{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:38:28Z","timestamp":1792643908187,"version":"4.5.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["242210"],"award-info":[{"award-number":["242210"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["2005105"],"award-info":[{"award-number":["2005105"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Health Qual Life Outcomes"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12955-015-0298-1","type":"journal-article","created":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T07:15:23Z","timestamp":1438326923000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["An up-date on health-related quality of life in myasthenia gravis -results from population based cohorts"],"prefix":"10.1186","volume":"13","author":[{"given":"M. I.","family":"Boldingh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Dekker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. H.","family":"Maniaol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Brunborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. F.","family":"Lipka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. H.","family":"Niks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J. G. M.","family":"Verschuuren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M. E.","family":"Tallaksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,8,1]]},"reference":[{"key":"298_CR1","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/mus.10035","volume":"25","author":"L Padua","year":"2002","unstructured":"Padua L, Evoli A, Aprile I, Caliandro P, D'Amico P, Rabini A, et al. Quality of life in patients with myasthenia gravis. Muscle Nerve. 2002;25:466\u20137.","journal-title":"Muscle Nerve"},{"key":"298_CR2","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/mus.1034","volume":"24","author":"RH Paul","year":"2001","unstructured":"Paul RH, Nash JM, Cohen RA, Gilchrist JM, Goldstein JM. Quality of life and well-being of patients with myasthenia gravis. Muscle Nerve. 2001;24:512\u20136.","journal-title":"Muscle Nerve"},{"key":"298_CR3","first-page":"41","volume":"31","author":"A Raggi","year":"2010","unstructured":"Raggi A, Leonardi M, Antozzi C, Confalonieri P, Maggi L, Cornelio F, et al. Concordance between severity of disease, disability and health-related quality of life in myasthenia gravis. NeurolSci. 2010;31:41\u20135.","journal-title":"NeurolSci"},{"key":"298_CR4","first-page":"98","volume":"257","author":"M Leonardi","year":"2010","unstructured":"Leonardi M, Raggi A, Antozzi C, Confalonieri P, Maggi L, Cornelio F, et al. The relationship between health, disability and quality of life in myasthenia gravis: results from an Italian study. JNeurol. 2010;257:98\u2013102. doi: 10.1007\/s00415-009-5279-z . Epub 2009 Aug 8.","journal-title":"JNeurol"},{"key":"298_CR5","first-page":"191","volume":"13","author":"A Rostedt","year":"2006","unstructured":"Rostedt A, Padua L, Stalberg EV. Correlation between regional myasthenic weakness and mental aspects of quality of life. EurJNeurol. 2006;13:191\u20133.","journal-title":"EurJNeurol"},{"key":"298_CR6","first-page":"2058","volume":"116","author":"A Rostedt","year":"2005","unstructured":"Rostedt A, Padua L, Stalberg EV. Correlation between a patient-derived functional questionnaire and abnormal neuromuscular transmission in Myasthenia Gravis patients. ClinNeurophysiol. 2005;116:2058\u201364.","journal-title":"ClinNeurophysiol"},{"key":"298_CR7","first-page":"1473","volume":"257","author":"Y Winter","year":"2010","unstructured":"Winter Y, Schepelmann K, Spottke AE, Claus D, Grothe C, Schroder R, et al. Health-related quality of life in ALS, myasthenia gravis and facioscapulohumeral muscular dystrophy. JNeurol. 2010;257:1473\u201381.","journal-title":"JNeurol"},{"key":"298_CR8","first-page":"1375","volume":"33","author":"IZ Basta","year":"2012","unstructured":"Basta IZ, Pekmezovic TD, Peric SZ, Kisic-Tepavcevic DB, Rakocevic-Stojanovic VM, Stevic ZD, et al. Assessment of health-related quality of life in patients with myasthenia gravis in Belgrade (Serbia). NeurolSci. 