{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:05:53Z","timestamp":1790057153315,"version":"4.0.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":43,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Postdoctoral Scientific Research Start-up Fund","award":["C-2023-BSH33"],"award-info":[{"award-number":["C-2023-BSH33"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"DOI":"10.1186\/s12951-026-04912-2","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:45:49Z","timestamp":1786369549000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Breaking the ROS inflammation loop: a hierarchical nanozyme natural enzyme cascade for acetaminophen induced acute liver injury"],"prefix":"10.1186","volume":"24","author":[{"given":"Mengmeng","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"issue":"3","key":"4912_CR1","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1002\/hep.32689","volume":"77","author":"RJ Fontana","year":"2023","unstructured":"Fontana RJ, Liou I, Reuben A, Suzuki A, Fiel MI, Lee W, et al. AASLD practice guidance on drug, herbal, and dietary supplement-induced liver injury. Hepatology. 2023;77(3):1036\u201365.","journal-title":"Hepatology"},{"issue":"10","key":"4912_CR2","doi-asserted-by":"publisher","first-page":"3952","DOI":"10.1007\/s10620-024-08602-7","volume":"69","author":"JA Rule","year":"2024","unstructured":"Rule JA, Ajayi F, James LP, Tujios SR, Sussman NL, Rakela JL, Ganger D, Bass NL, Reuben A, Stravitz RT, Lee WM. Acute Liver Failure Study, Differentiating Ischemic Hepatitis from Acetaminophen Overdose in Acute Liver Failure: Role of Acetaminophen Adducts-Ischemic Hepatitis vs Acetaminophen Overdose. Dig Dis Sci. 2024;69(10):3952\u201361.","journal-title":"Dig Dis Sci"},{"issue":"9","key":"4912_CR3","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1111\/liv.15262","volume":"42","author":"X Li","year":"2022","unstructured":"Li X, Tang J, Mao Y. Incidence and risk factors of drug-induced liver injury. Liver Int. 2022;42(9):1999\u20132014.","journal-title":"Liver Int"},{"issue":"1","key":"4912_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113591","volume":"43","author":"CJ Yang","year":"2024","unstructured":"Yang CJ, Chang HC, Sung PC, Ge MC, Tang HY, Cheng ML, et al. Oral fecal transplantation enriches Lachnospiraceae and butyrate to mitigate acute liver injury. Cell Rep. 2024;43(1):113591.","journal-title":"Cell Rep"},{"issue":"10201","key":"4912_CR5","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/S0140-6736(19)31894-X","volume":"394","author":"RT Stravitz","year":"2019","unstructured":"Stravitz RT, Lee WM. Acute liver failure. Lancet. 2019;394(10201):869\u201381.","journal-title":"Lancet"},{"issue":"6","key":"4912_CR6","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1016\/j.jhep.2017.07.005","volume":"67","author":"WM Lee","year":"2017","unstructured":"Lee WM. Acetaminophen (APAP) hepatotoxicity-Isn\u2019t it time for APAP to go away? J Hepatol. 2017;67(6):1324\u201331.","journal-title":"J Hepatol"},{"issue":"5","key":"4912_CR7","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1007\/s00204-024-03696-4","volume":"98","author":"K Jomova","year":"2024","unstructured":"Jomova K, Alomar SY, Alwasel SH, Nepovimova E, Kuca K, Valko M. Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants. Arch Toxicol. 