{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T20:11:41Z","timestamp":1784664701065,"version":"3.55.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12957-018-1384-8","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T08:42:13Z","timestamp":1527756133000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The clinicopathological significance of Ki67 in papillary thyroid carcinoma: a suitable indicator?"],"prefix":"10.1186","volume":"16","author":[{"given":"Jingdong","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyi","family":"Gui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglong","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0101-1855","authenticated-orcid":false,"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,31]]},"reference":[{"key":"1384_CR1","first-page":"1637","volume":"11","author":"H Arshad","year":"2010","unstructured":"Arshad H, Ahmad Z, Hasan SH. Gliomas: correlation of histologic grade, Ki67 and p53 expression with patient survival. Asian Pac J Cancer Prev. 2010;11:1637\u201340.","journal-title":"Asian Pac J Cancer Prev"},{"key":"1384_CR2","doi-asserted-by":"publisher","first-page":"472","DOI":"10.4103\/0377-4929.85077","volume":"54","author":"M Choudhury","year":"2011","unstructured":"Choudhury M, Singh S, Agarwal S. Diagnostic utility of Ki67 and p53 immunostaining on solitary thyroid nodule\u2014a cytohistological and radionuclide scintigraphic study. Indian J Pathol Microbiol. 2011;54:472\u20135.","journal-title":"Indian J Pathol Microbiol"},{"key":"1384_CR3","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1186\/s13000-014-0230-8","volume":"9","author":"Y Chen","year":"2014","unstructured":"Chen Y, Klingen TA, Wik E, Aas H, Vigeland E, Liest\u00f8l K, et al. Breast cancer stromal elastosis is associated with mammography screening detection, low Ki67 expression and favourable prognosis in a population-based study. Diagn Pathol. 2014;9:230.","journal-title":"Diagn Pathol"},{"key":"1384_CR4","first-page":"4033","volume":"19","author":"C Midulla","year":"1999","unstructured":"Midulla C, De Iorio P, Nagar C, Pisani T, Cenci M, Valli C, et al. Immunohistochemical expression of p53, nm23-HI, Ki67 and DNA ploidy: correlation with lymph node status and other clinical pathologic parameters in breast cancer. Anticancer Res. 1999;19:4033\u20137.","journal-title":"Anticancer Res"},{"key":"1384_CR5","first-page":"1","volume":"291","author":"B Skytting","year":"2000","unstructured":"Skytting B. Synovial sarcoma. A Scandinavian Sarcoma Group project. Acta Orthop. 2000;291:1\u201328.","journal-title":"Acta Orthop"},{"key":"1384_CR6","first-page":"66","volume":"48","author":"IN Soomro","year":"1998","unstructured":"Soomro IN, Holmes J, Whimster WF. Predicting prognosis in lung cancer: use of proliferation marker, Ki67 monoclonal antibody. J Pak Med Assoc. 1998;48:66\u20139.","journal-title":"J Pak Med Assoc"},{"key":"1384_CR7","first-page":"25","volume":"44","author":"S Enestrom","year":"1998","unstructured":"Enestrom S, Vavruch L, Franlund B, Nordenskjold B. Ki-67 antigen expression as a prognostic factor in primary and recurrent astrocytomas. Neurochirurgie. 1998;44:25\u201330.","journal-title":"Neurochirurgie"},{"key":"1384_CR8","first-page":"137","volume":"16","author":"C Madsen","year":"1997","unstructured":"Madsen C, Schr\u00f8der HD. Ki-67 immunoreactivity in meningiomas\u2014determination of the proliferative potential of meningiomas using the monoclonal antibody Ki-67. Clin Neuropathol. 1997;16:137\u201342.","journal-title":"Clin Neuropathol"},{"key":"1384_CR9","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1002\/(SICI)1097-0045(19991101)41:3<166::AID-PROS3>3.0.CO;2-E","volume":"41","author":"VS Khoo","year":"1999","unstructured":"Khoo VS, Pollack A, Cowen D, Joon DL, Patel N, Terry NH, et al. Relationship of Ki-67 labeling index to DNA-ploidy, S-phase fraction, and outcome in prostate cancer treated with radiotherapy. Prostate. 1999;41:166\u201372.","journal-title":"Prostate"},{"key":"1384_CR10","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/S0090-4295(99)00107-7","volume":"54","author":"G Ahlgren","year":"1999","unstructured":"Ahlgren G, Pedersen K, Lundberg S, Aus G, Hugosson J, Abrahamsson PA. Tumor cell proliferation in prostate cancer after 3 months of neoadjuvant LHRH analogue treatment is a prognostic marker of recurrence after radical prostatectomy. Urology. 