{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T11:37:59Z","timestamp":1774525079228,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Science and Technology department of Zhejiang province.","award":["NO 2014C33128"],"award-info":[{"award-number":["NO 2014C33128"]}]},{"name":"Zhejiang provincial health and Family Planning Commission.","award":["No C2015W162."],"award-info":[{"award-number":["No C2015W162."]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Health Qual Life Outcomes"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12955-019-1200-3","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T13:02:33Z","timestamp":1564059753000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Fatigue in chronic hepatitis B patients is significant and associates with autonomic dysfunction"],"prefix":"10.1186","volume":"17","author":[{"given":"Hong","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo Qing","family":"Ru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li Li","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,7,25]]},"reference":[{"key":"1200_CR1","doi-asserted-by":"publisher","first-page":"58","DOI":"10.7326\/0003-4819-147-1-200707030-00010","volume":"147","author":"CL Lai","year":"2007","unstructured":"Lai CL, Yuen MF. The natural history and treatment of chronic hepatitis B: a critical evaluation of standard treatment criteria and end points. Ann Intern Med. 2007;147:58\u201361.","journal-title":"Ann Intern Med"},{"key":"1200_CR2","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1002\/hep.23190","volume":"50","author":"AS Lok","year":"2009","unstructured":"Lok AS, McMahon BJ. Chronic hepatitis B: update. Hepatology. 2009;50:661\u20132. \n                              https:\/\/doi.org\/10.1002\/hep.23190\n                              \n                           .","journal-title":"Hepatology"},{"key":"1200_CR3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/hep.21692","volume":"46","author":"BMR Spiegel","year":"2007","unstructured":"Spiegel BMR, Bolus R, Han S, Tong M, Esrailian E, Talley J, et al. Development and validation of a disease-targeted quality of life instrument in chronic hepatitis B : the hepatitis B quality of life instrument, version 1.0. Hepatology. 2007;46:113\u201321. \n                              https:\/\/doi.org\/10.1002\/hep.21692\n                              \n                           .","journal-title":"Hepatology."},{"key":"1200_CR4","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1002\/jmv.21508","volume":"81","author":"LC Quarantini","year":"2009","unstructured":"Quarantini LC, Mirada-Scippa A, Batista-Neves S, Powell VB, Abreu N. Moural l, et al. a neourophychologic study comparing patients infected with HBV and HBV without psychiatric comorbidities. J Med Virol. 2009;81:1184\u20138. \n                              https:\/\/doi.org\/10.1002\/jmv.21508\n                              \n                           .","journal-title":"J Med Virol"},{"key":"1200_CR5","doi-asserted-by":"publisher","first-page":"A19","DOI":"10.1097\/MEG.0b013e3283470256","volume":"59","author":"NJL Patanwala l","year":"2010","unstructured":"Patanwala l NJL, Elliot C, Frith J, Ghazala C, Pairman J, et al. Functional capacity is significantly impaired in primary biliary cirrhosis and related to orthostatic symptoms. Gut. 2010;59:A19\u201320. \n                              https:\/\/doi.org\/10.1097\/MEG.0b013e3283470256\n                              \n                           .","journal-title":"Gut"},{"key":"1200_CR6","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.cgh.2007.11.021","volume":"6","author":"JL Newton","year":"2008","unstructured":"Newton JL, Pairman J, Sutcliffe K, Wilton K, Jones DEJ. A predictive model for fatigue and its aetiological associations in primary biliary cirrhosis. Clin Gastroenterol Hepatol. 2008;6:228\u20133. \n                              https:\/\/doi.org\/10.1016\/j.cgh.2007.11.021\n                              \n                           .","journal-title":"Clin Gastroenterol Hepatol"},{"key":"1200_CR7","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1001\/archinte.1995.00430190101014","volume":"155","author":"CH Bombardier","year":"1995","unstructured":"Bombardier CH, Buchwald D. Outcome and prognosis of patients with chronic fatigue vs. chronic fatigue syndrome. Arch Intern Med. 1995;155:2105\u201310.","journal-title":"Arch Intern Med"},{"issue":"suppl 1","key":"1200_CR8","doi-asserted-by":"publisher","first-page":"S79","DOI":"10.1093\/clinids\/18.Supplement_1.S79","volume":"18","author":"JD Fisk","year":"1994","unstructured":"Fisk JD, Flrtvo RG. RossL, et al. measuring the functional impact of fatigue initial validation of the fatigue impact scale. Clin Infect Dis. 1994;18(suppl 1):S79\u201383.","journal-title":"Clin Infect Dis"},{"key":"1200_CR9","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1093\/qjmed\/hcp091","volume":"102","author":"DEJ Jones","year":"2009","unstructured":"Jones DEJ, Gray JC, Newton JL. Perceived fatigue is comparable between different disease groups. QJM. 2009;102:617\u201324. \n                              https:\/\/doi.org\/10.1093\/qjmed\/hcp091\n                              \n                           .","journal-title":"QJM"},{"key":"1200_CR10","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.jhep.2010.05.026","volume":"53","author":"DEJ Jones","year":"2010","unstructured":"Jones DEJ, Al-rifai A, Firith J, Patanwala I, Newton JL. The independent effects of fatigue and UDCA therapy on morta;ity in primary biliary cirrhosis: results of a 9 year follow-up. J Hepatol. 