{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:42:18Z","timestamp":1792788138660,"version":"4.5.0"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Fundamental Research Funds for the Central Universities","award":["YG2026QNB30"],"award-info":[{"award-number":["YG2026QNB30"]}]},{"name":"the National Natural Science Foundation of China","award":["12474450"],"award-info":[{"award-number":["12474450"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Chongqing Talent Program","award":["2024030029"],"award-info":[{"award-number":["2024030029"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"DOI":"10.1186\/s12951-026-05014-9","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:04:26Z","timestamp":1788401066000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Simultaneous broad-spectrum antibacterial and regenerative therapy for diabetic wounds using sonosensitive peptide composite hydrogel"],"prefix":"10.1186","volume":"24","author":[{"given":"Yao","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baicheng","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghua","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingchao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunrui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"5014_CR1","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1001\/jama.2023.10578","volume":"330","author":"DG Armstrong","year":"2023","unstructured":"Armstrong DG, Tan TW, Boulton AJM, Bus SA. Diabetic foot ulcers: a review. JAMA. 2023;330:62\u201375. https:\/\/doi.org\/10.1001\/jama.2023.10578.","journal-title":"JAMA"},{"key":"5014_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.2337\/dci22-0043","volume":"46","author":"K McDermott","year":"2023","unstructured":"McDermott K, Fang M, Boulton AJM, Selvin E, Hicks CW. Etiology, epidemiology, and disparities in the burden of diabetic foot ulcers. Diabetes Care. 2023;46:209\u201321. https:\/\/doi.org\/10.2337\/dci22-0043.","journal-title":"Diabetes Care"},{"key":"5014_CR3","doi-asserted-by":"publisher","first-page":"1332032","DOI":"10.3389\/fendo.2024.1332032","volume":"15","author":"XG Yang","year":"2024","unstructured":"Yang XG, Peng Z, Liu X, Liu XL, Lu S. A narrative review of the measurement methods for biomechanical properties of plantar soft tissue in patients with diabetic foot. Front Endocrinol (Lausanne). 2024;15:1332032. https:\/\/doi.org\/10.3389\/fendo.2024.1332032.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"5014_CR4","doi-asserted-by":"publisher","first-page":"e48030","DOI":"10.7759\/cureus.48030","volume":"15","author":"S Sanjeeviraj","year":"2023","unstructured":"Sanjeeviraj S, et al. A cohort study on the outcome of diabetic foot ulcers. Cureus. 2023;15:e48030. https:\/\/doi.org\/10.7759\/cureus.48030.","journal-title":"Cureus"},{"key":"5014_CR5","doi-asserted-by":"publisher","first-page":"e3644","DOI":"10.1002\/dmrr.3644","volume":"40","author":"P Chen","year":"2024","unstructured":"Chen P, et al. Guidelines on interventions to enhance healing of foot ulcers in people with diabetes (IWGDF 2023 update). Diabetes Metab Res Rev. 2024;40:e3644. https:\/\/doi.org\/10.1002\/dmrr.3644.","journal-title":"Diabetes Metab Res Rev"},{"key":"5014_CR6","doi-asserted-by":"publisher","first-page":"e3687","DOI":"10.1002\/dmrr.3687","volume":"40","author":"E Senneville","year":"2024","unstructured":"Senneville E, et al. IWGDF\/IDSA guidelines on the diagnosis and treatment of diabetes-related foot infections (IWGDF\/IDSA 2023). Diabetes Metab Res Rev. 2024;40:e3687. https:\/\/doi.org\/10.1002\/dmrr.3687.","journal-title":"Diabetes Metab Res