{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:35:33Z","timestamp":1760369733238,"version":"3.37.3"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T00:00:00Z","timestamp":1622851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T00:00:00Z","timestamp":1622851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The incidence of gallbladder carcinoma (GBM) in China has increased in recent years. Here, the functional mechanism of lncRNA TTN-AS1 in GBC was preliminary elucidated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The expression levels of lncRNA TTN-AS1, miR-107, and HMGA1 in tissues and cell lines were assessed by RT-qPCR. Cell proliferation was measured by MTT assays. Cell invasion and migration abilities were evaluated by Transwell assays. The relationship between miR-107 and lncRNA TTN-AS1 or HMGA1 was confirmed by luciferase reporter assay.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Upregulation of lncRNA TTN-AS1 and downregulation of miR-107 were detected in GBC. Furthermore, the expressions between TTN-AS1 and miR-107 were mutually inhibited in GBC. Functionally, lncRNA TTN-AS1 promoted cell viability and motility in GBC by sponging miR-107. In addition, miR-107 directly targets HMGA1. And HMGA1 can be positively regulated by lncRNA TTN-AS1 in GBC. Furthermore, HMGA1 promoted GBC progression by interacting with lncRNA TTN-AS1\/miR-107 axis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>LncRNA TTN-AS1 acted as a tumor promoter in GBC by sponging miR-107 and upregulating HMGA1.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12957-021-02279-2","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T14:03:01Z","timestamp":1622901781000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["LncRNA TTN-AS1 acts as a tumor promoter in gallbladder carcinoma by regulating miR-107\/HMGA1 axis"],"prefix":"10.1186","volume":"19","author":[{"given":"Zhaoxia","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaosheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongfeng","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9811-4775","authenticated-orcid":false,"given":"Han","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,5]]},"reference":[{"issue":"2","key":"2279_CR1","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1634\/theoncologist.2009-0302","volume":"15","author":"AX Zhu","year":"2010","unstructured":"Zhu AX, Hong TS, Hezel AF, Kooby DA. Current management of gallbladder carcinoma. Oncologist. 2010;15(2):168\u201381. https:\/\/doi.org\/10.1634\/theoncologist.2009-0302.","journal-title":"Oncologist."},{"issue":"5","key":"2279_CR2","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.7314\/APJCP.2013.14.5.2711","volume":"14","author":"V Srivastava","year":"2013","unstructured":"Srivastava V, Patel B, Kumar M, Shukla M, Pandey M. Cyclin D1, retinoblastoma and p16 protein expression in carcinoma of the gallbladder. Asian Pac J Cancer Prev. 2013;14(5):2711\u20135. https:\/\/doi.org\/10.7314\/APJCP.2013.14.5.2711.","journal-title":"Asian Pac J Cancer Prev"},{"issue":"8","key":"2279_CR3","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1002\/jso.20531","volume":"93","author":"M Pandey","year":"2006","unstructured":"Pandey M. Environmental pollutants in gallbladder carcinogenesis. J Surg Oncol. 