2010;53:911\u20137. \n                              https:\/\/doi.org\/10.1016\/j.jhep.2010.05.026\n                              \n                           .","journal-title":"J Hepatol"},{"key":"1200_CR11","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1136\/gut.2007.139303","volume":"57","author":"JL Newton","year":"2008","unstructured":"Newton JL, Jones DEJ, Henderson E, Kane L, Wilton K, Burt AD, et al. Fatigue in non-alcoholic fatty liver disease is sever and associates with inactivity and excessive daytime sleepiness but not with liver disease severity or insulin resistance. Gut. 2008;57:807\u201313. \n                              https:\/\/doi.org\/10.1136\/gut.2007.139303\n                              \n                           .","journal-title":"Gut"},{"key":"1200_CR12","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1046\/j.1365-2893.2002.00364.x","volume":"9","author":"T Poynard","year":"2002","unstructured":"Poynard T, Cacoub P, Ratziu V. MyersRP, Dezailles MH, Mercadier a, fatigue in patients with hepatitis C. J Vir Hep. 2002;9:295\u2013303.","journal-title":"J Vir Hep"},{"key":"1200_CR13","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/S1665-2681(19)31269-4","volume":"14","author":"MP Karine","year":"2015","unstructured":"Karine MP, Mychelle M-d-J, Renato D-O, DDD A, Carlos T, Maria IS, et al. The fatigue impact scale for daily use in patients with hepatitis B virus and hepatitis C virus chronic infections. Ann Hepatol. 2015;14:310\u20136.","journal-title":"Ann Hepatol"},{"key":"1200_CR14","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1007\/s10620-015-4006-0","volume":"61","author":"ME Donna","year":"2016","unstructured":"Donna ME, Abdus SW, Geoffrey J, Mandana K, Mauricio LM, Robert JF. Et al. fatigue in patients with chronic hepatitis B living in North America: results from the hepatitis B research network (HBRN). Dig Dis Sci. 2016;61:1186\u201396. \n                              https:\/\/doi.org\/10.1007\/s10620-015-4006-0\n                              \n                           .","journal-title":"Dig Dis Sci"},{"key":"1200_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/gut.44.1.1","volume":"44","author":"Z Younossi","year":"1999","unstructured":"Younossi Z, Guyatt G, King M, King D, Bohprai N. Development of a disease-specific health-related quality of lifeindex for chronic liver disease. GUT. 1999;44:1\u20136.","journal-title":"GUT"},{"key":"1200_CR16","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1177\/1073191108324440","volume":"16","author":"P Rast","year":"2009","unstructured":"Rast P, Zimprich D, Van Boxtel M, Jolles J. Factor structure and measurement invariance of the cognitive failures questionnaire across the adult life span. Assessment. 2009;16:145.","journal-title":"Assessment"},{"key":"1200_CR17","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/S0010-440X(99)90093-7","volume":"40","author":"AC Wagle","year":"1999","unstructured":"Wagle AC, Berrios GE, Ho L. The cognitive failure questionnaire in psychiatry. Compr Psychiatry. 1999;40:478.","journal-title":"Compr Psychiatry"},{"key":"1200_CR18","doi-asserted-by":"publisher","first-page":"S79","DOI":"10.1093\/clinids\/18.Supplement_1.S79","volume":"18","author":"JD Fisk","year":"1994","unstructured":"Fisk JD, Ritvo PG, Ross L, Haase DA, Marrie TJ, Schlech WF. Measuring the functional impact of fatigue:initial validation of the fatigue impact scale. Clin Infect Dis. 1994;18:S79.","journal-title":"Clin Infect Dis"},{"key":"1200_CR19","doi-asserted-by":"publisher","first-page":"330","DOI":"10.4065\/80.3.330","volume":"80","author":"C Schrezenmaier","year":"2005","unstructured":"Schrezenmaier C, Gehrking JA, Hines SM, Low PA, Benrud LM, Sandroni P. Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures. Mao Clin Proc. 2005;80:330\u20137.","journal-title":"Mao Clin Proc"},{"key":"1200_CR20","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","volume":"14","author":"MW Johns","year":"1991","unstructured":"Johns MW. A new method for measuring daytime sleepiness:the Epworth sleepiness scale. Sleep. 1991;14:540\u20137.","journal-title":"Sleep"},{"key":"1200_CR21","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/hep.510240201","volume":"24","author":"P Bedossa","year":"1996","unstructured":"Bedossa P, Poynard T. An algorithm for the grading of activity in chronic hepatitis C. the METVIR cooperative study group. Hepatology. 1996;24:289\u201393.","journal-title":"Hepatology."},{"key":"1200_CR22","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1002\/hep.21230","volume":"44","author":"JL Newton","year":"2006","unstructured":"Newton JL, Gibson GJ, Tomlison M, Wilton K, Jones D. Fatigue in primary biliary cirrhosis is associated with excessive daytime somnolence. Hepatology. 