Assarsson E, Fredriksson S. Homogeneous Antibody-Based Proximity Extension Assays Provide Sensitive and Specific Detection of Low-Abundant Proteins in Human Blood. Nucleic Acids Res. 2011;39(15):e102\u2013102. https:\/\/doi.org\/10.1093\/nar\/gkr424.","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"4782_CR21","doi-asserted-by":"publisher","first-page":"20220175","DOI":"10.1002\/EXP.20220175","volume":"3","author":"XCR Deng","year":"2023","unstructured":"Deng XCR, Su D, Ma X, Han X, Wang S, Xia Y, Yang Z, Gong N, Jia Y, Gao X. X.Ren. Visual Genetic Typing of Glioma Using Proximity-Anchored in Situ Spectral Coding Amplification. Exploration. 2023;3(5):20220175. https:\/\/doi.org\/10.1002\/EXP.20220175.","journal-title":"Exploration"},{"issue":"2","key":"4782_CR22","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/nchem.2872","volume":"10","author":"JY Kishi","year":"2018","unstructured":"Kishi JY, Schaus TE, Gopalkrishnan N, Xuan F, Yin P. Programmable Autonomous Synthesis of Single-Stranded DNA. Nat Chem. 2018;10(2):155\u201364. https:\/\/doi.org\/10.1038\/nchem.2872.","journal-title":"Nat Chem"},{"key":"4782_CR23","doi-asserted-by":"publisher","first-page":"101965","DOI":"10.1016\/j.ctrv.2020.101965","volume":"84","author":"F Schettini","year":"2020","unstructured":"Schettini F, Pascual T, Conte B, Chic N, Bras\u00f3-Maristany F, Galv\u00e1n P, Mart\u00ednez O, Adamo B, Vidal M, Mu\u00f1oz M, Fern\u00e1ndez-Martinez A, Rognoni C, Griguolo G, Guarneri V, Conte PF, Locci M, Brase JC, Gonzalez-Farre B, Villagrasa P, De Placido S, Schiff R, Veeraraghavan J, Rimawi MF, Osborne CK, Pernas S, Perou CM, Carey LA, Prat A. HER2-Enriched Subtype and Pathological Complete Response in HER2-Positive Breast Cancer: A Systematic Review and Meta-Analysis. Cancer Treat Rev. 2020;84:101965. https:\/\/doi.org\/10.1016\/j.ctrv.2020.101965.","journal-title":"Cancer Treat Rev"},{"issue":"1","key":"4782_CR24","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/s41392-025-02181-3","volume":"10","author":"C Liu","year":"2025","unstructured":"Liu C, Sun L, Niu N, Hou P, Chen G, Wang H, Zhang Z, Jiang X, Xu Q, Zhao Y, Wang Y, Shi Y, Liu M, Yang Y, Qian W, Wang J, Liu C. Molecular Classification of Hormone Receptor-Positive \/HER2-Positive Breast Cancer Reveals Potential Neoadjuvant Therapeutic Strategies. Signal Transduct Target Ther. 2025;10(1):97. https:\/\/doi.org\/10.1038\/s41392-025-02181-3.","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"4782_CR25","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1002\/cac2.12632","volume":"45","author":"A Azad","year":"2024","unstructured":"Azad A, Arshad M, Generali D, Feldinger K, Gijsen M, Strina C, Cappelletti M, Andreis D, Leek R, Haider S, Kellokumpu-Lehtinen P-L, Roxanis I, Harris AL, Shaaban AM, Joensuu H, Kong A. PTPN9 Regulates HER3 Phosphorylation during Trastuzumab Treatment and Loss of PTPN9 Is a Potential Biomarker for Trastuzumab Resistance in HER2 Positive Breast Cancer. Cancer Commun. 2024;45(1):68\u201373. https:\/\/doi.org\/10.1002\/cac2.12632.","journal-title":"Cancer Commun"},{"key":"4782_CR26","doi-asserted-by":"publisher","first-page":"101078","DOI":"10.1016\/j.drup.2024.101078","volume":"74","author":"L Yang","year":"2024","unstructured":"Yang L, Bhattacharya A, Peterson D, Li Y, Liu X, Marangoni E, Robila V, Zhang Y. Targeted Dual Degradation of HER2 and EGFR Obliterates Oncogenic Signaling, Overcomes Therapy Resistance, and Inhibits Metastatic Lesions in HER2-Positive Breast Cancer Models. Drug Resist Updat. 2024;74:101078. https:\/\/doi.org\/10.1016\/j.drup.2024.101078.","journal-title":"Drug Resist Updat"},{"issue":"3","key":"4782_CR27","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/s41568-020-00322-0","volume":"21","author":"S Kumagai","year":"2021","unstructured":"Kumagai S, Koyama S, Nishikawa H. Antitumour Immunity Regulated by Aberrant ERBB Family Signalling. Nat Rev Cancer. 