Rev"},{"key":"5014_CR7","doi-asserted-by":"publisher","first-page":"265sr266","DOI":"10.1126\/scitranslmed.3009337","volume":"6","author":"SA Eming","year":"2014","unstructured":"Eming SA, Martin P, Tomic-Canic M. Wound repair and regeneration: mechanisms, signaling, and translation. Sci Transl Med. 2014;6:265sr266. https:\/\/doi.org\/10.1126\/scitranslmed.3009337.","journal-title":"Sci Transl Med"},{"key":"5014_CR8","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41572-022-00377-3","volume":"8","author":"V Falanga","year":"2022","unstructured":"Falanga V, et al. Chronic wounds. Nat Rev Dis Primers. 2022;8:50. https:\/\/doi.org\/10.1038\/s41572-022-00377-3.","journal-title":"Nat Rev Dis Primers"},{"key":"5014_CR9","doi-asserted-by":"publisher","unstructured":"Burgess JL, Wyant WA, Abujamra A, Kirsner B, R. S., Jozic I. Diabetic wound-healing science. Med (Kaunas). 2021;57. https:\/\/doi.org\/10.3390\/medicina57101072.","DOI":"10.3390\/medicina57101072"},{"key":"5014_CR10","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.trsl.2021.05.006","volume":"236","author":"AE Louiselle","year":"2021","unstructured":"Louiselle AE, Niemiec SM, Zgheib C, Liechty KW. Macrophage polarization and diabetic wound healing. Transl Res. 2021;236:109\u201316. https:\/\/doi.org\/10.1016\/j.trsl.2021.05.006.","journal-title":"Transl Res"},{"key":"5014_CR11","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/s41467-021-27801-8","volume":"13","author":"G Theocharidis","year":"2022","unstructured":"Theocharidis G, et al. Single cell transcriptomic landscape of diabetic foot ulcers. Nat Commun. 2022;13:181. https:\/\/doi.org\/10.1038\/s41467-021-27801-8.","journal-title":"Nat Commun"},{"key":"5014_CR12","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1111\/wrr.12954","volume":"29","author":"R Wan","year":"2021","unstructured":"Wan R, et al. Diabetic wound healing: the impact of diabetes on myofibroblast activity and its potential therapeutic treatments. Wound Repair Regen. 2021;29:573\u201381. https:\/\/doi.org\/10.1111\/wrr.12954.","journal-title":"Wound Repair Regen"},{"key":"5014_CR13","doi-asserted-by":"publisher","first-page":"116072","DOI":"10.1016\/j.ejmech.2023.116072","volume":"265","author":"S Ji","year":"2024","unstructured":"Ji S, et al. Antimicrobial peptides: an alternative to traditional antibiotics. Eur J Med Chem. 2024;265:116072. https:\/\/doi.org\/10.1016\/j.ejmech.2023.116072.","journal-title":"Eur J Med Chem"},{"key":"5014_CR14","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/nri.2016.29","volume":"16","author":"RE Hancock","year":"2016","unstructured":"Hancock RE, Haney EF, Gill EE. The immunology of host defence peptides: beyond antimicrobial activity. Nat Rev Immunol. 2016;16:321\u201334. https:\/\/doi.org\/10.1038\/nri.2016.29.","journal-title":"Nat Rev Immunol"},{"key":"5014_CR15","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/s41579-021-00585-w","volume":"19","author":"REW Hancock","year":"2021","unstructured":"Hancock REW, Alford MA, Haney EF. Antibiofilm activity of host defence peptides: complexity provides opportunities. Nat Rev Microbiol. 2021;19:786\u201397. https:\/\/doi.org\/10.1038\/s41579-021-00585-w.","journal-title":"Nat Rev Microbiol"},{"key":"5014_CR16","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1021\/acs.biochem.6b01071","volume":"56","author":"MC Gagnon","year":"2017","unstructured":"Gagnon MC, et al. Influence of the length and charge on the activity of alpha-helical amphipathic antimicrobial peptides. Biochemistry. 