{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:26:59Z","timestamp":1787740019144,"version":"build-2784847793"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Colorectal cancer (CRC), the third most commonly diagnosed malignant carcinoma and the third most common cause of carcinoma-related mortality, continues to be a major international health problem. And approximately 33% of patients suffer from recurrence after radical surgery. Free malignant cell implanting in the peritoneum is generally accepted as one of the main reasons of such outcome. We did this present clinical study with the aim of evaluating the effects and safety of intraoperative intraperitoneal chemotherapy (IOC) on patients suffering from colorectal cancer, with hoping to find a novel, effective, and available approach to deal with malignant cell implanting during surgeries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 391 patients who went through colorectal radical surgery were considered eligible between June 1, 2017, and December 31, 2018. 220 patients were treated with surgery without IOC, while other 171 patients received surgery plus IOC. Clinical characteristics, operative findings, postoperative short-term outcomes, disease-free survival (DFS), and overall survival (OS) were compared between these above 2 groups in the selected population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      The present research included 391 patients (251 men and 140 women) who underwent surgery without IOC (\n                      <jats:italic>n<\/jats:italic>\n                      = 171) or surgery plus IOC (\n                      <jats:italic>n<\/jats:italic>\n                      = 220), with a mean (SD) age of 60.4 (9.7) years in the surgery without IOC group and 60.6 (8.7) in the surgery plus IOC group (\n                      <jats:italic>P<\/jats:italic>\n                      =.85). No significant differences were witnessed between the two groups in surgery-related information and postoperative complications. It is worth noting that IOC independent of other factors was associated with a favor prognosis in CRC patients with stage II\/III (HR 0.50, 95%CI 0.30\u20130.82,\n                      <jats:italic>P<\/jats:italic>\n                      =.006). Moreover, for patients with stage II colorectal carcinoma, DFS did not differ between two groups (\n                      <jats:italic>P<\/jats:italic>\n                      =.553, Kaplan-Meier log-rank), and OS was no exception. In stage III CRC patients, the estimated DFS rate for patients receiving IOC was 82.2% and patients without IOC was 66.4% after 3 years, which demonstrated that IOC was associated with a favorable prognosis in stage III patients (\n                      <jats:italic>P<\/jats:italic>\n                      =.012, Kaplan-Meier log-rank). Furthermore, the differences were still remained between the two groups when considering the influence about postoperative chemotherapy (\n                      <jats:italic>P<\/jats:italic>\n                      =.014, Kaplan-Meier log-rank). IOC can also significantly improve patients\u2019 overall survival whether they get treatment with POC (\n                      <jats:italic>P<\/jats:italic>\n                      =.006, Kaplan-Meier log-rank;\n                      <jats:italic>P<\/jats:italic>\n                      =.025, Kaplan-Meier log-rank).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the present study, we have found that surgery plus IOC generated a favorable prognosis for stage III CRC patients but not stage II without any side-effects when the dosage of lobaplatin was 0.1g\/L. As a new, safe, and simple procedure, IOC therapy is easily performed\u2014and does not require any special devices or techniques. Thus, IOC is a promising and exciting therapeutic strategy for patients with CRC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12957-021-02197-3","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T13:03:31Z","timestamp":1616418211000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect and safety of intraoperative intraperitoneal chemotherapy on patients suffering from colorectal cancer"],"prefix":"10.1186","volume":"19","author":[{"given":"An","family":"Shang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1288-016X","authenticated-orcid":false,"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,22]]},"reference":[{"issue":"2","key":"2197_CR1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3322\/ca.2007.0010","volume":"58","author":"A