{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:38:30Z","timestamp":1787020710876,"version":"build-2736575974"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004047","name":"Karolinska Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Health Qual Life Outcomes"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In many settings, Tuberculosis (TB) represents a catastrophic life event that substantially impairs a person\u2019s Health-Related Quality of Life (HRQoL). We aimed to measure HRQoL among people with TB in Viet Nam at initiation and throughout treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study took place in four provinces from Oct-2020 to Sep-2022. Persons initiated on TB treatment were consecutively recruited across three pathways to access care: passive case finding (NTP); active case finding (ACF); and private sector engagement (PPM). We conducted the EuroQol\u20135-Dimension\u20135-Level (EQ-5D-5L) survey during the intensive, continuation, and post-treatment phase. We described participant characteristics, assessed the survey\u2019s psychometric properties, and calculated utility indexes using a Vietnamese value set. We reported these alongside visual analog scale (EQ-VAS) scores and EQ-5D-5L dimensions by treatment stage, care pathway and other participant characteristics. Mixed-effect Tobit models were fitted to identify relevant associations with HRQoL, which we compared to general population benchmarks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We recruited 585 participants (23.6% female) with a median age of 51 years. EQ-5D-5L dimensions at baseline showed that 53.8% experienced\n                      <jats:italic>pain\/discomfort<\/jats:italic>\n                      and 35.0% felt\n                      <jats:italic>anxiety\/depression<\/jats:italic>\n                      , while 33.8%, 30.4%, and 9.6% reported problems with carrying out\n                      <jats:italic>usual activities<\/jats:italic>\n                      ,\n                      <jats:italic>mobility<\/jats:italic>\n                      , and\n                      <jats:italic>self-care<\/jats:italic>\n                      , respectively. The mean utility index was 0.83 (95% confidence interval: [0.82, 0.85]) and mean EQ-VAS was 67.1 (95%CI: [65.6, 68.6]). Post-treatment, HRQoL improved significantly on all dimensions and composite measures. While utility indexes were at parity with general population benchmarks (0.90; 95%CI: [0.89, 0.92] vs. 0.91), self-reported EQ-VAS scores remained significantly lower (79.4; 95%CI: [78.1, 80.6] vs. 87.4). HRQoL was higher at baseline in the ACF versus the NTP cohorts on utility index (0.87 vs. 0.82;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) and EQ-VAS score (70.4 vs. 65.5;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015). The EQ-5D-5L tool demonstrated moderate to high validity on Cronbach\u2019s alpha (0.75\u2009\u2264\u2009\u03b1\u2009\u2264\u20090.84) and Spearman\u2019s rho (0.4679\u2009\u2264\u2009\n                      <jats:italic>\u03c1<\/jats:italic>\n                      <jats:sub>0<\/jats:sub>\n                      \u2009\u2264\u20090.5651) across treatment stages and various known groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TB significantly impairs HRQoL among affected Vietnamese people. While treatment partially remedies these impairments, they may persist post-TB. Hence, physical, psychological and social rehabilitation during and after therapy should receive more attention. We found evidence that ACF may mitigate TB-related declines in HRQoL, but tailored studies are needed to substantiate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12955-025-02369-9","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T21:18:45Z","timestamp":1745356725000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A life that\u2019s worth living \u2013 measuring health-related quality of life among people treated for tuberculosis in Viet Nam: a longitudinal EQ-5D-5L survey"],"prefix":"10.1186","volume":"23","author":[{"given":"Luan Nguyen Quang","family":"Vo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Forse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew James","family":"Codlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huy Ba","family":"Huynh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja Maria Christine","family":"Wiemers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Creswell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Minh Ha","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan Huu","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoa Binh","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luong","family":"Van Dinh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhung Viet","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Wingfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi","family":"Sidney Annerstedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jad","family":"Shedrawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut","family":"L\u00f6nnroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"2369_CR1","doi-asserted-by":"crossref","unstructured":"Paulson T, Epidemiology. 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Ethical approval for study-specific data collection was granted by the Ethical Review Board for Biomedical Research at Ha Noi University of Public Health (300\/2020\/YTCC-HD3 dated 17 July 2020; Amendments: 160\/2021\/YTCC-HD3 dated 12 April 2021, 345\/2021\/YTCC-HD3 dated 19 August 2021) and the Board of Ethics for Biomedical Research at Pham Ngoc Thach Hospital (1225\/PNTH-HDDD dated 16 September 2020; Amendment: 359\/PNT-HDDD dated 02 April 2021). Routine interventions were approved by the Ministry of Health (128\/QD-BYT, dated 17 January 2020; 413\/QD-BYT, dated 21 January 2021) and the HCMC People\u2019s Committee (2681\/QD-UBND, dated 29 July 2020; 3083\/QD-UBND, dated 23 August 2021). All participants included in the analysis had provided informed written consent. 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