1999;54:329\u201334.","journal-title":"Urology"},{"key":"1384_CR11","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/S1470-2045(09)70262-1","volume":"11","author":"R Yerushalmi","year":"2010","unstructured":"Yerushalmi R, Woods R, Ravdin PM, Hayes MM, Gelmon KA. Ki67 in breast cancer: prognostic and predictive potential. Lancet Oncol. 2010;11:174\u201383.","journal-title":"Lancet Oncol"},{"key":"1384_CR12","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1093\/annonc\/mdr304","volume":"22","author":"A Goldhirsch","year":"2011","unstructured":"Goldhirsch A, Wood WC, Coates AS, Gelber RD, Th\u00fcrlimann B, Senn HJ. Strategies for subtypes-dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol. 2011;22:1736\u201347.","journal-title":"Ann Oncol"},{"key":"1384_CR13","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1001\/jamaoto.2014.1","volume":"140","author":"L Davies","year":"2014","unstructured":"Davies L, Welch HG. Current thyroid cancer trends in the United States. JAMA Otolaryngol Head Neck Surg. 2014;140:317\u201322.","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"1384_CR14","doi-asserted-by":"publisher","first-page":"5921","DOI":"10.7314\/APJCP.2014.15.14.5921","volume":"15","author":"XY Liu","year":"2014","unstructured":"Liu XY, Zhu LJ, Cui D, Wang ZX, Chen HH, Duan Y, et al. Annual financial impact of thyroidectomies for nodular thyroid disease in China. Asian Pac J Cancer Prev. 2014;15:5921\u20136.","journal-title":"Asian Pac J Cancer Prev"},{"key":"1384_CR15","doi-asserted-by":"publisher","first-page":"R43","DOI":"10.1530\/JOE-17-0266","volume":"235","author":"MA Zaballos","year":"2017","unstructured":"Zaballos MA, Santisteban P. Key signaling pathways in thyroid cancer. J Endocrinol. 2017;235:R43\u201361.","journal-title":"J Endocrinol"},{"key":"1384_CR16","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.cell.2014.09.050","volume":"159","author":"Cancer Genome Atlas Research Network","year":"2014","unstructured":"Cancer Genome Atlas Research Network. Integrated genomic characterization of papillary thyroid carcinoma. Cell. 2014;159:676\u201390.","journal-title":"Cell"},{"key":"1384_CR17","first-page":"634170","volume":"2011","author":"Y Ito","year":"2010","unstructured":"Ito Y, Miyauchi A. Thyroidectomy and lymph node dissection in papillary thyroid carcinoma. J Thyroid Res. 2010;2011:634170.","journal-title":"J Thyroid Res"},{"key":"1384_CR18","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1210\/jc.2015-2917","volume":"101","author":"X Shi","year":"2016","unstructured":"Shi X, Liu R, Basolo F, Giannini R, Shen X, Teng D, et al. Differential clinicopathological risk and prognosis of major papillary thyroid cancer variants. J Clin Endocrinol Metab. 2016;101:264\u201374.","journal-title":"J Clin Endocrinol Metab"},{"key":"1384_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/CCO.0000000000000148","volume":"27","author":"R Vigneri","year":"2015","unstructured":"Vigneri R, Malandrino P, Vigneri P. The changing epidemiology of thyroid cancer: why is incidence increasing. Curr Opin Oncol. 2015;27:1\u20137.","journal-title":"Curr Opin Oncol"},{"key":"1384_CR20","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1089\/thy.2013.0308","volume":"24","author":"B Guay","year":"2014","unstructured":"Guay B, Johnson-Obaseki S, McDonald JT, Connell C, Corsten M. Incidence of differentiated thyroid cancer by socioeconomic status and urban residence: Canada 1991\u20132006. Thyroid. 2014;24:552\u20135.","journal-title":"Thyroid"},{"key":"1384_CR21","doi-asserted-by":"publisher","first-page":"158","DOI":"10.5858\/arpa.2014-0468-RA","volume":"140","author":"PA Moghaddam","year":"2016","unstructured":"Moghaddam PA, Virk R, Sakhdari A, Prasad ML, Cosar EF, Khan A. Five top stories in thyroid pathology. Arch Pathol Lab Med. 2016;140:158\u201370.","journal-title":"Arch Pathol Lab Med"},{"key":"1384_CR22","first-page":"341","volume":"8","author":"K Sethi","year":"2010","unstructured":"Sethi K, Sarkar S, Das S, Mohanty B, Mandal M. Biomarkers for the diagnosis of thyroid cancer. J Exp Ther Oncol. 