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This study aimed to assess the relationship between childhood VI and HRQoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study was conducted among children aged 2 to 18 years in selected districts of the Ashanti Region, Ghana. Comprehensive ocular assessments including visual acuity (VA), refraction, and anterior and posterior segment evaluations were performed. Health-related quality of life was measured using the PedsQL 4.0 across physical, emotional, social, and school functioning domains. Data were analyzed using descriptive statistics, independent-sample t-tests, and linear regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 581 children participated (mean\u2009\u00b1\u2009SD age: 8.64\u2009\u00b1\u20094.00 years), with females representing 53.0% of the sample. Both child-reported and parent-reported scores showed significantly reduced HRQoL among children with VI across all PedsQL domains compared with children without VI, with school (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and emotional (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) functions of child-reported showing statistical significance. Presenting VI was a significant predictor of poor overall HRQoL in both simple (\u03b2= -10.351,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and multiple linear regression models (\u03b2= -5.650,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016). No significant associations (p &gt; 0.05) were found between HRQoL and sociodemographic variables, including sex, age, ethnicity, work status, and health insurance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Childhood VI is associated with substantial reductions in multiple dimensions of HRQoL. These findings underscore the need to strengthen early detection, clinical management, and school-based vision support services to improve pediatric eye care in Ghana.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12955-026-02565-1","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T10:46:48Z","timestamp":1782557208000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Childhood visual impairment and health-related quality of life in Ghana: evidence from a cross-sectional study"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6428-7676","authenticated-orcid":false,"given":"Nana Akwasi Owusu","family":"Mensah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3522-5012","authenticated-orcid":false,"given":"Josephine Ampomah","family":"Boateng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4501-8602","authenticated-orcid":false,"given":"Isaiah","family":"Osei Duah Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5035-3655","authenticated-orcid":false,"given":"Albert Kwadjo Amoah","family":"Andoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9577-1599","authenticated-orcid":false,"given":"Godsway Commanda","family":"Osei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7916-0175","authenticated-orcid":false,"given":"Sylvester","family":"Kyeremeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7347-4159","authenticated-orcid":false,"given":"Sylvia","family":"Agyekum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6135-7111","authenticated-orcid":false,"given":"Gabriel Kwaku","family":"Agbeshie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2142-6513","authenticated-orcid":false,"given":"Werner","family":"Eisenbarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6683-249X","authenticated-orcid":false,"given":"Kwadwo Owusu","family":"Akuffo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,27]]},"reference":[{"issue":"1","key":"2565_CR1","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s41687-025-00893-2","volume":"9","author":"S Adhikari","year":"2025","unstructured":"Adhikari S, et al. 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