2021;21(3):181\u201397. https:\/\/doi.org\/10.1038\/s41568-020-00322-0.","journal-title":"Nat Rev Cancer"},{"issue":"8","key":"4782_CR28","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1007\/s12094-017-1629-y","volume":"19","author":"A Sett","year":"2017","unstructured":"Sett A, Borthakur BB, Bora U. Selection of DNA Aptamers for Extra Cellular Domain of Human Epidermal Growth Factor Receptor 2 to Detect HER2 Positive Carcinomas. Clin Transl Oncol. 2017;19(8):976\u201388. https:\/\/doi.org\/10.1007\/s12094-017-1629-y.","journal-title":"Clin Transl Oncol"},{"issue":"4","key":"4782_CR29","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.bbrc.2014.09.023","volume":"453","author":"D-L Wang","year":"2014","unstructured":"Wang D-L, Song Y-L, Zhu Z, Li X-L, Zou Y, Yang H-T, Wang J-J, Yao P-S, Pan R-J, Yang CJ, Kang D-Z. Selection of DNA Aptamers against Epidermal Growth Factor Receptor with High Affinity and Specificity. Biochem Biophys Res Commun. 2014;453(4):681\u20135. https:\/\/doi.org\/10.1016\/j.bbrc.2014.09.023.","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"4782_CR30","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.7150\/thno.31943","volume":"9","author":"L Xu","year":"2019","unstructured":"Xu L, Liu S, Yang T, Shen Y, Zhang Y, Huang L, Zhang L, Ding S, Song F, Cheng W. DNAzyme Catalyzed Tyramide Depositing Reaction for In Situ Imaging of Protein Status on the Cell Surface. Theranostics. 2019;9(7):1993\u20132002. https:\/\/doi.org\/10.7150\/thno.31943.","journal-title":"Theranostics"},{"issue":"7","key":"4782_CR31","doi-asserted-by":"publisher","first-page":"e16","DOI":"10.1038\/oncsis.2012.16","volume":"1","author":"F Henjes","year":"2012","unstructured":"Henjes F, Bender C, von der Heyde S, Braun L, Mannsperger HA, Schmidt C, Wiemann S, Hasmann M, Aulmann S, Beissbarth T, Korf U. Strong EGFR Signaling in Cell Line Models of ERBB2-Amplified Breast Cancer Attenuates Response towards ERBB2-Targeting Drugs. Oncogenesis. 2012;1(7):e16\u201316. https:\/\/doi.org\/10.1038\/oncsis.2012.16.","journal-title":"Oncogenesis"},{"issue":"2","key":"4782_CR32","doi-asserted-by":"publisher","first-page":"R44","DOI":"10.1186\/bcr2866","volume":"13","author":"L DeFazio-Eli","year":"2011","unstructured":"DeFazio-Eli L, Strommen K, Dao-Pick T, Parry G, Goodman L, Winslow J. Quantitative Assays for the Measurement of HER1-HER2 Heterodimerization and Phosphorylation in Cell Lines and Breast Tumors: Applications for Diagnostics and Targeted Drug Mechanism of Action. Breast Cancer Res. 2011;13(2):R44. https:\/\/doi.org\/10.1186\/bcr2866.","journal-title":"Breast Cancer Res"},{"issue":"1","key":"4782_CR33","doi-asserted-by":"publisher","first-page":"13307","DOI":"10.1038\/ncomms13307","volume":"7","author":"S Needham","year":"2016","unstructured":"Needham S, Roberts S, Arkhipov A, et al. EGFR oligomerization organizes kinase-active dimers into competent signalling platforms. Nat Commun. 2016;7(1):13307. https:\/\/doi.org\/10.1038\/ncomms13307.","journal-title":"Nat Commun"},{"issue":"6","key":"4782_CR34","doi-asserted-by":"publisher","first-page":"e1500165","DOI":"10.1126\/sciadv.1500165","volume":"1","author":"DB Peckys","year":"2015","unstructured":"Peckys DB, Korf U, de Jonge N. Local variations of HER2 dimerization in breast cancer cells discovered by correlative fluorescence and liquid electron microscopy. Sci adv. 2015;1(6):e1500165. https:\/\/doi.org\/10.1126\/sciadv.1500165.","journal-title":"Sci adv"},{"issue":"1","key":"4782_CR35","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1186\/s12951-024-02600-7","volume":"22","author":"S Spaziani","year":"2024","unstructured":"Spaziani S, Esposito A, Barisciano G, Quero G, Elumalai S, Leo M, Colantuoni V, Mangini M, Pisco M, Sabatino L, De Luca AC, Cusano A. Combined SERS-Raman Screening of HER2-Overexpressing or Silenced Breast Cancer Cell Lines. J Nanobiotechnol. 