{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:11:17Z","timestamp":1789063877522,"version":"build-2803163510"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T00:00:00Z","timestamp":1672617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T00:00:00Z","timestamp":1672617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Zhejiang Province Medical Project","award":["2020KY248"],"award-info":[{"award-number":["2020KY248"]}]},{"name":"Ningbo Public Welfare Science and Technology Project","award":["202002N3163"],"award-info":[{"award-number":["202002N3163"]}]},{"name":"Scientific Research Program of Shanghai Science and Technology Commission","award":["No.201840357, SKW2038 and SKW1921"],"award-info":[{"award-number":["No.201840357, SKW2038 and SKW1921"]}]},{"name":"Scientific Research Program of Shanghai Science and Technology Commission","award":["No.201840357, SKW2038 and SKW1921"],"award-info":[{"award-number":["No.201840357, SKW2038 and SKW1921"]}]},{"name":"Scientific Research Program of Shanghai Science and Technology Commission","award":["No.201840357, SKW2038 and SKW1921"],"award-info":[{"award-number":["No.201840357, SKW2038 and SKW1921"]}]},{"name":"Clinical Research and Cultivation Project of Shanghai Tongji Hospital","award":["ITJ(ZD)1804"],"award-info":[{"award-number":["ITJ(ZD)1804"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Self-expanding metal stents (SEMS) served as a bridge to surgery (BTS). However, this method may be associated with worse long-term prognosis and relapse of CRC patients. Therefore, we attempted to clarify this in the angle of circulating tumor cells (CTCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicenter study was performed from March 2018 to January 2021. Thirty-two colorectal cancer patients with obstruction were selected, of which 21 patients were performed SEMS as a BTS while 11 patients were performed emergency surgery. Bloods samples were collected in two groups of patients for further detecting CTCs. In the SEMS group, the samples were collected before and after stent insert and after radical surgery performed. In the ES group, the samples were collected before stent insert and after emergency surgery performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The number of CTCs did not show statistically significant differences before and after stent placement (34.90 vs 38.33,\n                      <jats:italic>p<\/jats:italic>\n                      =0.90), neither between the SEMS group and ES group in initial CTC levels (34.90 vs 58.09,\n                      <jats:italic>p<\/jats:italic>\n                      =0.394). No significant differences (38.33 vs 58.09,\n                      <jats:italic>p<\/jats:italic>\n                      =0.632) were observed after stent insert in the SMES group and the initial CTC levels in the ES group. Moreover, no major differences (24.17 vs 42.27,\n                      <jats:italic>p<\/jats:italic>\n                      =0.225) were observed after radical operation performed in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The treatment of SEMS does not cause an increase in the number of CTC after stent insertion. Furthermore, there are may be other factors besides CTC to cause these poorer oncologic outcomes after SEMS placement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12957-022-02879-6","type":"journal-article","created":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T21:02:23Z","timestamp":1672606943000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Impact of endoscopic metallic stent placement and emergency surgery on detection of viable circulating tumor cells for acute malignant left-sided colonic obstruction"],"prefix":"10.1186","volume":"21","author":[{"given":"Zhizhan","family":"Ni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuepeng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenshen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huahao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhe","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bujun","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,2]]},"reference":[{"issue":"3","key":"2879_CR1","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1093\/annonc\/mdu253","volume":"26","author":"D Papamichael","year":"2015","unstructured":"Papamichael D, et al. Treatment of colorectal cancer in older patients: International Society of Geriatric Oncology (SIOG) consensus recommendations 2013. Ann Oncol. 2015;26(3):463\u201376.","journal-title":"Ann Oncol"},{"issue":"10","key":"2879_CR2","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1136\/gutjnl-2014-309086","volume":"64","author":"EH Schreuders","year":"2015","unstructured":"Schreuders EH, et al. Colorectal cancer screening: a global overview of existing programmes. Gut. 2015;64(10):1637\u201349.","journal-title":"Gut"},{"issue":"3","key":"2879_CR3","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.dld.2018.11.006","volume":"51","author":"E Rodrigues-Pinto","year":"2019","unstructured":"Rodrigues-Pinto E, et al. Bridge-to-surgery versus emergency surgery in the management of left-sided acute malignant colorectal obstruction - Efficacy, safety and long-term outcomes. Dig Liver Dis. 2019;51(3):364\u201372.","journal-title":"Dig Liver Dis"},{"issue":"11","key":"2879_CR4","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1055\/s-0034-1390700","volume":"46","author":"JE van Hooft","year":"2014","unstructured":"van Hooft JE, et al. Self-expandable metal stents for obstructing colonic and extracolonic cancer: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline. Endoscopy. 