{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:00:21Z","timestamp":1780052421620,"version":"3.53.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2023AFB776"],"award-info":[{"award-number":["2023AFB776"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"DOI":"10.1186\/s12957-025-04052-1","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T09:35:23Z","timestamp":1761816923000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical characteristics and surgical management of rare thoracic myelolipoma: experience from a single center with literature review"],"prefix":"10.1186","volume":"23","author":[{"given":"Zeguang","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingchuang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"4052_CR1","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1016\/j.athoracsur.2007.11.023","volume":"85","author":"M Vaziri","year":"2008","unstructured":"Vaziri M, Sadeghipour A, Pazooki A, Shoolami LZ. Primary mediastinal myelolipoma. Ann Thorac Surg. 2008;85:1805\u20136.","journal-title":"Ann Thorac Surg"},{"key":"4052_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2021.105997","volume":"83","author":"T Sakai","year":"2021","unstructured":"Sakai T, Aiba H, Nakagawa M, Hattori H, Murakami H, Kimura H. Myelolipoma mimicking osteosarcoma in the distal femur. Int J Surg Case Rep. 2021;83:105997.","journal-title":"Int J Surg Case Rep"},{"key":"4052_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-024-04682-1","volume":"18","author":"A Amate Neto","year":"2024","unstructured":"Amate Neto A, Preto FRC, de Moraes AT, Salom\u00e3o SL, Frederigue TB, de Nadai MN, et al. Rib myelolipoma: a case report. J Med Case Rep. 2024;18:377.","journal-title":"J Med Case Rep"},{"issue":"1","key":"4052_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-023-02608-z","volume":"23","author":"J Ji","year":"2023","unstructured":"Ji J, Zhong H, Ren X, He T, Xie G, Wang X. Bronchoscopic treatment of multiple bronchial myelolipomas: a case report and literature review. BMC Pulm Med. 2023;23(1):317.","journal-title":"BMC Pulm Med"},{"key":"4052_CR5","volume":"6","author":"Y Xiong","year":"2014","unstructured":"Xiong Y, Wang Y, Lin Y. Primary myelolipoma in posterior mediastinum. J Thorac Dis. 2014;6:E181\u2013187.","journal-title":"J Thorac Dis"},{"key":"4052_CR6","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1093\/icvts\/ivv112","volume":"21","author":"F Lin","year":"2015","unstructured":"Lin F, Pu Q, Ma L, Liu C, Mei J, Liao H, et al. Surgical treatment of primary mediastinal myelolipoma. Interact Cardiovasc Thorac Surg. 2015;21:206\u201310.","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"4052_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-024-02829-1","volume":"19","author":"L Xu","year":"2024","unstructured":"Xu L, Wen X, Feng SY. A case of posterior mediastinal myelolipoma and a literature review of its imaging manifestations. J Cardiothorac Surg. 2024;19:458.","journal-title":"J Cardiothorac Surg"},{"key":"4052_CR8","doi-asserted-by":"publisher","first-page":"862","DOI":"10.3892\/ol.2012.1085","volume":"5","author":"C Geng","year":"2013","unstructured":"Geng C, Liu N, Yang G, Qi M, Chen W. Primary mediastinal myelolipoma: a case report and review of the literature. Oncol Lett. 2013;5:862\u20134.","journal-title":"Oncol Lett"},{"key":"4052_CR9","doi-asserted-by":"publisher","first-page":"E39","DOI":"10.5489\/cuaj.824","volume":"4","author":"D Beiko","year":"2010","unstructured":"Beiko D, Roldan H, Sengupta SK, George RL. Laparoscopic excision of a large extra-adrenal perirenal myelolipoma. Can Urol Assoc J. 2010;4:E39-41.","journal-title":"Can Urol Assoc J"},{"key":"4052_CR10","first-page":"69","volume":"1","author":"ER Saleeby","year":"1925","unstructured":"Saleeby ER. Heterotopia of the bone marrow without apparent cause. Am J Pathol. 