{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:23:09Z","timestamp":1776468189281,"version":"3.51.2"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"DOI":"10.1186\/s12957-024-03600-5","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T02:17:04Z","timestamp":1732760224000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Nucleolar protein 3 promotes proliferation of bladder cancer cells through the PI3K-Akt pathway"],"prefix":"10.1186","volume":"22","author":[{"given":"Linfeng","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunyao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tinghao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junlong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junrui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyang","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"issue":"19","key":"3600_CR1","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1001\/jama.2020.17598","volume":"324","author":"CHAMIEK LENIS A T, LEC P M","year":"2020","unstructured":"Lenis A T, Lec P M, Chamie K. Bladder Cancer: a review [J]. Jama-Journal Am Med Association. 2020;324(19):1980\u201391.","journal-title":"Jama-Journal Am Med Association"},{"issue":"3","key":"3600_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H SUNG","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. Ca-a Cancer J Clin. 2021;71(3):209\u201349.","journal-title":"Ca-a Cancer J Clin"},{"key":"3600_CR3","doi-asserted-by":"publisher","first-page":"116172","DOI":"10.1016\/j.bcp.2024.116172","volume":"223","author":"X DING","year":"2024","unstructured":"Ding X, Jin Y, Shi X, et al. TDO2 promotes bladder cancer progression via AhR-mediated SPARC\/FILIP1L signaling [J]. Biochem Pharmacol. 2024;223:116172.","journal-title":"Biochem Pharmacol"},{"issue":"9","key":"3600_CR4","doi-asserted-by":"publisher","first-page":"5156","DOI":"10.1073\/pnas.95.9.5156","volume":"95","author":"T KOSEKI","year":"1998","unstructured":"Koseki T, Inohara N, Chen S, et al. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases [J]. Proc Natl Acad Sci USA. 1998;95(9):5156\u201360.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1\u20133","key":"3600_CR5","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/S0014-5793(03)00444-7","volume":"543","author":"YM HONG","year":"2003","unstructured":"Hong YM, Jo D G, Lee JY, et al. Down-regulation of ARC contributes to vulnerability of hippocampal neurons to ischemia\/hypoxia [J]. FEBS Lett. 2003;543(1\u20133):170\u20133.","journal-title":"FEBS Lett"},{"issue":"12","key":"3600_CR6","first-page":"E70","volume":"85","author":"EKHTERAED LIN Z W","year":"1999","unstructured":"Lin Z W Ekhterae D, Lundberg M S, et al. ARC inhibits cytochrome\u2009<\u2009i\u2009>\u2009c release from mitochondria and protects against hypoxia-induced apoptosis in heart-derived H9c2 cells [J]. Circul Res. 1999;85(12):E70\u20137.","journal-title":"Circul Res"},{"issue":"3","key":"3600_CR7","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.molcel.2021.01.018","volume":"81","author":"YJ NAM","year":"2021","unstructured":"Nam YJ, Mani K, Ashton A W, et al. Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions [J]. Mol Cell. 2021;81(3):638.","journal-title":"Mol Cell"},{"issue":"23","key":"3600_CR8","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1161\/CIRCULATIONAHA.111.034512","volume":"124","author":"AL ZAIMAN","year":"2011","unstructured":"Zaiman AL, Damico R, Thoms-Chesley A, et al. A critical role for the protein apoptosis Repressor with Caspase Recruitment Domain in Hypoxia-Induced Pulmonary hypertension [J]. Circulation. 2011;124(23):2533\u201342.","journal-title":"Circulation"},{"key":"3600_CR9","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.yjmcc.2020.08.003","volume":"147","author":"T LIU M X, YU","year":"2020","unstructured":"Liu M X, Yu T, Li M Y, et al. Apoptosis repressor with caspase recruitment domain promotes cell proliferation and phenotypic modulation through 14-3-3\u03b5\/YAP signaling in vascular smooth muscle cells [J]. J Mol Cell Cardiol. 