{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:08:28Z","timestamp":1788538108754,"version":"build-2803163510"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"DOI":"10.1186\/s12957-024-03613-0","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T15:22:00Z","timestamp":1734535320000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical and splenectomy-based treatment outcomes in 40 cases of hepatosplenic T-cell lymphoma: a comprehensive analysis"],"prefix":"10.1186","volume":"22","author":[{"family":"Mingyue-Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Yanhui-Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"3613_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.humpath.2018.01.005","volume":"74","author":"M Yabe","year":"2018","unstructured":"Yabe M, Miranda RN, Medeiros LJ. Hepatosplenic T-cell lymphoma: a review of clinicopathologic features, pathogenesis, and prognostic factors. Hum Pathol. 2018;74:5\u201316.","journal-title":"Hum Pathol"},{"key":"3613_CR2","unstructured":"Gaulard P, Jaffe ES, Krenacs L, Macon WR et al. Hepatosplenic T-cell lymphoma. In: Swerdlow SH, Campo E, eds. WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th ed. Lyon: IARC, 2017:381-2."},{"issue":"24","key":"3613_CR3","doi-asserted-by":"publisher","first-page":"5795","DOI":"10.1182\/blood-2011-12-396150","volume":"119","author":"M Travert","year":"2012","unstructured":"Travert M, Huang Y, de Leval L, et al. Molecular features of hepatosplenic T-cell lymphoma unravels potential novel therapeutic targets. Blood. 2012;119(24):5795\u2013806.","journal-title":"Blood"},{"issue":"7360","key":"3613_CR4","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature10351","volume":"476","author":"RD Morin","year":"2011","unstructured":"Morin RD, Mendez-Lago M, Mungall AJ, et al. Frequent mutation of histone-modifying genes in non-hodgkin lymphoma. Nature. 2011;476(7360):298\u2013303.","journal-title":"Nature"},{"issue":"4","key":"3613_CR5","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1158\/2159-8290.CD-16-0330","volume":"7","author":"M McKinney","year":"2017","unstructured":"McKinney M, Moffitt AB, Gaulard P, et al. The genetic basis of hepatosplenic T-cell lymphoma. Cancer Discov. 2017;7(4):369\u201379.","journal-title":"Cancer Discov"},{"issue":"7","key":"3613_CR6","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1111\/cas.12439","volume":"105","author":"Y Takahashi","year":"2014","unstructured":"Takahashi Y, Takata K, Kato S, Sato Y, Asano N, Ogino T, et al. Clinicopathological analysis of 17 primary cutaneous T-cell lymphoma of the \u03b3\u03b4 phenotype from Japan. Cancer Sci. 2014;105(7):912\u201323.","journal-title":"Cancer Sci"},{"key":"3613_CR7","doi-asserted-by":"publisher","unstructured":"Almeida Ramalho S, Abecasis F, Santos L, Leite V, Gon\u00e7alves D, Pintassilgo I, Broa AL. Hypercalcaemia: an extremely rare presentation of hepatosplenic T-cell lymphoma. EJCRIM. 2021;8. https:\/\/doi.org\/10.12890\/2020_002360.","DOI":"10.12890\/2020_002360"},{"key":"3613_CR8","doi-asserted-by":"publisher","first-page":"e228186","DOI":"10.1136\/bcr-2018-228186","volume":"12","author":"P Pateria","year":"2019","unstructured":"Pateria P, Martin A, Khor TS, et al. Hepatosplenic T cell lymphoma presenting as multiorgan failure. BMJ Case Rep. 2019;12:e228186. https:\/\/doi.org\/10.1136\/bcr-2018-228186.","journal-title":"BMJ Case Rep"},{"key":"3613_CR9","unstructured":"Irappa M, Gaurang M, Harsha P et al. Hepatosplenic Gamma Delta T-Cell Lymphoma (HSGDTCL): Two Rare Case Reports from Western India. IJHOSCR 2017;11(4):296\u2013300."