2024;98(5):1323\u201367.","journal-title":"Arch Toxicol"},{"issue":"26","key":"4912_CR8","doi-asserted-by":"publisher","first-page":"7282","DOI":"10.1080\/10408398.2021.1913400","volume":"62","author":"MN Islam","year":"2022","unstructured":"Islam MN, Rauf A, Fahad FI, Emran TB, Mitra S, Olatunde A, et al. Superoxide dismutase: an updated review on its health benefits and industrial applications. Crit Rev Food Sci Nutr. 2022;62(26):7282\u2013300.","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"1","key":"4912_CR9","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1002\/oby.21348","volume":"24","author":"C Perriotte-Olson","year":"2016","unstructured":"Perriotte-Olson C, Adi N, Manickam DS, Westwood RA, Desouza CV, Natarajan G, et al. Nanoformulated copper\/zinc superoxide dismutase reduces adipose inflammation in obesity. Obesity (Silver Spring). 2016;24(1):148\u201356.","journal-title":"Obesity (Silver Spring)"},{"issue":"4","key":"4912_CR10","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1097\/HEP.0000000000000458","volume":"78","author":"RT Stravitz","year":"2023","unstructured":"Stravitz RT, Fontana RJ, Karvellas C, Durkalski V, McGuire B, Rule JA, Tujios S, Lee WM. Acute Liver Failure Study, Future directions in acute liver failure. Hepatology. 2023;78(4):1266\u201389.","journal-title":"Hepatology"},{"issue":"3","key":"4912_CR11","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15619","volume":"45","author":"S Hwang","year":"2025","unstructured":"Hwang S, Hicks A, Hoo CZ, Kwon YS, Cho YE, Moore J, et al. Novel treatment of acute and acute-on-chronic liver failure: interleukin-22. Liver Int. 2025;45(3):e15619.","journal-title":"Liver Int"},{"key":"4912_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.141603","volume":"459","author":"C Yu","year":"2023","unstructured":"Yu C, Lv Y, Li X, Bao H, Cao X, Huang J, et al. SOD-functionalized gold nanoparticles as ROS scavenger and CT contrast agent for protection and imaging tracking of mesenchymal stem cells in idiopathic pulmonary fibrosis treatment. Chem Eng J. 2023;459:141603.","journal-title":"Chem Eng J"},{"key":"4912_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121437","volume":"283","author":"T Gui","year":"2022","unstructured":"Gui T, Luo L, Chhay B, Zhong L, Wei Y, Yao L, et al. Superoxide dismutase-loaded porous polymersomes as highly efficient antioxidant nanoparticles targeting synovium for osteoarthritis therapy. Biomaterials. 2022;283:121437.","journal-title":"Biomaterials"},{"key":"4912_CR14","doi-asserted-by":"publisher","first-page":"3302886","DOI":"10.1155\/2021\/3302886","volume":"2021","author":"L Zeng","year":"2021","unstructured":"Zeng L, Yu G, Yang K, Li J, Hao W, Chen H. The Efficacy of Antioxidative Stress Therapy on Oxidative Stress Levels in Rheumatoid Arthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Oxid Med Cell Longev. 2021;2021:3302886.","journal-title":"Oxid Med Cell Longev"},{"issue":"15","key":"4912_CR15","doi-asserted-by":"publisher","first-page":"18152","DOI":"10.1021\/acsami.1c03589","volume":"13","author":"X Sun","year":"2021","unstructured":"Sun X, Yu K, Zhou Y, Dong S, Hu W, Sun Y, et al. Self-assembled pH-sensitive polymeric nanoparticles for the inflammation-targeted delivery of Cu\/Zn-superoxide dismutase. ACS Appl Mater Interfaces. 2021;13(15):18152\u201364.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"7","key":"4912_CR16","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202007475","volume":"31","author":"Q Tang","year":"2021","unstructured":"Tang Q, Cao S, Ma T, Xiang X, Luo H, Borovskikh P, et al. Engineering biofunctional enzyme-mimics for catalytic therapeutics and diagnostics. Adv Funct Mater. 2021;31(7):2007475.","journal-title":"Adv Funct Mater"},{"key":"4912_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120706","volume":"271","author":"DY Zhang","year":"2021","unstructured":"Zhang DY, Younis MR, Liu H, Lei S, Wan Y, Qu J, et al. Multi-enzyme mimetic ultrasmall iridium nanozymes as reactive oxygen\/nitrogen species scavengers for acute kidney injury management. Biomaterials. 