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Direct irradiation adversely affects ovarian and endometrial function, compromising the fertility of women. While ovarian transposition is an established method to move the ovaries away from the radiation field, surgical procedures to displace the uterus are investigational. This study demonstrates the surgical options for uterine displacement in relation to the radiation dose received.\u00a0<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The uterine displacement techniques were carried out sequentially in a human female cadaver to demonstrate each procedure step by step and assess the uterine positions with dosimetric CT scans in a hybrid operating room. Two treatment plans (anal and rectal cancer) were simulated on each of the four dosimetric scans (1. anatomical position, 2. uterine suspension of the round ligaments to the abdominal wall 3. ventrofixation of the uterine fundus at the umbilical level, 4. uterine transposition). Treatments were planned on Eclipse\u00ae System (Varian Medical Systems\u00ae,USA) using Volumetric Modulated Arc Therapy. Data about maximum (Dmax) and mean (Dmean) radiation dose received and the volume receiving 14\u00a0Gy (V14Gy) were collected.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>All procedures were completed without technical complications. In the rectal cancer simulation with delivery of 50\u00a0Gy to the tumor, Dmax, Dmean and V14Gy to the uterus were respectively 52,8\u00a0Gy, 34,3\u00a0Gy and 30,5cc (1), 31,8\u00a0Gy, 20,2\u00a0Gy and 22.0cc (2), 24,4\u00a0Gy, 6,8\u00a0Gy and 5,5cc (3), 1,8\u00a0Gy, 0,6\u00a0Gy and 0,0cc (4). For anal cancer, delivering 64\u00a0Gy to the tumor respectively 46,7\u00a0Gy, 34,8\u00a0Gy and 31,3cc (1), 34,3\u00a0Gy, 20,0\u00a0Gy and 21,5cc (2), 21,8\u00a0Gy, 5,9\u00a0Gy and 2,6cc (3), 1,4\u00a0Gy, 0,7\u00a0Gy and 0,0cc (4).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The feasibility of several uterine displacement procedures was safely demonstrated. Increasing distance to the radiation field requires more complex surgical interventions to minimize radiation exposure. Surgical strategy needs to be tailored to the multidisciplinary treatment plan, and uterine transposition is the most technically complex with the least dose received.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12957-024-03423-4","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T07:02:40Z","timestamp":1717398160000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fertility-sparing uterine displacement for pelvic malignancies: surgical options and radiotherapy dosimetry on a human cadaver"],"prefix":"10.1186","volume":"22","author":[{"given":"Matteo","family":"Pavone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laure","family":"Waeldin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Seeliger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicol\u00f2","family":"Bizzarri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Mutter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Jarnet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonello","family":"Forgione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noel","family":"Georges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cherif","family":"Akladios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Scambia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Marescaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lise","family":"Lecointre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Querleu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,3]]},"reference":[{"key":"3423_CR1","first-page":"77","volume":"19","author":"S Mariani","year":"2019","unstructured":"Mariani S, Chiloiro G, Villa P, Meldolesi E, Barbaro B, Di Giorgio A, et al. 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