},{"issue":"6","key":"3613_CR10","doi-asserted-by":"publisher","first-page":"e463","DOI":"10.1097\/MPH.0000000000001537","volume":"42","author":"FJ Michelle","year":"2020","unstructured":"Michelle FJ, Bailey A, Valerie P, Opipari, et al. Hepatosplenic Alpha\/Beta T-cell Lymphoma as second malignancy in Young Adult patient with previously undiagnosed Ataxia-telangiectasia. J Pediatr Hematol Oncol. 2020;42(6):e463\u20135. https:\/\/doi.org\/10.1097\/MPH.0000000000001537.","journal-title":"J Pediatr Hematol Oncol"},{"issue":"1","key":"3613_CR11","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/ccr3.453","volume":"4","author":"S Abhijit","year":"2016","unstructured":"Abhijit S, Javier AS,Philip K. Progression of a hepatosplenic gamma delta T-cell leukemia\/lymphoma on hyperCVAD\/MTX and ara-C:literature review and our institutional treatment approach. Clin Case Rep. 2016;4(1):67\u201371. https:\/\/doi.org\/10.1002\/ccr3.453.","journal-title":"Clin Case Rep"},{"key":"3613_CR12","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1159\/000360126","volume":"6","author":"K Fran\u00e7ois","year":"2014","unstructured":"Fran\u00e7ois K, Maya B, Laurence de L, et al. Purpura of the Face and Neck: an atypical clinical presentation revealing a hepatosplenic T cell lymphoma. Case Rep Dermatol. 2014;6:37\u201342. https:\/\/doi.org\/10.1159\/000360126.","journal-title":"Case Rep Dermatol"},{"issue":"4","key":"3613_CR13","doi-asserted-by":"publisher","first-page":"19","DOI":"10.4322\/acr.2014.035","volume":"4","author":"VR Paes","year":"2014","unstructured":"Paes VR, Lima PP, Siqueira SAC. Hemophagocytic lymphohistiocytosis associated with hepatosplenic T-cell lymphoma: case report. Autopsy Case Rep [Internet]. 2014;4(4):19\u201324. https:\/\/doi.org\/10.4322\/acr.2014.035.","journal-title":"Autopsy Case Rep [Internet]"},{"key":"3613_CR14","doi-asserted-by":"crossref","unstructured":"Hui PJHJ-N, Li, et al. Successful second allogeneic stem-cell transplantation from the same sibling donor for a patient with recurrent hepatosplenic gamma-delta (g\/d) T-cell lymphoma. Volume 97. Medicine; 2018. p. 44. e1294110.1097\/MD0000000000012941.","DOI":"10.1097\/MD.0000000000012941"},{"key":"3613_CR15","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.2169\/internalmedicine.53.2236","volume":"53","author":"T Seiji","year":"2014","unstructured":"Seiji T, Mitsuteru N,Hiromi F, et al. Hepatosplenic Gamma-delta T-cell Lymphoma Associated with Epstein-Barr Virus. Intern Med. 2014;53:2079\u201382. https:\/\/doi.org\/10.2169\/internalmedicine.53.2236.","journal-title":"Intern Med"},{"issue":"47","key":"3613_CR16","doi-asserted-by":"publisher","first-page":"10465","DOI":"10.3748\/wjg.v22.i47.10465","volume":"22","author":"M Maartje","year":"2016","unstructured":"Maartje M, van de Meeberg,Lauranne AAP, Derikx,Harm AM, Sinnige, et al. Hepatosplenic T-cell lymphoma in a 47-year-old Crohn\u2019s disease patient on thiopurine monotherapy. World J Gastroenterol. 2016;22(47):10465\u201370. https:\/\/doi.org\/10.3748\/wjg.v22.i47.10465.","journal-title":"World J Gastroenterol"},{"key":"3613_CR17","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1159\/000493350","volume":"26","author":"C Joana","year":"2019","unstructured":"Joana C, V\u00edtor MP, Fernando J, et al. Hepatosplenic T-Cell lymphoma: a rare complication of Monotherapy with thiopurines in Crohn\u2019s Disease. GE Port J Gastroenterol. 