2021;271:120706.","journal-title":"Biomaterials"},{"issue":"10","key":"4912_CR18","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202211147","volume":"36","author":"L Zhang","year":"2024","unstructured":"Zhang L, Wang H, Qu X. Biosystem-inspired engineering of nanozymes for biomedical applications. Adv Mater. 2024;36(10):2211147.","journal-title":"Adv Mater"},{"issue":"39","key":"4912_CR19","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202408277","volume":"63","author":"X Liu","year":"2024","unstructured":"Liu X, Gao M, Qin Y, Xiong Z, Zheng H, Willner I, et al. Exploring nanozymes for organic substrates: building nano-organelles. Angew Chem Int Ed Engl. 2024;63(39):e202408277.","journal-title":"Angew Chem Int Ed Engl"},{"issue":"45","key":"4912_CR20","doi-asserted-by":"publisher","first-page":"14267","DOI":"10.1002\/anie.201708573","volume":"56","author":"N Singh","year":"2017","unstructured":"Singh N, Savanur MA, Srivastava S, D\u2019Silva P, Mugesh G. A redox modulatory Mn3O4 nanozyme with multi-enzyme activity provides efficient cytoprotection to human cells in a Parkinson\u2019s disease model. Angew Chem Int Ed Engl. 2017;56(45):14267\u201371.","journal-title":"Angew Chem Int Ed Engl"},{"issue":"8","key":"4912_CR21","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202402372","volume":"14","author":"H Cao","year":"2025","unstructured":"Cao H, Jiang J, Chen L, Gao L. Mimicomes: mimicking multienzyme system by artificial design. Adv Healthc Mater. 2025;14(8):e2402372.","journal-title":"Adv Healthc Mater"},{"issue":"1","key":"4912_CR22","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1021\/acsnano.1c07205","volume":"16","author":"G Huang","year":"2022","unstructured":"Huang G, Zang J, He L, Zhu H, Huang J, Yuan Z, Chen T, Xu A. Bioactive Nanoenzyme Reverses Oxidative Damage and Endoplasmic Reticulum Stress in Neurons under Ischemic Stroke. ACS Nano. 2022;16(1):431\u201352.","journal-title":"ACS Nano"},{"issue":"3","key":"4912_CR23","doi-asserted-by":"publisher","first-page":"2428","DOI":"10.1021\/acsnano.6b06245","volume":"11","author":"SA MacParland","year":"2017","unstructured":"MacParland SA, Tsoi KM, Ouyang B, Ma XZ, Manuel J, Fawaz A, Ostrowski MA, Alman BA, Zilman A, Chan WC, McGilvray ID. Phenotype Determines Nanoparticle Uptake by Human Macrophages from Liver and Blood. ACS Nano. 2017;11(3):2428\u201343.","journal-title":"ACS Nano"},{"key":"4912_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104731","volume":"86","author":"D Ezhilarasan","year":"2023","unstructured":"Ezhilarasan D, Shree Harini K. Nanodrug delivery: strategies to circumvent nanoparticle trafficking by Kupffer cells in the liver. J Drug Deliv Sci Technol. 2023;86:104731.","journal-title":"J Drug Deliv Sci Technol"},{"issue":"1","key":"4912_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43308-w","volume":"14","author":"X Shan","year":"2023","unstructured":"Shan X, Li J, Liu J, Feng B, Zhang T, Liu Q, et al. Targeting ferroptosis by poly(acrylic) acid coated Mn3O4 nanoparticles alleviates acute liver injury. Nat Commun. 