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Immunohistochemical analysis was conducted to evaluate the expression of PD-L1 and the infiltration of CD8+ T cells.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In the total cohort, the results showed that CD8<jats:sup>+<\/jats:sup> TIL density was positively correlated with tumoral (<jats:italic>p<\/jats:italic>\u00a0=\u20090.0001) and stromal PD-L1 expression (<jats:italic>p<\/jats:italic>\u00a0=\u20090.0102). But there were no correlation between schistosomiasis and CD8+ TILs and PD-L1. Furthermore, CD8<jats:sup>+<\/jats:sup> TIL density (<jats:italic>p<\/jats:italic>\u2009=\u20090.010), schistosomiasis (<jats:italic>p<\/jats:italic>\u2009=\u20090.042) were independent predictive factors for overall survival (OS). Stromal PD-L1 (sPD-L1) was correlated with OS (<jats:italic>p\u2009=\u20090.046<\/jats:italic>), but it was not an independent predictor. In patients without schistosomiasis, CD8\u2009+\u2009T cells (<jats:italic>p<\/jats:italic>\u2009=\u20090.002) and sPD-L1 (<jats:italic>p<\/jats:italic>\u2009=\u20090.005) were associated with better OS. In patients with schistosomiasis, CD8\u2009+\u2009T cells were independent prognosis factor (<jats:italic>p<\/jats:italic>\u2009=\u20090.045).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The study showed that CD8+ TILs was an independent predictive factor for OS in CRC and SCRC patients. The expression of PD-L1 was positively associated with CD8\u2009+\u2009TILs density. There were no correlation between schistosomiasis and CD8\u2009+\u2009TILs and PD-L1. Stromal PD-L1 but not tPD-L1 was significantly associated with OS, whereas it was not an independent prognostic factor.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12957-021-02433-w","type":"journal-article","created":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T15:02:39Z","timestamp":1636297359000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Correlation between schistosomiasis and CD8+ T cell and stromal PD-L1 as well as the different prognostic role of CD8+ T cell and PD-L1 in schistosomal-associated colorectal cancer and non-schistosomal-associated colorectal cancer"],"prefix":"10.1186","volume":"19","author":[{"given":"Weixia","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Jing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jican","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dacheng","family":"Bu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanchao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meihong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junxia","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,7]]},"reference":[{"issue":"3","key":"2433_CR1","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1093\/annonc\/mdu253","volume":"26","author":"D Papamichael","year":"2015","unstructured":"Papamichael D, Audisio RA, Glimelius B, et al. 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