{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:27:07Z","timestamp":1783571227781,"version":"3.55.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T00:00:00Z","timestamp":1547596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12957-019-1563-2","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T10:02:34Z","timestamp":1547632954000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Routine preoperative mechanical bowel preparation with additive oral antibiotics is associated with a reduced risk of anastomotic leakage in patients undergoing elective oncologic resection for colorectal cancer"],"prefix":"10.1186","volume":"17","author":[{"given":"Peter C.","family":"Ambe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Zarras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Stodolski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingfu","family":"Wirjawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Zirngibl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,16]]},"reference":[{"issue":"4","key":"1563_CR1","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s00384-016-2744-x","volume":"32","author":"B Gessler","year":"2017","unstructured":"Gessler B, Eriksson O, Angenete E. Diagnosis, treatment, and consequences of anastomotic leakage in colorectal surgery. Int J Color Dis. 2017;32(4):549\u201356.","journal-title":"Int J Color Dis"},{"issue":"6","key":"1563_CR2","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1097\/SLA.0000000000001011","volume":"262","author":"S Markar","year":"2015","unstructured":"Markar S, Gronnier C, Duhamel A, Mabrut J-Y, Bail J-P, Carrere N, Lefevre JH, Brigand C, Vaillant J-C, Adham M. The impact of severe anastomotic leak on long-term survival and cancer recurrence after surgical resection for esophageal malignancy. Ann Surg. 2015;262(6):972\u201380.","journal-title":"Ann Surg"},{"issue":"1","key":"1563_CR3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1007\/s11605-006-0049-z","volume":"11","author":"WL Law","year":"2007","unstructured":"Law WL, Choi HK, Lee YM, Ho JW, Seto CL. Anastomotic leakage is associated with poor long-term outcome in patients after curative colorectal resection for malignancy. J Gastrointest Surg. 2007;11(1):8\u201315.","journal-title":"J Gastrointest Surg"},{"issue":"5","key":"1563_CR4","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1097\/SLA.0b013e3182a6f2fc","volume":"259","author":"P-M Krarup","year":"2014","unstructured":"Krarup P-M, Nordholm-Carstensen A, Jorgensen LN, Harling H. Anastomotic leak increases distant recurrence and long-term mortality after curative resection for colonic cancer: a nationwide cohort study. Ann Surg. 2014;259(5):930\u20138.","journal-title":"Ann Surg"},{"issue":"4","key":"1563_CR5","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1007\/s00268-014-2887-2","volume":"39","author":"S Nachiappan","year":"2015","unstructured":"Nachiappan S, Askari A, Malietzis G, Giacometti M, White I, Jenkins JT, Kennedy RH, Faiz O. The impact of anastomotic leak and its treatment on cancer recurrence and survival following elective colorectal cancer resection. World J Surg. 2015;39(4):1052\u20138.","journal-title":"World J Surg"},{"issue":"4","key":"1563_CR6","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1002\/bjs.9748","volume":"102","author":"E Esp\u00edn","year":"2015","unstructured":"Esp\u00edn E, Ciga M, Pera M, Ortiz H, Project SRC, Lujan J, Fraccalvieri D, Biondo S, Ciga M, Esp\u00ed A. Oncological outcome following anastomotic leak in rectal surgery. Br J Surg. 2015;102(4):416\u201322.","journal-title":"Br J Surg"},{"issue":"1","key":"1563_CR7","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.amjsurg.2014.10.022","volume":"210","author":"HP van't Sant","year":"2015","unstructured":"van't Sant HP, Kamman A, Hop WC, Van Der Heijden M, Lange JF, Contant CM. The influence of mechanical bowel preparation on long-term survival in patients surgically treated for colorectal cancer. Am