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Survival curves were constructed by using the Kaplan-Meier (K-M) method. Univariate and multivariate Cox proportional hazard regression models were performed to identify associations with outcome variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Colorectal cancer patients with schistosomiasis (CRC-S) were significantly older (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) than the patients without schistosomiasis (CRC-NS). However, there were no significant differences between CRC-S and CRC-NS patients in other clinicopathological features. Schistosomiasis was associated with adverse overall survival (OS) upon K-M analysis (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0277). By univariate and multivariate analysis, gender (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.003), TNM stage (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), schistosomiasis (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.025), lymphovascular invasion (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.030), and lymph nodes positive for CRC (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) were all independent predictors in the whole cohort. When patients were stratified according to clinical stage and lymph node metastasis state, schistosomiasis was also an independent predictor in patients with stage III\u2013IV tumors and in patients with lymph node metastasis, but not in patients with stage I\u2013II tumors and in patients without lymph node metastasis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Schistosomiasis was significantly correlated with OS, and it was an independent prognostic factor for OS in the whole cohort. When patients were stratified according to clinical stage and lymph node metastasis state, schistosomiasis was still an independently unfavorable prognosis factor for OS in patients with stage III\u2013IV tumors or patients with lymph node metastasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12957-020-01925-5","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T10:36:51Z","timestamp":1593599811000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Comparison of non-schistosomal colorectal cancer and schistosomal colorectal cancer"],"prefix":"10.1186","volume":"18","author":[{"given":"Weixia","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dacheng","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meihong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jican","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxia","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,1]]},"reference":[{"issue":"7225","key":"1925_CR1","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/457036b","volume":"457","author":"A Mantovani","year":"2009","unstructured":"Mantovani A. 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