2014;46(11):990\u20131053.","journal-title":"Endoscopy"},{"issue":"4","key":"2879_CR5","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1002\/bjs.8689","volume":"99","author":"CJ Tan","year":"2012","unstructured":"Tan CJ, Dasari BV, Gardiner K. Systematic review and meta-analysis of randomized clinical trials of self-expanding metallic stents as a bridge to surgery versus emergency surgery for malignant left-sided large bowel obstruction. Br J Surg. 2012;99(4):469\u201376.","journal-title":"Br J Surg"},{"issue":"5","key":"2879_CR6","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1159\/000433561","volume":"32","author":"PJ Tanis","year":"2015","unstructured":"Tanis PJ, et al. Resection of Obstructive Left-Sided Colon Cancer at a National Level: A Prospective Analysis of Short-Term Outcomes in 1,816 Patients. Dig Surg. 2015;32(5):317\u201324.","journal-title":"Dig Surg"},{"key":"2879_CR7","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1186\/1479-5876-10-222","volume":"10","author":"A de Albuquerque","year":"2012","unstructured":"de Albuquerque A, et al. Prognostic and predictive value of circulating tumor cell analysis in colorectal cancer patients. J Transl Med. 2012;10:222.","journal-title":"J Transl Med"},{"issue":"2","key":"2879_CR8","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.lungcan.2015.09.008","volume":"90","author":"Q Tu","year":"2015","unstructured":"Tu Q, et al. CellSearch technology applied to the detection and quantification of tumor cells in CSF of patients with lung cancer leptomeningeal metastasis. Lung Cancer. 2015;90(2):352\u20137.","journal-title":"Lung Cancer"},{"issue":"1","key":"2879_CR9","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s12893-021-01144-z","volume":"21","author":"Y Cao","year":"2021","unstructured":"Cao Y, et al. Propensity score-matched comparison of stenting as a bridge to surgery and emergency surgery for acute malignant left-sided colonic obstruction. BMC Surg. 2021;21(1):148.","journal-title":"BMC Surg"},{"issue":"3","key":"2879_CR10","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1007\/s13577-021-00500-8","volume":"34","author":"Y Lu","year":"2021","unstructured":"Lu Y, et al. FlowCell-enriched circulating tumor cells as a predictor of lung cancer metastasis. Hum Cell. 2021;34(3):945\u201351.","journal-title":"Hum Cell"},{"issue":"3","key":"2879_CR11","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1067\/S0016-5107(03)00023-3","volume":"58","author":"TH Baron","year":"2003","unstructured":"Baron TH, Harewood GC. Enteral self-expandable stents. Gastrointest Endosc. 2003;58(3):421\u201333.","journal-title":"Gastrointest Endosc"},{"issue":"25","key":"2879_CR12","first-page":"822","volume":"117","author":"HC Engell","year":"1955","unstructured":"Engell HC. Cancer cells in the circulating blood; a clinical study on the occurrence of cancer cells in the peripheral blood and in venous blood draining the tumour area at operation. Ugeskr Laeger. 1955;117(25):822\u20133.","journal-title":"Ugeskr Laeger"},{"issue":"1","key":"2879_CR13","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1186\/s12885-017-3704-8","volume":"17","author":"C Yang","year":"2017","unstructured":"Yang C, et al. Prognostic and clinicopathological significance of circulating tumor cells detected by RT-PCR in non-metastatic colorectal cancer: a meta-analysis and systematic review. BMC Cancer. 2017;17(1):725.","journal-title":"BMC Cancer"},{"key":"2879_CR14","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1186\/1471-2407-14-976","volume":"14","author":"X Huang","year":"2014","unstructured":"Huang X, et al. Relationship between circulating tumor cells and tumor response in colorectal cancer patients treated with chemotherapy: a meta-analysis. BMC Cancer. 2014;14:976.","journal-title":"BMC Cancer"},{"issue":"1","key":"2879_CR15","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s12967-018-1521-8","volume":"16","author":"C Yang","year":"2018","unstructured":"Yang C, et al. Wedge-shaped microfluidic chip for circulating tumor cells isolation and its clinical significance in gastric cancer. J Transl Med. 2018;16(1):139.","journal-title":"J Transl Med"},{"key":"2879_CR16","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.mam.2019.06.002","volume":"69","author":"M Marcuello","year":"2019","unstructured":"Marcuello M, et al. Circulating biomarkers for early detection and clinical management of colorectal cancer. Mol Asp Med. 2019;69:107\u201322.","journal-title":"Mol Asp Med"},{"issue":"8","key":"2879_CR17","doi-asserted-by":"publisher","first-page":"4589","DOI":"10.1073\/pnas.95.8.4589","volume":"95","author":"E Racila","year":"1998","unstructured":"Racila E, et al. Detection and characterization of carcinoma cells in the blood. Proc Natl Acad Sci U S A. 1998;95(8):4589\u201394.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"2879_CR18","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.molonc.2016.01.007","volume":"10","author":"MM Ferreira","year":"2016","unstructured":"Ferreira MM, Ramani VC, Jeffrey SS. Circulating tumor cell technologies. Mol Oncol. 