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Radical surgery according to soft tissue tumors can lead to persistent pain and neurological deficits. This study aims to evaluate clinical outcomes of patients treated by a visceral- \/ neurosurgical approach. 33 patients with a retroperitoneal nerve tumor underwent surgery between 01\/2002 and 12\/2022 at our department. A visceral surgeon provided access to the retroperitoneal space, followed by micro-neurosurgical tumor preparation under neuromonitoring. Clinical examination and MRI were performed 12 weeks after surgery and further 3 months (WHO grade\u2009&gt;\u20091) or 12 months (WHO grade 1). Further examinations were based on MRI findings and residual symptoms with median follow-up time of 24 months. One patient was treated for two distinct masses resulting in a total of 34 histological findings. Schwannomas (<jats:italic>n<\/jats:italic>\u2009=\u200915; 44.1%) and neurofibromas (<jats:italic>n<\/jats:italic>\u2009=\u200910; 29.4%) were the most common tumors. Long-term improvements were noted in radicular pain (15\/18 patients; 83.3%), motor deficits (7\/16 patients; 43.8%), abdominal discomfort and pain (5\/7 patients; 71.4%). Recurrences were observed in 3\/33 (9,1%) patients. This study represents the largest series of retroperitoneal BPNSTs treated with microsurgical techniques. Prospective multicenter studies are warranted to establish standardized treatment guidelines.<\/jats:p>","DOI":"10.1186\/s12957-024-03557-5","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T02:01:44Z","timestamp":1729562504000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comprehensive neurosurgical and visceral surgical therapy of retroperitoneal nerve tumors: a descriptive and retrospective analysis"],"prefix":"10.1186","volume":"22","author":[{"given":"Martin","family":"Petkov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Kornmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute Marlies","family":"B\u00e4zner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Minzenmay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Pala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Pedro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Rainer","family":"Wirtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Antoniadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"3557_CR1","doi-asserted-by":"crossref","unstructured":"Brennan C et al. 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