2006;93(8):640\u20133. https:\/\/doi.org\/10.1002\/jso.20531.","journal-title":"J Surg Oncol"},{"issue":"6","key":"2279_CR4","doi-asserted-by":"publisher","first-page":"349","DOI":"10.3322\/canjclin.51.6.349","volume":"51","author":"EC Lazcano-Ponce","year":"2001","unstructured":"Lazcano-Ponce EC, Miquel JF, Munoz N, Herrero R, Ferrecio C, Wistuba II, et al. Epidemiology and molecular pathology of gallbladder cancer. CA Cancer J Clin. 2001;51(6):349\u201364. https:\/\/doi.org\/10.3322\/canjclin.51.6.349.","journal-title":"CA Cancer J Clin."},{"key":"2279_CR5","doi-asserted-by":"publisher","first-page":"100173","DOI":"10.1016\/j.ctarc.2020.100173","volume":"23","author":"R Dixit","year":"2020","unstructured":"Dixit R, Pandey M, Tripathi SK, Dwivedi AND, Shukla VK. Genetic mutational analysis of beta-catenin gene affecting GSK-3beta phosphorylation plays a role in gallbladder carcinogenesis: results from a case control study. Cancer Treat Res Commun. 2020;23:100173. https:\/\/doi.org\/10.1016\/j.ctarc.2020.100173.","journal-title":"Cancer Treat Res Commun"},{"issue":"1","key":"2279_CR6","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s12029-015-9794-0","volume":"47","author":"R Dixit","year":"2016","unstructured":"Dixit R, Singh G, Pandey M, Basu S, Bhartiya SK, Singh KK, et al. Association of methylenetetrahydrafolate reductase gene polymorphism (MTHFR) in patients with gallbladder cancer. J Gastrointest Cancer. 2016;47(1):55\u201360. https:\/\/doi.org\/10.1007\/s12029-015-9794-0.","journal-title":"J Gastrointest Cancer"},{"issue":"9","key":"2279_CR7","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/nrc1429","volume":"4","author":"II Wistuba","year":"2004","unstructured":"Wistuba II, Gazdar AF. Gallbladder cancer: lessons from a rare tumour. Nat Rev Cancer. 2004;4(9):695\u2013706. https:\/\/doi.org\/10.1038\/nrc1429.","journal-title":"Nat Rev Cancer."},{"issue":"2","key":"2279_CR8","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1245\/s10434-013-3292-z","volume":"21","author":"XS Wu","year":"2014","unstructured":"Wu XS, Shi LB, Li ML, Ding Q, Weng H, Wu WG, et al. Evaluation of two inflammation-based prognostic scores in patients with resectable gallbladder carcinoma. Ann Surg Oncol. 2014;21(2):449\u201357. https:\/\/doi.org\/10.1245\/s10434-013-3292-z.","journal-title":"Ann Surg Oncol."},{"issue":"3","key":"2279_CR9","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1007\/s10620-016-4438-1","volume":"62","author":"R Dixit","year":"2017","unstructured":"Dixit R, Pandey M, Tripathi SK, Dwivedi AN, Shukla VK. Comparative analysis of mutational profile of sonic hedgehog gene in gallbladder cancer. Dig Dis Sci. 2017;62(3):708\u201314. https:\/\/doi.org\/10.1007\/s10620-016-4438-1.","journal-title":"Dig Dis Sci"},{"key":"2279_CR10","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.gene.2018.12.086","volume":"694","author":"C Liang","year":"2019","unstructured":"Liang C, Yang P, Han T, Wang RY, Xing XL, Si AF, et al. Long non-coding RNA DILC promotes the progression of gallbladder carcinoma. Gene. 2019;694:102\u201310. https:\/\/doi.org\/10.1016\/j.gene.2018.12.086.","journal-title":"Gene."},{"issue":"1","key":"2279_CR11","first-page":"15","volume":"6","author":"SH Wang","year":"2016","unstructured":"Wang SH, Wu XC, Zhang MD, Weng MZ, Zhou D, Quan ZW. Upregulation of H19 indicates a poor prognosis in gallbladder carcinoma and promotes epithelial-mesenchymal transition. Am J Cancer Res. 2016;6(1):15\u201326.","journal-title":"Am J Cancer Res."