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Retrospective analysis and follow-up were performed for each patient. Multivariate analysis of prognostic factors was performed using Cox\u2019s regression model.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>For all the 98 cases of MSSCC, the 5-year overall survival (OS) and disease-free survival (DFS) rates were 31.0% and 29.3%, respectively. Among 98 patient, 33 patients were treated with systemic treatment (NON-SUR), 19 patients underwent neoadjuvant chemotherapy and\/or radiotherapy followed by surgery (CT\/RT+SUR), 38 patients received surgery followed by chemotherapy and\/or radiotherapy (SUR+RT\/CT), and 8 patients were performed surgery alone (SUR).The OS rate for each group was 27.3%, 57.9%, 30.6% and 37.5%, respectively, while the DFS was 21.2%, 36.8%, 31.6% and 25.0%, respectively. The OS rate of CT\/RT+SUR was significantly higher than that of NON-SUR and SUR+CT\/RT groups (<jats:italic>P<\/jats:italic> &lt; 0.05). Multivariate analysis revealed that smoking, low differentiation, and advanced T stage were independent risk factors for OS, while low differentiation and advanced N stage for DFS.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Surgery-based treatment is still the first-line therapeutic strategy for MSSCC. And neoadjuvant chemoradiotherapy followed by surgery is highly recommended for MSSCC patients, especially those with advanced tumors or requesting high quality of life.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12957-020-01862-3","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T17:03:09Z","timestamp":1588784589000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Retrospective analysis of 98 cases of maxillary sinus squamous cell carcinoma and therapeutic exploration"],"prefix":"10.1186","volume":"18","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8985-2186","authenticated-orcid":false,"given":"Wenchao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,6]]},"reference":[{"issue":"3","key":"1862_CR1","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.ijrobp.2006.09.023","volume":"67","author":"BS Hoppe","year":"2007","unstructured":"Hoppe BS, Stegman LD, Zelefsky MJ, et al. 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