2017;56:1680\u201395. https:\/\/doi.org\/10.1021\/acs.biochem.6b01071.","journal-title":"Biochemistry"},{"key":"5014_CR17","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1038\/s41551-025-01377-w","volume":"9","author":"X Zhang","year":"2025","unstructured":"Zhang X, et al. A sonosensitive diphenylalanine-based broad-spectrum antimicrobial peptide. Nat Biomed Eng. 2025;9:1349\u201365. https:\/\/doi.org\/10.1038\/s41551-025-01377-w.","journal-title":"Nat Biomed Eng"},{"key":"5014_CR18","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.pbiomolbio.2006.07.005","volume":"93","author":"G Ter Haar","year":"2007","unstructured":"Ter Haar G. Therapeutic applications of ultrasound. Prog Biophys Mol Biol. 2007;93:111\u201329. https:\/\/doi.org\/10.1016\/j.pbiomolbio.2006.07.005.","journal-title":"Prog Biophys Mol Biol"},{"key":"5014_CR19","doi-asserted-by":"publisher","first-page":"e2403224","DOI":"10.1002\/adhm.202403224","volume":"14","author":"D Zhuge","year":"2025","unstructured":"Zhuge D, et al. Ultrasound-triggered oxygen release system for accelerating wound healing of diabetic foot ulcers. Adv Healthc Mater. 2025;14:e2403224. https:\/\/doi.org\/10.1002\/adhm.202403224.","journal-title":"Adv Healthc Mater"},{"key":"5014_CR20","doi-asserted-by":"publisher","first-page":"15962","DOI":"10.1021\/acsnano.3c04134","volume":"17","author":"L Shang","year":"2023","unstructured":"Shang L, et al. Ultrasound-augmented multienzyme-like nanozyme hydrogel spray for promoting diabetic wound healing. ACS Nano. 2023;17:15962\u201377. https:\/\/doi.org\/10.1021\/acsnano.3c04134.","journal-title":"ACS Nano"},{"key":"5014_CR21","doi-asserted-by":"publisher","first-page":"e16882","DOI":"10.1002\/advs.202516882","volume":"13","author":"M Li","year":"2026","unstructured":"Li M, et al. Ultrasound controlled-release hydrogel promotes diabetic wound healing via neuroimmune modulation and synergistic ROS scavenging. Adv Sci (Weinh). 2026;13:e16882. https:\/\/doi.org\/10.1002\/advs.202516882.","journal-title":"Adv Sci (Weinh)"},{"key":"5014_CR22","doi-asserted-by":"publisher","first-page":"e2504829","DOI":"10.1002\/adma.202504829","volume":"37","author":"H Li","year":"2025","unstructured":"Li H, et al. Nanozyme-reinforced hydrogel spray as a reactive oxygen species-driven oxygenator to accelerate diabetic wound healing. Adv Mater. 2025;37:e2504829. https:\/\/doi.org\/10.1002\/adma.202504829.","journal-title":"Adv Mater"},{"key":"5014_CR23","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1038\/s41467-026-68376-6","volume":"17","author":"Z Hu","year":"2026","unstructured":"Hu Z, et al. Near-infrared light-driven nanomotors-based microneedles for the active therapy of bacterial infected acne. Nat Commun. 2026;17:1675. https:\/\/doi.org\/10.1038\/s41467-026-68376-6.","journal-title":"Nat Commun"},{"key":"5014_CR24","first-page":"78","volume":"28","author":"M Litwiniuk","year":"2016","unstructured":"Litwiniuk M, Krejner A, Speyrer MS, Gauto AR, Grzela T. Hyaluronic acid in inflammation and tissue regeneration. Wounds. 2016;28:78\u201388.","journal-title":"Wounds"},{"key":"5014_CR25","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-023-00473-9","author":"Y Chen","year":"2023","unstructured":"Chen Y, et al. Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties. Mil Med Res. 2023. https:\/\/doi.org\/10.1186\/s40779-023-00473-9.","journal-title":"Mil Med Res"},{"key":"5014_CR26","doi-asserted-by":"publisher","first-page":"120824","DOI":"10.1016\/j.carbpol.2023.120824","volume":"312","author":"W Tan","year":"2023","unstructured":"Tan W, et al. Dual-drug loaded polysaccharide-based self-healing hydrogels with multifunctionality for promoting diabetic wound healing. Carbohydr Polym. 