{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:01:14Z","timestamp":1785326474998,"version":"3.55.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The role of renal artery embolization (RAE) in the therapeutic armamentarium is always controversial. The present study aimed to assess the safety and the surgical outcomes of the instant renal artery embolization (I-RAE) prior to nephrectomy and thrombectomy in patients with locally advanced renal cell carcinoma (RCC) with venous thrombus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective analysis of 54 patients treated with nephrectomy and thrombectomy between January 2012 and January 2019. Twenty-four patients were treated with I-RAE before surgery. Thirty patients received surgery alone (non-RAE group). The patient demographics, operation time, blood loss, transfusion requirements, complications, and other surgical parameters were analyzed between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean tumor size in the I-RAE group was significantly larger than that in the non-RAE group (11.1\u2009cm versus 7.9\u2009cm;\n                      <jats:italic>p<\/jats:italic>\n                      = .001). The mean estimated blood loss was significantly lower in the I-RAE group compared to that in the non-RAE group (596\u2009ml versus 827\u2009ml;\n                      <jats:italic>p<\/jats:italic>\n                      = .015), and the patients in the non-RAE group were more likely to receive blood transfusion (red blood cell, RBC units, 4\u2009U versus 6\u2009U,\n                      <jats:italic>p<\/jats:italic>\n                      = .025; plasma volume, 200\u2009ml versus 400\u2009ml,\n                      <jats:italic>p<\/jats:italic>\n                      = .01). No differences were found in operative duration, ICU stay, perioperative complications, and length of postoperative hospitalization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Instant preoperative adjuvant renal artery embolization (I-RAE) is a safe technique. It facilitates nephrectomy and thrombectomy by reducing blood loss, transfusion requirements, and complications of delayed operations, providing urologists with a reliable option for treatment of locally advanced RCC with tumor thrombus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12957-020-01985-7","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T10:02:54Z","timestamp":1597399374000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Adjuvant instant preoperative renal artery embolization facilitates the radical nephrectomy and thrombectomy in locally advanced renal cancer with venous thrombus: a retrospective study of 54 cases"],"prefix":"10.1186","volume":"18","author":[{"given":"Guangxin","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4272-2891","authenticated-orcid":false,"given":"Wei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"key":"1985_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","volume":"69","author":"RL Siegel","year":"2019","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69:7\u201334.","journal-title":"CA Cancer J Clin"},{"key":"1985_CR2","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.eururo.2018.08.036","volume":"75","author":"U Capitanio","year":"2019","unstructured":"Capitanio U, Bensalah K, Bex A, Boorjian SA, Bray F, Coleman J, et al. Epidemiology of renal cell carcinoma. Eur Urol. 2019;75:74\u201384.","journal-title":"Eur Urol"},{"key":"1985_CR3","doi-asserted-by":"crossref","unstructured":"Almgard LE, Fernstrom I, Haverling M, Ljungqvist A. Treatment of renal adenocarcinoma by embolic occlusion of the renal circulation. Br J Urol. 1973.","DOI":"10.1111\/j.1464-410X.1973.tb06806.x"},{"key":"1985_CR4","doi-asserted-by":"crossref","unstructured":"Turini D, Nicita G, Fiorelli C, Selli C, Villari N. Selective transcatheter arterial embolization of renal carcinoma: an original technique. J Urol. 1976.","DOI":"10.1016\/S0022-5347(17)58840-0"},{"key":"1985_CR5","doi-asserted-by":"crossref","unstructured":"Zargar H, Addison B, Mccall J, Bartlett A, Buckley B, Rice M. Renal artery embolization prior to nephrectomy for locally advanced renal cell carcinoma. ANZ J Surg. 2014.","DOI":"10.1111\/ans.12545"},{"key":"1985_CR6","doi-asserted-by":"crossref","unstructured":"May M, Brookman-Amissah S, Pflanz S, Roigas J, Hoschke B, Kendel F. Pre-operative renal arterial embolisation does not provide survival benefit in patients with radical nephrectomy for renal cell carcinoma. Br J Radiol. 2009.","DOI":"10.1259\/bjr\/17514226"},{"key":"1985_CR7","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.urology.2008.12.084","volume":"74","author":"VS Subramanian","year":"2009","unstructured":"Subramanian VS, Stephenson AJ, Goldfarb DA, Fergany AF, Novick AC, Krishnamurthi V. 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The role of embolization\/chemoembolization in the treatment of renal cell carcinoma. Prog Clin Biol Res. 1989;303:697\u2013705.","journal-title":"Prog Clin Biol Res"},{"key":"1985_CR14","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/S0022-5347(17)50556-X","volume":"131","author":"AV Kaisary","year":"1984","unstructured":"Kaisary AV, Williams G, Riddle PR. The role of preoperative embolization in renal cell carcinoma. J Urol. 1984;131:641\u20136.","journal-title":"J Urol"},{"key":"1985_CR15","doi-asserted-by":"crossref","unstructured":"Nakano H, Nihira H, Toge T. Treatment of renal cancer patients by transcatheter embolization and its effect on lymphocyte proliferative responses. J Urol. 1983.","DOI":"10.1016\/S0022-5347(17)50935-0"},{"key":"1985_CR16","doi-asserted-by":"crossref","unstructured":"Chopra S, Simone G, Metcalfe C, de Castro Abreu AL, Nabhani J, Ferriero M, et al. 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Urol Int. 1992.","DOI":"10.1159\/000282428"}],"container-title":["World Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-020-01985-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12957-020-01985-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-020-01985-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T18:37:33Z","timestamp":1667759853000},"score":1,"resource":{"primary":{"URL":"https:\/\/wjso.biomedcentral.com\/articles\/10.1186\/s12957-020-01985-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,14]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1985"],"URL":"https:\/\/doi.org\/10.1186\/s12957-020-01985-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-28801\/v1","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-28801\/v2","asserted-by":"object"}]},"ISSN":["1477-7819"],"issn-type":[{"value":"1477-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,14]]},"assertion":[{"value":"13 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study involving human participants was approved by the institutional review board of the Shandong Provincial Hospital (no. 2019-133). Written consent was obtained from all the participants. The methods were carried out in accordance with the approved guidelines. All clinical research was performed on the basis of the principles expressed in the Declaration of Helsinki.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"206"}}