2006;44:91\u20138. \n                              https:\/\/doi.org\/10.1002\/hep.21230\n                              \n                           .","journal-title":"Hepatology"},{"key":"1200_CR23","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1007\/s10620-006-9708-x","volume":"52","author":"J Kallman","year":"2007","unstructured":"Kallman J, O\u2019Neil MM, Larive B, Boparai N, Calabrese L, Younossi ZM. Fatigue and heath-related quality of life in chronic hepatitis C virus infection. Dig Dis Sci. 2007;52:2531\u20139. \n                              https:\/\/doi.org\/10.1007\/s10620-006-9708-x\n                              \n                           .","journal-title":"Dig Dis Sci"},{"key":"1200_CR24","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1111\/j.1365-2036.2009.04181.x","volume":"31","author":"KD Kistler","year":"2010","unstructured":"Kistler KD, Molleston J, Unalp A, Abrams SH, Behling C, Schwimmer JB. Symptoms and quality of life in obese children and adolescents with non-alcoholic fatty liver disease. Aliment Pharmacol Therapy. 2010;31:396\u2013406. \n                              https:\/\/doi.org\/10.1111\/j.1365-2036.2009.04181.x\n                              \n                           .","journal-title":"Aliment Pharmacol Therapy"},{"key":"1200_CR25","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1016\/j.jhep.2007.03.006","volume":"46","author":"DEJ Jone","year":"2007","unstructured":"Jone DEJ. Fatigue in cholestatic liver disease: is it all in mind? J Hepatol. 2007;46:992\u20134. \n                              https:\/\/doi.org\/10.1016\/j.jhep.2007.03.006\n                              \n                           .","journal-title":"J Hepatol"},{"key":"1200_CR26","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/j.jhep.2007.01.036","volume":"46","author":"E Van Os","year":"2007","unstructured":"Van Os E, Van den Broek WW, Mulder PGH, Ter Borg PCJ, Bruijn JA, Van Buuren HR. Depression in patients with primary biliary cirrhosis and primary sclerosing cholangitis. J Hepatol. 2007;46:1099\u2013103. \n                              https:\/\/doi.org\/10.1016\/j.jhep.2007.01.036\n                              \n                           .","journal-title":"J Hepatol"},{"key":"1200_CR27","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jpsychores.2014.11.011","volume":"78","author":"D Zalai","year":"2015","unstructured":"Zalai D, Sherman M, McShane K, Shapiro CM, Carney CE. The importance of fatigue cognitions in chronic hepatitis C infection. J Psycho Research. 2015;78:193\u20138. \n                              https:\/\/doi.org\/10.1016\/j.jpsychores.2014.11.011\n                              \n                           .","journal-title":"J Psycho Research"},{"key":"1200_CR28","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1136\/gut.2005.080267","volume":"55","author":"K Weissenborn","year":"2006","unstructured":"Weissenborn K, Ennen JC, Bokemeyer M, Ahl B, Wurster U, Tillman H, et al. Monoaminergic neurotransmission is altered in hepatitis C infected patients with chronic fatigue and cognitive impairment. Gut. 2006;55:1535\u20137. \n                              https:\/\/doi.org\/10.1136\/gut.2005.080267\n                              \n                           .","journal-title":"Gut"},{"key":"1200_CR29","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1002\/hep.26365","volume":"58","author":"GF Mells","year":"2013","unstructured":"Mells GF, Pells G, Newton JL, Bathgate AJ, Burroughs AK, Heneghan MA, et al. Impact of primary biliary cirrhosis on perceived quality of life: the UK-PBC national study. Hepatology. 2013;58:273\u201383. \n                              https:\/\/doi.org\/10.1002\/hep.26365\n                              \n                           .","journal-title":"Hepatology"}],"container-title":["Health and Quality of Life Outcomes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12955-019-1200-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12955-019-1200-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12955-019-1200-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T23:04:25Z","timestamp":1595545465000},"score":1,"resource":{"primary":{"URL":"https:\/\/hqlo.biomedcentral.com\/articles\/10.1186\/s12955-019-1200-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,25]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1200"],"URL":"https:\/\/doi.org\/10.1186\/s12955-019-1200-3","relation":{},"ISSN":["1477-7525"],"issn-type":[{"value":"1477-7525","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,25]]},"assertion":[{"value":"16 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study protocol was reviewed and approved by the ethics committee of Zhejiang Provincial People\u2019s Hospital.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All patients signed an informed consent from prior to screening in accordance with regulatory and local Ethics committee requirements.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"130"}}