2023;312:120824. https:\/\/doi.org\/10.1016\/j.carbpol.2023.120824.","journal-title":"Carbohydr Polym"},{"key":"5014_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/biom14030320","author":"S Bhattacharjya","year":"2024","unstructured":"Bhattacharjya S, Zhang Z, Ramamoorthy A. LL-37: structures, antimicrobial activity, and influence on amyloid-related diseases. Biomolecules. 2024. https:\/\/doi.org\/10.3390\/biom14030320.","journal-title":"Biomolecules"},{"key":"5014_CR28","doi-asserted-by":"publisher","unstructured":"Pan G, et al. Photothermal\/photodynamic synergistic antibacterial hydrogel dressing with pH\/glucose dual responsive pirfenidone release for diabetic foot ulcers. Adv Funct Mater. 2025. https:\/\/doi.org\/10.1002\/adfm.202416205","DOI":"10.1002\/adfm.202416205"},{"key":"5014_CR29","doi-asserted-by":"publisher","first-page":"114858","DOI":"10.1016\/j.jconrel.2026.114858","volume":"394","author":"H Li","year":"2026","unstructured":"Li H, et al. Hydrogel-immobilized coacervate droplets enable microenvironment-responsive sustained drug release to accelerate diabetic foot ulcers healing. J Control Release. 2026;394:114858. https:\/\/doi.org\/10.1016\/j.jconrel.2026.114858.","journal-title":"J Control Release"},{"key":"5014_CR30","doi-asserted-by":"publisher","first-page":"eaed4981","DOI":"10.1126\/sciadv.aed4981","volume":"12","author":"L Zhao","year":"2026","unstructured":"Zhao L, et al. Self-regulating hydrogel for diabetic wound healing: From animal models to a pilot clinical study. Sci Adv. 2026;12:eaed4981. https:\/\/doi.org\/10.1126\/sciadv.aed4981.","journal-title":"Sci Adv"},{"key":"5014_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-70771-y","author":"X Li","year":"2026","unstructured":"Li X, et al. Low-intensity focused ultrasound-activated piezoelectric gel bandage for diabetic wound repair and neuropathic pain relief. Nat Commun. 2026. https:\/\/doi.org\/10.1038\/s41467-026-70771-y.","journal-title":"Nat Commun"},{"key":"5014_CR32","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1186\/s12951-025-03859-0","volume":"23","author":"W Qiao","year":"2025","unstructured":"Qiao W, et al. An oral engineered cerium-peptide composite microsphere inhibits inflammatory bowel disease and reverses chronic fibrosis. J Nanobiotechnol. 2025;23:791. https:\/\/doi.org\/10.1186\/s12951-025-03859-0.","journal-title":"J Nanobiotechnol"},{"key":"5014_CR33","doi-asserted-by":"publisher","first-page":"e2306632","DOI":"10.1002\/adma.202306632","volume":"35","author":"X Qi","year":"2023","unstructured":"Qi X, et al. An immunomodulatory hydrogel by hyperthermia-assisted self-cascade glucose depletion and ROS scavenging for diabetic foot ulcer wound therapeutics. Adv Mater. 2023;35:e2306632. https:\/\/doi.org\/10.1002\/adma.202306632.","journal-title":"Adv Mater"},{"key":"5014_CR34","doi-asserted-by":"publisher","first-page":"e2310162","DOI":"10.1002\/advs.202310162","volume":"11","author":"Q Wu","year":"2024","unstructured":"Wu Q, et al. Spermidine-functionalized injectable hydrogel reduces inflammation and enhances healing of acute and diabetic wounds in situ. Adv Sci (Weinh). 2024;11:e2310162. https:\/\/doi.org\/10.1002\/advs.202310162.","journal-title":"Adv Sci (Weinh)"},{"key":"5014_CR35","doi-asserted-by":"publisher","first-page":"e2200521","DOI":"10.1002\/adma.202200521","volume":"34","author":"Y Qian","year":"2022","unstructured":"Qian Y, et al. Immunoregulation in diabetic wound repair with a photoenhanced glycyrrhizic acid hydrogel scaffold. Adv Mater. 