{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:38:38Z","timestamp":1787236718416,"version":"build-2736575974"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12957-019-1613-9","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T13:04:28Z","timestamp":1556024668000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Retrospective analysis of 51 intralesionally treated cases with progressed giant cell tumor of the bone: local adjuvant use of hydrogen peroxide reduces the risk for tumor recurrence"],"prefix":"10.1186","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7619-0195","authenticated-orcid":false,"given":"Georg W.","family":"Omlor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Streit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Gantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Merle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Germann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunhild","family":"Mechtersheimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Fellenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhard","family":"Lehner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,4,23]]},"reference":[{"key":"1613_CR1","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1007\/s00264-006-0215-7","volume":"30","author":"M Werner","year":"2006","unstructured":"Werner M. Giant cell tumour of bone: morphological, biological and histogenetical aspects. Int Orthop. 2006;30:484\u20139.","journal-title":"Int Orthop"},{"key":"1613_CR2","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s00264-005-0061-z","volume":"30","author":"LM Jeys","year":"2006","unstructured":"Jeys LM, Suneja R, Chami G, Grimer RJ, Carter SR, Tillman RM. Impending fractures in giant cell tumours of the distal femur: incidence and outcome. Int Orthop. 2006;30:135\u20138.","journal-title":"Int Orthop"},{"key":"1613_CR3","doi-asserted-by":"publisher","first-page":"106","DOI":"10.2106\/00004623-198769010-00018","volume":"69","author":"M Campanacci","year":"1987","unstructured":"Campanacci M, Baldini N, Boriani S, Sudanese A. Giant-cell tumor of bone. J Bone Joint Surg Am. 1987;69:106\u201314.","journal-title":"J Bone Joint Surg Am"},{"key":"1613_CR4","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1186\/1477-7819-12-261","volume":"12","author":"A Muheremu","year":"2014","unstructured":"Muheremu A, Niu X. Pulmonary metastasis of giant cell tumor of bones. World J Surg Oncol. 2014;12:261.","journal-title":"World J Surg Oncol."},{"key":"1613_CR5","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1007\/s00432-008-0370-x","volume":"134","author":"M Balke","year":"2008","unstructured":"Balke M, Schremper L, Gebert C, Ahrens H, Streitbuerger A, Koehler G, Hardes J, Gosheger G. Giant cell tumor of bone: treatment and outcome of 214 cases. J Cancer Res Clin Oncol. 2008;134:969\u201378.","journal-title":"J Cancer Res Clin Oncol"},{"key":"1613_CR6","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1302\/0301-620X.96B1.31763","volume":"96","author":"AE Wijsbek","year":"2014","unstructured":"Wijsbek AE, Vazquez-Garcia BL, Grimer RJ, Carter SR, Abudu AA, Tillman RM, Jeys L. Giant cell tumour of the proximal femur: is joint-sparing management ever successful? Bone Joint J. 2014;96:127\u201331.","journal-title":"Bone Joint J"},{"key":"1613_CR7","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1007\/s00264-017-3536-9","volume":"41","author":"C Errani","year":"2017","unstructured":"Errani C, Tsukamoto S, Mavrogenis AF. How safe and effective is denosumab for bone giant cell tumour? Int Orthop. 2017;41:2397\u2013400.","journal-title":"Int Orthop"},{"key":"1613_CR8","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/s12957-018-1459-6","volume":"16","author":"H Urakawa","year":"2018","unstructured":"Urakawa H, Yonemoto T, Matsumoto S, Takagi T, Asanuma K, Watanuki M, Takemoto A, Naka N, Matsumoto Y, Kawai A, Kunisada T, Kubo T, Emori M, Hiraga H, Hatano H, Tsukushi S, Nishida Y, Akisue T, Morii T, Takahashi M, Nagano A, Yoshikawa H, Sato K, Kawano M, Hiraoka K, Tanaka K, Iwamoto Y, Ozaki T. Clinical outcome of primary giant cell tumor of bone after curettage with or without perioperative denosumab in Japan: from a questionnaire for JCOG 1610 study. World J Surg Oncol. 