2019;26:279\u201384. https:\/\/doi.org\/10.1159\/000493350.","journal-title":"GE Port J Gastroenterol"},{"key":"3613_CR18","doi-asserted-by":"publisher","unstructured":"Petrova M, Gomes MM, Carda JPN et al. Hepatosplenic T-cell lymphoma in a young immunocompetent man. BMJ Case Rep.2016;Published online: [please include Day Month Year].https:\/\/doi.org\/10.1136\/bcr-2016-214414","DOI":"10.1136\/bcr-2016-214414"},{"issue":"2","key":"3613_CR19","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3978\/j.issn.2078-6891.2013.017","volume":"4","author":"C Jonah","year":"2013","unstructured":"Jonah C, Eduardo H, Darshan K, et al. Hepatosplenic alpha\/beta T-cell lymphoma masquerading as cirrhosis. J Gastrointest Oncol. 2013;4(2):131\u20136. https:\/\/doi.org\/10.3978\/j.issn.2078-6891.2013.017.","journal-title":"J Gastrointest Oncol"},{"key":"3613_CR20","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1002\/jha2.565","volume":"3","author":"L Shin","year":"2022","unstructured":"Shin L, Yusuke K, Kei F, et al. An unusual case of hepatosplenic T-cell lymphoma-like unclassifiable T\/NK-cell lymphoma accompanied by acute myeloid leukemia. eJHaem. 2022;3:1335\u20138. https:\/\/doi.org\/10.1002\/jha2.565.","journal-title":"eJHaem"},{"key":"3613_CR21","doi-asserted-by":"publisher","unstructured":"Philippa A, Moosa P, Jenifer V et al. Hepatosplenic T-cell lymphoma: a case series.Hematology\/Oncology and stem cell therapy.2015;8(2);78\u201384.https:\/\/doi.org\/10.1016\/j.hemonc.2014.09.006","DOI":"10.1016\/j.hemonc.2014.09.006"},{"key":"3613_CR22","doi-asserted-by":"publisher","unstructured":"Yana P, Amy SC,Amanda LR et al. Targeting EZH2 for the treatment of hepatosplenic T-cell lymphoma.Blood advanceds.2020;4(7);1265\u2013DOI1269:. https:\/\/doi.org\/10.1182\/bloodadvances.2019001256","DOI":"10.1182\/bloodadvances.2019001256"},{"issue":"35","key":"3613_CR23","doi-asserted-by":"publisher","first-page":"171","DOI":"10.7504\/nk2015010601","volume":"2","author":"CAO Lei","year":"2015","unstructured":"Lei CAO, Lei FAN, Li WANG, et al. Clinical analysis of one case of hepatosplenic \u03b3\/\u03b4 lymphoma [J]. Chin J Practical Intern Med. 2015;2(35):171\u20133. https:\/\/doi.org\/10.7504\/nk2015010601.","journal-title":"Chin J Practical Intern Med"},{"issue":"11","key":"3613_CR24","doi-asserted-by":"publisher","first-page":"990","DOI":"10.13201\/j.issn.1004-2806.2015.11.022","volume":"28","author":"LI Rong,Bao","year":"2015","unstructured":"Rong,Bao LI, Xiupeng SHENYE, et al. A case of hepatosplenic \u03b3\u03b4T cell lymphoma and literature review[J]. J ClinHematol(China). 2015;28(11):990\u20132. https:\/\/doi.org\/10.13201\/j.issn.1004-2806.2015.11.022.","journal-title":"J ClinHematol(China)"},{"issue":"3","key":"3613_CR25","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3969\/j.issn.2095-5227.2019.03.018","volume":"40","author":"LI Yanfen","year":"2019","unstructured":"Yanfen LI, Yu ZHAO, Quanshun WANG, et al. Hepatosplenic\u03b3\u03b4T-cell lymphoma: a report of 4 cases and literature review[J]. Acad J Chin PLA Med Sch. 2019;40(3):276\u20139. https:\/\/doi.org\/10.3969\/j.issn.2095-5227.2019.03.018.","journal-title":"Acad J Chin PLA Med Sch"},{"issue":"3","key":"3613_CR26","first-page":"590","volume":"24","author":"WANG Caixia","year":"2009","unstructured":"Caixia WANG, CHANG Hong. HepatosplenicT cell lymphoma: report on a series of 2 patients and correlative literature Review[J]. West China Med J. 2009;24(3):590\u20132.","journal-title":"West China Med J"},{"key":"3613_CR27","doi-asserted-by":"publisher","unstructured":"Saran FENG, Qian LIU. One case of hepotasplenic \u03b3\u03b4 lymphoma with systemic lupus erythematosus and literature review [J]. J Shandong University(Health Sciences). 