{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:22:59Z","timestamp":1772166179262,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"DOI":"10.1186\/s12957-025-04006-7","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T10:29:47Z","timestamp":1761042587000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tumor invasion loci in resected margins of perihilar cholangiocarcinoma and their impact on survival: a retrospective 13-year longitudinal cohort study"],"prefix":"10.1186","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9879-6403","authenticated-orcid":false,"given":"Yury","family":"Kovalenko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1788-9681","authenticated-orcid":false,"given":"Anna","family":"Olifir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6904-9318","authenticated-orcid":false,"given":"Andrei","family":"Glotov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6267-8237","authenticated-orcid":false,"given":"Anatoly","family":"Popov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1176-1203","authenticated-orcid":false,"given":"Sergey","family":"Trifonov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5724-6034","authenticated-orcid":false,"given":"Dmitry","family":"Blagovestnov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4643-0252","authenticated-orcid":false,"given":"Tatyana","family":"Shevchenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5958-3608","authenticated-orcid":false,"given":"Beslan","family":"Gurmikov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7631-8149","authenticated-orcid":false,"given":"Nina","family":"Loginova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9636-3807","authenticated-orcid":false,"given":"Yury","family":"Zharikov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"issue":"1","key":"4006_CR1","first-page":"6","volume":"48","author":"SH Landis","year":"1998","unstructured":"Landis SH, Murray T, Bolden S, Wingo PA. Cancer statistics. CA Cancer J Clin. 1998;48(1):6\u201329.","journal-title":"CA Cancer J Clin"},{"issue":"9","key":"4006_CR2","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/s41575-020-0310-z","volume":"17","author":"JM Banales","year":"2020","unstructured":"Banales JM, Marin JJG, Lamarca A, et al. Cholangiocarcinoma 2020: the next horizon in mechanisms and management. Nat Rev Gastroenterol Hepatol. 2020;17(9):557\u201388.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"4006_CR3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1080\/14737140.2022.1999809","volume":"22","author":"DB Hewitt","year":"2022","unstructured":"Hewitt DB, Brown ZJ, Pawlik TM. Surgical management of intrahepatic cholangiocarcinoma. Expert Rev Anticancer Ther. 2022;22(1):27\u201338.","journal-title":"Expert Rev Anticancer Ther"},{"issue":"4","key":"4006_CR4","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.surg.2017.08.011","volume":"163","author":"K Komaya","year":"2018","unstructured":"Komaya K, Ebata T, Yokoyama Y, et al. Recurrence after curative-intent resection of perihilar cholangiocarcinoma: analysis of a large cohort with a close postoperative follow-up approach. Surgery. 2018;163(4):732\u20138.","journal-title":"Surgery"},{"issue":"3","key":"4006_CR5","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1007\/s12029-020-00390-3","volume":"51","author":"B Moazzami","year":"2020","unstructured":"Moazzami B, Majidzadeh -AK, Dooghaie-Moghadam A, et al. Cholangiocarcinoma: state of the Art. J Gastrointest Cancer. 2020;51(3):774\u201381.","journal-title":"J Gastrointest Cancer"},{"issue":"5","key":"4006_CR6","doi-asserted-by":"publisher","first-page":"100737","DOI":"10.1016\/j.aohep.2022.100737","volume":"27","author":"A Elvevi","year":"2022","unstructured":"Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S. Clinical treatment of cholangiocarcinoma: an updated comprehensive review. Ann Hepatol. 2022;27(5):100737. https:\/\/doi.org\/10.1016\/j.aohep.2022.100737.","journal-title":"Ann Hepatol"},{"issue":"1","key":"4006_CR7","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1001\/archsurg.2011.771","volume":"147","author":"G Nuzzo","year":"2012","unstructured":"Nuzzo G, Giuliante F, Ardito F, et al. Improvement in perioperative and long-term outcome after surgical treatment of hilar cholangiocarcinoma: results of an Italian multicenter analysis of 440 patients. Arch Surg. 2012;147(1):26\u201334.","journal-title":"Arch Surg"},{"key":"4006_CR8","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.jamcollsurg.2015.09.005","volume":"221","author":"B Groot Koerkamp","year":"2015","unstructured":"Groot Koerkamp B, Wiggers JK, Allen PJ, et al. Recurrence rate and pattern of perihilar cholangiocarcinoma after curative intent resection. J Am Coll Surg. 2015;221:1041\u20139.","journal-title":"J Am Coll