},{"issue":"1","key":"2279_CR12","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.bbrc.2019.04.050","volume":"514","author":"J Luo","year":"2019","unstructured":"Luo J, Liu Z. Long non-coding RNA TTN-AS1 promotes the progression of lung adenocarcinoma by regulating PTEN\/PI3K\/AKT signaling pathway. Biochem Biophys Res Commun. 2019;514(1):140\u20137. https:\/\/doi.org\/10.1016\/j.bbrc.2019.04.050.","journal-title":"Biochem Biophys Res Commun."},{"issue":"19","key":"2279_CR13","doi-asserted-by":"publisher","first-page":"8374","DOI":"10.18632\/aging.102325","volume":"11","author":"D Fu","year":"2019","unstructured":"Fu D, Lu C, Qu X, Li P, Chen K, Shan L, et al. LncRNA TTN-AS1 regulates osteosarcoma cell apoptosis and drug resistance via the miR-134-5p\/MBTD1 axis. Aging. 2019;11(19):8374\u201385. https:\/\/doi.org\/10.18632\/aging.102325.","journal-title":"Aging."},{"issue":"18","key":"2279_CR14","doi-asserted-by":"publisher","first-page":"7816","DOI":"10.26355\/eurrev_201909_18991","volume":"23","author":"JF Luo","year":"2019","unstructured":"Luo JF, Xu J, Zheng JZ. Long non-coding RNA TTN-AS1 promotes cell proliferation and inhibits cell apoptosis in prostatic cancer by sponging miR-193a-5p. Eur Rev Med Pharmacol Sci. 2019;23(18):7816\u201325. https:\/\/doi.org\/10.26355\/eurrev_201909_18991.","journal-title":"Eur Rev Med Pharmacol Sci."},{"issue":"8","key":"2279_CR15","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/s41419-019-1811-y","volume":"10","author":"Y Jia","year":"2019","unstructured":"Jia Y, Duan Y, Liu T, Wang X, Lv W, Wang M, et al. LncRNA TTN-AS1 promotes migration, invasion, and epithelial mesenchymal transition of lung adenocarcinoma via sponging miR-142-5p to regulate CDK5. Cell Death Dis. 2019;10(8):573. https:\/\/doi.org\/10.1038\/s41419-019-1811-y.","journal-title":"Cell Death Dis."},{"issue":"6","key":"2279_CR16","doi-asserted-by":"publisher","first-page":"967","DOI":"10.3727\/096504016X14803476672380","volume":"25","author":"F Liu","year":"2017","unstructured":"Liu F, Liu S, Ai F, Zhang D, Xiao Z, Nie X, et al. miR-107 promotes proliferation and inhibits apoptosis of colon cancer cells by targeting prostate apoptosis response-4 (Par4). Oncol Res. 2017;25(6):967\u201374. https:\/\/doi.org\/10.3727\/096504016X14803476672380.","journal-title":"Oncol Res."},{"issue":"5","key":"2279_CR17","first-page":"5168","volume":"8","author":"JJ Zhang","year":"2015","unstructured":"Zhang JJ, Wang CY, Hua L, Yao KH, Chen JT, Hu JH. miR-107 promotes hepatocellular carcinoma cell proliferation by targeting Axin2. Int J Clin Exp Pathol. 2015;8(5):5168\u201374.","journal-title":"Int J Clin Exp Pathol."},{"issue":"2","key":"2279_CR18","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.yexcr.2017.10.033","volume":"361","author":"J Xiong","year":"2017","unstructured":"Xiong J, Wang D, Wei A, Lu H, Tan C, Li A, et al. Deregulated expression of miR-107 inhibits metastasis of PDAC through inhibition PI3K\/Akt signaling via caveolin-1 and PTEN. Exp Cell Res. 2017;361(2):316\u201323. https:\/\/doi.org\/10.1016\/j.yexcr.2017.10.033.","journal-title":"Exp Cell Res."},{"key":"2279_CR19","doi-asserted-by":"crossref","unstructured":"Zhang X, Jin K, Luo JD, Liu B, Xie LP. MicroRNA-107 inhibits proliferation of prostate cancer cells by targeting cyclin E1. Neoplasma. 2019;2019.","DOI":"10.4149\/neo_2018_181105N825"},{"issue":"2","key":"2279_CR20","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.bbrc.2019.03.009","volume":"512","author":"Z Tang","year":"2019","unstructured":"Tang Z, Fang Y, Du R. MicroRNA-107 induces cell cycle arrests by directly targeting cyclin E1 in ovarian cancer. Biochem Biophys Res Commun. 