{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:15:53Z","timestamp":1793142953419,"version":"4.5.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Policy Evaluation Fund Project for Guangxi thalassaemia Comprehensive Control Program"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Health Qual Life Outcomes"],"DOI":"10.1186\/s12955-024-02307-1","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T21:01:57Z","timestamp":1730149317000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Health-related quality of life and associated factors among children with Transfusion-dependent \u03b2-thalassaemia: a cross-sectional study in Guangxi Province"],"prefix":"10.1186","volume":"22","author":[{"given":"Jingyi","family":"Qiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingxing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junling","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingwen","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanyan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"2307_CR1","doi-asserted-by":"crossref","unstructured":"Farmakis D, Porter J, Taher A, Domenica Cappellini M, Angastiniotis M, Eleftheriou A. 2021 Thalassaemia International Federation Guidelines for the Management of Transfusion-dependent Thalassemia. Hemasphere. 2022;6(8):e732.","DOI":"10.1097\/HS9.0000000000000732"},{"key":"2307_CR2","doi-asserted-by":"crossref","unstructured":"Cappellini MD, Farmakis D, Porter J, Taher A. 2021 Guidelines For The Management of Transfusion Dependent Thalassaemia (TDT). 4th ed. Cyprus: Thalassaemia International Federation; 2021.","DOI":"10.1097\/HS9.0000000000000732"},{"issue":"5","key":"2307_CR3","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1111\/j.1399-0004.2007.00791.x","volume":"71","author":"HF Pan","year":"2007","unstructured":"Pan HF, Long GF, Li Q, Feng YN, Lei ZY, Wei HW, et al. Current status of thalassemia in minority populations in Guangxi, China. Clin Genet. 2007;71(5):419\u201326.","journal-title":"Clin Genet"},{"issue":"2","key":"2307_CR4","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/bjh.18671","volume":"201","author":"P Hokland","year":"2023","unstructured":"Hokland P, Daar S, Khair W, Sheth S, Taher AT, Torti L, et al. Thalassaemia\u2014A global view. Br J Haematol. 2023;201(2):199\u2013214.","journal-title":"Br J Haematol"},{"issue":"6","key":"2307_CR5","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1111\/ejh.13512","volume":"105","author":"A Kattamis","year":"2020","unstructured":"Kattamis A, Forni GL, Aydinok Y, Viprakasit V. Changing patterns in the epidemiology of \u03b2-thalassemia. Eur J Haematol. 2020;105(6):692\u2013703.","journal-title":"Eur J Haematol"},{"issue":"20","key":"2307_CR6","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1056\/NEJMra1404415","volume":"371","author":"FB Piel","year":"2014","unstructured":"Piel FB, Weatherall DJ. The \u03b1-thalassemias. N Engl J Med. 2014;371(20):1908\u201316.","journal-title":"N Engl J Med"},{"key":"2307_CR7","unstructured":"Eleftheriou A, Angastiniotis M. Global thalassaemia review 2023. Nicosia (CY): Thalassaemia International Federation. 2023; 2024."},{"issue":"11","key":"2307_CR8","first-page":"889","volume":"43","author":"Red Blood Cell Diseases (Anemia) Gr","year":"2022","unstructured":"Red Blood Cell Diseases (Anemia) Group, Chinese Society of Hematology, Chinese Medical Association. Chinese Guideline for diagnosis and treatment of transfusion-dependent \u03b2-Thalassemia (2022 Edition). Chin J Hematol. 2022;43(11):889\u201396. [Article in Chinese].","journal-title":"Chin J Hematol"},{"issue":"11","key":"2307_CR9","doi-asserted-by":"publisher","first-page":"520","DOI":"10.47102\/annals-acadmedsg.V45N11p520","volume":"45","author":"GG Gan","year":"2016","unstructured":"Gan GG, Hue YL, Sathar J. Factors affecting quality of life in adult patients with Thalassaemia Major and Intermedia. Ann Acad Med Singap. 