2012;33:1375\u201381.","journal-title":"NeurolSci"},{"key":"298_CR9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/1477-7525-8-129","volume":"8","author":"S Twork","year":"2010","unstructured":"Twork S, Wiesmeth S, Klewer J, Pohlau D, Kugler J. Quality of life and life circumstances in German myasthenia gravis patients. Health QualLife Outcomes. 2010;8:129.","journal-title":"Health QualLife Outcomes"},{"key":"298_CR10","first-page":"1167","volume":"93","author":"K Kulkantrakorn","year":"2010","unstructured":"Kulkantrakorn K, Jarungkiatkul W. Quality of life of myasthenia gravis patients. JMedAssocThai. 2010;93:1167\u201371.","journal-title":"JMedAssocThai"},{"key":"298_CR11","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3109\/00207454.2013.853664","volume":"124","author":"A Ariatti","year":"2014","unstructured":"Ariatti A, Stefani M, Miceli P, Benuzzi F, Galassi G. Prognostic factors and health-related quality of life in ocular Myasthenia Gravis (OMG). Int J Neurosci. 2014;124:427\u201335.","journal-title":"Int J Neurosci"},{"key":"298_CR12","first-page":"225","volume":"224","author":"C Busch","year":"1996","unstructured":"Busch C, Machens A, Pichlmeier U, Emskotter T, Izbicki JR. Long-term outcome and quality of life after thymectomy for myasthenia gravis. AnnSurg. 1996;224:225\u201332.","journal-title":"AnnSurg"},{"key":"298_CR13","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/1471-2377-14-142","volume":"14","author":"S Suzuki","year":"2014","unstructured":"Suzuki S, Murai H, Imai T, Nagane Y, Masuda M, Tsuda E, et al. Quality of life in purely ocular myasthenia in Japan. BMC Neurol. 2014;14:142.","journal-title":"BMC Neurol"},{"key":"298_CR14","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3109\/08916930903518107","volume":"43","author":"DB Sanders","year":"2010","unstructured":"Sanders DB, Evoli A. Immunosuppressive therapies in myasthenia gravis. Autoimmunity. 2010;43:428\u201335.","journal-title":"Autoimmunity"},{"key":"298_CR15","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1196\/annals.1405.012","volume":"1132","author":"A Evoli","year":"2008","unstructured":"Evoli A, Bianchi MR, Riso R, Minicuci GM, Batocchi AP, Servidei S, et al. Response to therapy in myasthenia gravis with anti-MuSK antibodies. Ann N Y Acad Sci. 2008;1132:76\u201383.","journal-title":"Ann N Y Acad Sci"},{"key":"298_CR16","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/mus.22006","volume":"44","author":"JT Guptill","year":"2011","unstructured":"Guptill JT, Sanders DB, Evoli A. Anti-MuSK antibody myasthenia gravis: clinical findings and response to treatment in two large cohorts. Muscle Nerve. 2011;44:36\u201340.","journal-title":"Muscle Nerve"},{"key":"298_CR17","first-page":"701","volume":"10","author":"F Romi","year":"2003","unstructured":"Romi F, Gilhus NE, Varhaug JE, Myking A, Aarli JA. Disease severity and outcome in thymoma myasthenia gravis: a long-term observation study. EurJNeurol. 2003;10:701\u20136.","journal-title":"EurJNeurol"},{"key":"298_CR18","first-page":"417","volume":"78","author":"EH Niks","year":"2007","unstructured":"Niks EH, Kuks JB, Verschuuren JJ. Epidemiology of myasthenia gravis with anti-muscle specific kinase antibodies in The Netherlands. JNeurolNeurosurgPsychiatry. 2007;78:417\u20138.","journal-title":"JNeurolNeurosurgPsychiatry"},{"key":"298_CR19","first-page":"453","volume":"20","author":"AH Maniaol","year":"2013","unstructured":"Maniaol AH, Boldingh M, Brunborg C, Harbo HF, Tallaksen CM. Smoking and socio-economic status may affect myasthenia gravis. EurJNeurol. 2013;20:453\u201360.","journal-title":"EurJNeurol"},{"key":"298_CR20","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000431036","volume":"44","author":"MI Boldingh","year":"2015","unstructured":"Boldingh MI, Maniaol AH, Brunborg C, Dekker L, Heldal AT, Lipka AF, et al. Geographical Distribution of Myasthenia Gravis in Northern Europe - Results from a Population-Based Study from Two Countries. Neuroepidemiology. 