{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:23:21Z","timestamp":1793381001940,"version":"4.5.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12957-017-1231-3","type":"journal-article","created":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T11:35:43Z","timestamp":1503488143000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Rectal carcinoma and multiple gastrointestinal stromal tumors (GIST) of the small intestine in a patient with neurofibromatosis type 1: a case report"],"prefix":"10.1186","volume":"15","author":[{"given":"Yuhei","family":"Hakozaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2842-2005","authenticated-orcid":false,"given":"Shinichi","family":"Sameshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppei","family":"Tatsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Okuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukinori","family":"Yamagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamaki","family":"Noie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Oya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieko","family":"Shimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumoto","family":"Katagiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,23]]},"reference":[{"key":"1231_CR1","doi-asserted-by":"crossref","unstructured":"Sobin LHGM, Wittekind C. TNM classification of malignant tumours (ed 7). West Sussex, UK: Wiley-Blackwell; 2009.","DOI":"10.1002\/9780471420194.tnmc26"},{"key":"1231_CR2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/01.pas.0000176433.81079.bd","volume":"30","author":"M Miettinen","year":"2006","unstructured":"Miettinen M, Fetsch JF, Sobin LH, Lasota J. Gastrointestinal stromal tumors in patients with neurofibromatosis 1: a clinicopathologic and molecular genetic study of 45 cases. Am J Surg Pathol. 2006;30:90\u20136.","journal-title":"Am J Surg Pathol"},{"key":"1231_CR3","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1200\/JCO.2015.60.9107","volume":"33","author":"HJ Schmoll","year":"2015","unstructured":"Schmoll HJ, Tabernero J, Maroun J, de Braud F, Price T, Van Cutsem E, Hill M, Hoersch S, Rittweger K, Haller DG. Capecitabine plus oxaliplatin compared with fluorouracil\/folinic acid as adjuvant therapy for stage III colon cancer: final results of the NO16968 randomized controlled phase III trial. J Clin Oncol. 2015;33:3733\u201340.","journal-title":"J Clin Oncol"},{"key":"1231_CR4","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S1470-2045(09)70033-6","volume":"10","author":"H Brems","year":"2009","unstructured":"Brems H, Beert E, de Ravel T, Legius E. Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type 1. Lancet Oncol. 2009;10:508\u201315.","journal-title":"Lancet Oncol"},{"key":"1231_CR5","first-page":"197","volume":"36","author":"JM McGaughran","year":"1999","unstructured":"McGaughran JM, Harris DI, Donnai D, Teare D, MacLeod R, Westerbeek R, Kingston H, Super M, Harris R, Evans DG. A clinical study of type 1 neurofibromatosis in north west England. J Med Genet. 1999;36:197\u2013203.","journal-title":"J Med Genet"},{"key":"1231_CR6","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/jmg.39.5.311","volume":"39","author":"DG Evans","year":"2002","unstructured":"Evans DG, Baser ME, McGaughran J, Sharif S, Howard E, Moran A. Malignant peripheral nerve sheath tumours in neurofibromatosis 1. J Med Genet. 2002;39:311\u20134.","journal-title":"J Med Genet"},{"key":"1231_CR7","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1055\/s-0034-1382021","volume":"226","author":"T Rosenbaum","year":"2014","unstructured":"Rosenbaum T, Wimmer K. Neurofibromatosis type 1 (NF1) and associated tumors. Klin Padiatr. 2014;226:309\u201315.","journal-title":"Klin Padiatr"},{"key":"1231_CR8","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/labinvest.2016.142","volume":"97","author":"M Kiuru","year":"2017","unstructured":"Kiuru M, Busam KJ. The NF1 gene in tumor syndromes and melanoma. Lab Investig. 2017;97:146\u201357.","journal-title":"Lab Investig"},{"key":"1231_CR9","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1074\/jbc.M115.703710","volume":"291","author":"Y Hirata","year":"2016","unstructured":"Hirata Y, Brems H, Suzuki M, Kanamori M, Okada M, Morita R, Llano-Rivas I, Ose T, Messiaen L, Legius E, Yoshimura A. Interaction between a domain of the negative regulator of the Ras-ERK pathway, SPRED1 protein, and the GTPase-activating protein-related domain of neurofibromin is implicated in Legius syndrome and neurofibromatosis Type 1. J Biol Chem. 2016;291:3124\u201334.","journal-title":"J Biol Chem"},{"key":"1231_CR10","first-page":"852","volume":"5","author":"A Agaimy","year":"2012","unstructured":"Agaimy A, Vassos N, Croner RS. Gastrointestinal manifestations of neurofibromatosis type 1 (Recklinghausen's disease): clinicopathological spectrum with pathogenetic considerations. Int J Clin Exp Pathol. 