{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:46:32Z","timestamp":1792197992605,"version":"4.4.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tumor-to-tumor metastasis is a rare, yet important entity. Patients with a history of renal cell carcinoma (RCC) may have tumor deposits to the thyroid gland preceding or following their initial cancer diagnosis for many years. The diagnosis can be challenging, and clinicians must remain suspicious of a newly found thyroid nodule in a patient with a history of RCC. In this review, we report a case of a patient with RCC who was incidentally found to have a thyroid nodule on surveillance imaging found to be consistent with tumor-to-tumor metastasis from RCC into papillary thyroid carcinoma. It is imperative to consider this diagnosis as the thyroid is the most common site of spread, and treatment with partial or total thyroidectomy has led to improved survival.<\/jats:p>","DOI":"10.1186\/s12957-023-03220-5","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T22:02:07Z","timestamp":1700604127000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Tumor-to-tumor spread: a case report and literature review of renal cell carcinoma metastasis into thyroid cancer"],"prefix":"10.1186","volume":"21","author":[{"given":"Cassidy","family":"Gawlik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Lane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Horattas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"issue":"4","key":"3220_CR1","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1111\/ans.16482","volume":"91","author":"R Tjahjono","year":"2021","unstructured":"Tjahjono R, Phung D, Gurney H, Gupta R, Riffat F, Palme CE. Thyroid gland metastasis from renal cell carcinoma: a case series and literature review. ANZ J Surg. 2021;91(4):708\u201315. https:\/\/doi.org\/10.1111\/ans.16482. Epub 2020 Dec 14 PMID: 33319504.","journal-title":"ANZ J Surg"},{"issue":"12","key":"3220_CR2","doi-asserted-by":"publisher","first-page":"3017","DOI":"10.3390\/cancers14123017","volume":"14","author":"Q Tang","year":"2022","unstructured":"Tang Q, Wang Z. Metastases to the thyroid gland: what can we do? Cancers (Basel). 2022;14(12):3017. https:\/\/doi.org\/10.3390\/cancers14123017. PMID:35740683;PMCID:PMC9221047.","journal-title":"Cancers (Basel)"},{"issue":"4","key":"3220_CR3","doi-asserted-by":"publisher","first-page":"e23742","DOI":"10.7759\/cureus.23742","volume":"14","author":"F Badawi","year":"2022","unstructured":"Badawi F, Meliti A. Tumor-to-tumor metastasis of renal cell carcinoma to a follicular variant of papillary thyroid carcinoma: a case report and literature review. Cureus. 2022;14(4):e23742. https:\/\/doi.org\/10.7759\/cureus.23742. PMID:35509741;PMCID:PMC9057635.","journal-title":"Cureus"},{"issue":"3","key":"3220_CR4","doi-asserted-by":"publisher","first-page":"79","DOI":"10.14740\/wjon1279","volume":"11","author":"SA Padala","year":"2020","unstructured":"Padala SA, Barsouk A, Thandra KC, Saginala K, Mohammed A, Vakiti A, Rawla P, Barsouk A. Epidemiology of renal cell carcinoma. World J Oncol. 2020;11(3):79\u201387. https:\/\/doi.org\/10.14740\/wjon1279. Epub 2020 May 14. PMID: 32494314; PMCID: PMC7239575.","journal-title":"World J Oncol."},{"issue":"2","key":"3220_CR5","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s12022-016-9425-8","volume":"27","author":"M Kefeli","year":"2016","unstructured":"Kefeli M, Mete O. An unusual solitary thyroid nodule with bloody follicles: metastatic renal cell carcinoma within an infiltrative follicular variant papillary carcinoma. Endocr Pathol. 