Jemal","year":"2008","unstructured":"Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008. CA Cancer J Clin. 2008;58(2):71\u201396. https:\/\/doi.org\/10.3322\/ca.2007.0010 published Online First: Epub Date.","journal-title":"CA Cancer J Clin"},{"issue":"4","key":"2197_CR2","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1136\/gutjnl-2015-310912","volume":"66","author":"M Arnold","year":"2017","unstructured":"Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2017;66(4):683\u201391. https:\/\/doi.org\/10.1136\/gutjnl-2015-310912 published Online First: Epub Date.","journal-title":"Gut"},{"issue":"6","key":"2197_CR3","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/j.amjsurg.2013.08.035","volume":"207","author":"YT Lan","year":"2014","unstructured":"Lan YT, Chang SC, Yang SH, et al. Comparison of clinicopathological characteristics and prognosis between early and late recurrence after curative surgery for colorectal cancer. Am J Surg. 2014;207(6):922\u201330. https:\/\/doi.org\/10.1016\/j.amjsurg.2013.08.035 published Online First: Epub Date.","journal-title":"Am J Surg"},{"issue":"8","key":"2197_CR4","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1245\/s10434-018-6539-x","volume":"25","author":"NR Sluiter","year":"2018","unstructured":"Sluiter NR, Rovers KP, Salhi Y, et al. Metachronous peritoneal metastases after adjuvant chemotherapy are associated with poor outcome after cytoreduction and HIPEC. Ann Surg Oncol. 2018;25(8):2347\u201356. https:\/\/doi.org\/10.1245\/s10434-018-6539-x published Online First: Epub Date.","journal-title":"Ann Surg Oncol"},{"issue":"12","key":"2197_CR5","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1046\/j.1365-2168.2002.02274.x","volume":"89","author":"DG Jayne","year":"2002","unstructured":"Jayne DG, Fook S, Loi C, Seow-Choen F. Peritoneal carcinomatosis from colorectal cancer. Br J Surg. 2002;89(12):1545\u201350. https:\/\/doi.org\/10.1046\/j.1365-2168.2002.02274.x published Online First: Epub Date.","journal-title":"Br J Surg"},{"issue":"10","key":"2197_CR6","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1097\/dcr.0000000000000858","volume":"60","author":"K Arakawa","year":"2017","unstructured":"Arakawa K, Kawai K, Ishihara S, et al. Prognostic significance of peritoneal metastasis in stage IV colorectal cancer patients with R0 resection: a multicenter, retrospective study. Dis Colon Rectum. 2017;60(10):1041\u20139. https:\/\/doi.org\/10.1097\/dcr.0000000000000858 published Online First: Epub Date.","journal-title":"Dis Colon Rectum"},{"issue":"7","key":"2197_CR7","doi-asserted-by":"publisher","first-page":"e368","DOI":"10.1016\/s1470-2045(19)30318-3","volume":"20","author":"M Alyami","year":"2019","unstructured":"Alyami M, H\u00fcbner M, Grass F, et al. Pressurised intraperitoneal aerosol chemotherapy: rationale, evidence, and potential indications. Lancet Oncol. 2019;20(7):e368\u2013e77. https:\/\/doi.org\/10.1016\/s1470-2045(19)30318-3 published Online First: Epub Date.","journal-title":"Lancet Oncol"},{"issue":"2","key":"2197_CR8","first-page":"678","volume":"9","author":"T Marutsuka","year":"2003","unstructured":"Marutsuka T, Shimada S, Shiomori K, Hayashi N, Yagi Y, Yamane T, Ogawa M. Mechanisms of peritoneal metastasis after operation for non-serosa-invasive gastric carcinoma: an ultrarapid detection system for intraperitoneal free cancer cells and a prophylactic strategy for peritoneal metastasis. Clin Cancer Res. 2003;9(2):678\u201385.","journal-title":"Clin Cancer Res"},{"key":"2197_CR9","doi-asserted-by":"publisher","first-page":"340380","DOI":"10.1155\/2012\/340380","volume":"2012","author":"M Kuramoto","year":"2012","unstructured":"Kuramoto M, Shimada S, Ikeshima S, et al. A proposal of a practical and optimal prophylactic strategy for peritoneal recurrence. J Oncol. 2012;2012:340380. https:\/\/doi.org\/10.1155\/2012\/340380 published Online First: Epub Date.","journal-title":"J Oncol"},{"key":"2197_CR10","doi-asserted-by":"publisher","unstructured":"Glehen O, Osinsky D, Beaujard AC, Gilly FN. Natural history of peritoneal carcinomatosis from nongynecologic malignancies. Surg Oncol Clin N Am 2003;12(3):729-739, xiii doi: https:\/\/doi.org\/10.1016\/s1055-3207(03)00044-9[published Online First: Epub Date]|.","DOI":"10.1016\/s1055-3207(03)00044-9"},{"issue":"11","key":"2197_CR11","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1016\/j.ejso.2019.06.020","volume":"45","author":"M Tonello","year":"2019","unstructured":"Tonello M, Sommariva A, Pirozzolo G, Mattara G, Pilati P, et al. Eur J Surg Oncol. 