2024;22(1):350. https:\/\/doi.org\/10.1186\/s12951-024-02600-7.","journal-title":"J Nanobiotechnol"},{"issue":"1","key":"4782_CR36","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s13058-017-0855-0","volume":"19","author":"SE Smith","year":"2017","unstructured":"Smith SE, Mellor P, Ward AK, Kendall S, McDonald M, Vizeacoumar FS, Vizeacoumar FJ, Napper S, Anderson DH. Molecular Characterization of Breast Cancer Cell Lines through Multiple Omic Approaches. Breast Cancer Res. 2017;19(1):65. https:\/\/doi.org\/10.1186\/s13058-017-0855-0.","journal-title":"Breast Cancer Res"},{"issue":"7888","key":"4782_CR37","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/s41586-021-04084-z","volume":"600","author":"D Diwanji","year":"2021","unstructured":"Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N. Structures of the HER2\u2013HER3\u2013NRG1\u03b2 Complex Reveal a Dynamic Dimer Interface. Nature. 2021;600(7888):339\u201343. https:\/\/doi.org\/10.1038\/s41586-021-04084-z.","journal-title":"Nature"},{"issue":"1","key":"4782_CR38","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3892\/ijo_00000125","volume":"34","author":"D Patel","year":"2009","unstructured":"Patel D, Bassi R, Hooper A, Prewett M, Hicklin DJ, Kang X. Anti-Epidermal Growth Factor Receptor Monoclonal Antibody Cetuximab Inhibits EGFR\/HER-2 Heterodimerization and Activation. Int J Oncol. 2009;34(1):25\u201332. https:\/\/doi.org\/10.3892\/ijo_00000125.","journal-title":"Int J Oncol"},{"key":"4782_CR39","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41421-023-00523-5","volume":"9","author":"X Bai","year":"2023","unstructured":"Bai X, Sun P, Wang X, Long C, Liao S, Dang S, Zhuang S, Du Y, Zhang X, Li N, He K, Zhang Z. Structure and Dynamics of the EGFR\/HER2 Heterodimer. Cell Discov. 2023;9:18. https:\/\/doi.org\/10.1038\/s41421-023-00523-5.","journal-title":"Cell Discov"},{"issue":"5","key":"4782_CR40","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nrd.2017.79","volume":"16","author":"M Cully","year":"2017","unstructured":"Cully M. Belt and Braces for BCR\u2013ABL. Nat Rev Drug Discov. 2017;16(5):313\u2013313. https:\/\/doi.org\/10.1038\/nrd.2017.79.","journal-title":"Nat Rev Drug Discov"},{"key":"4782_CR41","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.cytogfr.2025.05.001","volume":"83","author":"T Shammas","year":"2025","unstructured":"Shammas T, Peiris MN, Meyer AN, Donoghue DJ. BCR-ABL: The Molecular Mastermind behind Chronic Myeloid Leukemia. Cytokine Growth Factor Rev. 2025;83:45\u201358. https:\/\/doi.org\/10.1016\/j.cytogfr.2025.05.001.","journal-title":"Cytokine Growth Factor Rev"},{"issue":"22","key":"4782_CR42","doi-asserted-by":"publisher","first-page":"5453","DOI":"10.1182\/blood.V128.22.5453.5453","volume":"128","author":"WM Elbjeirami","year":"2016","unstructured":"Elbjeirami WM, Alabdulwahab AS, ELSayed HG, Abdelghaffer NA, Elnagdi N, Al-Jedani H, Abd Allatif N, Al Shaikh A, Al-Allaf F. Response to Imatinib in E13a2 Versus E14a2 BCR-ABL Fusion Transcripts in Chronic Myeloid Leukemia Saudi Patients. Blood. 2016;128(22):5453\u20135453. https:\/\/doi.org\/10.1182\/blood.V128.22.5453.5453.","journal-title":"Blood"},{"issue":"5","key":"4782_CR43","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1038\/s41375-018-0341-4","volume":"33","author":"M Baccarani","year":"2019","unstructured":"Baccarani M, Castagnetti F, Gugliotta G, Rosti G, Soverini S, Albeer A, Pfirrmann M. The Proportion of Different BCR-ABL1 Transcript Types in Chronic Myeloid Leukemia. Int Overv Leukemia. 2019;33(5):1173\u201383. https:\/\/doi.org\/10.1038\/s41375-018-0341-4.","journal-title":"Int Overv Leukemia"},{"issue":"1","key":"4782_CR44","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1471-2407-4-25","volume":"4","author":"S Mundhada","year":"2004","unstructured":"Mundhada S, Luthra R, Cano P. Association of HLA Class I and Class II Genes with Bcr-Abl Transcripts in Leukemia Patients with t(9;22) (Q34;Q11). BMC Cancer. 