2018;16:160.","journal-title":"World J Surg Oncol."},{"key":"1613_CR9","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1186\/s12957-018-1478-3","volume":"16","author":"J Engellau","year":"2018","unstructured":"Engellau J, Seeger L, Grimer R, Henshaw R, Gelderblom H, Choy E, Chawla S, Reichardt P, O'Neal M, Feng A, Jacobs I, Roberts ZJ, Braun A, Bach BA. Assessment of denosumab treatment effects and imaging response in patients with giant cell tumor of bone. World J Surg Oncol. 2018;16:191.","journal-title":"World J Surg Oncol."},{"key":"1613_CR10","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1007\/s00264-012-1664-9","volume":"36","author":"H Wang","year":"2012","unstructured":"Wang H, Wan N, Hu Y. Giant cell tumour of bone: a new evaluating system is necessary. Int Orthop. 2012;36:2521\u20137.","journal-title":"Int Orthop"},{"key":"1613_CR11","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s00264-017-3664-2","volume":"42","author":"DX Lun","year":"2018","unstructured":"Lun DX, Hu YC, Yang XG, Wang Z, Yu XC, Wu SJ, Ye ZM, Wang H. Development and proposal of a scoring system for giant cell tumour of the bone around the knee. Int Orthop. 2018;42:203\u201313.","journal-title":"Int Orthop"},{"key":"1613_CR12","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1007\/s00264-006-0154-3","volume":"30","author":"JH Oh","year":"2006","unstructured":"Oh JH, Yoon PW, Lee SH, Cho HS, Kim WS, Kim HS. Surgical treatment of giant cell tumour of long bone with anhydrous alcohol adjuvant. Int Orthop. 2006;30:490\u20134.","journal-title":"Int Orthop"},{"key":"1613_CR13","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s00264-006-0146-3","volume":"30","author":"F Malek","year":"2006","unstructured":"Malek F, Krueger P, Hatmi ZN, Malayeri AA, Faezipour H, O\u2019Donnell RJ. Local control of long bone giant cell tumour using curettage, burring and bone grafting without adjuvant therapy. Int Orthop. 2006;30:495\u20138.","journal-title":"Int Orthop"},{"key":"1613_CR14","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1097\/01.blo.0000128280.59965.e3","volume":"424","author":"P Saiz","year":"2004","unstructured":"Saiz P, Virkus W, Piasecki P, Templeton A, Shott S, Gitelis S. Results of giant cell tumor of bone treated with intralesional excision. Clin Orthop Relat Res. 2004;424:221\u20136.","journal-title":"Clin Orthop Relat Res"},{"key":"1613_CR15","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1097\/00003086-200204000-00029","volume":"397","author":"RE Turcotte","year":"2002","unstructured":"Turcotte RE, Wunder JS, Isler MH, Bell RS, Schachar N, Masri BA, Moreau G, Davis AM. Giant cell tumor of long bone: a Canadian Sarcoma Group study. Clin Orthop Relat Res. 2002;397:248\u201358.","journal-title":"Clin Orthop Relat Res"},{"key":"1613_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ctrv.2009.09.002","volume":"36","author":"C Errani","year":"2010","unstructured":"Errani C, Ruggieri P, Asenzio MA, Toscano A, Colangeli S, Rimondi E, Rossi G, Longhi A, Mercuri M. Giant cell tumor of the extremity: a review of 349 cases from a single institution. Cancer Treat Rev. 2010;36:1\u20137.","journal-title":"Cancer Treat Rev"},{"key":"1613_CR17","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1080\/17453670710014815","volume":"79","author":"AH Kivioja","year":"2008","unstructured":"Kivioja AH, Blomqvist C, Hietaniemi K, Trovik C, Walloe A, Bauer HC, Jorgensen PH, Bergh P, Folleras G. Cement is recommended in intralesional surgery of giant cell tumors: a Scandinavian Sarcoma Group study of 294 patients followed for a median time of 5 years. Acta Orthop. 