2016;10(3):374\u201394.","journal-title":"Mol Oncol"},{"issue":"22","key":"2879_CR19","doi-asserted-by":"publisher","first-page":"4393","DOI":"10.1007\/s00018-014-1693-1","volume":"71","author":"O Gires","year":"2014","unstructured":"Gires O, Stoecklein NH. Dynamic EpCAM expression on circulating and disseminating tumor cells: causes and consequences. Cell Mol Life Sci. 2014;71(22):4393\u2013402.","journal-title":"Cell Mol Life Sci"},{"issue":"4","key":"2879_CR20","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.3390\/genes6041053","volume":"6","author":"CF Pixberg","year":"2015","unstructured":"Pixberg CF, et al. Characterization of DNA Methylation in Circulating Tumor Cells. Genes (Basel). 2015;6(4):1053\u201375.","journal-title":"Genes (Basel)"},{"issue":"4","key":"2879_CR21","doi-asserted-by":"publisher","first-page":"R118","DOI":"10.1186\/bcr3243","volume":"14","author":"V Muller","year":"2012","unstructured":"Muller V, et al. Prognostic impact of circulating tumor cells assessed with the CellSearch System and AdnaTest Breast in metastatic breast cancer patients: the DETECT study. Breast Cancer Res. 2012;14(4):R118.","journal-title":"Breast Cancer Res"},{"issue":"3","key":"2879_CR22","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s10549-008-0290-0","volume":"118","author":"AM Sieuwerts","year":"2009","unstructured":"Sieuwerts AM, et al. Molecular characterization of circulating tumor cells in large quantities of contaminating leukocytes by a multiplex real-time PCR. Breast Cancer Res Treat. 2009;118(3):455\u201368.","journal-title":"Breast Cancer Res Treat"},{"key":"2879_CR23","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/712827","volume":"2014","author":"D Nesteruk","year":"2014","unstructured":"Nesteruk D, et al. Evaluation of prognostic significance of circulating tumor cells detection in rectal cancer patients treated with preoperative radiotherapy: prospectively collected material data. Biomed Res Int. 2014;2014:712827.","journal-title":"Biomed Res Int"},{"issue":"1","key":"2879_CR24","first-page":"400","volume":"15","author":"S Yamashita","year":"2018","unstructured":"Yamashita S, et al. Impact of endoscopic stent insertion on detection of viable circulating tumor cells from obstructive colorectal cancer. Oncol Lett. 2018;15(1):400\u20136.","journal-title":"Oncol Lett"},{"issue":"1","key":"2879_CR25","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12885-020-6560-x","volume":"20","author":"JG Han","year":"2020","unstructured":"Han JG, et al. Efficacy and safety of self-expanding metallic stent placement followed by neoadjuvant chemotherapy and scheduled surgery for treatment of obstructing left-sided colonic cancer. BMC Cancer. 2020;20(1):57.","journal-title":"BMC Cancer"},{"issue":"11","key":"2879_CR26","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1007\/s00595-016-1333-5","volume":"46","author":"N Haraguchi","year":"2016","unstructured":"Haraguchi N, et al. Colonic stenting as a bridge to surgery for obstructive colorectal cancer: advantages and disadvantages. Surg Today. 2016;46(11):1310\u20137.","journal-title":"Surg Today"},{"issue":"3","key":"2879_CR27","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s00384-012-1556-x","volume":"28","author":"HJ Kim","year":"2013","unstructured":"Kim HJ, et al. Higher rate of perineural invasion in stent-laparoscopic approach in comparison to emergent open resection for obstructing left-sided colon cancer. Int J Color Dis. 2013;28(3):407\u201314.","journal-title":"Int J Color Dis"},{"issue":"9","key":"2879_CR28","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1002\/bjs.5790","volume":"94","author":"K Maruthachalam","year":"2007","unstructured":"Maruthachalam K, et al. Tumour cell dissemination following endoscopic stent insertion. Br J Surg. 2007;94(9):1151\u20134.","journal-title":"Br J Surg"},{"issue":"3","key":"2879_CR29","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1245\/s10434-017-6300-x","volume":"25","author":"G Takahashi","year":"2018","unstructured":"Takahashi G, et al. Oncological Assessment of Stent Placement for Obstructive Colorectal Cancer from Circulating Cell-Free DNA and Circulating Tumor DNA Dynamics. Ann Surg Oncol. 2018;25(3):737\u201344.","journal-title":"Ann Surg Oncol"}],"container-title":["World Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-022-02879-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12957-022-02879-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-022-02879-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T01:04:45Z","timestamp":1672880685000},"score":1,"resource":{"primary":{"URL":"https:\/\/wjso.biomedcentral.com\/articles\/10.1186\/s12957-022-02879-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,2]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["2879"],"URL":"https:\/\/doi.org\/10.1186\/s12957-022-02879-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2215418\/v1","asserted-by":"object"}]},"ISSN":["1477-7819"],"issn-type":[{"value":"1477-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,2]]},"assertion":[{"value":"29 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by the institutional review board of Tongji Hospital Affiliated to Tongji University (approved no. KYSB-2017-007). The clinical trial was registered (ChiCTR-OON-17010877). Written consent was obtained from all the participants before study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1"}}