2022;34:e2200521. https:\/\/doi.org\/10.1002\/adma.202200521.","journal-title":"Adv Mater"},{"key":"5014_CR36","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1089\/wound.2013.0517","volume":"3","author":"KE Johnson","year":"2014","unstructured":"Johnson KE, Wilgus TA. Vascular endothelial growth factor and angiogenesis in the regulation of cutaneous wound repair. Adv Wound Care (New Rochelle). 2014;3:647\u201361. https:\/\/doi.org\/10.1089\/wound.2013.0517.","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"5014_CR37","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41556-018-0237-6","volume":"21","author":"S Dekoninck","year":"2019","unstructured":"Dekoninck S, Blanpain C. Stem cell dynamics, migration and plasticity during wound healing. Nat Cell Biol. 2019;21:18\u201324. https:\/\/doi.org\/10.1038\/s41556-018-0237-6.","journal-title":"Nat Cell Biol"},{"key":"5014_CR38","doi-asserted-by":"publisher","first-page":"7680","DOI":"10.1021\/acsami.1c23461","volume":"14","author":"Z Xu","year":"2022","unstructured":"Xu Z, Liu G, Huang J, Wu J. Novel glucose-responsive antioxidant hybrid hydrogel for enhanced diabetic wound repair. ACS Appl Mater Interfaces. 2022;14:7680\u20139. https:\/\/doi.org\/10.1021\/acsami.1c23461.","journal-title":"ACS Appl Mater Interfaces"},{"key":"5014_CR39","doi-asserted-by":"publisher","first-page":"7856","DOI":"10.1038\/s41467-023-43364-2","volume":"14","author":"J Huang","year":"2023","unstructured":"Huang J, et al. A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing. Nat Commun. 2023;14:7856. https:\/\/doi.org\/10.1038\/s41467-023-43364-2.","journal-title":"Nat Commun"},{"key":"5014_CR40","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/sj.jid.5700613","volume":"127","author":"B Hinz","year":"2007","unstructured":"Hinz B. Formation and function of the myofibroblast during tissue repair. J Invest Dermatol. 2007;127:526\u201337. https:\/\/doi.org\/10.1038\/sj.jid.5700613.","journal-title":"J Invest Dermatol"},{"key":"5014_CR41","doi-asserted-by":"publisher","unstructured":"Qi X, et al. An immunoregulation hydrogel with controlled hyperthermia-augmented oxygenation and ROS scavenging for treating diabetic foot ulcers. Adv Funct Mater. 2024. . https:\/\/doi.org\/10.1002\/adfm.202400489","DOI":"10.1002\/adfm.202400489"},{"key":"5014_CR42","doi-asserted-by":"publisher","unstructured":"Guo Q, et al. NF-kappaB in biology and targeted therapy: new insights and translational implications. Signal Transduct Target Ther. 2024;9. https:\/\/doi.org\/10.1038\/s41392-024-01757-9.","DOI":"10.1038\/s41392-024-01757-9"},{"key":"5014_CR43","doi-asserted-by":"publisher","unstructured":"Hoffmann A, Cheng G, Baltimore D. NF-kappaB: master regulator of cellular responses in health and disease. Immun Inflamm. 2025;1. https:\/\/doi.org\/10.1007\/s44466-025-00014-0.","DOI":"10.1007\/s44466-025-00014-0"},{"key":"5014_CR44","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/s41577-022-00792-3","volume":"23","author":"G Van Loo","year":"2023","unstructured":"Van Loo G, Bertrand MJM. Death by TNF: a road to inflammation. Nat Rev Immunol. 2023;23:289\u2013303. https:\/\/doi.org\/10.1038\/s41577-022-00792-3.","journal-title":"Nat Rev Immunol"},{"key":"5014_CR45","doi-asserted-by":"publisher","first-page":"184394","DOI":"10.1016\/j.bbamem.2024.184394","volume":"1867","author":"CH Lo","year":"2025","unstructured":"Lo CH. TNF receptors: Structure-function relationships and therapeutic targeting strategies. Biochim Biophys Acta Biomembr. 2025;1867:184394. https:\/\/doi.org\/10.1016\/j.bbamem.2024.184394.","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"5014_CR46","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-026-04106-w","author":"YQ Shen","year":"2026","unstructured":"Shen YQ, et al. A single-dose of PDGFB circular RNA enables sustained growth factor expression to accelerate diabetic wound healing. J Nanobiotechnol. 