J Surg. 2015;210(1):106\u201310.","journal-title":"Am J Surg"},{"issue":"7","key":"1563_CR8","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1002\/bjs.1800740711","volume":"74","author":"AD Irving","year":"1987","unstructured":"Irving AD, Scrimgeour D. Mechanical bowel preparation for colonic resection and anastomosis. Br J Surg. 1987;74(7):580\u20131.","journal-title":"Br J Surg"},{"issue":"2","key":"1563_CR9","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1001\/jamasurg.2017.3827","volume":"153","author":"E Vo","year":"2018","unstructured":"Vo E, Massarweh NN, Chai CY, Cao HST, Zamani N, Abraham S, Adigun K, Awad SS. Association of the addition of oral antibiotics to mechanical bowel preparation for left colon and rectal cancer resections with reduction of surgical site infections. JAMA surgery. 2018;153(2):114\u201321.","journal-title":"JAMA surgery"},{"issue":"4","key":"1563_CR10","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s00384-018-2991-0","volume":"33","author":"PC Ambe","year":"2018","unstructured":"Ambe PC, Godde D, Storkel S, Zirngibl H, Bonicke L. Extra nodular metastasis is a poor prognostic factor for overall survival in node-positive patients with colorectal cancer. Int J Color Dis. 2018;33(4):403\u20139.","journal-title":"Int J Color Dis"},{"issue":"1","key":"1563_CR11","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s12957-017-1227-z","volume":"15","author":"PC Ambe","year":"2017","unstructured":"Ambe PC, Jansen S, Zirngibl H. New trend in colorectal cancer in Germany: are young patients at increased risk for advanced colorectal cancer? World J Surg Oncol. 2017;15(1):159.","journal-title":"World J Surg Oncol"},{"issue":"4","key":"1563_CR12","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1111\/j.1463-1318.2008.01735.x","volume":"11","author":"W Hohenberger","year":"2009","unstructured":"Hohenberger W, Weber K, Matzel K, Papadopoulos T, Merkel S. Standardized surgery for colonic cancer: complete mesocolic excision and central ligation--technical notes and outcome. Color Dis. 2009;11(4):354\u201364 discussion 364-355.","journal-title":"Color Dis"},{"issue":"8","key":"1563_CR13","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1001\/archsurg.133.8.894","volume":"133","author":"RJ Heald","year":"1998","unstructured":"Heald RJ, Moran BJ, Ryall RD, Sexton R, MacFarlane JK. Rectal cancer: the Basingstoke experience of total mesorectal excision, 1978-1997. Arch Surg. 1998;133(8):894\u20139.","journal-title":"Arch Surg"},{"issue":"2","key":"1563_CR14","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.jamcollsurg.2013.04.018","volume":"217","author":"DM Hari","year":"2013","unstructured":"Hari DM, Leung AM, Lee JH, Sim MS, Vuong B, Chiu CG, Bilchik AJ. AJCC Cancer Staging Manual 7th edition criteria for colon cancer: do the complex modifications improve prognostic assessment? J Am Coll Surg. 2013;217(2):181\u201390.","journal-title":"J Am Coll Surg"},{"issue":"3","key":"1563_CR15","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.surg.2009.10.012","volume":"147","author":"NN Rahbari","year":"2010","unstructured":"Rahbari NN, Weitz J, Hohenberger W, Heald RJ, Moran B, Ulrich A, Holm T, Wong WD, Tiret E, Moriya Y. Definition and grading of anastomotic leakage following anterior resection of the rectum: a proposal by the International Study Group of Rectal Cancer. Surgery. 2010;147(3):339\u201351.","journal-title":"Surgery"},{"issue":"2","key":"1563_CR16","first-page":"323","volume":"132","author":"RL Nichols","year":"1971","unstructured":"Nichols RL, Condon RE. Preoperative preparation of the colon. Surg Gynecol Obstet. 