2015;44:221-31.","journal-title":"Neuroepidemiology"},{"key":"298_CR21","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1159\/000297753","volume":"34","author":"AH Maniaol","year":"2010","unstructured":"Maniaol AH, Brunborg C, Tallaksen CM. Development and validation of a self-administered questionnaire for myasthenia gravis patients. Neuroepidemiology. 2010;34:253\u201361.","journal-title":"Neuroepidemiology"},{"key":"298_CR22","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/S0895-4356(98)00097-3","volume":"51","author":"NK Aaronson","year":"1998","unstructured":"Aaronson NK, Muller M, Cohen PD, Essink-Bot ML, Fekkes M, Sanderman R, et al. Translation, validation, and norming of the Dutch language version of the SF-36 Health Survey in community and chronic disease populations. J Clin Epidemiol. 1998;51:1055\u201368.","journal-title":"J Clin Epidemiol"},{"key":"298_CR23","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/S0895-4356(98)00098-5","volume":"51","author":"JH Loge","year":"1998","unstructured":"Loge JH, Kaasa S, Hjermstad MJ, Kvien TK. Translation and performance of the Norwegian SF-36 Health Survey in patients with rheumatoid arthritis. I. Data quality, scaling assumptions, reliability, and construct validity. J Clin Epidemiol. 1998;51:1069\u201376.","journal-title":"J Clin Epidemiol"},{"key":"298_CR24","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1177\/14034948980260040401","volume":"26","author":"JH Loge","year":"1998","unstructured":"Loge JH, Kaasa S. Short form 36 (SF-36) health survey: normative data from the general Norwegian population. Scand J Soc Med. 1998;26:250\u20138.","journal-title":"Scand J Soc Med"},{"key":"298_CR25","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/ane.12142","volume":"129","author":"G Klevan","year":"2014","unstructured":"Klevan G, Jacobsen CO, Aarseth JH, Myhr KM, Nyland H, Glad S, et al. Health related quality of life in patients recently diagnosed with multiple sclerosis. Acta Neurol Scand. 2014;129:21\u20136.","journal-title":"Acta Neurol Scand"},{"key":"298_CR26","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.parkreldis.2013.07.010","volume":"19","author":"B Muller","year":"2013","unstructured":"Muller B, Assmus J, Herlofson K, Larsen JP, Tysnes OB. Importance of motor vs. non-motor symptoms for health-related quality of life in early Parkinson\u2019s disease. Parkinsonism Relat Disord. 2013;19:1027\u201332.","journal-title":"Parkinsonism Relat Disord"},{"key":"298_CR27","volume-title":"SF-36 Health Survey: Manual and Interpretation Guide","author":"JE Ware Jr","year":"1993","unstructured":"Ware Jr JE, Snow KK, Kosinski M. SF-36 Health Survey: Manual and Interpretation Guide. 2000th ed. Lincoln RI: QualityMetric, Incorporated; 1993.","edition":"2000"},{"key":"298_CR28","volume-title":"SF-36 Physical & Mental Health Summary scales: A manual for Users of Version 1, Second edition","author":"JE Ware Jr","year":"2001","unstructured":"Ware Jr JE, Kosinski MA. SF-36 Physical & Mental Health Summary scales: A manual for Users of Version 1, Second edition. 2nd ed. Lincoln, Rhode Island: QualityMetric Incorporated; 2001.","edition":"2"},{"key":"298_CR29","first-page":"571","volume":"31","author":"K Kulkantrakorn","year":"2010","unstructured":"Kulkantrakorn K, Sawanyawisuth K, Tiamkao S. Factors correlating quality of life in patients with myasthenia gravis. NeurolSci. 2010;31:571\u20133.","journal-title":"NeurolSci"},{"key":"298_CR30","doi-asserted-by":"crossref","unstructured":"Utsugisawa K, Suzuki S, Nagane Y, Masuda M, Murai H, Imai T, et al. Health-related quality of life and treatment targets in myasthenia gravis. Muscle Nerve. 