Surg"},{"key":"4006_CR9","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1097\/01.sla.0000251366.62632.d3","volume":"245","author":"ML DeOliveira","year":"2007","unstructured":"DeOliveira ML, Cunningham SC, Cameron JL, et al. Cholangiocarcinoma: Thirty-one-year experience with 564 patients at a single institution. Ann Surg. 2007;245:755\u201362.","journal-title":"Ann Surg"},{"key":"4006_CR10","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1097\/01.sla.0000129491.43855.6b","volume":"240","author":"S Kondo","year":"2004","unstructured":"Kondo S, Hirano S, Ambo Y, et al. Forty consecutive resections of hilar cholangiocarcinoma with no postoperative mortality and no positive ductal margins: results of a prospective study. Ann Surg. 2004;240:95\u2013101.","journal-title":"Ann Surg"},{"issue":"34","key":"4006_CR11","doi-asserted-by":"publisher","first-page":"e119","DOI":"10.1097\/MD.0000000000011999","volume":"97","author":"Z Tang","year":"2018","unstructured":"Tang Z, Yang Y, Zhao Z, Wei K, Meng W, Li X. The clinicopathological factors associated with prognosis of patients with resectable Perihilar cholangiocarcinoma: a systematic review and meta-analysis. Med (Baltim). 2018;97(34):e119-99.","journal-title":"Med (Baltim)"},{"issue":"4","key":"4006_CR12","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.hpb.2018.08.017","volume":"21","author":"I Hosokawa","year":"2019","unstructured":"Hosokawa I, Shimizu H, Yoshitomi H, et al. Outcomes of left trisectionectomy and right hepatectomy for perihilar cholangiocarcinoma. HPB. 2019;21(4):489\u201398.","journal-title":"HPB"},{"issue":"24","key":"4006_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14246126","volume":"14","author":"M De Bellis","year":"2022","unstructured":"De Bellis M, Mastrosimini MG, Conci S, et al. The prognostic role of true radical resection in perihilar cholangiocarcinoma after improved evaluation of radial margin status. Cancers (Basel). 2022;14(24):6126.","journal-title":"Cancers (Basel)"},{"issue":"10","key":"4006_CR14","doi-asserted-by":"publisher","first-page":"4115","DOI":"10.1016\/j.asjsur.2022.12.043","volume":"46","author":"YF Hu","year":"2023","unstructured":"Hu YF, Hu HJ, Lv TR, et al. Should more aggressive surgical resection be considered in the treatment for bismuth types I and II hilar cholangiocarcinoma? A meta-analysis. Asian J Surg. 2023;46(10):4115\u201323.","journal-title":"Asian J Surg"},{"key":"4006_CR15","first-page":"1","volume-title":"TNM classification of malignant tumours","author":"LH Sobin","year":"2009","unstructured":"Sobin LH, Gospodarowicz MK, Wittekind C. TNM classification of malignant tumours. New York: seventh ed. Wiley; 2009. pp. 1\u2013253."},{"issue":"3","key":"4006_CR16","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1097\/SLA.0000000000003305","volume":"273","author":"K Shinohara","year":"2021","unstructured":"Shinohara K, Ebata T, Shimoyama Y, et al. A study on radial margin status in resected perihilar cholangiocarcinoma. Ann Surg. 2021;273(3):572\u20138.","journal-title":"Ann Surg"},{"issue":"4","key":"4006_CR17","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s00428-019-02621-w","volume":"475","author":"E Roos","year":"2019","unstructured":"Roos E, Franken LC, Soer EC, et al. Lost in translation: confusion on resection and dissection planes hampers the interpretation of pathology reports for perihilar cholangiocarcinoma. Virchows Arch. 2019;475(4):435\u201343.","journal-title":"Virchows Arch"},{"issue":"5","key":"4006_CR18","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/j.jhep.2011.12.010","volume":"56","author":"D Chatelain","year":"2012","unstructured":"Chatelain D, Farges O, Fuks D, et al. Assessment of pathology reports on hilar cholangiocarcinoma: the results of a nationwide, multicenter survey performed by the AFC-HC-2009 study group. J Hepatol. 2012;56(5):1121\u20138.","journal-title":"J Hepatol"},{"issue":"3","key":"4006_CR19","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1245\/s10434-020-09105-1","volume":"28","author":"S Stremitzer","year":"2021","unstructured":"Stremitzer S, Stift J, Laengle J, et al. Prognosis and circumferential margin in patients with resected hilar cholangiocarcinoma. Ann Surg Oncol. 2021;28(3):1493\u20138.","journal-title":"Ann Surg Oncol"},{"key":"4006_CR20","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.suronc.2020.02.013","volume":"33","author":"YA Kovalenko","year":"2020","unstructured":"Kovalenko YA, Zharikov YO, Konchina NA, et al. Perihilar cholangiocarcinoma: a different concept for radical resection. Surg Oncol. 