1971;132(2):323\u201337.","journal-title":"Surg Gynecol Obstet"},{"issue":"9","key":"1563_CR17","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1002\/bjs.4651","volume":"91","author":"K Slim","year":"2004","unstructured":"Slim K, Vicaut E, Panis Y, Chipponi J. Meta-analysis of randomized clinical trials of colorectal surgery with or without mechanical bowel preparation. Br J Surg. 2004;91(9):1125\u201330.","journal-title":"Br J Surg"},{"issue":"2","key":"1563_CR18","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1097\/SLA.0b013e318193425a","volume":"249","author":"K Slim","year":"2009","unstructured":"Slim K, Vicaut E, Launay-Savary MV, Contant C, Chipponi J. Updated systematic review and meta-analysis of randomized clinical trials on the role of mechanical bowel preparation before colorectal surgery. Ann Surg. 2009;249(2):203\u20139.","journal-title":"Ann Surg"},{"issue":"1","key":"1563_CR19","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1097\/DCR.0000000000000524","volume":"59","author":"M Chen","year":"2016","unstructured":"Chen M, Song X, Chen LZ, Lin ZD, Zhang XL. Comparing mechanical bowel preparation with both oral and systemic antibiotics versus mechanical bowel preparation and systemic antibiotics alone for the prevention of surgical site infection after elective colorectal surgery. Dis Colon Rectum. 2016;59(1):70\u20138.","journal-title":"Dis Colon Rectum"},{"issue":"6","key":"1563_CR20","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1097\/SLA.0000000000001125","volume":"261","author":"MS Morris","year":"2015","unstructured":"Morris MS, Graham LA, Chu DI, Cannon JA, Hawn MT. Oral antibiotic bowel preparation significantly reduces surgical site infection rates and readmission rates in elective colorectal surgery. Ann Surg. 2015;261(6):1034\u201340.","journal-title":"Ann Surg"},{"issue":"4","key":"1563_CR21","doi-asserted-by":"publisher","first-page":"519","DOI":"10.3748\/wjg.v24.i4.519","volume":"24","author":"KE Rollins","year":"2018","unstructured":"Rollins KE, Javanmard-Emamghissi H, Lobo DN. Impact of mechanical bowel preparation in elective colorectal surgery: a meta-analysis. World J Gastroenterol. 2018;24(4):519.","journal-title":"World J Gastroenterol"},{"issue":"4","key":"1563_CR22","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1097\/SLA.0000000000002159","volume":"267","author":"SE Koller","year":"2018","unstructured":"Koller SE, Bauer KW, Egleston BL, Smith R, Philp MM, Ross HM, Esnaola NF. Comparative effectiveness and risks of bowel preparation before elective colorectal surgery. Ann Surg. 2018;267(4):734\u201342.","journal-title":"Ann Surg"},{"issue":"3","key":"1563_CR23","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1097\/SLA.0000000000001416","volume":"262","author":"RP Kiran","year":"2015","unstructured":"Kiran RP, Murray AC, Chiuzan C, Estrada D, Forde K. Combined preoperative mechanical bowel preparation with oral antibiotics significantly reduces surgical site infection, anastomotic leak, and ileus after colorectal surgery. Ann Surg. 2015;262(3):416\u201325 discussion 423-415.","journal-title":"Ann Surg"}],"container-title":["World Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-019-1563-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12957-019-1563-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-019-1563-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T19:03:54Z","timestamp":1579115034000},"score":1,"resource":{"primary":{"URL":"https:\/\/wjso.biomedcentral.com\/articles\/10.1186\/s12957-019-1563-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,16]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1563"],"URL":"https:\/\/doi.org\/10.1186\/s12957-019-1563-2","relation":{},"ISSN":["1477-7819"],"issn-type":[{"value":"1477-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,16]]},"assertion":[{"value":"4 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A written consent was received from all patients or their legal representatives for the use of their data in this study. Ethics approval was received from the Board of Review at the Witten \/ Herdecke University (Approval Nr. 05\/2015).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"A consent for publication was granted by all patients included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"20"}}