{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:35:15Z","timestamp":1790832915558,"version":"4.1.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Health Qual Life Outcomes"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The objective of this study was to investigate the current status of fertility quality of life (QoL) and explore the influencing factors for infertile women with repeated implantation failure (RIF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The sample consisted of 137 infertile women with RIF who were under treatment from January 2019 to December 2019 in the Reproductive Medical Center of Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine in China. A general information questionnaire, FertiQoL scale, perceived social support scale (PSSS), self-rating anxiety scale (SAS), and self-rating depression scale (SDS) were used to analyse the fertility QoL and related factors of RIF patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The total fertility QoL score of RIF patients was 60.44\u2009\u00b1\u200911.60. The results of multivariate regression analysis showed that residence, financial difficulties, male infertility, BMI index, depression, and family social support were the main factors that influenced the fertility QoL of RIF patients (adjusted R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.762).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Based on the results of this study, RIF patients\u2019 psychological status must be addressed. Corresponding interventions such as building a sound family and social support system, creating a good medical environment and offering diverse health education should be provided to improve the fertility QoL of RIF patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12955-021-01666-3","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T07:06:05Z","timestamp":1611558365000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["The analysis of fertility quality of life and the influencing factors of patients with repeated implantation failure"],"prefix":"10.1186","volume":"19","author":[{"given":"Ying","family":"Ni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenye","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0269-5566","authenticated-orcid":false,"given":"Aijun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,25]]},"reference":[{"issue":"3","key":"1666_CR1","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.pec.2005.07.015","volume":"59","author":"L Schmidt","year":"2005","unstructured":"Schmidt L, Holstein B, Christensen U, et al. Does infertility cause marital benefit? An epidemiological study of 2250 women and men in fertility treatment. Patient Educ Couns. 2005;59(3):244\u201351.","journal-title":"Patient Educ Couns"},{"issue":"1","key":"1666_CR2","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.rbmo.2013.08.011","volume":"28","author":"C Coughlan","year":"2014","unstructured":"Coughlan C, Ledger W, Wang Q, et al. Recurrent implantation failure: definition and management. Reprod Biomed Online. 2014;28(1):14\u201338.","journal-title":"Reprod Biomed Online"},{"issue":"1","key":"1666_CR3","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.rbmo.2017.04.004","volume":"35","author":"J Mak","year":"2017","unstructured":"Mak J, chung c, chung J, , et al. The effect of endometrial scratch on natural-cycle cryopreserved embryo transfer outcomes: a randomized controlled study. Reprod Biomed Online. 2017;35(1):28\u201336.","journal-title":"Reprod Biomed Online"},{"issue":"1","key":"1666_CR4","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s12955-018-0956-1","volume":"16","author":"R Omani-Samani","year":"2018","unstructured":"Omani-Samani R, Ghaheri A, Navid B, Sepidarkish M, Maroufizadeh S. Prevalence of generalized anxiety disorder and its related factors among infertile patients in Iran: a cross-sectional study. Health Qual Life Outcomes. 2018;16(1):129.","journal-title":"Health Qual Life Outcomes"},{"issue":"4","key":"1666_CR5","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1007\/s11136-017-1781-4","volume":"27","author":"M Zurlo","year":"2018","unstructured":"Zurlo M, Volta D, Vallone F. Predictors of quality of life and psychological health in infertile couples: the moderating role of duration of infertility. Qual Life Res. 2018;27(4):945\u201354.","journal-title":"Qual Life Res"},{"key":"1666_CR6","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.fertnstert.2006.11.158","volume":"88","author":"BC Cooper","year":"2007","unstructured":"Cooper BC, Gerber JR, McGettrick AL, et al. Perceived infertility-related stress correlates with in vitro fertilization outcome. Fertil Steril. 