2020;147:35\u201348.","journal-title":"J Mol Cell Cardiol"},{"key":"3600_CR10","doi-asserted-by":"crossref","unstructured":"Li T D, Huang M W, Sun N et al. Tumorigenesis of basal muscle invasive bladder cancer was mediated by PTEN protein degradation resulting from <\u2009i\u2009>\u2009SNHG1\u2009upregulation [J]. J Experimental Clin Cancer Res, 2024, 43(1).","DOI":"10.1186\/s13046-024-02966-4"},{"key":"3600_CR11","doi-asserted-by":"crossref","unstructured":"Xie B, Lin J T, Chen X W et al. CircXRN2 suppresses tumor progression driven by histone lactylation through activating the Hippo pathway in human bladder cancer [J]. Mol Cancer, 2023, 22(1).","DOI":"10.1186\/s12943-023-01856-1"},{"key":"3600_CR12","doi-asserted-by":"crossref","unstructured":"Rezaei S, Nikpanjeh N, Rezaee A et al. PI3K\/Akt signaling in urological cancers: tumorigenesis function, therapeutic potential, and therapy response regulation [J]. Eur J Pharmacol, 2023, 955.","DOI":"10.1016\/j.ejphar.2023.175909"},{"issue":"3","key":"3600_CR13","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1084\/jem.20162089","volume":"214","author":"B STANLEY R F, PISZCZATOWSKI R T, BAR","year":"2017","unstructured":"Stanley R F, Piszczatowski R T, Bartholdy B, et al. A myeloid tumor suppressor role for <\u2009i\u2009>\u2009NOL3 [J]. J Exp Med. 2017;214(3):753\u201371.","journal-title":"J Exp Med"},{"key":"3600_CR14","doi-asserted-by":"crossref","unstructured":"Tong H, Li T H, Gao S et al. An epithelial-mesenchymal transition-related long noncoding RNA signature correlates with the prognosis and progression in patients with bladder cancer [J]. Biosci Rep, 2021, 41(1).","DOI":"10.1042\/BSR20203944"},{"key":"3600_CR15","doi-asserted-by":"crossref","unstructured":"Liu K, Lan D F, Li C Y et al. A double-edged sword: role of apoptosis repressor with caspase recruitment domain (ARC) in tumorigenesis and ischaemia\/reperfusion (I\/R) injury [J]. Apoptosis, 2023, 28(3\u20134): 313\u2009\u2013\u200925.","DOI":"10.1007\/s10495-022-01802-4"},{"issue":"5","key":"3600_CR16","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.febslet.2007.01.050","volume":"581","author":"HUNTER A L","year":"2007","unstructured":"Hunter A L, Zhang J C, Chen S C, et al. Apoptosis repressor with caspase recruitment domain (ARC) inhibits myogenic differentiation [J]. FEBS Lett. 2007;581(5):879\u201384.","journal-title":"FEBS Lett"},{"issue":"10","key":"3600_CR17","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.2337\/db16-1352","volume":"66","author":"T TEMPLIN A T, SAMARASEKERA","year":"2017","unstructured":"Templin A T, Samarasekera T, Meier D T, et al. Apoptosis Repressor with Caspase Recruitment Domain ameliorates amyloid-Induced \u03b2-Cell apoptosis and JNK pathway activation [J]. Diabetes. 2017;66(10):2636\u201345.","journal-title":"Diabetes"},{"key":"3600_CR18","doi-asserted-by":"crossref","unstructured":"Ke YJ, Yan H H, Chen L W, et al. Apoptosis repressor with caspase recruitment domain deficiency accelerates ischemia\/reperfusion (I\/R)-induced acute kidney injury by suppressing inflammation and apoptosis: the role of AKT\/mTOR signaling [J]. Biomedicine & Pharmacotherapy; 2019. p. 112.","DOI":"10.1016\/j.biopha.2019.108681"},{"issue":"6","key":"3600_CR19","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1158\/0008-5472.CAN-18-0921","volume":"79","author":"CARTER B Z","year":"2019","unstructured":"Carter B Z, Mak P Y, Wang X M, et al. An ARC-Regulated IL1\u03b2\/Cox-2\/PGE2\/\u03b2-Catenin\/ARC Circuit Controls Leukemia-Microenvironment Interactions and confers Drug Resistance in AML [J]. Cancer Res. 2019;79(6):1165\u201377.","journal-title":"Cancer Res"},{"key":"3600_CR20","doi-asserted-by":"crossref","unstructured":"He QL, Li Z Q Yin JB et al. Prognostic significance of autophagy-relevant gene markers in Colorectal Cancer [J]. Front Oncol, 2021, 11.","DOI":"10.3389\/fonc.2021.566539"},{"issue":"4","key":"3600_CR21","doi-asserted-by":"publisher","first-page":"3753","DOI":"10.1002\/jcp.29270","volume":"235","author":"Q LI","year":"2020","unstructured":"Li Q, Yang J, Zhang J, et al. Inhibition of microRNA-327 ameliorates ischemia\/reperfusion injury-induced cardiomyocytes apoptosis through targeting apoptosis repressor with caspase recruitment domain [J]. J Cell Physiol. 2020;235(4):3753\u201367.","journal-title":"J Cell Physiol"},{"issue":"2","key":"3600_CR22","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1007\/s10495-008-0296-4","volume":"14","author":"LI Y Z","year":"2009","unstructured":"Li Y Z, Ge X L, Liu X, H. The cardioprotective effect of postconditioning is mediated by ARC through inhibiting mitochondrial apoptotic pathway [J]. Apoptosis. 