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This review aims to explore the emerging role of herbal nanogels as a promising nanotechnology-based drug delivery system for skin cancer therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive review of recent literature was conducted focusing on nanogel-based drug delivery systems, herbal bioactive compounds, and stimulus-responsive nanotechnology approaches for cancer treatment, particularly skin cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nanogels, defined as crosslinked nanoscale polymeric networks, have gained significant attention due to their high drug-loading capacity, tunable physicochemical properties, and ability to respond to various internal and external stimuli. They can be synthesized using techniques such as emulsion methods, micro-molding, and photolithography, allowing precise control over size and morphology. Advanced stimulus-responsive nanogels, including tumor microenvironment-sensitive and ligand-targeted systems (e.g., LHRH-targeted nanogels), enable controlled and site-specific drug release. Recent developments in herbal nanogels integrate plant-derived bioactive compounds within nanogel matrices, enhancing solubility, stability, and therapeutic efficiency against skin cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Herbal nanogels represent a promising interdisciplinary approach combining nanotechnology and phytomedicine, offering targeted, less invasive, and potentially more effective treatment options for skin cancer. Despite significant progress, challenges such as clinical translation, large-scale production, and long-term safety evaluation remain. Continued research in smart and multifunctional nanogel systems may significantly advance future skin cancer therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12951-026-04788-2","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T02:27:01Z","timestamp":1784341621000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emerging role of herbal nanogel formulations in skin cancer therapy: mechanistic insights and translational advances in nanomedicine"],"prefix":"10.1186","volume":"24","author":[{"given":"Suraj","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishabha","family":"Malviya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phool","family":"Chandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathvik Belagodu","family":"Sridhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javedh","family":"Shareef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun","family":"Wadhwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Arockiam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"issue":"3","key":"4788_CR1","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/s13346-019-00675-1","volume":"10","author":"RK Khurana","year":"2020","unstructured":"Khurana RK, Kaur R, Lohan S, et al. 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