{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T01:01:32Z","timestamp":1780966892724,"version":"3.54.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":45,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100011696","name":"Shahed University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011696","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"DOI":"10.1186\/s12957-026-04379-3","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T07:55:12Z","timestamp":1777103712000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of angiogenesis and epithelial\u2013mesenchymal transition markers (CD31, VEGF, and E-Cadherin) in prostatic cancer patients: a multi-omics study"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5377-2991","authenticated-orcid":false,"given":"Sina","family":"Shahshenas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8817-2215","authenticated-orcid":false,"given":"Mohammadreza","family":"Jalali Nadoushan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8316-9511","authenticated-orcid":false,"given":"Hossein","family":"Yarmohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9590-2776","authenticated-orcid":false,"given":"Masood","family":"Soltanipur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,25]]},"reference":[{"issue":"6","key":"4379_CR1","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.euo.2021.09.006","volume":"4","author":"G Gandaglia","year":"2021","unstructured":"Gandaglia G, Leni R, Bray F, Fleshner N, Freedland SJ, Kibel A, et al. Epidemiology and prevention of prostate cancer. Eur Urol Oncol. 2021;4(6):877\u201392. https:\/\/doi.org\/10.1016\/j.euo.2021.09.006.","journal-title":"Eur Urol Oncol"},{"issue":"2","key":"4379_CR2","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3322\/caac.20066","volume":"60","author":"AM Wolf","year":"2010","unstructured":"Wolf AM, Wender RC, Etzioni RB, Thompson IM, D\u2019Amico AV, Volk RJ, et al. American Cancer Society guideline for the early detection of prostate cancer: update 2010. Cancer J Clin. 2010;60(2):70\u201398. https:\/\/doi.org\/10.3322\/caac.20066.","journal-title":"Cancer J Clin"},{"key":"4379_CR3","doi-asserted-by":"publisher","unstructured":"Inamura K. Prostatic cancers: understanding their molecular pathology and the 2016 WHO classification. Oncotarget. 2018;9(18):14723\u201314737. https:\/\/doi.org\/10.18632\/oncotarget.24515.","DOI":"10.18632\/oncotarget.24515"},{"issue":"3","key":"4379_CR4","doi-asserted-by":"publisher","first-page":"363","DOI":"10.30699\/IJP.2023.2002657.3116","volume":"18","author":"M Soltanipur","year":"2023","unstructured":"Soltanipur M, Jalali Nadoushan M, Yarmohammadi H. Evaluation of Cytokeratin-7 and Cytokeratin-19 Expression Relationship with Gleason Score in Prostatic Adenocarcinoma. Iran J Pathol. 2023;18(3):363\u20139. https:\/\/doi.org\/10.30699\/IJP.2023.2002657.3116.","journal-title":"Iran J Pathol"},{"issue":"1","key":"4379_CR5","doi-asserted-by":"publisher","first-page":"12054","DOI":"10.1038\/s41598-018-30535-1","volume":"8","author":"E Arvaniti","year":"2018","unstructured":"Arvaniti E, Fricker KS, Moret M, Rupp N, Hermanns T, Fankhauser C, et al. Automated Gleason grading of prostate cancer tissue microarrays via deep learning. Sci Rep. 2018;8(1):12054. https:\/\/doi.org\/10.1038\/s41598-018-30535-1.","journal-title":"Sci Rep"},{"key":"4379_CR6","unstructured":"Iczkowski KA. Gleason grading 2024 [updated November 20, 2024. Available from: https:\/\/www.pathologyoutlines.com\/topic\/prostategrading.html"},{"issue":"10","key":"4379_CR7","doi-asserted-by":"publisher","first-page":"9871","DOI":"10.21037\/qims-2025-439","volume":"15","author":"Z Xie","year":"2025","unstructured":"Xie Z, Zeng J, Tian H, Mai Z, Xiao Y, Zhou Y, et al. Multiscale Fourier transform multiple instance learning for the Gleason grading of prostate cancer from whole-slide images. Quant Imaging Med Surg. 2025;15(10):9871\u201394. https:\/\/doi.org\/10.21037\/qims-2025-439.","journal-title":"Quant Imaging Med Surg"},{"issue":"5","key":"4379_CR8","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1097\/mou.0000000000000320","volume":"26","author":"C Magi-Galluzzi","year":"2016","unstructured":"Magi-Galluzzi C, Montironi R, Epstein JI. Contemporary Gleason grading and novel Grade Groups in clinical practice. Curr Opin Urol. 2016;26(5):488\u201392. https:\/\/doi.org\/10.1097\/mou.0000000000000320.","journal-title":"Curr Opin Urol"},{"issue":"3","key":"4379_CR9","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/j.urology.2013.10.026","volume":"83","author":"ED Crawford","year":"2014","unstructured":"Crawford ED, Stone NN, Evan YY, Koo PJ, Freedland SJ, Slovin SF, et al. Challenges and recommendations for early identification of metastatic disease in prostate cancer. Urology. 