2004;4(1):25. https:\/\/doi.org\/10.1186\/1471-2407-4-25.","journal-title":"BMC Cancer"},{"issue":"51","key":"4782_CR45","doi-asserted-by":"publisher","first-page":"16134","DOI":"10.1021\/bi048634w","volume":"43","author":"V Rapozzi","year":"2004","unstructured":"Rapozzi V, Xodo LE. Efficient Silencing of Bcr\/Abl Oncogene by Single- and Double-Stranded siRNAs Targeted against B2a2 Transcripts. Biochemistry. 2004;43(51):16134\u201341. https:\/\/doi.org\/10.1021\/bi048634w.","journal-title":"Biochemistry"},{"issue":"9","key":"4782_CR46","doi-asserted-by":"publisher","first-page":"3357","DOI":"10.1182\/blood.V91.9.3357","volume":"91","author":"GW Dewald","year":"1998","unstructured":"Dewald GW, Wyatt WA, Juneau AL, Carlson RO, Zinsmeister AR, Jalal SM, Spurbeck JL, Silver RT. Highly Sensitive Fluorescence In Situ Hybridization Method to Detect Double BCR\/ABL Fusion and Monitor Response to Therapy in Chronic Myeloid Leukemia. Blood. 1998;91(9):3357\u201365. https:\/\/doi.org\/10.1182\/blood.V91.9.3357.","journal-title":"Blood"},{"issue":"4980","key":"4782_CR47","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1126\/science.2237408","volume":"250","author":"DC Tkachuk","year":"1990","unstructured":"Tkachuk DC, Westbrook CA, Andreeff M, Donlon TA, Cleary ML, Suryanarayan K, Homge M, Redner A, Gray J, Pinkel D. Detection of Bcr-Abl Fusion in Chronic Myelogeneous Leukemia by in Situ Hybridization. Science. 1990;250(4980):559\u201362. https:\/\/doi.org\/10.1126\/science.2237408.","journal-title":"Science"},{"key":"4782_CR48","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1038\/s41592-026-03082-1","volume":"23","author":"A Ashesh","year":"2026","unstructured":"Ashesh A, Carrara F, Zubarev I, Galinova V, Croft M, Pezzotti M, Gong D, Casagrande F, Colombo E, Giussani S, Restelli E, Cammarota E, Battagliotti JM, Klena N, Di Sante M, Adhikari R, Feliciano D, Pigino G, Taverna E, Harschnitz O, Maghelli N, Scherer N, Dalle Nogare DE, Deschamps J, Pasqualini F, Jug F, Microplit. Semantic Unmixing of Fluorescent Microscopy Data. Nat Methods. 2026;23:1047\u201357. https:\/\/doi.org\/10.1038\/s41592-026-03082-1.","journal-title":"Nat Methods"},{"key":"4782_CR49","doi-asserted-by":"publisher","first-page":"11608","DOI":"10.1038\/s41467-025-66654-3","volume":"16","author":"Z Lu","year":"2025","unstructured":"Lu Z, Chen W, Sun F, Fan J, Li X, Fu Z, Jin M, Wu J, Dai Q. Leveraging Spatial\u2013Angular Redundancy for Self\u2013Supervised Denoising of 3D Fluorescence Imaging without Temporal Dependency. Nat Commun. 2025;16:11608. https:\/\/doi.org\/10.1038\/s41467-025-66654-3.","journal-title":"Nat Commun"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-026-04782-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-026-04782-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-026-04782-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:01:55Z","timestamp":1792695715000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-026-04782-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,5]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4782"],"URL":"https:\/\/doi.org\/10.1186\/s12951-026-04782-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-9062242\/v1","asserted-by":"object"}]},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,5]]},"assertion":[{"value":"8 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2026","order":6,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":7,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: \u201cequally contributed note\u201d has been updated.","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Blood and bone marrow samples were collected from CML patients at The First Affiliated Hospital of Chongqing Medical University (Ethics approval: 2024-102-01).","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"903"}}