2007;88:714\u20137.","journal-title":"Fertil Steril"},{"issue":"3","key":"1666_CR7","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1080\/13625180802049187","volume":"13","author":"A Drosdzol","year":"2008","unstructured":"Drosdzol A, Skrzypulec V. Quality of life and sexual functioning of Polish infertile couples. Eur J Contracept Reprod Health Care. 2008;13(3):271\u20138.","journal-title":"Eur J Contracept Reprod Health Care"},{"issue":"1","key":"1666_CR8","first-page":"57","volume":"14","author":"A Keramat","year":"2014","unstructured":"Keramat A, Masomi SZ, Mousavi SA, et al. Quality of life and its related factors in infertile couples. J Res Health Sci. 2014;14(1):57\u201363.","journal-title":"J Res Health Sci"},{"issue":"2","key":"1666_CR9","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.ijgo.2013.08.006","volume":"124","author":"C Coughlan","year":"2014","unstructured":"Coughlan C, Walters S, Ledger W, et al. A comparison of psychological stress among women with and without reproductive failure. Int J Gynecol Obstetr. 2014;124(2):143.","journal-title":"Int J Gynecol Obstetr"},{"issue":"2","key":"1666_CR10","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1080\/13548506.2016.1153681","volume":"22","author":"S Maroufizadeh","year":"2017","unstructured":"Maroufizadeh S, Ghaheri A, Omani SR. Factors associated with poor quality of life among Iranian infertile women undergoing IVF. Psychol Health Med. 2017;22(2):145\u201351.","journal-title":"Psychol Health Med"},{"key":"1666_CR11","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.ijgo.2010.02.015","volume":"110","author":"IMA Hassanin","year":"2010","unstructured":"Hassanin IMA, Abd-El-Raheem T, Shahin AY. Primary infertility and health-related quality of life in Upper Egypt. Int J Gynecol Obstetr. 2010;110:118\u201321.","journal-title":"Int J Gynecol Obstetr"},{"key":"1666_CR12","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.ejogrb.2013.06.029","volume":"170","author":"A Karabulut","year":"2013","unstructured":"Karabulut A, OzkanS ON. Predictors of fertility quality of life (FertiQoL) in infertile women: analysis of confounding factors. Eur J Obstet Gynecol Reprod Biol. 2013;170:193\u20137.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"2","key":"1666_CR13","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3109\/0167482X.2010.481337","volume":"31","author":"JR Chachamovich","year":"2010","unstructured":"Chachamovich JR, Chachamovich E, Ezer H, et al. Investigating quality of life and health-related quality of life in infertility: a systematic review. J Psychosom Obst Gyn. 2010;31(2):101\u201310.","journal-title":"J Psychosom Obst Gyn"},{"key":"1666_CR14","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1186\/1472-6963-8-186","volume":"8","author":"B Rashidi","year":"2008","unstructured":"Rashidi B, Montazeri A, Ramezanzadeh F, et al. Health-related quality of life in infertile couples receiving IVF or ICSI treatment. BMC Health Serv Res. 2008;8:186.","journal-title":"BMC Health Serv Res"},{"issue":"2","key":"1666_CR15","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.tjog.2013.04.009","volume":"52","author":"PY Hsu","year":"2013","unstructured":"Hsu PY, Lin MW, Hwang JL, et al. The fertility quality of life (FertiQoL) questionnaire in Taiwanese infertile couples. Taiwan Assoc Obstetr Gynecol. 2013;52(2):204\u20139.","journal-title":"Taiwan Assoc Obstetr Gynecol"},{"issue":"2","key":"1666_CR16","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.fertnstert.2011.02.046","volume":"96","author":"J Boivin","year":"2011","unstructured":"Boivin J, Takefman J, Braverman A. The fertility quality of life (FertiQoL) tool: development and general psychometric properties. Fertil Steril. 2011;96(2):409\u201315.","journal-title":"Fertil Steril"},{"issue":"1","key":"1666_CR17","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/nhs.12167","volume":"17","author":"SH Kahyaoglu","year":"2015","unstructured":"Kahyaoglu SH, Balkanli KP. Quality of life in women with infertility via the FertiQoL and the Hospital Anxiety and Depression Scales. Nurs Health Sci. 2015;17(1):84\u20139.","journal-title":"Nurs Health Sci"},{"issue":"1","key":"1666_CR18","first-page":"91","volume":"12","author":"BJ Namavar","year":"2018","unstructured":"Namavar BJ, Mansouri M, Forouhari S, et al. Quality of life and its Influencing factors of couples referred to an infertility center in Shiraz. Iran Int J Fertil Steril. 2018;12(1):91.","journal-title":"Iran Int J Fertil Steril"},{"issue":"1","key":"1666_CR19","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1207\/s15327752jpa5201_2","volume":"52","author":"GD Zimet","year":"1988","unstructured":"Zimet GD, Dahlem NW, Zimet SG, et al. The multidimensional scale of perceived social support. J Person Assess. 1988;52(1):30\u201341.","journal-title":"J Person Assess"},{"issue":"6","key":"1666_CR20","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/S0033-3182(71)71479-0","volume":"12","author":"W Zung","year":"1971","unstructured":"Zung W. A rating instrument for anxiety disorders. Psychosomatics. 1971;12(6):371\u20139.","journal-title":"Psychosomatics"},{"key":"1666_CR21","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1001\/archpsyc.1965.01720310065008","volume":"12","author":"Zung wA self-rating depression scale","year":"1965","unstructured":"Zung wA self-rating depression scale. Arch Gen Psychiatry. 