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Changes in EQ-5D-5L profile from enrolment were examined using the Paretian classification of health change (PCHC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At enrolment, selfcare and pain\/discomfort were the EQ-5D-5L dimensions with the least and most reported problems, respectively. The percentages of participants reporting improvements in EQ-5D-5L dimensions ranged from 12.9% (14.0%) for selfcare to 33.0% (38.4%) for pain\/discomfort at 3 (12) months follow-ups. The corresponding percentages in reporting worsening ranged from 8.0% for selfcare to 15.4% for usual activities at 3 months and from 10.0% for selfcare to 16.4% for mobility at 12 months. At all timepoints, \u201cslight problems\u201d in the pain\/discomfort dimension and no problems in other dimensions (the EQ-5D-5L profile \u201c11121\u201d) was the most common profile. The PCHC analysis suggested that at 3\/12 months follow-ups, the EQ-5D-5L profiles improved for 46.9%\/50.4% of participants, worsened for 19.5%\/20.1%, showed mixed changes for 19.7%\/18.7% and remained unchanged for 13.9%\/10.9%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this single-arm registry study, about half of participants reported improved EQ-5D-5L profiles at 3 and 12 months following digital education and exercise therapy, while one-fifth reported worsening and another one-fifth showed mixed changes, indicating heterogeneous HRQoL trajectories and the need for tailored participant support.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12955-026-02634-5","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:12:23Z","timestamp":1789823543000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in health-related quality of life: a longitudinal registry study among over 15,000 participants of a digital education and exercise therapy for knee and hip osteoarthritis using EQ-5D-5L"],"prefix":"10.1186","volume":"24","author":[{"given":"Ali","family":"Kiadaliri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Dell\u2019Isola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armaghan","family":"Mahmoudian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif E","family":"Dahlberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L Stefan","family":"Lohmander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"issue":"2","key":"2634_CR1","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1080\/17453674.2017.1404791","volume":"89","author":"AA Kiadaliri","year":"2018","unstructured":"Kiadaliri AA, Lohmander LS, Moradi-Lakeh M, Petersson IF, Englund M. 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