2008;79:86\u201393.","journal-title":"Acta Orthop"},{"key":"1613_CR18","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s12957-016-0871-z","volume":"14","author":"D Li","year":"2016","unstructured":"Li D, Zhang J, Li Y, Xia J, Yang Y, Ren M, Liao Y, Yu S, Li X, Shen Y, Zhang Y, Yang Z. Surgery methods and soft tissue extension are the potential risk factors of local recurrence in giant cell tumor of bone. World J Surg Oncol. 2016;14:114.","journal-title":"World J Surg Oncol."},{"key":"1613_CR19","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1186\/1471-2474-15-330","volume":"15","author":"ZH Gao","year":"2014","unstructured":"Gao ZH, Yin JQ, Xie XB, Zou CY, Huang G, Wang J, Shen JN. Local control of giant cell tumors of the long bone after aggressive curettage with and without bone cement. BMC Musculoskelet Disord. 2014;15:330.","journal-title":"BMC Musculoskelet Disord"},{"key":"1613_CR20","doi-asserted-by":"publisher","first-page":"811","DOI":"10.2106\/00004623-199906000-00008","volume":"81","author":"HR Blackley","year":"1999","unstructured":"Blackley HR, Wunder JS, Davis AM, White LM, Kandel R, Bell RS. Treatment of giant-cell tumors of long bones with curettage and bone-grafting. J Bone Joint Surg Am. 1999;81:811\u201320.","journal-title":"J Bone Joint Surg Am"},{"key":"1613_CR21","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/1477-7819-11-156","volume":"11","author":"D Zuo","year":"2013","unstructured":"Zuo D, Zheng L, Sun W, Fu D, Hua Y, Cai Z. Contemporary adjuvant polymethyl methacrylate cementation optimally limits recurrence in primary giant cell tumor of bone patients compared to bone grafting: a systematic review and meta-analysis. World J Surg Oncol. 2013;11:156.","journal-title":"World J Surg Oncol"},{"key":"1613_CR22","doi-asserted-by":"publisher","unstructured":"Algawahmed H, Turcotte R, Farrokhyar F, Ghert M. High-speed burring with and without the use of surgical adjuvants in the intralesional management of giant cell tumor of bone: a systematic review and meta-analysis. Sarcoma. 2010. https:\/\/doi.org\/10.1155\/2010\/586090 .","DOI":"10.1155\/2010\/586090"},{"key":"1613_CR23","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.2106\/JBJS.D.02771","volume":"90","author":"WT Becker","year":"2008","unstructured":"Becker WT, Dohle J, Bernd L, Braun A, Cserhati M, Enderle A, Hovy L, Matejovsky Z, Szendroi M, Trieb K, Tunn PU. Local recurrence of giant cell tumor of bone after intralesional treatment with and without adjuvant therapy. J Bone Joint Surg Am. 2008;90:1060\u20137.","journal-title":"J Bone Joint Surg Am"},{"key":"1613_CR24","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/00003086-199301000-00035","volume":"286","author":"WF Enneking","year":"1993","unstructured":"Enneking WF, Dunham W, Gebhardt MC, Malawar M, Pritchard DJ. A system for the functional evaluation of reconstructive procedures after surgical treatment of tumors of the musculoskeletal system. Clin Orthop Relat Res. 1993;286:241\u20136.","journal-title":"Clin Orthop Relat Res"},{"key":"1613_CR25","doi-asserted-by":"publisher","unstructured":"Fellenberg J, Kunz P, S\u00e4hr H, Depeweg D. Overexpression of inosine 5\u2032-monophosphate dehydrogenase type II mediates chemoresistance to human osteosarcoma cells. PLoS One. 2010. https:\/\/doi.org\/10.1371\/journal.pone.0012179 .","DOI":"10.1371\/journal.pone.0012179"},{"key":"1613_CR26","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1097\/00003086-199802000-00031","volume":"347","author":"NC Nicholson","year":"1998","unstructured":"Nicholson NC, Ramp WK, Kneisl JS, Kaysinger KK. Hydrogen peroxide inhibits giant cell tumor and osteoblast metabolism in vitro. Clin Orthop Relat Res. 1998;347:250\u201360.","journal-title":"Clin Orthop Relat Res"},{"key":"1613_CR27","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1302\/0301-620X.92B10.23495","volume":"92","author":"Y Gortzak","year":"2010","unstructured":"Gortzak Y, Kandel R, Deheshi B, Werier J, Turcotte RE, Ferguson PC, Wunder JS. The efficacy of chemical adjuvants on giant-cell tumour of bone. An in vitro study. J Bone Joint Surg Br. 2010;92:1475\u20139.","journal-title":"J Bone Joint Surg Br"},{"key":"1613_CR28","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.1007\/s00264-016-3292-2","volume":"40","author":"N Lujic","year":"2016","unstructured":"Lujic N, Sopta J, Kovacevic R, Stevanovic V, Davidovic R. Recurrence of giant cell tumour of bone: role of p53, cyclin D1, \u03b2-catenin and Ki67. Int Orthop. 