1965;12:63\u201370.","journal-title":"Arch Gen Psychiatry"},{"issue":"1","key":"1666_CR22","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.ejogrb.2013.06.029","volume":"170","author":"A Karabulut","year":"2013","unstructured":"Karabulut A. Predictors of fertility quality of life (FertiQoL) in infertile women: analysis of confounding factors. Eur J Obstet Gynecol Reprod Biol. 2013;170(1):193\u20137.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"1666_CR23","doi-asserted-by":"crossref","unstructured":"Ying L Y, Wu L H, Loke A Y. The experience of Chinese couples undergoing in vitro fertilization treatment: perception of the treatment process and partner support. PLoS One. 2015;10 (10).","DOI":"10.1371\/journal.pone.0139691"},{"issue":"3","key":"1666_CR24","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1177\/1557988317695901","volume":"11","author":"B Yang","year":"2017","unstructured":"Yang B, Zhang J, Qi Y, et al. Assessment on occurrences of depression and anxiety and associated risk factors in the infertile Chinese men. Am J Mens Health. 2017;11(3):767\u201374.","journal-title":"Am J Mens Health"},{"issue":"2","key":"1666_CR25","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3109\/0167482X.2010.481337","volume":"31","author":"JR Chachamovich","year":"2010","unstructured":"Chachamovich JR, Chachamovich E, Ezer H, et al. Investigating quality of life and health-related quality of life in infertility: a systematic review. J Psychosom Obstet Gynaecol. 2010;31(2):101\u201310.","journal-title":"J Psychosom Obstet Gynaecol"},{"issue":"1","key":"1666_CR26","first-page":"57","volume":"14","author":"A Keramat","year":"2014","unstructured":"Keramat A, Masoomi SZ, Mousavi SA, et al. Quality of life and its related factors in infertile couples. J Res Health Sci. 2014;14(1):57\u201363.","journal-title":"J Res Health Sci"},{"issue":"5","key":"1666_CR27","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1093\/humupd\/dmm017","volume":"13","author":"A Maheshwari","year":"2007","unstructured":"Maheshwari A, Stofberg L, Bhattacharya S. Effect of overweight and obesity on assisted reproductive technology - a systematic review. Hum Reprod Update. 2007;13(5):433\u201344.","journal-title":"Hum Reprod Update"},{"issue":"3","key":"1666_CR28","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.fertnstert.2007.07.1290","volume":"90","author":"M Metwally","year":"2008","unstructured":"Metwally M, Ong KJ, Ledger WL, et al. Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta - analysis of the evidence. Fertil Steril. 2008;90(3):714\u201326.","journal-title":"Fertil Steril"},{"issue":"4","key":"1666_CR29","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1093\/humrep\/den017","volume":"23","author":"Z Veleva","year":"2008","unstructured":"Veleva Z, Tiitinen A, Vilska S, et al. High and low BMI increase the risk of miscarriage after IVF \/ ICSI and FET. Hum Reprod. 2008;23(4):878\u201384.","journal-title":"Hum Reprod"},{"issue":"3","key":"1666_CR30","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.fertnstert.2011.07.485","volume":"96","author":"K Parker","year":"2011","unstructured":"Parker K, Wong B, Link B, et al. Does body mass index (BMI) affect IVF outcomes? Fertil Steril. 2011;96(3):124.","journal-title":"Fertil Steril"},{"issue":"6","key":"1666_CR31","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/S1472-6483(10)60142-3","volume":"16","author":"I Matalliotakis","year":"2008","unstructured":"Matalliotakis I, Cakmak H, Sakkas D, et al. Impact of body mass index on IVF and ICSI outcome: a retrospective study. Reprod Biomed Online. 2008;16(6):778\u201383.","journal-title":"Reprod Biomed Online"},{"issue":"10","key":"1666_CR32","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1093\/humrep\/dew175","volume":"31","author":"S Nanette","year":"2016","unstructured":"Nanette S, Esther Eisenberg JC, Trussell, , et al. Fertility-related quality of life from two RCT cohorts with infertility: unexplained infertility and polycystic ovary syndrome. Hum Reprod. 2016;31(10):2268\u201379.","journal-title":"Hum Reprod"},{"issue":"1","key":"1666_CR33","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/sj.ijo.0803701","volume":"32","author":"KM Scott","year":"2008","unstructured":"Scott KM, Bruffaerts R, Simon GE, et al. Obesity and mental disorders in the general population: results from the world mental health surveys. Int J Obes (Lond). 2008;32(1):192\u2013200.","journal-title":"Int J Obes (Lond)"},{"issue":"6","key":"1666_CR34","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.annepidem.2007.12.009","volume":"18","author":"D Barry","year":"2008","unstructured":"Barry D, Pietrzak RH, Petry NM. Gender differences in associations between body mass index and DSM-IV mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Ann Epidemiol. 2008;18(6):458\u201366.","journal-title":"Ann Epidemiol"},{"issue":"5","key":"1666_CR35","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1016\/j.fertnstert.2015.02.018","volume":"103","author":"SR Holley","year":"2015","unstructured":"Holley SR, Pasch LA, Bleil ME, et al. Prevalence and predictors of major depressive disorder for fertility treatment patients and their partners. Fertil Steril. 