{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:58:31Z","timestamp":1793649511118,"version":"4.5.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100007847","name":"Jilin Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["20210101457JC"],"award-info":[{"award-number":["20210101457JC"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007847","name":"Jilin Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["20210101457JC"],"award-info":[{"award-number":["20210101457JC"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"DOI":"10.1186\/s12957-025-03899-8","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T05:45:49Z","timestamp":1750657549000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Elevated drain fluid calprotectin as a predictor of early anastomotic leakage in colorectal surgery"],"prefix":"10.1186","volume":"23","author":[{"given":"Limian","family":"Ling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongchao","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"issue":"1","key":"3899_CR1","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s10151-024-02932-4","volume":"28","author":"DJ Nijssen","year":"2024","unstructured":"Nijssen DJ, Wienholts K, Postma MJ, et al. The economic impact of anastomotic leakage after colorectal surgery: a systematic review[J]. Tech Coloproctol. 2024;28(1):55.","journal-title":"Tech Coloproctol"},{"issue":"2","key":"3899_CR2","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s00384-015-2468-3","volume":"31","author":"V Kornmann","year":"2016","unstructured":"Kornmann V, van Ramshorst B, van Dieren S, et al. Early complication detection after colorectal surgery (CONDOR): study protocol for a prospective clinical diagnostic study[J]. Int J Colorectal Dis. 2016;31(2):459\u201364.","journal-title":"Int J Colorectal Dis"},{"issue":"5","key":"3899_CR3","doi-asserted-by":"publisher","first-page":"745","DOI":"10.4240\/wjgs.v15.i5.745","volume":"15","author":"V Tonini","year":"2023","unstructured":"Tonini V, Zanni M. Impact of anastomotic leakage on long-term prognosis after colorectal cancer surgery[J]. World J Gastrointest Surg. 2023;15(5):745\u201356.","journal-title":"World J Gastrointest Surg"},{"key":"3899_CR4","doi-asserted-by":"crossref","unstructured":"Zarnescu EC, Zarnescu NO, Costea R. Updates of risk factors for anastomotic leakage after colorectal Surgery[J]. Diagnostics (Basel). 2021;11(12):2382.","DOI":"10.3390\/diagnostics11122382"},{"issue":"1","key":"3899_CR5","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s00384-023-04438-1","volume":"38","author":"R Li","year":"2023","unstructured":"Li R, Zhou J, Zhao S, et al. Prediction model of anastomotic leakage after anterior resection for rectal cancer-based on nomogram and multivariate analysis with 1995 patients[J]. Int J Colorectal Dis. 2023;38(1):139.","journal-title":"Int J Colorectal Dis"},{"issue":"12","key":"3899_CR6","doi-asserted-by":"publisher","first-page":"3555","DOI":"10.1038\/s41591-024-03280-4","volume":"30","author":"J Zheng","year":"2024","unstructured":"Zheng J, Sun Q, Zhang M, et al. Noninvasive, microbiome-based diagnosis of inflammatory bowel disease[J]. Nat Med. 2024;30(12):3555\u201367.","journal-title":"Nat Med"},{"key":"3899_CR7","doi-asserted-by":"crossref","unstructured":"Ukashi O, Kopylov U, Ungar B et al. Fecal calprotectin diagnostic level gradient along the small bowel in patients with Crohn\u2019s disease[J]. J Crohns Colitis, 2024;19(1):jjae123.","DOI":"10.1093\/ecco-jcc\/jjae123"},{"key":"3899_CR8","doi-asserted-by":"crossref","unstructured":"Rochette L, Dogon G, Rigal E et al. Involvement of Oxidative Stress in Protective Cardiac Functions of Calprotectin[J]. Cells, 2022,11(7).","DOI":"10.3390\/cells11071226"},{"key":"3899_CR9","doi-asserted-by":"publisher","first-page":"223","DOI":"10.2147\/JIR.S250675","volume":"13","author":"M Niemela","year":"2020","unstructured":"Niemela M, Niemela O, Bloigu R, et