{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:05:17Z","timestamp":1792202717228,"version":"4.4.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T00:00:00Z","timestamp":1673222400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T00:00:00Z","timestamp":1673222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It is known that specimen collection followed by histopathological workup is the core of evidence-based medical therapy of musculoskeletal tumors. There exist many controversies about how a biopsy should be performed. While some centers recommend minimal invasive biopsy procedures, mostly the core needle biopsy (CNB), others prefer the incisional biopsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose of the study<\/jats:title>\n                    <jats:p>This study aimed to determine the accuracy of incisional biopsy for malignant tumors in the musculoskeletal system. Moreover, advantages and disadvantages to other biopsy methods are discussed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, single-center study about 844 incisional biopsies (benign and malignant) analysis the diagnostic accuracy of 332 malignant tumors, concerning the final histopathological result. In addition, surgical complications are analyzed to find the best way to plan and treat patients timely and correct. Secondary endpoints are the patients age, the pure operation time, as well as the type of tumor, and the subsequent therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In summary, incisional biopsy corresponded a sensitivity of 100% for malignancy in 844 incisional biopsies and a specificity of 97.6% in 332 malignant tumors, but it features greater operative expense (incision\/suture 23.5 min) and the risk of general anesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The method of biopsy should be tailored to the individual patient and the experience of the center performing the procedure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12957-022-02883-w","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T03:03:54Z","timestamp":1673233434000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The diagnostic accuracy of 332 incisional biopsies in patients with malignant tumors in the musculoskeletal system"],"prefix":"10.1186","volume":"21","author":[{"given":"Michael","family":"Dirks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas K.","family":"Ewerbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias M.","family":"Ballhause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Wei\u00df","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Luebke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Schlickewei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Heinz","family":"Frosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Priemel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,9]]},"reference":[{"issue":"10","key":"2883_CR1","doi-asserted-by":"publisher","first-page":"2774","DOI":"10.1007\/s11999-010-1422-5","volume":"468","author":"SC Adams","year":"2010","unstructured":"Adams SC, et al. Office-based core needle biopsy of bone and soft tissue malignancies: an accurate alternative to open biopsy with infrequent complications. Clin Orthop Relat Res. 2010;468(10):2774\u201380.","journal-title":"Clin Orthop Relat Res"},{"issue":"3","key":"2883_CR2","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1007\/s11999-012-2656-1","volume":"471","author":"Hasham M Alvi","year":"2013","unstructured":"Alvi Hasham M, Damron Timothy A. Prophylactic stabilization for bone metastases, myeloma, or lymphoma: do we need to protect the entire bone? Clin Orthop Relat Res. 2013;471(3):706\u201314.","journal-title":"Clin Orthop Relat Res"},{"issue":"1","key":"2883_CR3","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1186\/s12913-022-07891-w","volume":"22","author":"Tobias M Ballhause","year":"2022","unstructured":"Ballhause Tobias M, et al. Diagnostic delay in soft tissue tumors: a single-center study of a university cancer center with a focus on health services research. BMC Health Services Research. 2022;22(1):452.","journal-title":"BMC Health Services Research"},{"issue":"3","key":"2883_CR4","first-page":"32","volume":"108","author":"H Bannasch","year":"2011","unstructured":"Bannasch H, et al. The diagnosis and treatment of soft tissue sarcomas of the limbs. Dtsch Arztebl Int. 2011;108(3):32\u20138.","journal-title":"Dtsch Arztebl Int"},{"issue":"9","key":"2883_CR5","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1002\/cncr.32735","volume":"126","author":"E Birgin","year":"2020","unstructured":"Birgin E, et al. Core needle biopsy versus incisional biopsy for differentiation of soft-tissue sarcomas: A systematic review and meta-analysis. Cancer. 2020;126(9):1917\u201328.","journal-title":"Cancer"},{"key":"2883_CR6","unstructured":"Claviez, Alexander 2019. S1_Hodgkin_Lymphom_. AWMF online."},{"issue":"1","key":"2883_CR7","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41572-020-00216-3","volume":"6","author":"RE Coleman","year":"2020","unstructured":"Coleman RE, et al. Bone metastases. Nat Rev Dis Primers. 2020;6(1):83.","journal-title":"Nat Rev Dis Primers"},{"key":"2883_CR8","doi-asserted-by":"crossref","unstructured":"E. Koscielniak, T. Klingebiel 2017. S1_Weichteilsarkome. AWMF online.","DOI":"10.1007\/978-3-662-43686-8_27"},{"key":"2883_CR9","doi-asserted-by":"publisher","first-page":"538152","DOI":"10.1155\/2013\/538152","volume":"2013","author":"C Errani","year":"2013","unstructured":"Errani C, et al. Current concepts in the biopsy of musculoskeletal tumors. ScientificWorldJournal. 