2016;40:2393\u20139.","journal-title":"Int Orthop"},{"key":"1613_CR29","doi-asserted-by":"publisher","first-page":"118","DOI":"10.5435\/JAAOS-21-02-118","volume":"21","author":"KA Raskin","year":"2013","unstructured":"Raskin KA, Schwab JH, Mankin HJ, Springfield DS, Hornicek FJ. Giant cell tumor of bone. J Am Acad Orthop Surg. 2013;21:118\u201326.","journal-title":"J Am Acad Orthop Surg"},{"key":"1613_CR30","doi-asserted-by":"publisher","unstructured":"Noh BJ, Park YK. Giant cell tumor of bone: updated molecular pathogenesis and tumor biology. Hum Pathol. 2018. https:\/\/doi.org\/10.1016\/j.humpath.2018.06.017 .","DOI":"10.1016\/j.humpath.2018.06.017"},{"key":"1613_CR31","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/1749-799X-5-85","volume":"5","author":"Y Matsumoto","year":"2010","unstructured":"Matsumoto Y, Okada Y, Fukushi J, Kamura S, Fujiwara T, Iida K, Koga M, Matsuda S, Harimaya K, Sakamoto A, Iwamoto Y. Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone. J Orthop Surg Res. 2010;5:85.","journal-title":"J Orthop Surg Res"},{"key":"1613_CR32","doi-asserted-by":"publisher","unstructured":"Rutkowski P, Gaston L, Borkowska A, Stacchiotti S, Gelderblom H, Baldi GG, Palmerini E, Casali P, Gronchi A, Parry M, Campanacci DA, Scoccianti G, Wagrodzki M, Ferrari S, Dijkstra S, Pie\u0144kowski A, Grimer R. Denosumab treatment of inoperable or locally advanced giant cell tumor of bone - multicenter analysis outside clinical trial. Eur J Surg Oncol. 2018. https:\/\/doi.org\/10.1016\/j.ejso.2018.03.020 .","DOI":"10.1016\/j.ejso.2018.03.020"},{"key":"1613_CR33","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.ejca.2017.01.028","volume":"76","author":"E Palmerini","year":"2017","unstructured":"Palmerini E, Chawla NS, Ferrari S, Sudan M, Picci P, Marchesi E, Leopardi MP, Syed I, Sankhala KK, Parthasarathy P, Mendanha WE, Pierini M, Paioli A, Chawla SP. Denosumab in advanced\/unresectable giant-cell tumour of bone (GCTB): for how long? Eur J Cancer. 2017;76:118\u201324.","journal-title":"Eur J Cancer"},{"key":"1613_CR34","first-page":"260","volume":"6","author":"K Jamshidi","year":"2018","unstructured":"Jamshidi K, Gharehdaghi M, Hajialiloo SS, Mirkazemi M, Ghaffarzadehgan K, Izanloo A. Denosumab in patients with giant cell tumor and its recurrence: a systematic review. Arch Bone Jt Surg. 2018;6:260\u20138.","journal-title":"Arch Bone Jt Surg"}],"container-title":["World Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-019-1613-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12957-019-1613-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-019-1613-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T13:30:25Z","timestamp":1663335025000},"score":1,"resource":{"primary":{"URL":"https:\/\/wjso.biomedcentral.com\/articles\/10.1186\/s12957-019-1613-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,23]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1613"],"URL":"https:\/\/doi.org\/10.1186\/s12957-019-1613-9","relation":{},"ISSN":["1477-7819"],"issn-type":[{"value":"1477-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,23]]},"assertion":[{"value":"23 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Approval was given by our ethical committee of the University of Heidelberg, Germany (vote number S-053\/2017 and S-359\/2010).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent was obtained from all patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"73"}}