al. Serum calprotectin, a marker of neutrophil activation, and other mediators of inflammation in response to various types of extreme physical exertion in healthy Volunteers[J]. J Inflamm Res. 2020;13:223\u201331.","journal-title":"J Inflamm Res"},{"issue":"1","key":"3899_CR10","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.arcmed.2019.04.003","volume":"50","author":"J Simioni","year":"2019","unstructured":"Simioni J, Skare TL, Campos A, et al. Fecal calprotectin, gut inflammation and Spondyloarthritis[J]. Arch Med Res. 2019;50(1):41\u20136.","journal-title":"Arch Med Res"},{"issue":"1","key":"3899_CR11","doi-asserted-by":"publisher","first-page":"2701","DOI":"10.1038\/s41467-024-46973-7","volume":"15","author":"J Ma","year":"2024","unstructured":"Ma J, Li Y, Li P, et al. S100A8\/A9 as a prognostic biomarker with causal effects for post-acute myocardial infarction heart failure[J]. Nat Commun. 2024;15(1):2701.","journal-title":"Nat Commun"},{"issue":"2","key":"3899_CR12","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s10096-023-04729-z","volume":"43","author":"FM Agreda","year":"2024","unstructured":"Agreda FM, Origuen J, Rodriguez-Goncer I, et al. Predictive value of fecal calprotectin and lactoferrin levels for negative outcomes in clostridioides difficile infection[J]. Eur J Clin Microbiol Infect Dis. 2024;43(2):313\u201324.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"1","key":"3899_CR13","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s10238-023-01257-0","volume":"24","author":"W Sbeit","year":"2024","unstructured":"Sbeit W, Maamoun B, Azzam S, et al. Ascites fluid calprotectin level is highly accurate in diagnosing spontaneous bacterial peritonitis: a preliminary proof of concept prospective study[J]. Clin Exp Med. 2024;24(1):25.","journal-title":"Clin Exp Med"},{"issue":"2","key":"3899_CR14","doi-asserted-by":"publisher","first-page":"e14111","DOI":"10.1111\/eci.14111","volume":"54","author":"M Fortuny","year":"2024","unstructured":"Fortuny M, Sarrias MR, Torner M, et al. Systematic review of the role of calprotectin in cirrhosis[J]. Eur J Clin Invest. 2024;54(2):e14111.","journal-title":"Eur J Clin Invest"},{"key":"3899_CR15","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jss.2021.12.019","volume":"273","author":"B Su\u2019A","year":"2022","unstructured":"Su\u2019A B, Milne T, Jaung R, et al. Detection of anastomotic leakage following elective colonic surgery: results of the prospective biomarkers and anastomotic leakage (BALL) Study[J]. J Surg Res. 2022;273:85\u201392.","journal-title":"J Surg Res"},{"issue":"3","key":"3899_CR16","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.amjsurg.2013.09.024","volume":"208","author":"N Komen","year":"2014","unstructured":"Komen N, Slieker J, Willemsen P, et al. Acute phase proteins in drain fluid: a new screening tool for colorectal anastomotic leakage? The APPEAL study: analysis of parameters predictive for evident anastomotic leakage[J]. Am J Surg. 2014;208(3):317\u201323.","journal-title":"Am J Surg"},{"key":"3899_CR17","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.amsu.2018.09.008","volume":"35","author":"C Paasch","year":"2018","unstructured":"Paasch C, Rink S, Steinbach M, et al. Bilirubin, urobilinogen, pancreas elastase and bile acid in drain fluid. The GBUP-study: analysis of biomarkers for a colorectal anastomotic leakage[J]. Ann Med Surg (Lond). 2018;35:44\u201350.","journal-title":"Ann Med Surg (Lond)"},{"issue":"21","key":"3899_CR18","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.3748\/wjg.v24.i21.2247","volume":"24","author":"A Sciuto","year":"2018","unstructured":"Sciuto A, Merola G, De Palma GD, et al. Predictive factors for anastomotic leakage after laparoscopic colorectal surgery[J]. World J Gastroenterol. 