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It is questionable whether fatigue is sufficiently covered by the EQ-5D. This study investigated whether fatigue is covered by the existing domains of the EQ-5D.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A Dutch general population sample completed the EQ-5D (3L and 5L version) and the Rivermead Post-Concussion\u00a0Symptoms Questionnaire (RPQ), of which the fatigue item was used. Outcomes were compared between participants with and without a chronic health condition. Convergent validity was assessed, and multivariate regression analyses was used to predict the RPQ fatigue item from the EQ-5D-3L and EQ-5D-5L domains separately.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>3027 people completed the survey, of whom 52% had\u2009\u2265\u20091 chronic health condition. Fatigue was reported by 48% of the participants. Fatigue was moderately correlated to the EQ-5D domains \u2018pain\/discomfort\u2019, \u2018usual activities\u2019, and \u2018anxiety\/depression\u2019 for the 3L (r\u2009=\u20090.379\u20130.426) and 5L version (r\u2009=\u20090.411\u20130.469). For the 5L, also a moderate correlation with \u2018mobility\u2019 (r\u2009=\u20090.335) was observed. The remaining correlations were weak. All EQ-5D-3L and 5L domains except for \u2018mobility\u2019 were significantly associated with the RPQ fatigue item (unstandardized Beta\u2009=\u2009\u2212\u20090.20\u20130.67; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01 to <jats:italic>p<\/jats:italic>\u2009=\u20090.04). Comparable outcomes were found for participants with and without\u2009\u2265\u20091 chronic health condition.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The extent to which fatigue is covered by the EQ-5D domains is small to moderate, with the EQ-5D-5L being slightly more sensitive to capture fatigue compared to the EQ-5D-3L. An extra fatigue item for the EQ-5D may add value, as fatigue is not fully captured by the existing domains, both in people with and without a chronic health condition.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12955-021-01771-3","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T10:03:07Z","timestamp":1619690587000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The relation between EQ-5D and fatigue in a Dutch general population sample: an explorative study"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9571-576X","authenticated-orcid":false,"given":"I.","family":"Spronk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4331-3141","authenticated-orcid":false,"given":"S.","family":"Polinder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8364-1086","authenticated-orcid":false,"given":"G. 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