2012;5:852\u201362.","journal-title":"Int J Clin Exp Pathol"},{"key":"1231_CR11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/00000658-197201000-00015","volume":"175","author":"RD Brasfield","year":"1972","unstructured":"Brasfield RD, Das Gupta TK. Von Recklinghausen\u2019s disease: a clinicopathological study. Ann Surg. 1972;175:86\u2013104.","journal-title":"Ann Surg"},{"key":"1231_CR12","first-page":"398570","volume":"2013","author":"PF Salvi","year":"2013","unstructured":"Salvi PF, Lorenzon L, Caterino S, Antolino L, Antonelli MS, Balducci G. Gastrointestinal stromal tumors associated with neurofibromatosis 1: a single centre experience and systematic review of the literature including 252 cases. Int J Surg Oncol. 2013;2013:398570.","journal-title":"Int J Surg Oncol"},{"key":"1231_CR13","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1097\/01.pas.0000159775.77912.15","volume":"29","author":"J Andersson","year":"2005","unstructured":"Andersson J, Sihto H, Meis-Kindblom JM, Joensuu H, Nupponen N, Kindblom LG. NF1-associated gastrointestinal stromal tumors have unique clinical, phenotypic, and genotypic characteristics. Am J Surg Pathol. 2005;29:1170\u20136.","journal-title":"Am J Surg Pathol"},{"key":"1231_CR14","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00535-015-1132-6","volume":"51","author":"T Nishida","year":"2016","unstructured":"Nishida T, Tsujimoto M, Takahashi T, Hirota S, Blay JY, Wataya-Kaneda M. Gastrointestinal stromal tumors in Japanese patients with neurofibromatosis type I. J Gastroenterol. 2016;51:571\u20138.","journal-title":"J Gastroenterol"},{"key":"1231_CR15","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s12022-013-9239-x","volume":"24","author":"G Serio","year":"2013","unstructured":"Serio G, Zampatti C, Ballabio A, Ricci R, Martini M, Zurleni F. Neurofibromatosis 1 presenting with multiple duodenal GISTS associated with a somatostatin-producing D cell neoplasm. Endocr Pathol. 2013;24:100\u20135.","journal-title":"Endocr Pathol"},{"key":"1231_CR16","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1002\/(SICI)1097-0142(19970601)79:11<2125::AID-CNCR9>3.0.CO;2-N","volume":"79","author":"ME Zoller","year":"1997","unstructured":"Zoller ME, Rembeck B, Oden A, Samuelsson M, Angervall L. Malignant and benign tumors in patients with neurofibromatosis type 1 in a defined Swedish population. Cancer. 1997;79:2125\u201331.","journal-title":"Cancer"},{"key":"1231_CR17","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4174\/jkss.2012.82.4.205","volume":"82","author":"ET Kim","year":"2012","unstructured":"Kim ET, Namgung H, Shin HD, Lee SI, Kwon JE, Chang MC, Park DG. Oncologic manifestations of neurofibromatosis type 1 in Korea. J Korean Surg Soc. 2012;82:205\u201310.","journal-title":"J Korean Surg Soc"},{"key":"1231_CR18","doi-asserted-by":"crossref","first-page":"156","DOI":"10.4174\/astr.2014.87.3.156","volume":"87","author":"IY Kim","year":"2014","unstructured":"Kim IY, Cho MY, Kim YW. Synchronous multiple colonic adenocarcinomas arising in patient with neurofibromatosis type 1. Ann Surg Treat Res. 2014;87:156\u201360.","journal-title":"Ann Surg Treat Res"},{"key":"1231_CR19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.semcdb.2016.02.007","volume":"52","author":"E Rad","year":"2016","unstructured":"Rad E, Tee AR. Neurofibromatosis type 1: Fundamental insights into cell signalling and cancer. Semin Cell Dev Biol. 2016;52:39\u201346.","journal-title":"Semin Cell Dev Biol"},{"key":"1231_CR20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0092-8674(92)90408-5","volume":"69","author":"Y Li","year":"1992","unstructured":"Li Y, Bollag G, Clark R, Stevens J, Conroy L, Fults D, Ward K, Friedman E, Samowitz W, Robertson M, et al. Somatic mutations in the neurofibromatosis 1 gene in human tumors. Cell. 1992;69:275\u201381.","journal-title":"Cell"}],"container-title":["World Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-017-1231-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T12:33:58Z","timestamp":1719405238000},"score":1,"resource":{"primary":{"URL":"http:\/\/wjso.biomedcentral.com\/articles\/10.1186\/s12957-017-1231-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,23]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1231"],"URL":"https:\/\/doi.org\/10.1186\/s12957-017-1231-3","relation":{},"ISSN":["1477-7819"],"issn-type":[{"value":"1477-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,23]]},"article-number":"160"}}