2018;56(6):87\u201390. https:\/\/doi.org\/10.6040\/j.issn.1671-7554.0.2018.099.","DOI":"10.6040\/j.issn.1671-7554.0.2018.099"},{"issue":"3","key":"3613_CR28","doi-asserted-by":"publisher","first-page":"255","DOI":"10.3969\/j.issn.1004-583x.2018.03.016","volume":"33","author":"HE Ziyan","year":"2018","unstructured":"Ziyan HE, Junxia MENG, Chunlai LUAN, et al. One case of hepotasplenic eldly \u03b1\u03b2 lymphoma and literature review[J]. Clin Focus. 2018;33(3):255\u201361. https:\/\/doi.org\/10.3969\/j.issn.1004-583x.2018.03.016.","journal-title":"Clin Focus"},{"issue":"5","key":"3613_CR29","first-page":"640","volume":"26","author":"MIAO Ying","year":"2010","unstructured":"Ying MIAO, Xiumin QI, Chunjin HUANG, et al. Two cases of Hepatosplenic T-cell lymphoma. [J] J Clin Exp Pathol. 2010;26(5):640\u20131.","journal-title":"[J] J Clin Exp Pathol"},{"key":"3613_CR30","unstructured":"Li-ping ZHANG,XIA, Yun-jin,LONG, Zhi-guo et al. Hepatosplenic T-cell Lymphoma Complicated Viral Hepatitis Type B Secondary to Cirrhosis: A Case Report and Literature Review[J]. J HBUM.2011;30(4);495\u2013499."},{"key":"3613_CR31","doi-asserted-by":"publisher","unstructured":"Yinli ZHANG, Pengfei SHI et al. YANG fan. Clinical Analysis of 4 Cases of Hepatosplenic T-cell Lymphoma [J]. Zhejiang Medicine.2022;44(17):1880\u20131882. https:\/\/doi.org\/10.12056\/j.issn.1006-2785.2022.44.17.2022-636","DOI":"10.12056\/j.issn.1006-2785.2022.44.17.2022-636"},{"issue":"11","key":"3613_CR32","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.3109\/10428194.2014.889821","volume":"55","author":"M Calvaruso","year":"2015","unstructured":"Calvaruso M, Gulino A, Buffa S, et al. Challenges and new prospects in hepatosplenic \u03b3\u03b4 T-cell lymphoma[J]. Leuk Lymphoma. 2015;55(11):2457\u201365.","journal-title":"Leuk Lymphoma"},{"issue":"1","key":"3613_CR33","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/ajg.2012.334","volume":"108","author":"P Deepak","year":"2013","unstructured":"Deepak P, Sifuentes H, Sherid M. Et. T-cell non-hodgkin\u2019s lymphomas reported to the FDA AERS with tumor necrosis factor-alpha(TNF-alpha) inhibitors: results of the REFURBISH study[J]. Am J Gastroenterol. 2013;108(1):99\u2013105.","journal-title":"Am J Gastroenterol"},{"issue":"5","key":"3613_CR34","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.cgh.2014.05.015","volume":"13","author":"DS Kotlyar","year":"2015","unstructured":"Kotlyar DS, Lewis JD, Beaugerie L, et al. Risk of lymphoma in patients with inflammatory bowel disease treated with azathioprine and 6-mercaptopurine: a meta-analysis[J]. Clin Gastroenterol Hepatol. 2015;13(5):847\u201358.","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"12","key":"3613_CR35","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1016\/j.humpath.2011.01.034","volume":"42","author":"C Lu","year":"2011","unstructured":"Lu C, Tang Y, Yang Q, et al. Hepatosplenic T-cell lymphoma: clinicopathologic, immunophenotypic, and molecular characterization of17 Chinese cases[J]. Hum Pathol. 2011;42(12):1965\u201378.","journal-title":"Hum Pathol"},{"key":"3613_CR36","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.anndiagpath.2016.10.005","volume":"26","author":"M Yabe","year":"2017","unstructured":"Yabe M, Medeiros LJ, Daneshbod Y, et al. Hepatosplenic T-cell lymphoma arising in patients with immunodysregulatory disorders: a study of 7 patients who did not receive tumor necrosis factor-alpha inhibitor therapy and literature review [J]. Ann Diagn Pathol. 