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Perioperative complications and postoperative prognosis were compared between the laparoscopic surgery (LS) and open surgery (OS) groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>After screening 313 HCCA patients, 68 patients were eligible for the study in the LS group (<jats:italic>n<\/jats:italic> = 40) and OS group (<jats:italic>n<\/jats:italic> = 28). Kaplan-Meier survival curve analysis revealed that overall survival &gt; 2 years and 3-year disease-free survival (DFS) were more common in the LS than OS group, but the rate of 2-year DFS was lower in the LS group than OS group. Cox multivariate regression analysis revealed age (&lt; 65 years), radical resection, and postoperative adjuvant therapy were associated with reduced risk of death (hazard ratio [HR] = 0.380, 95% confidence interval [CI] = 0.150\u20130.940, <jats:italic>P<\/jats:italic> = 0.036; <jats:italic>HR<\/jats:italic> = 0.080, 95% <jats:italic>CI<\/jats:italic> = 0.010\u20130.710, <jats:italic>P<\/jats:italic> = 0.024 and <jats:italic>HR<\/jats:italic> = 0.380, 95% <jats:italic>CI<\/jats:italic> = 0.150\u20130.960, <jats:italic>P<\/jats:italic> = 0.040), whereas preoperative biliary drainage was an independent factor associated with increased risk of death (<jats:italic>HR<\/jats:italic> = 2.810, 95% <jats:italic>CI<\/jats:italic> = 1.130\u20136.950, <jats:italic>P<\/jats:italic> = 0.026). Perineuronal invasion was identified as an independent risk factor affecting DFS (<jats:italic>HR<\/jats:italic> = 5.180, 95% <jats:italic>CI<\/jats:italic> = 1.170\u201322.960, <jats:italic>P<\/jats:italic> = 0.030).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Compared with OS, laparoscopic HCCA resection does not significantly differ in terms of clinical efficacy. Age (<jats:bold>&lt;<\/jats:bold>65 years), radical resection, and postoperative adjuvant therapy reduce the risk of death, and preoperative biliary drainage increases the risk of death.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12957-024-03327-3","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T04:12:41Z","timestamp":1708315961000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Survival analysis of laparoscopic surgery and open surgery for hilar cholangiocarcinoma: a retrospective cohort study"],"prefix":"10.1186","volume":"22","author":[{"given":"Yaolin","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilin","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Xian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfu","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingdong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"key":"3327_CR1","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/0002-9343(65)90178-6","volume":"38","author":"G Klatskin","year":"1965","unstructured":"Klatskin G. 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