2023;14(1):7598.","journal-title":"Nat Commun"},{"issue":"9","key":"4912_CR26","doi-asserted-by":"publisher","first-page":"5347","DOI":"10.1021\/acs.chemrev.2c00879","volume":"123","author":"KY Wang","year":"2023","unstructured":"Wang KY, Zhang J, Hsu YC, Lin H, Han Z, Pang J, Yang Z, Liang RR, Shi W, Zhou HC. Bioinspired Framework Catalysts: From Enzyme Immobilization to Biomimetic Catalysis. Chem Rev. 2023;123(9):5347\u2013420.","journal-title":"Chem Rev"},{"issue":"21","key":"4912_CR27","doi-asserted-by":"publisher","first-page":"e202200751","DOI":"10.1002\/asia.202200751","volume":"17","author":"JJ Li","year":"2022","unstructured":"Li JJ, Yin L, Wang ZF, Jing YC, Jiang ZL, Ding Y, Wang HS. Enzyme-Immobilized Metal-Organic Frameworks: From Preparation to Application. Chem Asian J. 2022;17(21):e202200751.","journal-title":"Chem Asian J"},{"key":"4912_CR28","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.1039\/D4GC05154H","volume":"27","author":"H Tang","year":"2025","unstructured":"Tang H, Fan D, Chen Y, Han S. Exploring enzyme\u2013MOF (metal\u2013organic framework) catalytic systems: trade-offs between enzyme activity and MOF stability. Green Chem. 2025;27:2605\u201328.","journal-title":"Green Chem"},{"issue":"1","key":"4912_CR29","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.1038\/s41467-022-29772-w","volume":"13","author":"J Mu","year":"2022","unstructured":"Mu J, Li C, Shi Y, Liu G, Zou J, Zhang DY, Jiang C, Wang X, He L, Huang P, Yin Y, Chen X. Protective effect of platinum nano-antioxidant and nitric oxide against hepatic ischemia-reperfusion injury. Nat Commun. 2022;13(1):2513.","journal-title":"Nat Commun"},{"key":"4912_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121322","volume":"281","author":"X Ge","year":"2022","unstructured":"Ge X, Wong R, Anisa A, Ma S. Recent development of metal-organic framework nanocomposites for biomedical applications. Biomaterials. 2022;281:121322.","journal-title":"Biomaterials"},{"key":"4912_CR31","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.jconrel.2024.08.011","volume":"374","author":"X Niu","year":"2024","unstructured":"Niu X, Xiao S, Huang R, Huang D, Aifantis KE, Yu H, et al. ZIF-8-modified hydrogel sequentially delivers angiogenic and osteogenic growth factors to accelerate vascularized bone regeneration. J Control Release. 2024;374:154\u201370.","journal-title":"J Control Release"},{"issue":"2","key":"4912_CR32","doi-asserted-by":"publisher","first-page":"3002","DOI":"10.1021\/acsami.4c17664","volume":"17","author":"SA Polash","year":"2025","unstructured":"Polash SA, Poddar A, Pyreddy S, Carraro F, D\u2019Angelo AM, Bryant G, et al. Phase characterization and bioactivity evaluation of nucleic acid-encapsulated biomimetically mineralized ZIF-8. ACS Appl Mater Interfaces. 2025;17(2):3002\u201312.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"3","key":"4912_CR33","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202301270","volume":"8","author":"D Wang","year":"2024","unstructured":"Wang D, Wu Q, Ren X, Niu M, Ren J, Meng X. Tunable zeolitic imidazolate framework-8 nanoparticles for biomedical applications. Small Methods. 2024;8(3):e2301270.","journal-title":"Small Methods"},{"issue":"1","key":"4912_CR34","doi-asserted-by":"publisher","DOI":"10.1002\/bmm2.12080","volume":"3","author":"J Zhang","year":"2025","unstructured":"Zhang J, Lovell JF, Shi J, Zhang Y. Nanomaterials for co-immobilization of multiple enzymes. BMEMat. 2025;3(1):e12080.","journal-title":"BMEMat"},{"issue":"12","key":"4912_CR35","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202206934","volume":"10","author":"Y Ling","year":"2023","unstructured":"Ling Y, Nie D, Huang Y, Deng M, Liu Q, Shi J, et al. Antioxidant cascade nanoenzyme antagonize inflammatory pain by modulating MAPK\/p-65 signaling pathway. Adv Sci. 2023;10(12):e2206934.","journal-title":"Adv Sci"},{"issue":"Pt A","key":"4912_CR36","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jcis.2023.10.019","volume":"654","author":"M Liu","year":"2024","unstructured":"Liu M, Wu H, Li Q, Liu H, Chen