2016;45(11):520\u20133.","journal-title":"Ann Acad Med Singap"},{"issue":"7","key":"2307_CR10","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1185\/03007990802160834","volume":"24","author":"L Scalone","year":"2008","unstructured":"Scalone L, Mantovani LG, Krol M, Rofail D, Ravera S, Bisconte MG, et al. Costs, quality of life, treatment satisfaction and compliance in patients with beta-thalassemia major undergoing iron chelation therapy: the ITHACA study. Curr Med Res Opin. 2008;24(7):1905\u201317.","journal-title":"Curr Med Res Opin"},{"issue":"4","key":"2307_CR11","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1111\/trf.12348","volume":"54","author":"E Vichinsky","year":"2014","unstructured":"Vichinsky E, Neumayr L, Trimble S, Giardina PJ, Cohen AR, Coates T, et al. Transfusion complications in Thalassemia patients: a report from the Centers for Disease Control and Prevention (CME). Transfusion. 2014;54(4):972\u201381. quiz 1.","journal-title":"Transfusion"},{"key":"2307_CR12","doi-asserted-by":"crossref","unstructured":"Tartaglione I, Carfora R, Brotto D, Barillari MR, Costa G, Perrotta S et al. Hearing loss in Beta-Thalassemia: systematic review. J Clin Med. 2021;11(1).","DOI":"10.3390\/jcm11010102"},{"issue":"2","key":"2307_CR13","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s11136-018-1986-1","volume":"28","author":"M Arian","year":"2019","unstructured":"Arian M, Mirmohammadkhani M, Ghorbani R, Soleimani M. Health-related quality of life (HRQoL) in beta-thalassemia major (\u03b2-TM) patients assessed by 36-item short form health survey (SF-36): a meta-analysis. Qual Life Res. 2019;28(2):321\u201334.","journal-title":"Qual Life Res"},{"issue":"10","key":"2307_CR14","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1002\/ajh.21826","volume":"85","author":"L Mednick","year":"2010","unstructured":"Mednick L, Yu S, Trachtenberg F, Xu Y, Kleinert DA, Giardina PJ, et al. Symptoms of depression and anxiety in patients with thalassemia: prevalence and correlates in the Thalassemia longitudinal cohort. Am J Hematol. 2010;85(10):802\u20135.","journal-title":"Am J Hematol"},{"issue":"10","key":"2307_CR15","doi-asserted-by":"publisher","first-page":"E261","DOI":"10.1002\/ajh.25584","volume":"94","author":"MD Cappellini","year":"2019","unstructured":"Cappellini MD, Kattamis A, Viprakasit V, Sutcharitchan P, Pariseau J, Laadem A, et al. Quality of life in patients with \u03b2-thalassemia: a prospective study of transfusion-dependent and non-transfusion-dependent patients in Greece, Italy, Lebanon, and Thailand. Am J Hematol. 2019;94(10):E261\u20134.","journal-title":"Am J Hematol"},{"issue":"1","key":"2307_CR16","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12955-018-0893-z","volume":"16","author":"GLA Hakeem","year":"2018","unstructured":"Hakeem GLA, Mousa SO, Moustafa AN, Mahgoob MH, Hassan EE. Health-related quality of life in pediatric and adolescent patients with transfusion-dependent \u00df-thalassemia in upper Egypt (single center study). Health Qual Life Outcomes. 2018;16(1):59.","journal-title":"Health Qual Life Outcomes"},{"issue":"10","key":"2307_CR17","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1007\/s11136-018-1911-7","volume":"27","author":"F Floris","year":"2018","unstructured":"Floris F, Comitini F, Leoni G, Moi P, Morittu M, Orecchia V, et al. Quality of life in sardinian patients with transfusion-dependent thalassemia: a cross-sectional study. Qual Life Res. 2018;27(10):2533\u20139.","journal-title":"Qual Life Res"},{"issue":"11","key":"2307_CR18","first-page":"2241","volume":"72","author":"GMJ Bukhari","year":"2022","unstructured":"Bukhari GMJ. Quality of life among beta-thalassemic major children presenting at Federal Government Hospital Islamabad, Pakistan. J Pak Med Assoc. 