2026. https:\/\/doi.org\/10.1186\/s12951-026-04106-w.","journal-title":"J Nanobiotechnol"},{"key":"5014_CR47","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.omtn.2021.03.015","volume":"24","author":"J Li","year":"2021","unstructured":"Li J, et al. The progress, prospects, and challenges of the use of non-coding RNA for diabetic wounds. Mol Ther Nucleic Acids. 2021;24:554\u201378. https:\/\/doi.org\/10.1016\/j.omtn.2021.03.015.","journal-title":"Mol Ther Nucleic Acids"},{"key":"5014_CR48","doi-asserted-by":"publisher","first-page":"102894","DOI":"10.1016\/j.mtbio.2026.102894","volume":"37","author":"F Wei","year":"2026","unstructured":"Wei F, Xie F, Chen B, Guo C, Ge M. Engineered catechol-based composite materials for diabetic wound healing. Mater Today Bio. 2026;37:102894. https:\/\/doi.org\/10.1016\/j.mtbio.2026.102894.","journal-title":"Mater Today Bio"},{"key":"5014_CR49","doi-asserted-by":"publisher","first-page":"e08854","DOI":"10.1002\/advs.202508854","volume":"12","author":"X Yan","year":"2025","unstructured":"Yan X, et al. Utilizing proteolytic-resistant nano-short peptide based on naphthyl tail-anchored to combat bacterial infections. Adv Sci (Weinh). 2025;12:e08854. https:\/\/doi.org\/10.1002\/advs.202508854.","journal-title":"Adv Sci (Weinh)"},{"key":"5014_CR50","doi-asserted-by":"publisher","first-page":"2432344","DOI":"10.1080\/22221751.2024.2432344","volume":"14","author":"D Jin","year":"2025","unstructured":"Jin D, et al. The E3 ligase RAD18-mediated ubiquitination of henipavirus matrix protein promotes its nuclear-cytoplasmic trafficking and viral egress. Emerg Microbes Infect. 2025;14:2432344. https:\/\/doi.org\/10.1080\/22221751.2024.2432344.","journal-title":"Emerg Microbes Infect"},{"key":"5014_CR51","doi-asserted-by":"publisher","first-page":"1136098","DOI":"10.3389\/fimmu.2023.1136098","volume":"14","author":"M Jiang","year":"2023","unstructured":"Jiang M, et al. The role of mesenchymal stem cell-derived EVs in diabetic wound healing. Front Immunol. 2023;14:1136098. https:\/\/doi.org\/10.3389\/fimmu.2023.1136098.","journal-title":"Front Immunol"},{"key":"5014_CR52","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1021\/cbe.5c00148","volume":"3","author":"Y Cui","year":"2026","unstructured":"Cui Y, et al. Self-generated NO\/ROS nanoreactor drives bacterial clearance and angiogenesis in diabetic wounds. Chem Bio Eng. 2026;3:340\u201350. https:\/\/doi.org\/10.1021\/cbe.5c00148.","journal-title":"Chem Bio Eng"},{"key":"5014_CR53","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1038\/s41467-026-68512-2","volume":"17","author":"Y Lin","year":"2026","unstructured":"Lin Y, et al. Intermittent fasting inhibits Tp53-driven glioma through gut microbiota-mediated methionine-m6A regulation. Nat Commun. 2026;17:1804. https:\/\/doi.org\/10.1038\/s41467-026-68512-2.","journal-title":"Nat Commun"},{"key":"5014_CR54","doi-asserted-by":"publisher","first-page":"e2415341","DOI":"10.1002\/advs.202415341","volume":"12","author":"L Zhao","year":"2025","unstructured":"Zhao L, et al. M6A modified miR-31-5p suppresses M1 macrophage polarization and autoimmune dry eye by targeting P2RX7. Adv Sci (Weinh). 2025;12:e2415341. https:\/\/doi.org\/10.1002\/advs.202415341.","journal-title":"Adv Sci (Weinh)"},{"key":"5014_CR55","doi-asserted-by":"publisher","first-page":"1607932","DOI":"10.3389\/fimmu.2025.1607932","volume":"16","author":"X Li","year":"2025","unstructured":"Li X, Zhang H, Zhou Y, Zhang L, Huang Y. M6A modification: a novel mechanism that regulates atherosclerosis via macrophage polarization. Front Immunol. 