2019;45(11):2003\u20138. https:\/\/doi.org\/10.1016\/j.ejso.2019.06.020 published Online First: Epub Date.","journal-title":"Eur J Surg Oncol"},{"issue":"11","key":"2197_CR12","doi-asserted-by":"publisher","first-page":"3299","DOI":"10.1245\/s10434-008-0070-4","volume":"15","author":"F Aarts","year":"2008","unstructured":"Aarts F, Bleichrodt RP, de Man B, Lomme R, Boerman OC, Hendriks T. The effects of adjuvant experimental radioimmunotherapy and hyperthermic intraperitoneal chemotherapy on intestinal and abdominal healing after cytoreductive surgery for peritoneal carcinomatosis in the rat. Ann Surg Oncol. 2008;15(11):3299\u2013307. https:\/\/doi.org\/10.1245\/s10434-008-0070-4 published Online First: Epub Date.","journal-title":"Ann Surg Oncol"},{"issue":"11","key":"2197_CR13","doi-asserted-by":"publisher","first-page":"3274","DOI":"10.1245\/s10434-007-9509-2","volume":"14","author":"F Aarts","year":"2007","unstructured":"Aarts F, Hendriks T, Boerman OC, Koppe MJ, Oyen WJ, Bleichrodt RP. A comparison between radioimmunotherapy and hyperthermic intraperitoneal chemotherapy for the treatment of peritoneal carcinomatosis of colonic origin in rats. Ann Surg Oncol. 2007;14(11):3274\u201382. https:\/\/doi.org\/10.1245\/s10434-007-9509-2 published Online First: Epub Date.","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"2197_CR14","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1038\/s41467-018-03210-2","volume":"9","author":"X Wu","year":"2018","unstructured":"Wu X, Tang P, Li S, et al. A randomized and open-label phase II trial reports the efficacy of neoadjuvant lobaplatin in breast cancer. Nat Commun. 2018;9(1):832. https:\/\/doi.org\/10.1038\/s41467-018-03210-2 published Online First: Epub Date.","journal-title":"Nat Commun"},{"issue":"3","key":"2197_CR15","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/s41419-019-1441-4","volume":"10","author":"J Yu","year":"2019","unstructured":"Yu J, Li S, Qi J, et al. Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells. Cell Death Dis. 2019;10(3):193. https:\/\/doi.org\/10.1038\/s41419-019-1441-4 published Online First: Epub Date.","journal-title":"Cell Death Dis"},{"key":"2197_CR16","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.biopha.2018.09.063","volume":"108","author":"L Shan","year":"2018","unstructured":"Shan L, Bai B, Lv Y, Xie B, Huang X, Zhu H. Lobaplatin suppresses proliferation and peritoneal metastasis of colorectal cancer in a preclinical model. Biomed Pharmacother. 2018;108:486\u201391. https:\/\/doi.org\/10.1016\/j.biopha.2018.09.063 published Online First: Epub Date.","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"2197_CR17","first-page":"442","volume":"24","author":"HT Zhou","year":"2019","unstructured":"Zhou HT, Jiang J, Guan X, et al. The short-term effect analysis of intraoperative intraperitoneal perfusion chemotherapy with lobaplatin for colorectal cancer. J BUON. 2019;24(2):442\u20138.","journal-title":"J BUON"},{"issue":"24","key":"2197_CR18","doi-asserted-by":"publisher","first-page":"5986","DOI":"10.7150\/jca.35450","volume":"10","author":"Z Liu","year":"2019","unstructured":"Liu Z, Zou Y, Rong Y, et al. Intraoperative chemotherapy with a novel regimen improved the therapeutic outcomes of colorectal cancer. J Cancer. 2019;10(24):5986\u201391. https:\/\/doi.org\/10.7150\/jca.35450 published Online First: Epub Date.","journal-title":"J Cancer"},{"issue":"11","key":"2197_CR19","doi-asserted-by":"publisher","first-page":"4173","DOI":"10.1007\/s00784-019-02856-6","volume":"23","author":"K Y\u0131lmaz","year":"2019","unstructured":"Y\u0131lmaz K, T\u00fcfenk\u00e7i P, Ad\u0131g\u00fczel M. The effects of QMix and EndoActivator on postoperative pain in mandibular molars with nonvital pulps: a randomized clinical trial. Clin Oral Investig. 2019;23(11):4173\u201380. https:\/\/doi.org\/10.1007\/s00784-019-02856-6 published Online First: Epub Date.","journal-title":"Clin Oral Investig"},{"issue":"1","key":"2197_CR20","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12871-016-0261-7","volume":"16","author":"R Laufenberg-Feldmann","year":"2016","unstructured":"Laufenberg-Feldmann R, Kappis B, Mauff S, Schmidtmann I, Ferner M. Prevalence of pain 6 months after surgery: a prospective observational study. BMC Anesthesiol. 