2022;72(11):2241\u20134.","journal-title":"J Pak Med Assoc"},{"issue":"4","key":"2307_CR19","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1080\/03630269.2021.1965617","volume":"45","author":"K Etemad","year":"2021","unstructured":"Etemad K, Mohseni P, Aghighi M, Bahadorimonfared A, Hantooshzadeh R, Taherpour N, et al. Quality of life and related factors in \u03b2-Thalassemia patients. Hemoglobin. 2021;45(4):245\u20139.","journal-title":"Hemoglobin"},{"issue":"2","key":"2307_CR20","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/s11136-020-02634-y","volume":"30","author":"V Goulas","year":"2021","unstructured":"Goulas V, Kouraklis-Symeonidis A, Manousou K, Lazaris V, Pairas G, Katsaouni P, et al. A multicenter cross-sectional study of the quality of life and iron chelation treatment satisfaction of patients with transfusion-dependent \u03b2-thalassemia, in routine care settings in Western Greece. Qual Life Res. 2021;30(2):467\u201377.","journal-title":"Qual Life Res"},{"issue":"5\u20136","key":"2307_CR21","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1080\/03630269.2018.1553183","volume":"42","author":"H Yasmeen","year":"2018","unstructured":"Yasmeen H, Hasnain S. Quality of life of Pakistani children with \u03b2-Thalassemia Major. Hemoglobin. 2018;42(5\u20136):320\u20135.","journal-title":"Hemoglobin"},{"issue":"3","key":"2307_CR22","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1111\/bjh.12631","volume":"164","author":"RJ Klaassen","year":"2014","unstructured":"Klaassen RJ, Barrowman N, Merelles-Pulcini M, Vichinsky EP, Sweeters N, Kirby-Allen M, et al. Validation and reliability of a disease-specific quality of life measure (the TranQol) in adults and children with Thalassaemia major. Br J Haematol. 2014;164(3):431\u20137.","journal-title":"Br J Haematol"},{"key":"2307_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4172\/2155-9864.1000150","volume":"4","author":"RJ Klaassen","year":"2013","unstructured":"Klaassen RJ, Alibhai SMH, Allen MK, Moreau KA, Pulcini MM, Forgie MA, et al. Introducing the Tran Qol: a New Disease-Specific Quality of Life measure for children and adults with Thalassemia Major. J Blood Disord Transfus. 2013;4:1\u20135.","journal-title":"J Blood Disord Transfus"},{"key":"2307_CR24","doi-asserted-by":"publisher","first-page":"102547","DOI":"10.1016\/j.bcmd.2021.102547","volume":"88","author":"JCM Lam","year":"2021","unstructured":"Lam JCM, Lee SY, Koh PL, Fong SZ, Abdul-Kadir NI, Lim CY, et al. Clinical and health-related quality of life outcomes of transfusion-dependent thalassaemia patients in Singapore. Blood Cells Mol Dis. 2021;88:102547.","journal-title":"Blood Cells Mol Dis"},{"key":"2307_CR25","doi-asserted-by":"crossref","unstructured":"Klonizakis P, Roy N, Papatsouma I, Mainou M, Christodoulou I, Pantelidou D et al. A cross-sectional, multicentric, Disease-Specific, Health-Related Quality of Life Study in Greek Transfusion Dependent Thalassemia patients. Healthc (Basel). 2024;12(5).","DOI":"10.3390\/healthcare12050524"},{"issue":"4","key":"2307_CR26","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1002\/jha2.282","volume":"2","author":"F Shah","year":"2021","unstructured":"Shah F, Telfer P, Velangi M, Pancham S, Wynn R, Pollard S, et al. Routine management, healthcare resource use and patient and carer-reported outcomes of patients with transfusion-dependent \u03b2-thalassaemia in the United Kingdom: a mixed methods observational study. EJHaem. 2021;2(4):738\u201349.","journal-title":"EJHaem"},{"issue":"1","key":"2307_CR27","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1002\/ajh.21896","volume":"86","author":"A Sobota","year":"2011","unstructured":"Sobota A, Yamashita R, Xu Y, Trachtenberg F, Kohlbry P, Kleinert DA, et al. Quality of life in Thalassemia: a comparison of SF-36 results from the Thalassemia longitudinal cohort to reported literature and the US norms. Am J Hematol. 