2017;26:16\u201322.","journal-title":"Ann Diagn Pathol"},{"issue":"13","key":"3613_CR37","doi-asserted-by":"publisher","first-page":"4261","DOI":"10.1182\/blood-2003-05-1675","volume":"102","author":"K Belhadj","year":"2003","unstructured":"Belhadj K, Reyes F, Farcet JP, et al. Hepatosplenic gammadelta T-cell lymphoma is a rare clinicopathologic entity with poor outcome: report on a series of 21 patients[J]. Blood. 2003;102(13):4261\u20139.","journal-title":"Blood"},{"key":"3613_CR38","doi-asserted-by":"crossref","unstructured":"Ramachandran S, Zaidi F, Aggarwal A et al. Recent advances in diagnostic and therapeutic guidelines for primary and secondary hemophagocytic lymphohistiocytosis[J]. Blood Cells Mol Dis 2017,64:53\u20137.","DOI":"10.1016\/j.bcmd.2016.10.023"},{"key":"3613_CR39","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/978-3-319-99716-2_9","volume":"176","author":"L Gowda","year":"2019","unstructured":"Gowda L, Foss F. Hepatosplenic T-cell lymphomas. Cancer Treat Res. 2019;176:185\u201393.","journal-title":"Cancer Treat Res"},{"issue":"6","key":"3613_CR40","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1200\/JOP.18.00594","volume":"15","author":"M Krishnan","year":"2019","unstructured":"Krishnan M, Lunning M. Hepatosplenic gamma-delta T-Cell lymphoma: who is on your speed dial? J Oncol Pract. 2019;15(6):307\u201312.","journal-title":"J Oncol Pract"},{"key":"3613_CR41","doi-asserted-by":"publisher","first-page":"8399","DOI":"10.2147\/IJGM.S335464","volume":"14","author":"LK Yajun","year":"2021","unstructured":"Yajun LK, Ch,Chaohui Z, et al. Survival Analysis of Hepatosplenic T Cell Lymphoma: a Population-based study using SEER. Int J Gen Med. 2021;14:8399\u2013411. https:\/\/doi.org\/10.2147\/IJGM.S335464.","journal-title":"Int J Gen Med"},{"issue":"6","key":"3613_CR42","doi-asserted-by":"publisher","first-page":"e318","DOI":"10.1038\/bcj.2015.43","volume":"5","author":"A Rashidi","year":"2015","unstructured":"Rashidi A, Cashen AF. Outcomes of allogeneic stem cell transplantation in hepatosplenic T-cell lymphoma[J]. Blood Cancer J. 2015;5(6):e318.","journal-title":"Blood Cancer J"},{"issue":"6","key":"3613_CR43","doi-asserted-by":"publisher","first-page":"E99","DOI":"10.1002\/ajh.24711","volume":"92","author":"U Durani","year":"2017","unstructured":"Durani U, Go RS. Incidence, clinical findings, and survival of hepatosplenic T-cell lymphoma in the United States.[J]. Am J Hematol. 2017;92(6):E99\u2013101.","journal-title":"Am J Hematol"}],"container-title":["World Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-024-03613-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12957-024-03613-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-024-03613-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T16:11:14Z","timestamp":1734538274000},"score":1,"resource":{"primary":{"URL":"https:\/\/wjso.biomedcentral.com\/articles\/10.1186\/s12957-024-03613-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,18]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3613"],"URL":"https:\/\/doi.org\/10.1186\/s12957-024-03613-0","relation":{},"ISSN":["1477-7819"],"issn-type":[{"value":"1477-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,18]]},"assertion":[{"value":"29 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental protocols were approved by the Ethics Committee of Huadong Hospital of Fudan University. Informed consent was obtained from all the participants. All methods were carried out in accordance with Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human ethics and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"330"}}