1925;1:69\u20137663.","journal-title":"Am J Pathol"},{"key":"4052_CR11","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jss.2016.08.076","volume":"207","author":"C Shen","year":"2017","unstructured":"Shen C, Zhou K, Lai Y, Fan J, Liu L, Che G. Review of primary extra-adrenal myelolipoma of the thorax. J Surg Res. 2017;207:131\u20137.","journal-title":"J Surg Res"},{"key":"4052_CR12","first-page":"71","volume":"3","author":"S Daneshmand","year":"2006","unstructured":"Daneshmand S, Quek ML. Adrenal myelolipoma: diagnosis and management. Urol J. 2006;3:71\u20134.","journal-title":"Urol J"},{"key":"4052_CR13","doi-asserted-by":"publisher","first-page":"E219","DOI":"10.21037\/jtd.2017.02.65","volume":"9","author":"Q Shi","year":"2017","unstructured":"Shi Q, Pan S, Bao Y, Fan H, Diao Y. Primary mediastinal myelolipoma: a case report and literature review. J Thorac Dis. 2017;9:E219\u201325.","journal-title":"J Thorac Dis"},{"key":"4052_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2021.01.026","volume":"362","author":"X Chen","year":"2021","unstructured":"Chen X, Wang H, Shu J. Multiple myelolipomas in bilateral posterior mediastinum. Am J Med Sci. 2021;362:e23\u20134.","journal-title":"Am J Med Sci"},{"key":"4052_CR15","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/0149-936X(84)90095-X","volume":"8","author":"K Kim","year":"1984","unstructured":"Kim K, Koo BC, Davis JT, Franco-Saenz R. Primary myelolipoma of mediastinum. J Comput Tomogr. 1984;8:119\u201323.","journal-title":"J Comput Tomogr"},{"key":"4052_CR16","first-page":"977","volume":"18","author":"DG Omdal","year":"1997","unstructured":"Omdal DG, Baird DE, Burton BS, Goodhue WW Jr., Giddens EM. Myelolipoma of the thoracic spine. AJNR Am J Neuroradiol. 1997;18:977\u20139.","journal-title":"AJNR Am J Neuroradiol"},{"key":"4052_CR17","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/S0003-4975(02)03667-6","volume":"74","author":"CJ Sabate","year":"2002","unstructured":"Sabate CJ, Shahian DM. Pulmonary myelolipoma. Ann Thorac Surg. 2002;74:573\u20135.","journal-title":"Ann Thorac Surg"},{"key":"4052_CR18","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1016\/j.ejcts.2004.08.024","volume":"26","author":"T Franiel","year":"2004","unstructured":"Franiel T, Fleischer B, Raab BW, F\u00fczesi L. Bilateral thoracic extraadrenal myelolipoma. Eur J Cardiothorac Surg. 2004;26:1220\u20132.","journal-title":"Eur J Cardiothorac Surg"},{"key":"4052_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbo.2022.100438","volume":"35","author":"J Cao","year":"2022","unstructured":"Cao J, Huang X, Cui N, Wang X, You C, Ni X, et al. Surgical management and outcome of extra-adrenal myelolipomas at unusual locations: a report of 11 cases in a single center. J Bone Oncol. 2022;35:100438.","journal-title":"J Bone Oncol"},{"key":"4052_CR20","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1159\/000088004","volume":"73","author":"K Mohan","year":"2006","unstructured":"Mohan K, Gosney JR, Holemans JA. Symptomatic mediastinal myelolipoma. Respiration. 2006;73:552.","journal-title":"Respiration"},{"key":"4052_CR21","first-page":"1","volume":"6","author":"KS Baker","year":"2012","unstructured":"Baker KS, Lee D, Huang M, Gould ES. Presacral myelolipoma: a case report and review of imaging findings. J Radiol Case Rep. 2012;6:1\u20139.","journal-title":"J Radiol Case Rep"},{"key":"4052_CR22","doi-asserted-by":"publisher","first-page":"470","DOI":"10.2214\/AJR.15.15280","volume":"207","author":"JJ Lee","year":"2016","unstructured":"Lee JJ, Dickson BC, Sreeharsha B, Gladdy RA, Thipphavong S. Presacral myelolipoma: diagnosis on imaging with pathologic and clinical correlation. AJR Am J Roentgenol. 2016;207:470\u201381.","journal-title":"AJR Am J Roentgenol"},{"key":"4052_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.05.041","volume":"103","author":"C Mehta","year":"2017","unstructured":"Mehta C, Raparia K, Bharat A. Anterior mediastinal myelolipoma. Ann Thorac Surg. 2017;103:e81.","journal-title":"Ann Thorac Surg"},{"key":"4052_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-019-0910-y","volume":"19","author":"HS Chung","year":"2019","unstructured":"Chung HS, Lee KM, Eom JS, Kim I, Park S, Ahn J, et al. Bronchoscopic management of solitary bronchial myelolipoma: a case report. BMC Pulm Med. 2019;19:151.","journal-title":"BMC Pulm Med"},{"key":"4052_CR25","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1177\/021849230201000227","volume":"10","author":"B Gao","year":"2002","unstructured":"Gao B, Sugimura H, Sugimura S, Hattori Y, Iriyama T, Kano H. Mediastinal myelolipoma. Asian