2014;83(3):664\u20139. https:\/\/doi.org\/10.1016\/j.urology.2013.10.026.","journal-title":"Urology"},{"issue":"3","key":"4379_CR10","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1159\/000544021","volume":"34","author":"J Kianparsa","year":"2025","unstructured":"Kianparsa J, Soltanipur M, Jalali Nadoushan M. Evaluation of the Relationship between CD44 Expression and Gleason Grade among Prostate Adenocarcinoma and Benign Prostatic Hyperplasia: A Cross-Sectional Study. Med Princ Pract. 2025;34(3):271\u201380. https:\/\/doi.org\/10.1159\/000544021.","journal-title":"Med Princ Pract"},{"issue":"1","key":"4379_CR11","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s12885-025-13456-x","volume":"25","author":"S Shahshenas","year":"2025","unstructured":"Shahshenas S, Hosseini SM, Yarmohammadi H, Soltanipur M, Jalali Nadoushan M. Expression of cytokeratin 19 in prostatic adenocarcinoma: a systematic review. BMC Cancer. 2025;25(1):52. https:\/\/doi.org\/10.1186\/s12885-025-13456-x.","journal-title":"BMC Cancer"},{"issue":"1","key":"4379_CR12","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1007\/s12070-024-05172-y","volume":"77","author":"M Soltanipur","year":"2025","unstructured":"Soltanipur M, Rohani Bastami M, Shahshenas S, Ghorbanniadelavar Z, Barouh A, Shadmand A, et al. Expression of proliferating cell nuclear antigen (PCNA) in nasal polyp: a systematic review and meta-analysis. Indian J Otolaryngol Head Neck Surg. 2025;77(1):608\u201319. https:\/\/doi.org\/10.1007\/s12070-024-05172-y.","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"4379_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2025.118023","volume":"186","author":"H Mahaki","year":"2025","unstructured":"Mahaki H, Nobari S, Tanzadehpanah H, Babaeizad A, Kazemzadeh G, Mehrabzadeh M, et al. Targeting VEGF signaling for tumor microenvironment remodeling and metastasis inhibition: therapeutic strategies and insights. Biomed Pharmacother. 2025;186:118023. https:\/\/doi.org\/10.1016\/j.biopha.2025.118023.","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"4379_CR14","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.kjms.2015.12.001","volume":"32","author":"E Kervancioglu","year":"2016","unstructured":"Kervancioglu E, Kosan M, Erinanc H, Gonulalan U, Oguzulgen AI, Coskun EZ, Ozkardes H. Predictive values of vascular endothelial growth factor and microvessel-density levels in initial biopsy for prostate cancer. Kaohsiung J Med Sci. 2016;32(2):74\u20139. https:\/\/doi.org\/10.1016\/j.kjms.2015.12.001.","journal-title":"Kaohsiung J Med Sci"},{"issue":"6","key":"4379_CR15","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/s41580-020-0237-9","volume":"21","author":"J Yang","year":"2020","unstructured":"Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, et al. Guidelines and definitions for research on epithelial\u2013mesenchymal transition. Nat Rev Mol Cell Biol. 2020;21(6):341\u201352. https:\/\/doi.org\/10.1038\/s41580-020-0237-9.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"16","key":"4379_CR16","doi-asserted-by":"publisher","first-page":"8972","DOI":"10.3390\/ijms25168972","volume":"25","author":"P Tomecka","year":"2024","unstructured":"Tomecka P, Kunachowicz D, G\u00f3rczy\u0144ska J, Gebuza M, Ku\u017anicki J, Skinderowicz K, et al. Factors determining epithelial-mesenchymal transition in cancer progression. Int J Mol Sci. 2024;25(16):8972. https:\/\/doi.org\/10.3390\/ijms25168972.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"4379_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12195-021-00694-9","volume":"15","author":"B Buyuk","year":"2022","unstructured":"Buyuk B, Jin S, Ye K. Epithelial-to-mesenchymal transition signaling pathways responsible for breast cancer metastasis. Cell Mol Bioeng. 