2013;2013:538152.","journal-title":"ScientificWorldJournal"},{"issue":"2","key":"2883_CR10","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1302\/2058-5241.2.160065","volume":"2","author":"G. Ulrich Exner","year":"2017","unstructured":"Exner G. Ulrich, et al. The tactics and technique of musculoskeletal biopsy. EFORT open reviews. 2017;2(2):51\u20137.","journal-title":"EFORT open reviews"},{"issue":"6","key":"2883_CR11","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s00256-002-0474-3","volume":"31","author":"A Hau","year":"2002","unstructured":"Hau A, et al. Accuracy of CT-guided biopsies in 359 patients with musculoskeletal lesions. Skeletal Radiol. 2002;31(6):349\u201353.","journal-title":"Skeletal Radiol"},{"key":"2883_CR12","doi-asserted-by":"crossref","unstructured":"Henze, G., et al. 2019. Onkologie. P\u00e4diatrie:571-604.","DOI":"10.1007\/978-3-662-57295-5_24"},{"issue":"1","key":"2883_CR13","first-page":"28","volume":"5","author":"J Issakov","year":"2003","unstructured":"Issakov J, et al. Computed tomography-guided core needle biopsy for bone and soft tissue tumors. Isr Med Assoc J. 2003;5(1):28\u201330.","journal-title":"Isr Med Assoc J"},{"issue":"11","key":"2883_CR14","doi-asserted-by":"publisher","first-page":"2992","DOI":"10.1007\/s11999-010-1401-x","volume":"468","author":"S Kasraeian","year":"2010","unstructured":"Kasraeian S, et al. A comparison of fine-needle aspiration, core biopsy, and surgical biopsy in the diagnosis of extremity soft tissue masses. Clin Orthop Relat Res. 2010;468(11):2992\u20133002.","journal-title":"Clin Orthop Relat Res"},{"key":"2883_CR15","doi-asserted-by":"crossref","unstructured":"Klein A, et al. Relative Sensitivity of Core-Needle Biopsy and Incisional Biopsy in the Diagnosis of Musculoskeletal Sarcomas. Cancers (Basel). 2021.","DOI":"10.3390\/cancers13061393"},{"key":"2883_CR16","doi-asserted-by":"crossref","unstructured":"Maroni, P., and P. Bendinelli 2020. Bone, a Secondary Growth Site of Breast and Prostate Carcinomas: Role of Osteocytes. Cancers (Basel) 12(7).","DOI":"10.3390\/cancers12071812"},{"issue":"1","key":"2883_CR17","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/jso.20504","volume":"94","author":"G Mitsuyoshi","year":"2006","unstructured":"Mitsuyoshi G, et al. Accurate diagnosis of musculoskeletal lesions by core needle biopsy. J Surg Oncol. 2006;94(1):21\u20137.","journal-title":"J Surg Oncol"},{"key":"2883_CR18","doi-asserted-by":"crossref","unstructured":"Piya Kiatisevi, 1, et al. 2013. Computed tomography\u2013guided core needle biopsy versus incisional biopsy in diagnosing musculoskeletal lesions. Journal of Orthopaedic Surgery.","DOI":"10.1177\/230949901302100218"},{"issue":"1","key":"2883_CR19","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/2047-783X-17-29","volume":"17","author":"F Pohlig","year":"2012","unstructured":"Pohlig F, et al. Percutaneous core needle biopsy versus open biopsy in diagnostics of bone and soft tissue sarcoma: a retrospective study. Eur J Med Res. 2012;17(1):29.","journal-title":"Eur J Med Res"},{"key":"2883_CR20","doi-asserted-by":"crossref","unstructured":"Soomers, V., et al. 2020. The sarcoma diagnostic interval: a systematic review on length, contributing factors and patient outcomes. ESMO Open 5(1).","DOI":"10.1136\/esmoopen-2019-000592"},{"issue":"2","key":"2883_CR21","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.N.00661","volume":"97","author":"F Traina","year":"2015","unstructured":"Traina F, et al. Current concepts in the biopsy of musculoskeletal tumors: AAOS exhibit selection. J Bone Joint Surg Am. 2015;97(2): e7.","journal-title":"J Bone Joint Surg Am"},{"key":"2883_CR22","doi-asserted-by":"crossref","unstructured":"Weiss, S., et al. 2021. Musculoskeletal Soft-Tissue Sarcoma: Quality Assessment of Initial MRI Reports Shows Frequent Deviation from ESSR Guidelines. Diagnostics (Basel) 11(4).","DOI":"10.3390\/diagnostics11040695"}],"container-title":["World Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-022-02883-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12957-022-02883-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-022-02883-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T03:05:05Z","timestamp":1673233505000},"score":1,"resource":{"primary":{"URL":"https:\/\/wjso.biomedcentral.com\/articles\/10.1186\/s12957-022-02883-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,9]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["2883"],"URL":"https:\/\/doi.org\/10.1186\/s12957-022-02883-w","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2090386\/v1","asserted-by":"object"}]},"ISSN":["1477-7819"],"issn-type":[{"value":"1477-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,9]]},"assertion":[{"value":"21 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Institutional Review Board approval (Ethikkommission der Hamburger \u00c4rztekammer) was given for retrospective registration (WF-071\/20).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed written consent for publication was obtained from the individuals to publish their data (including individual details, images, videos and presentations of case reports).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4"}}