2010;8:341\u201352.","journal-title":"J Exp Ther Oncol"},{"key":"1384_CR23","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1016\/j.suc.2009.06.012","volume":"89","author":"MA Kato","year":"2009","unstructured":"Kato MA, Fahey TJ. Molecular markers in thyroid cancer diagnostics. Surg Clin North Am. 2009;89:1139\u201355.","journal-title":"Surg Clin North Am"},{"key":"1384_CR24","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1083\/jcb.123.3.513","volume":"123","author":"C Schl\u00fcter","year":"1993","unstructured":"Schl\u00fcter C, Duchrow M, Wohlenberg C, Becker MH, Key G, Flad HD, et al. The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. J Cell Biol. 1993;123:513\u201322.","journal-title":"J Cell Biol"},{"key":"1384_CR25","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/S0968-0004(00)89072-6","volume":"20","author":"K Hofmann","year":"1995","unstructured":"Hofmann K, Bucher P. The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors. Trends Biochem Sci. 1995;20:347\u20139.","journal-title":"Trends Biochem Sci"},{"key":"1384_CR26","doi-asserted-by":"publisher","first-page":"4353","DOI":"10.7314\/APJCP.2013.14.7.4353","volume":"14","author":"S Haroon","year":"2013","unstructured":"Haroon S, Hashmi AA, Khurshid A, Kanpurwala MA, Mujtuba S, Malik B, et al. Ki67 index in breast cancer: correlation with other prognostic markers and potential in Pakistani patients. Asian Pac J Cancer Prev. 2013;14:4353\u20138.","journal-title":"Asian Pac J Cancer Prev"},{"key":"1384_CR27","doi-asserted-by":"publisher","first-page":"5155","DOI":"10.7314\/APJCP.2012.13.10.5155","volume":"13","author":"AA Tadbir","year":"2012","unstructured":"Tadbir AA, Pardis S, Ashkavandi ZJ, Najvani AD, Ashraf MJ, Taheri A, et al. Expression of Ki67 and CD105 as proliferation and angiogenesis markers in salivary gland tumors. Asian Pac J Cancer Prev. 2012;13:5155\u20139.","journal-title":"Asian Pac J Cancer Prev"},{"key":"1384_CR28","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1007\/s10549-011-1837-z","volume":"132","author":"E Luporsi","year":"2012","unstructured":"Luporsi E, Andr\u00e9 F, Spyratos F, Martin PM, Jacquemier J, Penault-Llorca F, et al. Ki-67: level of evidence and methodological considerations for its role in the clinical management of breast cancer: analytical and critical review. Breast Cancer Res Treat. 2012;132:895\u2013915.","journal-title":"Breast Cancer Res Treat"},{"key":"1384_CR29","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1038\/sj.bjc.6604951","volume":"100","author":"DM Berney","year":"2009","unstructured":"Berney DM, Gopalan A, Kudahetti S, Fisher G, Ambroisine L, Foster CS, et al. Ki-67 and outcome in clinically localized prostate cancer: analysis of conservatively treated prostate cancer patients from the Trans-Atlantic Prostate Group study. Br J Cancer. 2009;100:888\u201393.","journal-title":"Br J Cancer"},{"key":"1384_CR30","doi-asserted-by":"publisher","first-page":"3015","DOI":"10.1007\/s00268-010-0746-3","volume":"34","author":"Y Ito","year":"2010","unstructured":"Ito Y, Miyauchi A, Kakudo K, Hirokawa M, Kobayashi K, Miya A. Prognostic significance of ki-67 labeling index in papillary thyroid carcinoma. World J Surg. 2010;34:3015\u201321.","journal-title":"World J Surg"},{"key":"1384_CR31","doi-asserted-by":"publisher","first-page":"41752","DOI":"10.1038\/srep41752","volume":"7","author":"M Matsuse","year":"2017","unstructured":"Matsuse M, Yabuta T, Saenko V, Hirokawa M, Nishihara E, Suzuki K, et al. TERT promoter mutations and Ki-67 labeling index as a prognostic marker of papillary thyroid carcinomas: combination of two independent factors. Sci Rep. 2017;7:41752.","journal-title":"Sci Rep"},{"key":"1384_CR32","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1200\/JCO.2014.56.8253","volume":"33","author":"M Xing","year":"2015","unstructured":"Xing M, Alzahrani AS, Carson KA, Shong YK, Kim TY, Viola D, et al. Association between BRAF V600E mutation and recurrence of papillary thyroid cancer. J Clin Oncol. 2015;33:42\u201350.","journal-title":"J Clin Oncol"},{"key":"1384_CR33","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1159\/000347148","volume":"2","author":"A Miyauchi","year":"2013","unstructured":"Miyauchi A, Kudo T, Hirokawa M, Ito Y, Kihara M, Higashiyama T, et al. Ki-67 labeling index is a predictor of postoperative persistent disease and cancer growth and a prognostic indicator in papillary thyroid carcinoma. Eur Thyroid J. 2013;2:57\u201364.","journal-title":"Eur Thyroid J"},{"key":"1384_CR34","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.mehy.2012.12.015","volume":"80","author":"N Ranjbari","year":"2013","unstructured":"Ranjbari N, Rahim F. The Ki-67\/MIB-1 index level and recurrence of papillary thyroid carcinoma. Med Hypotheses. 