C, Yin F, Wang H, Zha Z, Wang F. Mn(3)O(4) nanozymes prevent acetaminophen-induced acute liver injury by attenuating oxidative stress and countering inflammation. J Colloid Interface Sci. 2024;654(Pt A):83\u201395.","journal-title":"J Colloid Interface Sci"},{"issue":"4","key":"4912_CR37","doi-asserted-by":"publisher","first-page":"FSO146","DOI":"10.4155\/fsoa-2016-0029","volume":"2","author":"A Adhikari","year":"2016","unstructured":"Adhikari A, Polley N, Darbar S, Bagchi D, Pal SK. Citrate functionalized Mn3O4 in nanotherapy of hepatic fibrosis by oral administration. Future Sci OA. 2016;2(4):FSO146.","journal-title":"Future Sci OA"},{"issue":"1","key":"4912_CR38","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0927-0256(96)00008-0","volume":"6","author":"G Kresse","year":"1996","unstructured":"Kresse G, Furthm\u00fcller J. Efficiency of ab-initio total energy calculations for metals and semiconductors using a plane-wave basis set. Comput Mater Sci. 1996;6(1):15\u201350.","journal-title":"Comput Mater Sci"},{"issue":"8","key":"4912_CR39","doi-asserted-by":"publisher","first-page":"086801","DOI":"10.1088\/0256-307X\/41\/8\/086801","volume":"41","author":"Y Tong","year":"2024","unstructured":"Tong Y, Yang Y. Quantum Tunneling Enhanced Hydrogen Desorption from Graphene Surface: Atomic versus Molecular Mechanism. Chin Phys Lett. 2024;41(8):086801.","journal-title":"Chin Phys Lett"},{"key":"4912_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpc.2021.108033","volume":"267","author":"V Wang","year":"2021","unstructured":"Wang V, Xu N, Liu J-C, Tang G, Geng W-T. VASPKIT: a user-friendly interface facilitating high-throughput computing and analysis using VASP code. Comput Phys Commun. 2021;267:108033.","journal-title":"Comput Phys Commun"},{"key":"4912_CR41","doi-asserted-by":"crossref","unstructured":"Rauf S, Ait Lahcen A, Aljedaibi A, Beduk T, de Oliveira Filho JI, Salama KN. Gold nanostructured laser-scribed graphene: a new electrochemical biosensing platform for potential point-of-care testing of disease biomarkers. Biosens Bioelectron. 2021;180:113116.","DOI":"10.1016\/j.bios.2021.113116"},{"issue":"20","key":"4912_CR42","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1177\/15353702231211862","volume":"248","author":"J Tian","year":"2023","unstructured":"Tian J, Zhang S, Li L, Lin X, Li Y, Zhao K, et al. Febuxostat ameliorates APAP-induced acute liver injury by activating Keap1\/Nrf2 and inhibiting TLR4\/NF-\u03baB p65 pathways. Exp Biol Med (Maywood). 2023;248(20):1864\u201376.","journal-title":"Exp Biol Med (Maywood)"},{"issue":"11","key":"4912_CR43","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302556","volume":"13","author":"A Wu","year":"2024","unstructured":"Wu A, Li M, Chen Y, Zhang W, Li H, Chen J, et al. Multienzyme active manganese oxide alleviates acute liver injury by mimicking redox regulatory system and inhibiting ferroptosis. Adv Healthc Mater. 2024;13(11):e2302556.","journal-title":"Adv Healthc Mater"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-026-04912-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-026-04912-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-026-04912-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:48:10Z","timestamp":1790056090000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12951-026-04912-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,10]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4912"],"URL":"https:\/\/doi.org\/10.1186\/s12951-026-04912-2","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,10]]},"assertion":[{"value":"9 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"889"}}