2018;24(21):2247\u201360.","journal-title":"World J Gastroenterol"},{"issue":"2","key":"3899_CR19","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.jamcollsurg.2008.10.015","volume":"208","author":"TP Kingham","year":"2009","unstructured":"Kingham TP, Pachter HL. Colonic anastomotic leak: risk factors, diagnosis, and treatment[J]. J Am Coll Surg. 2009;208(2):269\u201378.","journal-title":"J Am Coll Surg"},{"issue":"1","key":"3899_CR20","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1002\/bjs5.50106","volume":"3","author":"P Bostrom","year":"2019","unstructured":"Bostrom P, Haapamaki MM, Rutegard J, et al. Population-based cohort study of the impact on postoperative mortality of anastomotic leakage after anterior resection for rectal cancer[J]. BJS Open. 2019;3(1):106\u201311.","journal-title":"BJS Open"},{"issue":"4","key":"3899_CR21","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s00268-001-0256-4","volume":"26","author":"A Alves","year":"2002","unstructured":"Alves A, Panis Y, Trancart D, et al. Factors associated with clinically significant anastomotic leakage after large bowel resection: multivariate analysis of 707 patients[J]. World J Surg. 2002;26(4):499\u2013502.","journal-title":"World J Surg"},{"issue":"4","key":"3899_CR22","first-page":"384","volume":"21","author":"K Tao","year":"2018","unstructured":"Tao K, Gao J. [Risk factors for anastomotic leakage after rectal cancer surgery][J]. Zhonghua Wei Chang Wai Ke Za Zhi. 2018;21(4):384\u20137.","journal-title":"Zhonghua Wei Chang Wai Ke Za Zhi"},{"issue":"24","key":"3899_CR23","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.3748\/wjg.v28.i24.2758","volume":"28","author":"N Rama","year":"2022","unstructured":"Rama N, Lages M, Guarino M, et al. Usefulness of serum C-reactive protein and calprotectin for the early detection of colorectal anastomotic leakage: A prospective observational study[J]. World J Gastroenterol. 2022;28(24):2758\u201374.","journal-title":"World J Gastroenterol"},{"issue":"1","key":"3899_CR24","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.amjsurg.2015.06.018","volume":"212","author":"M Cikot","year":"2016","unstructured":"Cikot M, Kones O, Gedikbasi A, et al. The marker C-reactive protein is helpful in monitoring the integrity of anastomosis: plasma calprotectin[J]. Am J Surg. 2016;212(1):53\u201361.","journal-title":"Am J Surg"},{"key":"3899_CR25","doi-asserted-by":"crossref","unstructured":"Luo J, Wu H, Yang Y et al. Oxidative stress level as a predictor of anastomotic leakage after rectal Surgery[J]. Mediators Inflamm, 2021;2021:9968642.","DOI":"10.1155\/2021\/9968642"},{"issue":"4","key":"3899_CR26","first-page":"442","volume":"21","author":"Z Lyu","year":"2018","unstructured":"Lyu Z, Wu D, Cai G, et al. [Use of C response protein in predicting postoperative anastomotic leakage in patients with rectal cancer][J]. Zhonghua Wei Chang Wai Ke Za Zhi. 2018;21(4):442\u20137.","journal-title":"Zhonghua Wei Chang Wai Ke Za Zhi"},{"issue":"4","key":"3899_CR27","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.jamcollsurg.2014.06.011","volume":"219","author":"KW Reisinger","year":"2014","unstructured":"Reisinger KW, Poeze M, Hulsewe KW, et al. Accurate prediction of anastomotic leakage after colorectal surgery using plasma markers for intestinal damage and inflammation[J]. J Am Coll Surg. 2014;219(4):744\u201351.","journal-title":"J Am Coll Surg"},{"issue":"5","key":"3899_CR28","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1515\/cclm-2023-1164","volume":"62","author":"L Agnello","year":"2024","unstructured":"Agnello L, Buscemi S, Di Buono G, et al. Drainage fluid LDH and neutrophil to lymphocyte ratio as biomarkers for early detecting anastomotic leakage in patients undergoing colorectal surgery[J]. Clin Chem Lab Med. 2024;62(5):967\u201378.","journal-title":"Clin Chem Lab Med"},{"key":"3899_CR29","doi-asserted-by":"crossref","unstructured":"Shi J, Wu Z, Wu X et al. Early diagnosis of anastomotic leakage after colorectal cancer surgery using an inflammatory factors-based score system[J]. BJS