2009;14(2):164\u201372.","journal-title":"Apoptosis"},{"key":"3600_CR23","doi-asserted-by":"crossref","unstructured":"Roser C, T\u00f3th C, Renner M et al. Expression of apoptosis repressor with caspase recruitment domain (ARC) in familial adenomatous polyposis (FAP) adenomas and its correlation with DNA mismatch repair proteins, p53, Bcl-2, COX-2 and beta-catenin [J]. Cell Communication Signal, 2021, 19(1).","DOI":"10.1186\/s12964-020-00702-x"},{"issue":"9","key":"3600_CR24","doi-asserted-by":"publisher","first-page":"3540","DOI":"10.21037\/tau-21-581","volume":"10","author":"ZHANG F Y","year":"2021","unstructured":"Zhang F Y, Yu S C, Wu P J, et al. Discovery and construction of prognostic model for clear cell renal cell carcinoma based on single-cell and bulk transcriptome analysis [J]. Translational Androl Urol. 2021;10(9):3540\u2013.","journal-title":"Translational Androl Urol"},{"issue":"1\u20132","key":"3600_CR25","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s10495-020-01653-x","volume":"26","author":"J ZHANG","year":"2021","unstructured":"Zhang J, Zheng X X, Wang P Y, et al. Role of apoptosis repressor with caspase recruitment domain (ARC) in cell death and cardiovascular disease [J]. Apoptosis. 2021;26(1\u20132):24\u201337.","journal-title":"Apoptosis"},{"key":"3600_CR26","doi-asserted-by":"crossref","unstructured":"Su H, Peng C, Liu Y. Regulation of ferroptosis by PI3K\/Akt signaling pathway: a promising therapeutic axis in cancer [J]. Front Cell Dev Biology, 2024, 12.","DOI":"10.3389\/fcell.2024.1372330"},{"key":"3600_CR27","doi-asserted-by":"crossref","unstructured":"Zhou K L, Wu C L, Cheng W J, et al. Transglutaminase 3 regulates cutaneous squamous carcinoma differentiation and inhibits progression via PI3K-AKT signaling pathway-mediated keratin 14 degradation [J]. Volume 15. Cell Death & Disease; 2024. 4.","DOI":"10.1038\/s41419-024-06626-5"},{"key":"3600_CR28","doi-asserted-by":"crossref","unstructured":"Li JK, Jiang X L, Zhang Z, et al. Isoalantolactone exerts anti-melanoma effects via inhibiting PI3K\/AKT\/mTOR and STAT3 signaling in cell and mouse models [J]. Phytotherapy Research; 2024.","DOI":"10.1002\/ptr.8132"},{"key":"3600_CR29","doi-asserted-by":"crossref","unstructured":"Liu H, Zhang J H, Zhao Y J et al. CD93 regulates breast cancer growth and vasculogenic mimicry through the PI3K\/AKT\/SP2 signaling pathway activated by integrin \u03b21 [J]. J Biochem Mol Toxicol, 2024, 38(4).","DOI":"10.1002\/jbt.23688"},{"key":"3600_CR30","doi-asserted-by":"crossref","unstructured":"Peng Y, Wang Y Y, Zhou C et al. PI3K\/Akt\/mTOR pathway and its role in Cancer therapeutics: are we making Headway? [J]. Front Oncol, 2022, 12.","DOI":"10.3389\/fonc.2022.819128"},{"key":"3600_CR31","doi-asserted-by":"crossref","unstructured":"Leiphrakpam PD. Are C. PI3K\/Akt\/mTOR signaling pathway as a target for Colorectal Cancer treatment [J]. Int J Mol Sci, 2024, 25(6).","DOI":"10.3390\/ijms25063178"},{"issue":"1","key":"3600_CR32","doi-asserted-by":"publisher","first-page":"8694","DOI":"10.1038\/s41598-024-58539-0","volume":"14","author":"Z XU","year":"2024","unstructured":"Xu Z, Wu S, Tu J, et al. RACGAP1 promotes lung cancer cell proliferation through the PI3K\/AKT signaling pathway [J]. Sci Rep. 2024;14(1):8694.","journal-title":"Sci Rep"}],"container-title":["World Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-024-03600-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12957-024-03600-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-024-03600-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T03:19:18Z","timestamp":1732763958000},"score":1,"resource":{"primary":{"URL":"https:\/\/wjso.biomedcentral.com\/articles\/10.1186\/s12957-024-03600-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,28]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3600"],"URL":"https:\/\/doi.org\/10.1186\/s12957-024-03600-5","relation":{},"ISSN":["1477-7819"],"issn-type":[{"value":"1477-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,28]]},"assertion":[{"value":"19 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board (or Ethics Committee) of The First Affiliated Hospital of Chongqing Medical University (protocol code 2021-085 and 3 March 2021 of approval) for studies involving humans. The animal study protocol was approved by the Institutional Animal Care and Use Committee (IACUC) of Chongqing Medical University (IACUC-CQMU-2023-0226).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional Review Board Statement"}},{"value":"Informed consent was obtained from all subjects involved in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"316"}}