Cardiovasc Thorac Ann. 2002;10:189\u201390.","journal-title":"Asian Cardiovasc Thorac Ann"},{"key":"4052_CR26","doi-asserted-by":"publisher","unstructured":"Zhu GG, Witt BL, Winter Iii TC, Rogers DM. Multiple enlarging hepatic and retroperitoneal myelolipomas in the setting of Cushing disease. BMJ Case Rep. 2021;14. https:\/\/doi.org\/10.1136\/bcr-2020-239107","DOI":"10.1136\/bcr-2020-239107"},{"key":"4052_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6823-14-42","volume":"14","author":"MQ Almeida","year":"2014","unstructured":"Almeida MQ, Kaupert LC, Brito LP, Lerario AM, Mariani BM, Ribeiro M, et al. Increased expression of ACTH (MC2R) and androgen (AR) receptors in giant bilateral myelolipomas from patients with congenital adrenal hyperplasia. BMC Endocr Disord. 2014;14:42.","journal-title":"BMC Endocr Disord"},{"key":"4052_CR28","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052543","author":"V Kolli","year":"2024","unstructured":"Kolli V, Frucci E, da Cunha IW, Iben JR, Kim SA, Mallappa A, et al. Evidence of the role of inflammation and the hormonal environment in the pathogenesis of adrenal myelolipomas in congenital adrenal hyperplasia. Int J Mol Sci. 2024. https:\/\/doi.org\/10.3390\/ijms25052543.","journal-title":"Int J Mol Sci"},{"key":"4052_CR29","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/S2213-8587(21)00178-9","volume":"9","author":"J Calissendorff","year":"2021","unstructured":"Calissendorff J, Juhlin CC, Sundin A, Bancos I, Falhammar H. Adrenal myelolipomas. Lancet Diabetes Endocrinol. 2021;9:767\u201375.","journal-title":"Lancet Diabetes Endocrinol"},{"key":"4052_CR30","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s12020-017-1473-4","volume":"59","author":"\u00c1 Decmann","year":"2018","unstructured":"Decmann \u00c1, Perge P, T\u00f3th M, Igaz P. Adrenal myelolipoma: a comprehensive review. Endocrine. 2018;59:7\u201315.","journal-title":"Endocrine"},{"key":"4052_CR31","first-page":"46","volume":"103","author":"M Salemme","year":"2011","unstructured":"Salemme M, Rodella R, Fisogni S, Facchetti F. Nodular extramedullary hematopoiesis involving the adrenal gland. An uncommon cause of adrenal incidentaloma. Pathologica. 2011;103:46\u20139.","journal-title":"Pathologica"},{"issue":"Suppl 2","key":"4052_CR32","first-page":"324","volume":"8","author":"MR Gamberini","year":"2011","unstructured":"Gamberini MR, Prandini N, Chiodi E, Farneti C, Garani MC. Adrenal incidentaloma in thalassemia: a case report and literature review. Pediatr Endocrinol Rev. 2011;8(Suppl 2):324\u201330.","journal-title":"Pediatr Endocrinol Rev"},{"key":"4052_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.04.013","volume":"106","author":"I Goel","year":"2018","unstructured":"Goel I, Kaushik P, Anand R. Bilateral posterior mediastinal primary myelolipoma. Ann Thorac Surg. 2018;106:e235\u20137.","journal-title":"Ann Thorac Surg"},{"key":"4052_CR34","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/BF01738704","volume":"62","author":"HR Sch\u00f6n","year":"1984","unstructured":"Sch\u00f6n HR, Emmerich B, Arnold H, Maubach PA, Becker K, Rastetter J. Hemolytic anemia with pyruvate kinase deficiency presenting as paravertebral myelolipoma. Klin Wochenschr. 1984;62:133\u20137.","journal-title":"Klin Wochenschr"},{"key":"4052_CR35","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1378\/chest.104.5.1623","volume":"104","author":"VT De Montpr\u00e9ville","year":"1993","unstructured":"De Montpr\u00e9ville VT, Dulmet EM, Chapelier AR, Dartevelle PG, Verley JM. Extramedullary hematopoietic tumors of the posterior mediastinum related to asymptomatic refractory anemia. Chest. 1993;104:1623\u20134.","journal-title":"Chest"},{"issue":"4","key":"4052_CR36","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s11748-013-0230-8","volume":"62","author":"T Ema","year":"2014","unstructured":"Ema T, Kawano R. Myelolipoma of the posterior mediastinum: report of a case. Gen Thorac Cardiovasc Surg. 2014;62(4):241\u20133.","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"4052_CR37","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0165-4608(01)00592-1","volume":"134","author":"KC Chang","year":"2002","unstructured":"Chang KC, Chen PI, Huang ZH, Lin YM, Kuo PL. Adrenal myelolipoma with translocation (3;21)(q25;p11). Cancer Genet Cytogenet. 