2019;512(2):331\u20137. https:\/\/doi.org\/10.1016\/j.bbrc.2019.03.009.","journal-title":"Biochem Biophys Res Commun."},{"key":"2279_CR21","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.micpath.2018.04.060","volume":"121","author":"F Cheng","year":"2018","unstructured":"Cheng F, Yang Z, Huang F, Yin L, Yan G, Gong G. microRNA-107 inhibits gastric cancer cell proliferation and metastasis by targeting PI3K\/AKT pathway. Microb Pathog. 2018;121:110\u20134. https:\/\/doi.org\/10.1016\/j.micpath.2018.04.060.","journal-title":"Microb Pathog."},{"issue":"2","key":"2279_CR22","doi-asserted-by":"publisher","first-page":"690","DOI":"10.26355\/eurrev_201901_16882","volume":"23","author":"XF Wu","year":"2019","unstructured":"Wu XF, Lu JT, Chen W, Wang N, Meng JC, Zhou YH. Mechanism of LncRNA FOXC2-AC1 promoting lung cancer metastasis by regulating miR-107. Eur Rev Med Pharmacol Sci. 2019;23(2):690\u20138. https:\/\/doi.org\/10.26355\/eurrev_201901_16882.","journal-title":"Eur Rev Med Pharmacol Sci."},{"issue":"1","key":"2279_CR23","first-page":"36","volume":"9","author":"J Ren","year":"2019","unstructured":"Ren J, Yang M, Xu F, Chen J. microRNA-758 inhibits the malignant phenotype of osteosarcoma cells by directly targeting HMGA1 and deactivating the Wnt\/beta-catenin pathway. Am J Cancer Res. 2019;9(1):36\u201352.","journal-title":"Am J Cancer Res."},{"issue":"6","key":"2279_CR24","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1038\/bjc.2016.234","volume":"115","author":"KS Chandrasekaran","year":"2016","unstructured":"Chandrasekaran KS, Sathyanarayanan A, Karunagaran D. MicroRNA-214 suppresses growth, migration and invasion through a novel target, high mobility group AT-hook 1, in human cervical and colorectal cancer cells. Br J Cancer. 2016;115(6):741\u201351. https:\/\/doi.org\/10.1038\/bjc.2016.234.","journal-title":"Br J Cancer."},{"issue":"6","key":"2279_CR25","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/s41419-018-0683-x","volume":"9","author":"F Fu","year":"2018","unstructured":"Fu F, Wang T, Wu Z, Feng Y, Wang W, Zhou S, et al. HMGA1 exacerbates tumor growth through regulating the cell cycle and accelerates migration\/invasion via targeting miR-221\/222 in cervical cancer. Cell Death Dis. 2018;9(6):594. https:\/\/doi.org\/10.1038\/s41419-018-0683-x.","journal-title":"Cell Death Dis."},{"issue":"4","key":"2279_CR26","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.bbrc.2016.01.122","volume":"470","author":"WB Zhou","year":"2016","unstructured":"Zhou WB, Zhong CN, Luo XP, Zhang YY, Zhang GY, Zhou DX, et al. miR-625 suppresses cell proliferation and migration by targeting HMGA1 in breast cancer. Biochem Biophys Res Commun. 2016;470(4):838\u201344. https:\/\/doi.org\/10.1016\/j.bbrc.2016.01.122.","journal-title":"Biochem Biophys Res Commun."},{"issue":"1","key":"2279_CR27","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s12943-019-1097-9","volume":"18","author":"YP Hu","year":"2019","unstructured":"Hu YP, Jin YP, Wu XS, Yang Y, Li YS, Li HF, et al. LncRNA-HGBC stabilized by HuR promotes gallbladder cancer progression by regulating miR-502-3p\/SET\/AKT axis. Mol Cancer. 2019;18(1):167. https:\/\/doi.org\/10.1186\/s12943-019-1097-9.","journal-title":"Mol Cancer."