2020;33:270\u20135.","journal-title":"Surg Oncol"},{"issue":"3","key":"4006_CR21","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s00428-021-03231-1","volume":"480","author":"MA D\u2019Souza","year":"2022","unstructured":"D\u2019Souza MA, Al-Saffar HA, Fern\u00e1ndez Moro C, et al. Redefining resection margins and dissection planes in perihilar cholangiocarcinoma-radical resection is a rare event. Virchows Arch. 2022;480(3):557\u201364.","journal-title":"Virchows Arch"},{"issue":"3","key":"4006_CR22","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.surg.2023.05.014","volume":"174","author":"F Ratti","year":"2023","unstructured":"Ratti F, Marino R, Pedica F, et al. Radial and longitudinal margins in surgery of perihilar cholangiocarcinoma: when R1 definition is associated with different prognosis. Surgery. 2023;174(3):447\u201356.","journal-title":"Surgery"},{"issue":"3","key":"4006_CR23","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1002\/jhbp.211","volume":"22","author":"M Miyazaki","year":"2015","unstructured":"Miyazaki M, Ohtsuka M, Miyakawa S, et al. Classification of biliary tract cancers established by the Japanese society of Hepato-Biliary-Pancreatic surgery: 3(rd) english edition. J Hepatobiliary Pancreat Sci. 2015;22(3):181\u201396.","journal-title":"J Hepatobiliary Pancreat Sci"},{"issue":"2","key":"4006_CR24","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/his.13975","volume":"76","author":"ID Nagtegaal","year":"2020","unstructured":"Nagtegaal ID, Odze RD, Klimstra D, WHO classification of tumours editorial board, et al. The 2019 WHO classification of tumours of the digestive system. Histopathology. 2020;76(2):182\u20138.","journal-title":"Histopathology"},{"issue":"1","key":"4006_CR25","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1097\/SLA.0b013e3182708b57","volume":"258","author":"M Nagino","year":"2013","unstructured":"Nagino M, Ebata T, Yokoyama Y, et al. Evolution of surgical treatment for Perihilar cholangiocarcinoma: a single-center 34-year review of 574 consecutive resections. Ann Surg. 2013;258(1):129\u201340.","journal-title":"Ann Surg"},{"issue":"4","key":"4006_CR26","doi-asserted-by":"publisher","first-page":"e19","DOI":"10.5858\/134.4.e19","volume":"134","author":"MK Washington","year":"2010","unstructured":"Washington MK, Berlin J, Branton PA, et al. Protocol for the examination of specimens from patients with carcinoma of the Perihilar bile ducts. Arch Pathol Lab Med. 2010;134(4):e19\u201324.","journal-title":"Arch Pathol Lab Med"},{"issue":"7","key":"4006_CR27","doi-asserted-by":"publisher","first-page":"159","DOI":"10.4251\/wjgo.v5.i7.159","volume":"5","author":"VM Castellano-Meg\u00edas","year":"2013","unstructured":"Castellano-Meg\u00edas VM, Ibarrola-de Andr\u00e9s C, Colina-Ruizdelgado F. Pathological aspects of so called \"hilar cholangiocarcinoma\". World J Gastrointest Oncol 2013; 5(7):159-70.","journal-title":"World J Gastrointest Oncol"},{"key":"4006_CR28","doi-asserted-by":"crossref","unstructured":"Nakanuma Y, Sasaki M, Sato Y, et al. Multistep carcinogenesis of perihilar cholangiocarcinoma arising in the intrahepatic large bile ducts. World J Hepatol 2009; 1(1):35-42","DOI":"10.4254\/wjh.v1.i1.35"},{"key":"4006_CR29","doi-asserted-by":"crossref","unstructured":"Nakanuma Y, Jang KT, Fukushima N, et al. A statement by the Japan-Korea expert pathologists for future clinicopathological and molecular analyses toward consensus building of intraductal papillary neoplasm of the bile duct through several opinions at the present stage. J Hepatobiliary Pancreat Sci. 2018;25(3):181-87.","DOI":"10.1002\/jhbp.532"}],"container-title":["World Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-025-04006-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12957-025-04006-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-025-04006-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T16:49:48Z","timestamp":1762447788000},"score":1,"resource":{"primary":{"URL":"https:\/\/wjso.biomedcentral.com\/articles\/10.1186\/s12957-025-04006-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,21]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4006"],"URL":"https:\/\/doi.org\/10.1186\/s12957-025-04006-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6620965\/v1","asserted-by":"object"}]},"ISSN":["1477-7819"],"issn-type":[{"value":"1477-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,21]]},"assertion":[{"value":"8 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2025","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original article has been updated: ORCID were updated for the authors Yury Kovalenko, Sergei Trifonov and  Anatoly Popov.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study complied with the norms of the Declaration of Helsinki and was fully approved by the Local Ethics Committee of the A.V. Vishnevsky National Medical Research Center of Surgery under protocol No. 08\u201319 on May 6, 2019.All participants gave informed consent prior to the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors have given their consent for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"386"}}