2016;27(2):171\u20134. https:\/\/doi.org\/10.1007\/s12022-016-9425-8. PMID: 26951109.","journal-title":"Endocr Pathol"},{"issue":"1","key":"3220_CR6","doi-asserted-by":"publisher","first-page":"133","DOI":"10.4103\/0377-4929.200037","volume":"60","author":"KK Gowda","year":"2017","unstructured":"Gowda KK, Bal A, Agrawal P, Verma R, Das A. Tumor-to-tumor metastasis: small cell carcinoma lung metastasising into a follicular adenoma of the thyroid. Indian J Pathol Microbiol. 2017;60(1):133\u20135. https:\/\/doi.org\/10.4103\/0377-4929.200037. PMID: 28195115.","journal-title":"Indian J Pathol Microbiol."},{"key":"3220_CR7","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1002\/1097-0142(196809)22:3<635::AID-CNCR2820220320>3.0.CO;2-O","volume":"22","author":"LV Campbell Jr","year":"1968","unstructured":"Campbell LV Jr, Gilbert E, Chamberlain CR Jr, Watne AL. Metastases of cancer to cancer. Cancer. 1968;22:635\u201343. [PubMed] [Google Scholar].","journal-title":"Cancer."},{"issue":"1","key":"3220_CR8","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3390\/clinpract13010026","volume":"13","author":"C Manini","year":"2023","unstructured":"Manini C, Provenza C, Andr\u00e9s L, Imaz I, Guarch R, Nunziata R, L\u00f3pez JI. Tumor-to-tumor metastases involving clear cell renal cell carcinomas: a diagnostic challenge for pathologists needing clinical correlation. Clin Pract. 2023;13(1):288\u201396. https:\/\/doi.org\/10.3390\/clinpract13010026. PMID:36826168;PMCID:PMC9954947.","journal-title":"Clin Pract"},{"issue":"7","key":"3220_CR9","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1186\/1752-1947-7-265","volume":"10","author":"F Medas","year":"2013","unstructured":"Medas F, Cal\u00f2 PG, Lai ML, Tuveri M, Pisano G, Nicolosi A. Renal cell carcinoma metastasis to thyroid tumor: a case report and review of the literature. J Med Case Rep. 2013;10(7):265. https:\/\/doi.org\/10.1186\/1752-1947-7-265. PMID:24325865;PMCID:PMC3878860.","journal-title":"J Med Case Rep"},{"issue":"5","key":"3220_CR10","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.anndiagpath.2004.07.011","volume":"8","author":"L Qian","year":"2004","unstructured":"Qian L, Pucci R, Castro CY, Eltorky MA. Renal cell carcinoma metastatic to Hurthle cell adenoma of thyroid. Ann Diagn Pathol. 2004;8(5):305\u20138. https:\/\/doi.org\/10.1016\/j.anndiagpath.2004.07.011. PMID: 15494939.","journal-title":"Ann Diagn Pathol"},{"issue":"8","key":"3220_CR11","doi-asserted-by":"publisher","first-page":"703","DOI":"10.5858\/1999-123-0703-TTTMTF","volume":"123","author":"ZW Baloch","year":"1999","unstructured":"Baloch ZW, LiVolsi VA. Tumor-to-tumor metastasis to follicular variant of papillary carcinoma of thyroid. Arch Pathol Lab Med. 1999;123(8):703\u20136. https:\/\/doi.org\/10.5858\/1999-123-0703-TTTMTF. PMID: 10420227.","journal-title":"Arch Pathol Lab Med"},{"issue":"2","key":"3220_CR12","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1078\/0344-0338-00361","volume":"199","author":"A Ryska","year":"2003","unstructured":"Ryska A, C\u00e1p J. Tumor-to-tumor metastasis of renal cell carcinoma into oncocytic carcinoma of the thyroid. Report of a case and review of the literature. Pathol Res Pract. 2003;199(2):101\u20136. https:\/\/doi.org\/10.1078\/0344-0338-00361. PMID: 12747472.","journal-title":"Pathol Res Pract."},{"issue":"7","key":"3220_CR13","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1177\/10668969221081729","volume":"30","author":"JM Velez Torres","year":"2022","unstructured":"Velez Torres JM, Briski LM, Martinez Duarte E, Sadow PM, Kerr DA, Kryvenko ON. Metastatic clear cell renal cell carcinoma involving the thyroid gland: a clinicopathologic study of 17 patients. Int J Surg Pathol. 2022;30(7):743\u201352. https:\/\/doi.org\/10.1177\/10668969221081729. Epub 2022 Mar 7. PMID: 35253524; PMCID: PMC9427717.","journal-title":"Int J Surg Pathol."