2013;80:311\u20134.","journal-title":"Med Hypotheses"},{"key":"1384_CR35","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s10616-017-0141-0","volume":"70","author":"M Wang","year":"2018","unstructured":"Wang M, Gui C, Qiu S, Tang J, Peng Z. Periostin silencing suppresses the aggressive phenotype of thyroid carcinoma cells by suppressing the Akt\/thyroid stimulating hormone receptor axis. Cytotechnology. 2018;70:275\u201384.","journal-title":"Cytotechnology"},{"key":"1384_CR36","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.7314\/APJCP.2015.16.4.1605","volume":"16","author":"Y Zhou","year":"2015","unstructured":"Zhou Y, Jiang HG, Lu N, Lu BH, Chen ZH. Expression of Ki67 in papillary thyroid microcarcinoma and its clinical significance. Asian Pac J Cancer Prev. 2015;16:1605\u20138.","journal-title":"Asian Pac J Cancer Prev"},{"key":"1384_CR37","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0025-6196(12)61170-7","volume":"66","author":"MD Brennan","year":"1991","unstructured":"Brennan MD, Bergstralh EJ, van Heerden JA, McConahey WM. Follicular thyroid cancer treated at the Mayo Clinic, 1946 through 1970: initial manifestations, pathologic findings, therapy, and outcome. Mayo Clin Proc. 1991;66:11\u201322.","journal-title":"Mayo Clin Proc"},{"key":"1384_CR38","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/S0889-8529(18)30310-4","volume":"19","author":"ID Hay","year":"1990","unstructured":"Hay ID. Papillary thyroid carcinoma. Endocrinol Metab Clin N Am. 1990;19:545\u201376.","journal-title":"Endocrinol Metab Clin N Am"},{"key":"1384_CR39","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1007\/s10856-004-5745-1","volume":"15","author":"W Siggelkow","year":"2004","unstructured":"Siggelkow W, Faridi A, Klinge U, Rath W, Klosterhalfen B. Ki67, HSP70 and TUNEL for the specification of testing of silicone breast implants in vivo. J Mater Sci Mater Med. 2004;15:1355\u201360.","journal-title":"J Mater Sci Mater Med"},{"key":"1384_CR40","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.tripleo.2004.04.016","volume":"99","author":"M Edamatsu","year":"2005","unstructured":"Edamatsu M, Kumamoto H, Ooya K, Echigo S. Apoptosis-related factors in the epithelial components of dental follicles and dentigerous cysts associated with impacted third molars of the mandible. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:17\u201323.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"1384_CR41","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1002\/jcp.20494","volume":"206","author":"J Bullwinkel","year":"2006","unstructured":"Bullwinkel J, Baron-L\u00fchr B, L\u00fcdemann A, Wohlenberg C, Gerdes J, Scholzen T. Ki-67 protein is associated with ribosomal RNA transcription in quiescent and proliferating cells. J Cell Physiol. 2006;206:624\u201335.","journal-title":"J Cell Physiol"}],"container-title":["World Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-018-1384-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12957-018-1384-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-018-1384-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T19:09:30Z","timestamp":1559243370000},"score":1,"resource":{"primary":{"URL":"https:\/\/wjso.biomedcentral.com\/articles\/10.1186\/s12957-018-1384-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,31]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1384"],"URL":"https:\/\/doi.org\/10.1186\/s12957-018-1384-8","relation":{},"ISSN":["1477-7819"],"issn-type":[{"value":"1477-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,31]]},"assertion":[{"value":"14 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Institutional Review Board and Clinical Ethics Committee of Shanghai General Hospital, Shanghai Jiaotong University School of Medicine. The written informed consent from either the patients or their representatives was waived due to the retrospective nature of this study in accordance with the American Medical Association.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"100"}}