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Previous research has paid less attention to health-related quality of life and prospective studies on this topic are needed. The aim of this study was to assess changes in health-related quality of life after 10\u00a0years in a Norwegian Marfan syndrome cohort.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Forty-seven Marfan syndrome patients \u2265\u200918\u00a0years were investigated for all organ manifestations in the 1996 Ghent nosology and completed the self-reported questionnaire, Short-Form-36 Health Survey, at baseline in 2003\u20132004 and at follow-up in 2014\u20132015. Paired sample <jats:italic>t<\/jats:italic> tests were performed to compare means and multiple regression analyses were performed with age, sex, new cardiovascular and new non-cardiovascular pathology as predictors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>At 10-year follow-up: a significant decline was found in the physical domain. The mental domain was unchanged. Older age predicted a larger decline in physical health-related quality of life. None of the chosen Marfan-related variables predicted changes in any of the subscales of the Short-Form 36 Health Survey or in the physical or the mental domain.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Knowledge of decline in the physical domain, not related to organ affections, may be important in the follow-up of Marfan syndrome patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12955-020-01633-4","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T01:02:33Z","timestamp":1606784553000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Health-related quality of life in Marfan syndrome: a 10-year follow-up"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2792-8864","authenticated-orcid":false,"given":"Thy Thy","family":"Vanem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svend","family":"Rand-Hendriksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathrine","family":"Brunborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odd Ragnar","family":"Geiran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie","family":"R\u00f8e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,12,1]]},"reference":[{"issue":"9","key":"1633_CR1","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1111\/j.1651-2227.1997.tb15176.x","volume":"86","author":"J Fuchs","year":"1997","unstructured":"Fuchs J. 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