},{"issue":"4","key":"3220_CR14","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1046\/j.1563-2571.2002.02009.x","volume":"29","author":"G Wolf","year":"2002","unstructured":"Wolf G, Aigner RM, Humer-Fuchs U, Schwarz T, Krippl P, Wehrschuetz M. Renal cell carcinoma metastasis in a microfollicular adenoma of the thyroid gland. Acta Med Austriaca. 2002;29(4):141\u20132. https:\/\/doi.org\/10.1046\/j.1563-2571.2002.02009.x. PMID: 12424940.","journal-title":"Acta Med Austriaca"},{"issue":"4","key":"3220_CR15","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s12022-009-9087-x","volume":"20","author":"J Yu","year":"2009","unstructured":"Yu J, Nikiforova MN, Hodak SP, Yim JH, Cai G, Walls A, Nikiforov YE, Seethala RR. Tumor-to-tumor metastases to follicular variant of papillary thyroid carcinoma: histologic, immunohistochemical, and molecular studies of two unusual cases. Endocr Pathol. 2009;20(4):235\u201342. https:\/\/doi.org\/10.1007\/s12022-009-9087-x. PMID: 19707890. Winter.","journal-title":"Endocr Pathol."},{"issue":"4","key":"3220_CR16","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1111\/his.14246","volume":"78","author":"CA Ghossein","year":"2021","unstructured":"Ghossein CA, Khimraj A, Dogan S, Xu B. Metastasis to the thyroid gland: a single-institution 16-year experience. Histopathology. 2021;78(4):508\u201319. https:\/\/doi.org\/10.1111\/his.14246. Epub 2020 Nov 9. PMID: 32897542; PMCID: PMC8372534.","journal-title":"Histopathology."},{"issue":"6","key":"3220_CR17","first-page":"705","volume":"31","author":"MS Chacho","year":"1987","unstructured":"Chacho MS, Greenebaum E, Moussouris HF, Schreiber K, Koss LG. Value of aspiration cytology of the thyroid in metastatic disease. Acta Cytol. 1987;31(6):705\u201312. PMID: 3425131.","journal-title":"Acta Cytol."},{"issue":"12","key":"3220_CR18","doi-asserted-by":"publisher","first-page":"951976","DOI":"10.3389\/fonc.2022.951976","volume":"23","author":"MI Bellini","year":"2022","unstructured":"Bellini MI, Lori E, Forte F, Lauro A, Tripodi D, Amabile MI, Cantisani V, Varanese M, Ferent IC, Baldini E, Ulisse S, D\u2019Andrea V, Pironi D, Sorrenti S. Thyroid and renal cancers: a bidirectional association. Front Oncol. 2022;23(12):951976. https:\/\/doi.org\/10.3389\/fonc.2022.951976. PMID:36212468;PMCID:PMC9538481.","journal-title":"Front Oncol"},{"key":"3220_CR19","doi-asserted-by":"publisher","first-page":"153932","DOI":"10.1155\/2015\/153932","volume":"2015","author":"SL Wey","year":"2015","unstructured":"Wey SL, Chang KM. Tumor-to-tumor metastasis: lung carcinoma metastasizing to thyroid neoplasms. Case Rep Pathol. 2015;2015:153932. https:\/\/doi.org\/10.1155\/2015\/153932. Epub 2015 Jan 1. PMID: 25685581; PMCID: PMC4313001.","journal-title":"Case Rep Pathol."},{"issue":"2011","key":"3220_CR20","doi-asserted-by":"publisher","first-page":"238693","DOI":"10.4061\/2011\/238693","volume":"31","author":"TM Stevens","year":"2011","unstructured":"Stevens TM, Richards AT, Bewtra C, Sharma P. Tumors metastatic to thyroid neoplasms: a case report and review of the literature. Patholog Res Int. 2011;31(2011):238693. https:\/\/doi.org\/10.4061\/2011\/238693. PMID:21559195;PMCID:PMC3090057.","journal-title":"Patholog Res Int"},{"issue":"21","key":"3220_CR21","doi-asserted-by":"publisher","first-page":"3474","DOI":"10.12998\/wjcc.v7.i21.3474","volume":"7","author":"K Khaddour","year":"2019","unstructured":"Khaddour K, Marernych N, Ward WL, Liu J, Pappa T. Characteristics of clear cell renal cell carcinoma metastases to the thyroid gland: a systematic review. World J Clin Cases. 