2025;16:1607932. https:\/\/doi.org\/10.3389\/fimmu.2025.1607932.","journal-title":"Front Immunol"},{"key":"5014_CR56","doi-asserted-by":"publisher","first-page":"3458","DOI":"10.1007\/s10753-025-02277-6","volume":"48","author":"J Tang","year":"2025","unstructured":"Tang J, et al. VASP knockdown ameliorates lipopolysaccharide-induced acute lung injury with inhibition of M1 macrophage polarization through the cGMP-PKG signaling pathway. Inflammation. 2025;48:3458\u201371. https:\/\/doi.org\/10.1007\/s10753-025-02277-6.","journal-title":"Inflammation"},{"key":"5014_CR57","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaf090","author":"W Liu","year":"2025","unstructured":"Liu W, Zhao Z. Scupa: single-cell unified polarization assessment of immune cells using the single-cell foundation model. Bioinformatics. 2025. https:\/\/doi.org\/10.1093\/bioinformatics\/btaf090.","journal-title":"Bioinformatics"},{"key":"5014_CR58","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1002\/jum.16403","volume":"43","author":"X Guo","year":"2024","unstructured":"Guo X, et al. Latest progress of LIPUS in fracture healing: a mini-review. J Ultrasound Med. 2024;43:643\u201355. https:\/\/doi.org\/10.1002\/jum.16403.","journal-title":"J Ultrasound Med"},{"key":"5014_CR59","doi-asserted-by":"publisher","first-page":"961898","DOI":"10.3389\/fbioe.2022.961898","volume":"10","author":"Y Wang","year":"2022","unstructured":"Wang Y, et al. Low-intensity pulsed ultrasound promotes periodontal regeneration in a beagle model of furcation involvement. Front Bioeng Biotechnol. 2022;10:961898. https:\/\/doi.org\/10.3389\/fbioe.2022.961898.","journal-title":"Front Bioeng Biotechnol"},{"key":"5014_CR60","doi-asserted-by":"publisher","first-page":"14212","DOI":"10.1002\/anie.201906823","volume":"59","author":"X Lin","year":"2020","unstructured":"Lin X, Song J, Chen X, Yang H. Ultrasound-activated sensitizers and applications. Angew Chem Int Ed Engl. 2020;59:14212\u201333. https:\/\/doi.org\/10.1002\/anie.201906823.","journal-title":"Angew Chem Int Ed Engl"},{"key":"5014_CR61","doi-asserted-by":"publisher","first-page":"e2000076","DOI":"10.1002\/adhm.202000076","volume":"9","author":"X Liu","year":"2020","unstructured":"Liu X, et al. A biomimetic biphasic osteochondral scaffold with layer-specific release of stem cell differentiation inducers for the reconstruction of osteochondral defects. Adv Healthc Mater. 2020;9:e2000076. https:\/\/doi.org\/10.1002\/adhm.202000076.","journal-title":"Adv Healthc Mater"},{"key":"5014_CR62","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.3317","volume":"12","author":"D Kim","year":"2015","unstructured":"Kim D, Langmead B, Salzberg SL. HISAT: a fast spliced aligner with low memory requirements. Nat Methods. 2015;12:357\u201360. https:\/\/doi.org\/10.1038\/nmeth.3317.","journal-title":"Nat Methods"},{"key":"5014_CR63","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/nbt.3122","volume":"33","author":"M Pertea","year":"2015","unstructured":"Pertea M, et al. StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. Nat Biotechnol. 