2015;103(5):1332\u20139.","journal-title":"Fertil Steril"},{"issue":"5","key":"1666_CR36","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1093\/humrep\/der051","volume":"26","author":"JW Aarts","year":"2011","unstructured":"Aarts JW, van Empel IW, Boivin J, et al. Relationship between quality of life and distress in infertility: a validation study of the utch FertiQoL. Hum Reprod. 2011;26(5):1112\u20138.","journal-title":"Hum Reprod"},{"issue":"1","key":"1666_CR37","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/nhs.12167","volume":"17","author":"H Kahyaoglu Sut","year":"2014","unstructured":"Kahyaoglu Sut H, Balkanli KP. Quality of life in women with infertility via the FertiQoL and the Hospital Anxiety and Depression Scales. Nurs Health Sci. 2014;17(1):84\u201399.","journal-title":"Nurs Health Sci"},{"issue":"8","key":"1666_CR38","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1055\/s-0034-1368461","volume":"74","author":"T Wischmann","year":"2014","unstructured":"Wischmann T, Schilling K, Toth B, et al. Sexuality, self -esteem and partnership quality in infertile women and men. Geburtshilfe Frauenheilkd. 2014;74(8):759\u201363.","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"1666_CR39","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12905-017-0410-2","volume":"17","author":"E Lakatos","year":"2017","unstructured":"Lakatos E, Szigeti JF, Ujma PP, et al. Anxiety and depression among infertile women: a cross-sectional survey from Hungary. BMC Women\u2019s Health. 2017;17:48.","journal-title":"BMC Women's Health"},{"issue":"2","key":"1666_CR40","doi-asserted-by":"publisher","first-page":"109","DOI":"10.5603\/GP.a2017.0019","volume":"88","author":"G Paulina","year":"2017","unstructured":"Paulina G, Drozdowicz-Jastrz\u0119bska E, Barbara G, et al. Anxiety and depression in women undergoing infertility treatment. Ginekol Pol. 2017;88(2):109\u201312.","journal-title":"Ginekol Pol"},{"issue":"8","key":"1666_CR41","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1093\/humrep\/der157","volume":"26","author":"MV Martins","year":"2011","unstructured":"Martins MV, Peterson BD, Almeida VM, et al. Direct and indirect effects of perceived social support on women\u2032 s infertility -related stress. Hum Reprod. 2011;26(8):2113\u201321.","journal-title":"Hum Reprod"},{"key":"1666_CR42","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.ejogrb.2016.02.034","volume":"200","author":"F Yazdani","year":"2016","unstructured":"Yazdani F, Kazemi A, Fooladi MM, et al. The relations between marital quality, social support, social acceptance and coping strategies among the infertile Iranian couples. Eur J Obstet Gynecol Reprod Biol. 2016;200:58\u201362.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"4","key":"1666_CR43","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.jogn.2018.03.005","volume":"47","author":"C-Y Cheng","year":"2018","unstructured":"Cheng C-Y, Stevenson EL, Yang C-T, et al. Stress and quality of life for Taiwanese women who underwent infertility treatment. J Obstet Gynecol Neonatal Nurs. 2018;47(4):498\u2013508.","journal-title":"J Obstet Gynecol Neonatal Nurs"},{"issue":"9","key":"1666_CR44","doi-asserted-by":"publisher","first-page":"9068","DOI":"10.3390\/ijerph110909068","volume":"11","author":"J Takaki","year":"2014","unstructured":"Takaki J, Hibino Y. Family-related opinions and stressful situations associated with psychological distress in women undergoing infertility treatment. Int J Environ Res Public Health. 2014;11(9):9068\u201381.","journal-title":"Int J Environ Res Public Health"}],"container-title":["Health and Quality of Life Outcomes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12955-021-01666-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12955-021-01666-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12955-021-01666-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T07:17:38Z","timestamp":1611559058000},"score":1,"resource":{"primary":{"URL":"https:\/\/hqlo.biomedcentral.com\/articles\/10.1186\/s12955-021-01666-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,25]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1666"],"URL":"https:\/\/doi.org\/10.1186\/s12955-021-01666-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-68411\/v2","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-68411\/v3","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-68411\/v1","asserted-by":"object"}]},"ISSN":["1477-7525"],"issn-type":[{"value":"1477-7525","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,25]]},"assertion":[{"value":"28 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All patients provided their informed written consent. The study was approved by the Ethics Committee of Shanghai Ruijin Hospital and was conducted in accordance with the principles of the Declaration of Helsinki.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"32"}}