2019;7(21):3474\u201385. https:\/\/doi.org\/10.12998\/wjcc.v7.i21.3474. PMID:31750330;PMCID:PMC6854394.","journal-title":"World J Clin Cases"},{"issue":"3","key":"3220_CR22","doi-asserted-by":"publisher","first-page":"252","DOI":"10.14366\/usg.16037","volume":"36","author":"OK Song","year":"2017","unstructured":"Song OK, Koo JS, Kwak JY, Moon HJ, Yoon JH, Kim EK. Metastatic renal cell carcinoma in the thyroid gland: ultrasonographic features and the diagnostic role of core needle biopsy. Ultrasonography. 2017;36(3):252\u20139. https:\/\/doi.org\/10.14366\/usg.16037. Epub 2016 Nov 9. PMID: 27956733; PMCID: PMC5494867.","journal-title":"Ultrasonography."},{"issue":"9","key":"3220_CR23","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1002\/cncr.10901","volume":"95","author":"CS Heffess","year":"2002","unstructured":"Heffess CS, Wenig BM, Thompson LD. Metastatic renal cell carcinoma to the thyroid gland: a clinicopathologic study of 36 cases. Cancer. 2002;95(9):1869\u201378. https:\/\/doi.org\/10.1002\/cncr.10901. PMID: 12404280.","journal-title":"Cancer"},{"issue":"4","key":"3220_CR24","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s12105-009-0147-9","volume":"3","author":"OL Bohn","year":"2009","unstructured":"Bohn OL, De las Casas LE, Leon ME. Tumor-to-tumor metastasis: renal cell carcinoma metastatic to papillary carcinoma of thyroid-report of a case and review of the literature. Head Neck Pathol. 2009;3(4):327\u201330. https:\/\/doi.org\/10.1007\/s12105-009-0147-9. Epub 2009 Nov 15. PMID: 20596854; PMCID: PMC2811566.","journal-title":"Head Neck Pathol."},{"issue":"5","key":"3220_CR25","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1097\/PAS.0b013e3182147fa8","volume":"35","author":"A Cimino-Mathews","year":"2011","unstructured":"Cimino-Mathews A, Sharma R, Netto GJ. Diagnostic use of PAX8, CAIX, TTF-1, and TGB in metastatic renal cell carcinoma of the thyroid. Am J Surg Pathol. 2011;35(5):757\u201361. https:\/\/doi.org\/10.1097\/PAS.0b013e3182147fa8.","journal-title":"Am J Surg Pathol"},{"key":"3220_CR26","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.1002\/cncr.25836","volume":"117","author":"AL Alt","year":"2011","unstructured":"Alt AL, Boorjian SA, Lohse CM, Costello BA, Leibovich BC, Blute ML. Survival after complete surgical resection of multiple metas- tases from renal cell carcinoma. Cancer. 2011;117:2873\u201382.","journal-title":"Cancer"},{"issue":"1","key":"3220_CR27","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1756-6614-1-6","volume":"1","author":"G Dionigi","year":"2008","unstructured":"Dionigi G, Uccella S, Gandolfo M, Lai A, Bertocchi V, Rovera F, Tanda ML. Solitary intrathyroidal metastasis of renal clear cell carcinoma in a toxic substernal multinodular goiter. Thyroid Res. 2008;1(1):6. https:\/\/doi.org\/10.1186\/1756-6614-1-6. PMID:19014412;PMCID:PMC2596782.","journal-title":"Thyroid Res"}],"container-title":["World Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-023-03220-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12957-023-03220-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-023-03220-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T22:31:25Z","timestamp":1700605885000},"score":1,"resource":{"primary":{"URL":"https:\/\/wjso.biomedcentral.com\/articles\/10.1186\/s12957-023-03220-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,22]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["3220"],"URL":"https:\/\/doi.org\/10.1186\/s12957-023-03220-5","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3249123\/v1","asserted-by":"object"}]},"ISSN":["1477-7819"],"issn-type":[{"value":"1477-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,22]]},"assertion":[{"value":"9 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Reviewed and obtained from the patient on 8\/2\/2023.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"362"}}