2014.","DOI":"10.1002\/mus.24213"},{"key":"298_CR31","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.5692\/clinicalneurol.52.1043","volume":"52","author":"M Masuda","year":"2012","unstructured":"Masuda M, Utsugisawa K, Suzuki S, Nagane Y, Ito S, Kabasawa C, et al. The MG-QOL15 Japanese version: validation and associations with clinical factors. Rinsho Shinkeigaku. 2012;52:1043\u20136.","journal-title":"Rinsho Shinkeigaku"},{"key":"298_CR32","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1002\/mus.20734","volume":"35","author":"DE Stickler","year":"2007","unstructured":"Stickler DE, Stickler LL. Single-fiber electromyography during menstrual exacerbation and ovulatory suppression in MuSK antibody-positive myasthenia gravis. Muscle Nerve. 2007;35:808\u201311.","journal-title":"Muscle Nerve"},{"key":"298_CR33","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/mus.880160504","volume":"16","author":"JM Massey","year":"1993","unstructured":"Massey JM, Sanders DB. Single fiber electromyography in myasthenia gravis during pregnancy. Muscle Nerve. 1993;16:458\u201360.","journal-title":"Muscle Nerve"},{"key":"298_CR34","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1212\/01.wnl.0000263481.14289.90","volume":"68","author":"M Benatar","year":"2007","unstructured":"Benatar M, Kaminski HJ. Evidence report: the medical treatment of ocular myasthenia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2007;68:2144\u20139.","journal-title":"Neurology"},{"key":"298_CR35","doi-asserted-by":"crossref","unstructured":"Kerty E, Elsais A, Argov Z, Evoli A, Gilhus NE. EFNS\/ENS Guidelines for the treatment of ocular myasthenia. Eur J Neurol. 2014;21(5):687\u201393.","DOI":"10.1111\/ene.12359"},{"key":"298_CR36","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1212\/WNL.53.5.1098","volume":"53","author":"MW Nortvedt","year":"1999","unstructured":"Nortvedt MW, Riise T, Myhr KM, Nyland HI. Quality of life in multiple sclerosis: measuring the disease effects more broadly. Neurology. 1999;53:1098\u2013103.","journal-title":"Neurology"},{"key":"298_CR37","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.genm.2009.12.001","volume":"6","author":"E West","year":"2009","unstructured":"West E, Wallberg-Jonsson S. Health-related quality of life in Swedish men and women with early rheumatoid arthritis. Gend Med. 2009;6:544\u201354.","journal-title":"Gend Med"},{"key":"298_CR38","first-page":"1","volume":"2014","author":"T Uutela","year":"1990","unstructured":"Uutela T, Kautiainen H, Jarvenpaa S, Salomaa S, Hakala M, Hakkinen A. Patients with rheumatoid arthritis have better functional and working ability but poorer general health and higher comorbidity rates today than in the late. Scand J Rheumatol. 1990;2014:1\u20139.","journal-title":"Scand J Rheumatol"},{"key":"298_CR39","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/mus.20950","volume":"37","author":"D Grob","year":"2008","unstructured":"Grob D, Brunner N, Namba T, Pagala M. Lifetime course of myasthenia gravis. Muscle Nerve. 2008;37:141\u20139.","journal-title":"Muscle Nerve"},{"key":"298_CR40","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/mus.23245","volume":"46","author":"TM Burns","year":"2012","unstructured":"Burns TM, Graham CD, Rose MR, Simmons Z. Quality of life and measures of quality of life in patients with neuromuscular disorders. Muscle Nerve. 2012;46:9\u201325.","journal-title":"Muscle Nerve"}],"container-title":["Health and Quality of Life Outcomes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12955-015-0298-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12955-015-0298-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12955-015-0298-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T19:16:39Z","timestamp":1567019799000},"score":1,"resource":{"primary":{"URL":"http:\/\/hqlo.biomedcentral.com\/articles\/10.1186\/s12955-015-0298-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["298"],"URL":"https:\/\/doi.org\/10.1186\/s12955-015-0298-1","relation":{},"ISSN":["1477-7525"],"issn-type":[{"value":"1477-7525","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,1]]},"article-number":"115"}}