},{"issue":"18","key":"2279_CR28","doi-asserted-by":"publisher","first-page":"7678","DOI":"10.18632\/aging.102280","volume":"11","author":"S Li","year":"2019","unstructured":"Li S, Liu F, Pei Y, Wang W, Zheng K, Zhang X. Long noncoding RNA TTN-AS1 enhances the malignant characteristics of osteosarcoma by acting as a competing endogenous RNA on microRNA-376a thereby upregulating dickkopf-1. Aging. 2019;11(18):7678\u201393. https:\/\/doi.org\/10.18632\/aging.102280.","journal-title":"Aging."},{"issue":"04","key":"2279_CR29","doi-asserted-by":"publisher","first-page":"564","DOI":"10.4149\/neo_2018_180927N721","volume":"66","author":"MM Dong","year":"2019","unstructured":"Dong MM, Peng SJ, Yuan YN, Luo HP. LncRNA TTN-AS1 contributes to gastric cancer progression by acting as a competing endogenous RNA of miR-376b-3p. Neoplasma. 2019;66(04):564\u201375. https:\/\/doi.org\/10.4149\/neo_2018_180927N721.","journal-title":"Neoplasma."},{"issue":"10","key":"2279_CR30","doi-asserted-by":"publisher","first-page":"17131","DOI":"10.1002\/jcb.28973","volume":"120","author":"Y Zhong","year":"2019","unstructured":"Zhong Y, Wang J, Lv W, Xu J, Mei S, Shan A. LncRNA TTN-AS1 drives invasion and migration of lung adenocarcinoma cells via modulation of miR-4677-3p\/ZEB1 axis. J Cell Biochem. 2019;120(10):17131\u201341. https:\/\/doi.org\/10.1002\/jcb.28973.","journal-title":"J Cell Biochem."},{"issue":"5","key":"2279_CR31","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.3083","volume":"21","author":"Z Cui","year":"2019","unstructured":"Cui Z, Luo Z, Lin Z, Shi L, Hong Y, Yan C. Long non-coding RNA TTN-AS1 facilitates tumorigenesis of papillary thyroid cancer through modulating the miR-153-3p\/ZNRF2 axis. J Gene Med. 2019;21(5):e3083. https:\/\/doi.org\/10.1002\/jgm.3083.","journal-title":"J Gene Med."},{"key":"2279_CR32","doi-asserted-by":"crossref","unstructured":"Wang Y, Jiang F, Xiong Y, Cheng X, Qiu Z, Song R. LncRNA TTN-AS1 sponges miR-376a-3p to promote colorectal cancer progression via upregulating KLF15. Life Sci. 2019;116936.","DOI":"10.1016\/j.lfs.2019.116936"},{"issue":"4","key":"2279_CR33","doi-asserted-by":"publisher","first-page":"2956","DOI":"10.1016\/j.bbrc.2018.08.077","volume":"503","author":"P Chen","year":"2018","unstructured":"Chen P, Wang R, Yue Q, Hao M. Long non-coding RNA TTN-AS1 promotes cell growth and metastasis in cervical cancer via miR-573\/E2F3. Biochem Biophys Res Commun. 2018;503(4):2956\u201362. https:\/\/doi.org\/10.1016\/j.bbrc.2018.08.077.","journal-title":"Biochem Biophys Res Commun."},{"issue":"5","key":"2279_CR34","doi-asserted-by":"publisher","first-page":"3116","DOI":"10.3892\/or.2017.5546","volume":"37","author":"P Sharma","year":"2017","unstructured":"Sharma P, Saini N, Sharma R. miR-107 functions as a tumor suppressor in human esophageal squamous cell carcinoma and targets Cdc42. Oncol Rep. 2017;37(5):3116\u201327. https:\/\/doi.org\/10.3892\/or.2017.5546.","journal-title":"Oncol Rep."},{"issue":"1","key":"2279_CR35","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1186\/s12935-019-0968-x","volume":"19","author":"HY Zhang","year":"2019","unstructured":"Zhang HY, Xing MQ, Guo J, Zhao JC, Chen X, Jiang Z, et al. Long noncoding RNA DLX6-AS1 promotes neuroblastoma progression by regulating miR-107\/BDNF pathway. Cancer Cell Int. 2019;19(1):313. https:\/\/doi.org\/10.1186\/s12935-019-0968-x.","journal-title":"Cancer Cell Int."