2016;16(1):91. https:\/\/doi.org\/10.1186\/s12871-016-0261-7 published Online First: Epub Date.","journal-title":"BMC Anesthesiol"},{"issue":"2","key":"2197_CR21","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","volume":"240","author":"D Dindo","year":"2004","unstructured":"Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205\u201313. https:\/\/doi.org\/10.1097\/01.sla.0000133083.54934.ae published Online First: Epub Date.","journal-title":"Ann Surg"},{"issue":"1","key":"2197_CR22","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/bf02055676","volume":"40","author":"DI Obrand","year":"1997","unstructured":"Obrand DI, Gordon PH. Incidence and patterns of recurrence following curative resection for colorectal carcinoma. Dis Colon Rectum. 1997;40(1):15\u201324. https:\/\/doi.org\/10.1007\/bf02055676 published Online First: Epub Date.","journal-title":"Dis Colon Rectum"},{"issue":"4","key":"2197_CR23","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1080\/00015458.2015.11681109","volume":"115","author":"LF Abreu de Carvalho","year":"2015","unstructured":"Abreu de Carvalho LF, Scuderi V, Maes H, et al. Simultaneous parenchyma-preserving liver resection, cytoreductive surgery and intraperitoneal chemotherapy for stage IV colorectal cancer. Acta Chir Belg. 2015;115(4):261\u20137. https:\/\/doi.org\/10.1080\/00015458.2015.11681109 published Online First: Epub Date.","journal-title":"Acta Chir Belg"},{"issue":"7","key":"2197_CR24","doi-asserted-by":"publisher","first-page":"538","DOI":"10.4251\/wjgo.v11.i7.538","volume":"11","author":"ZJ Wang","year":"2019","unstructured":"Wang ZJ, Tao JH, Chen JN, et al. Intraoperative intraperitoneal chemotherapy increases the incidence of anastomotic leakage after anterior resection of rectal tumors. World J Gastrointest Oncol. 2019;11(7):538\u201350. https:\/\/doi.org\/10.4251\/wjgo.v11.i7.538 published Online First: Epub Date.","journal-title":"World J Gastrointest Oncol"},{"issue":"6","key":"2197_CR25","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.ejso.2015.08.161","volume":"42","author":"V Leung","year":"2016","unstructured":"Leung V, Huang N, Liauw W, Morris DL. High risk features of primary colorectal carcinomas which subsequently undergo peritonectomy. Eur J Surg Oncol. 2016;42(6):836\u201340. https:\/\/doi.org\/10.1016\/j.ejso.2015.08.161 published Online First: Epub Date.","journal-title":"Eur J Surg Oncol"},{"issue":"4","key":"2197_CR26","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1016\/s0016-5085(97)70119-7","volume":"112","author":"NA Shepherd","year":"1997","unstructured":"Shepherd NA, Baxter KJ, Love SB. The prognostic importance of peritoneal involvement in colonic cancer: a prospective evaluation. Gastroenterology. 1997;112(4):1096\u2013102. https:\/\/doi.org\/10.1016\/s0016-5085(97)70119-7 published Online First: Epub Date.","journal-title":"Gastroenterology"},{"issue":"10","key":"2197_CR27","first-page":"1006","volume":"18","author":"L Feng","year":"2015","unstructured":"Feng L, Liu Y, Wu X, Liu Q, Xia D, Xu L. Safety evaluation of intraoperative peritoneal chemotherapy with Lobaplatin for advanced colorectal cancers. Zhonghua Wei Chang Wai Ke Za Zhi. 2015;18(10):1006\u201310.","journal-title":"Zhonghua Wei Chang Wai Ke Za Zhi"}],"container-title":["World Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-021-02197-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12957-021-02197-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-021-02197-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T13:05:27Z","timestamp":1616418327000},"score":1,"resource":{"primary":{"URL":"https:\/\/wjso.biomedcentral.com\/articles\/10.1186\/s12957-021-02197-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,22]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2197"],"URL":"https:\/\/doi.org\/10.1186\/s12957-021-02197-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-142137\/v1","asserted-by":"object"}]},"ISSN":["1477-7819"],"issn-type":[{"value":"1477-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,22]]},"assertion":[{"value":"5 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by the institutional review board of The Second Hospital of Jilin University. Due to the retrospective design of the study, the local ethic committee confirmed that informed consent was not necessary from participants. The demand of patient informed consent was deserted because of the retrospective nature of this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"84"}}