2015;33:290\u20135. https:\/\/doi.org\/10.1038\/nbt.3122.","journal-title":"Nat Biotechnol"},{"key":"5014_CR64","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15:550. https:\/\/doi.org\/10.1186\/s13059-014-0550-8.","journal-title":"Genome Biol"},{"key":"5014_CR65","doi-asserted-by":"publisher","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","volume":"4","author":"G Dennis Jr","year":"2003","unstructured":"Dennis G Jr., et al. DAVID: database for annotation, visualization, and integrated discovery. Genome Biol. 2003;4:P3.","journal-title":"Genome Biol"},{"key":"5014_CR66","doi-asserted-by":"publisher","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","volume":"49","author":"D Szklarczyk","year":"2021","unstructured":"Szklarczyk D, et al. The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets. Nucleic Acids Res. 2021;49:D605\u201312. https:\/\/doi.org\/10.1093\/nar\/gkaa1074.","journal-title":"Nucleic Acids Res"},{"key":"5014_CR67","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s13059-019-1758-4","volume":"20","author":"D Otasek","year":"2019","unstructured":"Otasek D, Morris JH, Boucas J, Pico AR, Demchak B. Cytoscape automation: empowering workflow-based network analysis. Genome Biol. 2019;20:185. https:\/\/doi.org\/10.1186\/s13059-019-1758-4.","journal-title":"Genome Biol"},{"key":"5014_CR68","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13:2498\u2013504. https:\/\/doi.org\/10.1101\/gr.1239303.","journal-title":"Genome Res"},{"key":"5014_CR69","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-8-S4-S11","author":"CH Chin","year":"2014","unstructured":"Chin CH, et al. CytoHubba: identifying hub objects and sub-networks from complex interactome. BMC Syst Biol. 2014. https:\/\/doi.org\/10.1186\/1752-0509-8-S4-S11.","journal-title":"BMC Syst Biol"},{"key":"5014_CR70","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12920-023-01490-2","volume":"16","author":"Y Lin","year":"2023","unstructured":"Lin Y, et al. Weighted gene co-expression network analysis revealed T cell differentiation associated with the age-related phenotypes in COVID-19 patients. BMC Med Genomics. 2023;16:59. https:\/\/doi.org\/10.1186\/s12920-023-01490-2.","journal-title":"BMC Med Genomics"},{"key":"5014_CR71","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/nprot.2012.135","volume":"8","author":"EJ Want","year":"2013","unstructured":"Want EJ, et al. Global metabolic profiling of animal and human tissues via UPLC-MS. Nat Protoc. 2013;8:17\u201332. https:\/\/doi.org\/10.1038\/nprot.2012.135.","journal-title":"Nat Protoc"},{"key":"5014_CR72","doi-asserted-by":"publisher","first-page":"W398","DOI":"10.1093\/nar\/gkae253","volume":"52","author":"Z Pang","year":"2024","unstructured":"Pang Z, et al. MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation. Nucleic Acids Res. 2024;52:W398\u2013406. https:\/\/doi.org\/10.1093\/nar\/gkae253.","journal-title":"Nucleic Acids Res"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-026-05014-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-026-05014-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-026-05014-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:14:33Z","timestamp":1789658073000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12951-026-05014-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":72,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5014"],"URL":"https:\/\/doi.org\/10.1186\/s12951-026-05014-9","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]},"assertion":[{"value":"27 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All experimental and research procedures described in this manuscript have been conducted in strict compliance with the policy of the National Ministry of Health of China. All research procedures have obtained official approval from the Institutional Review Board of Chongqing Medical University (IACUC-CQMU-2025-11162). This study did not involve the use of human data or tissues. Thus, Consent to Participate: not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"880"}}