Open, 2022;6(3):zrac069.","DOI":"10.1093\/bjsopen\/zrac069"},{"issue":"2","key":"3899_CR30","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ijsu.2011.12.006","volume":"10","author":"AB Almeida","year":"2012","unstructured":"Almeida AB, Faria G, Moreira H, et al. Elevated serum C-reactive protein as a predictive factor for anastomotic leakage in colorectal surgery[J]. Int J Surg. 2012;10(2):87\u201391.","journal-title":"Int J Surg"},{"issue":"2","key":"3899_CR31","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.surg.2014.09.009","volume":"157","author":"DG Watt","year":"2015","unstructured":"Watt DG, Horgan PG, McMillan DC. Routine clinical markers of the magnitude of the systemic inflammatory response after elective operation: a systematic review[J]. Surgery. 2015;157(2):362\u201380.","journal-title":"Surgery"},{"issue":"3","key":"3899_CR32","doi-asserted-by":"publisher","first-page":"216","DOI":"10.7150\/ijms.8.216","volume":"8","author":"H Esme","year":"2011","unstructured":"Esme H, Kesli R, Apiliogullari B, et al. Effects of flurbiprofen on CRP, TNF-alpha, IL-6, and postoperative pain of thoracotomy[J]. Int J Med Sci. 2011;8(3):216\u201321.","journal-title":"Int J Med Sci"},{"issue":"4","key":"3899_CR33","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1128\/JCM.02284-16","volume":"55","author":"M Natesan","year":"2017","unstructured":"Natesan M, Corea E, Krishnananthasivam S, et al. Calprotectin as a biomarker for melioidosis disease progression and Management[J]. J Clin Microbiol. 2017;55(4):1205\u201310.","journal-title":"J Clin Microbiol"},{"issue":"3","key":"3899_CR34","first-page":"97","volume":"42","author":"FL Josifovikj","year":"2021","unstructured":"Josifovikj FL, Stardelova KG, Todorovska B, et al. Diagnostic potential of calprotectin for spontaneous bacterial peritonitis in patients withliver cirrhosis and Ascites[J]. Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2021;42(3):97\u2013106.","journal-title":"Pril (Makedon Akad Nauk Umet Odd Med Nauki)"},{"key":"3899_CR35","doi-asserted-by":"crossref","unstructured":"Loniewska B, Wegrzyn D, Adamek K et al. The influence of Maternal-Foetal parameters on concentrations of Zonulin and calprotectin in the blood and stool of healthy newborns during the first seven days of life. An observational prospective cohort Study[J]. J Clin Med. 2019;8(4):473.","DOI":"10.3390\/jcm8040473"},{"issue":"1","key":"3899_CR36","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1055\/s-0042-1757559","volume":"36","author":"WB Lyman","year":"2023","unstructured":"Lyman WB, Whitlow CB. Overuse of proximal fecal diversion in colorectal Surgery[J]. Clin Colon Rectal Surg. 2023;36(1):52\u20136.","journal-title":"Clin Colon Rectal Surg"}],"container-title":["World Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-025-03899-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12957-025-03899-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-025-03899-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T18:02:11Z","timestamp":1750701731000},"score":1,"resource":{"primary":{"URL":"https:\/\/wjso.biomedcentral.com\/articles\/10.1186\/s12957-025-03899-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,23]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3899"],"URL":"https:\/\/doi.org\/10.1186\/s12957-025-03899-8","relation":{},"ISSN":["1477-7819"],"issn-type":[{"value":"1477-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,23]]},"assertion":[{"value":"4 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study design was approved by the Second Affiliated Hospital of Zhejiang University School of Medicine (approval no: YS2020-055). Written informed consent was obtained from all individual participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All patients provided written informed consent before enrollment in the study and consent for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"247"}}