},{"issue":"5","key":"2279_CR36","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1159\/000493625","volume":"49","author":"X Rui","year":"2018","unstructured":"Rui X, Xu Y, Huang Y, Ji L, Jiang X. lncRNA DLG1-AS1 promotes cell proliferation by competitively binding with miR-107 and up-regulating ZHX1 expression in cervical cancer. Cell Physiol Biochem. 2018;49(5):1792\u2013803. https:\/\/doi.org\/10.1159\/000493625.","journal-title":"Cell Physiol Biochem."},{"issue":"6","key":"2279_CR37","doi-asserted-by":"publisher","first-page":"915","DOI":"10.7754\/Clin.Lab.2017.171114","volume":"64","author":"XP Jia","year":"2018","unstructured":"Jia XP, Meng LL, Fang JC, Wang HW, Chen J, Zhou J, et al. Aberrant expression of miR-142-3p and its target gene HMGA1 and FZD7 in breast cancer and its clinical significance. Clin Lab. 2018;64(6):915\u201321. https:\/\/doi.org\/10.7754\/Clin.Lab.2017.171114.","journal-title":"Clin Lab."},{"issue":"6","key":"2279_CR38","doi-asserted-by":"publisher","first-page":"8303","DOI":"10.3892\/ol.2018.8359","volume":"15","author":"J Liu","year":"2018","unstructured":"Liu J, Mi B, Wang Y, Shi C, Mi X, Lu Y, et al. miR-26a suppresses osteosarcoma migration and invasion by directly targeting HMGA1. Oncol Lett. 2018;15(6):8303\u201310. https:\/\/doi.org\/10.3892\/ol.2018.8359.","journal-title":"Oncol Lett."},{"issue":"5","key":"2279_CR39","first-page":"2149","volume":"8","author":"J Wang","year":"2016","unstructured":"Wang J, Xu X, Mo S, Tian Y, Wu J, Zhang J, et al. Involvement of microRNA-1297, a new regulator of HMGA1, in the regulation of glioma cell growth in vivo and in vitro. Am J Transl Res. 2016;8(5):2149\u201358.","journal-title":"Am J Transl Res."},{"issue":"15","key":"2279_CR40","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1016\/j.febslet.2013.06.021","volume":"587","author":"Y Lin","year":"2013","unstructured":"Lin Y, Chen H, Hu Z, Mao Y, Xu X, Zhu Y, et al. miR-26a inhibits proliferation and motility in bladder cancer by targeting HMGA1. FEBS Lett. 2013;587(15):2467\u201373. https:\/\/doi.org\/10.1016\/j.febslet.2013.06.021.","journal-title":"FEBS Lett."},{"issue":"5","key":"2279_CR41","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1159\/000358700","volume":"33","author":"G Xu","year":"2014","unstructured":"Xu G, Wang J, Jia Y, Shen F, Han W, Kang Y. MiR-142-3p functions as a potential tumor suppressor in human osteosarcoma by targeting HMGA1. Cell Physiol Biochem. 2014;33(5):1329\u201339. https:\/\/doi.org\/10.1159\/000358700.","journal-title":"Cell Physiol Biochem."}],"container-title":["World Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-021-02279-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12957-021-02279-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-021-02279-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T14:03:55Z","timestamp":1622901835000},"score":1,"resource":{"primary":{"URL":"https:\/\/wjso.biomedcentral.com\/articles\/10.1186\/s12957-021-02279-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,5]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2279"],"URL":"https:\/\/doi.org\/10.1186\/s12957-021-02279-2","relation":{},"ISSN":["1477-7819"],"issn-type":[{"type":"electronic","value":"1477-7819"}],"subject":[],"published":{"date-parts":[[2021,6,5]]},"assertion":[{"value":"22 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of Jinan Central Hospital Affiliated to Shandong University. Signed written informed consents were obtained from the patients and\/or guardians.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"163"}}