2002;134:77\u201380.","journal-title":"Cancer Genet Cytogenet"},{"key":"4052_CR38","doi-asserted-by":"publisher","unstructured":"Fonda P, de Santiago E, Guijarro M, Gamallo C. Mediastinal myelolipoma with leukocytosis. BMJ Case Rep. 2013;2013. https:\/\/doi.org\/10.1136\/bcr-2013-010349","DOI":"10.1136\/bcr-2013-010349"},{"key":"4052_CR39","doi-asserted-by":"publisher","first-page":"503","DOI":"10.4103\/IJPM.IJPM_295_18","volume":"62","author":"R Sachdev","year":"2019","unstructured":"Sachdev R, Goel RK, Goel S, Ahlawat K. An unusual presentation of mediastinal myelolipoma: a radiologico-pathological correlation. Indian J Pathol Microbiol. 2019;62:503\u20135.","journal-title":"Indian J Pathol Microbiol"},{"key":"4052_CR40","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520936972","volume":"48","author":"DA Qin","year":"2020","unstructured":"Qin DA, Ren XQ, Zheng S, Bi H. An unusual diagnosis of paravertebral lesions: mediastinal myelolipoma. J Int Med Res. 2020;48:300060520936972.","journal-title":"J Int Med Res"},{"key":"4052_CR41","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/s003300050985","volume":"10","author":"S Kawanami","year":"2000","unstructured":"Kawanami S, Watanabe H, Aoki T, Nakata H, Hayashi T, Kido M, et al. Mediastinal myelolipoma: CT and MRI appearances. Eur Radiol. 2000;10:691\u20133.","journal-title":"Eur Radiol"},{"key":"4052_CR42","doi-asserted-by":"publisher","first-page":"721","DOI":"10.2214\/ajr.171.3.9725304","volume":"171","author":"BF Kammen","year":"1998","unstructured":"Kammen BF, Elder DE, Fraker DL, Siegelman ES. Extraadrenal myelolipoma: MR imaging findings. AJR Am J Roentgenol. 1998;171:721\u20133.","journal-title":"AJR Am J Roentgenol"},{"key":"4052_CR43","first-page":"455","volume":"83","author":"A Avil\u00e9s-Salas","year":"2023","unstructured":"Avil\u00e9s-Salas A, V\u00e9lez-Valle A, Fern\u00e1ndez-Vargas OE, Arrieta O. [Primary mediastinal myelolipoma]. Med (B Aires). 2023;83:455\u20138.","journal-title":"Med (B Aires)"},{"key":"4052_CR44","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.936005","volume":"23","author":"AH AlSaffar","year":"2022","unstructured":"AlSaffar AH, AlEssa AM, AlSharkawy T, Alamoudi NB, Makhdom FA. Anterior mediastinal myelolipoma: a case report and review of the literature. Am J Case Rep. 2022;23:e936005.","journal-title":"Am J Case Rep"},{"key":"4052_CR45","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.radcr.2021.12.001","volume":"17","author":"HA Alsayegh","year":"2022","unstructured":"Alsayegh HA, Alhakeem RN, Almusallam WH, Alkhars AA, Alkhalaf J, Alsehaiw A, et al. A case of bilateral posterior mediastinal myelolipoma. Radiol Case Rep. 2022;17:656\u201361.","journal-title":"Radiol Case Rep"},{"key":"4052_CR46","first-page":"208","volume":"36","author":"R Sawhney","year":"2006","unstructured":"Sawhney R, McRae B, Lazarchick J. A rare case of a multifocal extra-adrenal myelolipoma with markedly hypocellular bone marrow. Ann Clin Lab Sci. 2006;36:208\u201311.","journal-title":"Ann Clin Lab Sci"}],"container-title":["World Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-025-04052-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12957-025-04052-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-025-04052-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:03:23Z","timestamp":1761822203000},"score":1,"resource":{"primary":{"URL":"https:\/\/wjso.biomedcentral.com\/articles\/10.1186\/s12957-025-04052-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,30]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4052"],"URL":"https:\/\/doi.org\/10.1186\/s12957-025-04052-1","relation":{},"ISSN":["1477-7819"],"issn-type":[{"value":"1477-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,30]]},"assertion":[{"value":"1 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was reviewed and approved by the Ethics Committee of Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology. (Approval No. TJ-IRB202505030).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All patients provided written informed consent in the study and consent for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"408"}}