2011;86(1):92\u20135.","journal-title":"Am J Hematol"},{"issue":"22","key":"2307_CR28","doi-asserted-by":"publisher","first-page":"3633","DOI":"10.1182\/blood.V128.22.3633.3633","volume":"128","author":"A Amid","year":"2016","unstructured":"Amid A, Leroux R, Merelles-Pulcini M, Yassobi S, Saliba AN, Ward R, et al. Factors impacting quality of life in Thalassemia patients; results from the Intercontinenthal collaborative study. Blood. 2016;128(22):3633.","journal-title":"Blood"},{"issue":"8","key":"2307_CR29","doi-asserted-by":"publisher","first-page":"924","DOI":"10.2174\/1574888X16666210203105340","volume":"16","author":"L Zhai","year":"2021","unstructured":"Zhai L, Liu Y, Huo R, Pan Z, Bin J, Li Z, et al. Quality of life in patients with \u03b2-thalassemia Major: short-term and long-term effects after Haematopoietic Stem Cell transplantation. Curr Stem Cell Res Ther. 2021;16(8):924\u201330.","journal-title":"Curr Stem Cell Res Ther"},{"issue":"7","key":"2307_CR30","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1080\/08880018.2023.2220733","volume":"40","author":"M Cikili-Uytun","year":"2023","unstructured":"Cikili-Uytun M, Eroglu M, Ertem M, \u0130leri DT, Ince E, G\u00fcnay Kilic B. Thalassemia patients in transfussion dependent period and after hematopoietic stem cell transplantation: how are the psychiatric status and life quality of these patients? Pediatr Hematol Oncol. 2023;40(7):617\u201328.","journal-title":"Pediatr Hematol Oncol"},{"issue":"6","key":"2307_CR31","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.bbmt.2010.09.011","volume":"17","author":"G Caocci","year":"2011","unstructured":"Caocci G, Efficace F, Ciotti F, Roncarolo MG, Vacca A, Piras E, et al. Prospective assessment of health-related quality of life in pediatric patients with beta-thalassemia following hematopoietic stem cell transplantation. Biology Blood Marrow Transplantation: J Am Soc Blood Marrow Transplantation. 2011;17(6):861\u20136.","journal-title":"Biology Blood Marrow Transplantation: J Am Soc Blood Marrow Transplantation"},{"issue":"5","key":"2307_CR32","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/bmt.2008.165","volume":"42","author":"DK Cheuk","year":"2008","unstructured":"Cheuk DK, Mok AS, Lee AC, Chiang AK, Ha SY, Lau YL, et al. Quality of life in patients with transfusion-dependent thalassemia after hematopoietic SCT. Bone Marrow Transpl. 2008;42(5):319\u201327.","journal-title":"Bone Marrow Transpl"},{"key":"2307_CR33","unstructured":"Beijing AngelMom Charity Foundation, China Philanthropy Research Institute. Blue Book of Thalassemia in China: Survey Report on the Prevention and Treatment of Thalassemia in China. (2020). 1st ed. Beijing, China: China Society Press; 2021. [in Chinese]."},{"issue":"2","key":"2307_CR34","doi-asserted-by":"publisher","first-page":"117","DOI":"10.4103\/0973-6247.83234","volume":"5","author":"N Choudhury","year":"2011","unstructured":"Choudhury N. Blood transfusion in borderless South Asia. Asian J Transfus Sci. 2011;5(2):117\u201320.","journal-title":"Asian J Transfus Sci"}],"container-title":["Health and Quality of Life Outcomes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12955-024-02307-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12955-024-02307-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12955-024-02307-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T21:05:12Z","timestamp":1730149512000},"score":1,"resource":{"primary":{"URL":"https:\/\/hqlo.biomedcentral.com\/articles\/10.1186\/s12955-024-02307-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,29]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2307"],"URL":"https:\/\/doi.org\/10.1186\/s12955-024-02307-1","relation":{},"ISSN":["1477-7525"],"issn-type":[{"value":"1477-7525","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,29]]},"assertion":[{"value":"24 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Medical Research Ethics Committee, School of Public Health, Fudan University (IRB#2022-07-0978). Patients provided written informed consent according to the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"93"}}