2022;15(1):1\u201313. https:\/\/doi.org\/10.1007\/s12195-021-00694-9.","journal-title":"Cell Mol Bioeng"},{"key":"4379_CR18","doi-asserted-by":"publisher","first-page":"S244","DOI":"10.1016\/j.semcancer.2015.03.008","volume":"35","author":"WG Jiang","year":"2015","unstructured":"Jiang WG, Sanders AJ, Katoh M, Ungefroren H, Gieseler F, Prince M, et al. Tissue invasion and metastasis: molecular, biological and clinical perspectives. Semin Cancer Biol. 2015;35:S244\u201375. https:\/\/doi.org\/10.1016\/j.semcancer.2015.03.008.","journal-title":"Semin Cancer Biol"},{"issue":"3","key":"4379_CR19","doi-asserted-by":"publisher","first-page":"4","DOI":"10.32607\/actanaturae.11010","volume":"12","author":"AV Gaponova","year":"2020","unstructured":"Gaponova AV, Rodin S, Mazina AA, Volchkov PV. Epithelial-mesenchymal transition: role in cancer progression and the perspectives of antitumor treatment. Acta Naturae. 2020;12(3):4\u201323. https:\/\/doi.org\/10.32607\/actanaturae.11010.","journal-title":"Acta Naturae"},{"issue":"1","key":"4379_CR20","doi-asserted-by":"publisher","first-page":"22288","DOI":"10.1038\/s41598-022-26831-6","volume":"12","author":"J Wang","year":"2022","unstructured":"Wang J, Guo Y, Xu D, Cui J, Wang Y, Su Y, et al. The immunolocalization of cluster of differentiation 31, phalloidin and alpha smooth muscle actin on vascular network of normal and ischemic rat brain. Sci Rep. 2022;12(1):22288. https:\/\/doi.org\/10.1038\/s41598-022-26831-6.","journal-title":"Sci Rep"},{"issue":"7","key":"4379_CR21","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1177\/0271678x231170041","volume":"43","author":"Z Zhang","year":"2023","unstructured":"Zhang Z, Gan Q, Han J, Tao Q, Qiu WQ, Madri JA. CD31 as a probable responding and gate-keeping protein of the blood-brain barrier and the risk of Alzheimer\u2019s disease. J Cereb Blood Flow Metab. 2023;43(7):1027\u201341. https:\/\/doi.org\/10.1177\/0271678x231170041.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"2","key":"4379_CR22","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1309\/ajcprhm8czh5emfd","volume":"143","author":"V Vanchinathan","year":"2015","unstructured":"Vanchinathan V, Mizramani N, Kantipudi R, Schwartz EJ, Sundram UN. The vascular marker CD31 also highlights histiocytes and histiocyte-like cells within cutaneous tumors. Am J Clin Pathol. 2015;143(2):177\u201385. https:\/\/doi.org\/10.1309\/ajcprhm8czh5emfd.","journal-title":"Am J Clin Pathol"},{"issue":"1","key":"4379_CR23","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4180-5","volume":"18","author":"A Schl\u00fcter","year":"2018","unstructured":"Schl\u00fcter A, Weller P, Kanaan O, Nel I, Heusgen L, H\u00f6ing B, et al. CD31 and VEGF are prognostic biomarkers in early-stage, but not in late-stage, laryngeal squamous cell carcinoma. BMC Cancer. 2018;18(1):272. https:\/\/doi.org\/10.1186\/s12885-018-4180-5.","journal-title":"BMC Cancer"},{"issue":"2","key":"4379_CR24","first-page":"921","volume":"35","author":"J Virman","year":"2015","unstructured":"Virman J, Bono P, Luukkaala T, Sunela K, Kujala P, Kellokumpu-Lehtinen PL. VEGFR3 and CD31 as prognostic factors in renal cell cancer. Anticancer Res. 2015;35(2):921\u20137. https:\/\/ar.iiarjournals.org\/content\/35\/2\/921.short.","journal-title":"Anticancer Res"},{"key":"4379_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14050511","author":"R Limani","year":"2024","unstructured":"Limani R, Le\u017e C, Kru\u0161lin B. Exploring the relationship between E-Cadherin and \u03b2-Catenin cell adhesion proteins and periacinar retraction clefting in prostatic adenocarcinoma. Diagnostics (Basel). 2024;14(5):511. https:\/\/doi.org\/10.3390\/diagnostics14050511","journal-title":"Diagnostics (Basel)"},{"issue":"5","key":"4379_CR26","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.otoeng.2024.02.003","volume":"75","author":"A Barouh","year":"2024","unstructured":"Barouh A, Jalali Nadoushan M, Soltanipur M. Comparison of proliferating cell nuclear antigen (PCNA) expression among nasal polyp and chronic rhinosinusitis. Acta Otorrinolaringol Esp (Engl Ed). 2024;75(5):310\u20135. https:\/\/doi.org\/10.1016\/j.otoeng.2024.02.003.","journal-title":"Acta Otorrinolaringol Esp (Engl Ed)"},{"issue":"4","key":"4379_CR27","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.patol.2024.05.005","volume":"57","author":"Z Ghorbanniadelavar","year":"2024","unstructured":"Ghorbanniadelavar Z, Jalali Nadoushan M, Soltanipur M. Comparison of B-cell lymphoma 2 (BCL-2) expression in disordered proliferative endometrium and simple endometrial hyperplasia. Rev Esp Patol. 2024;57(4):265\u201372. https:\/\/doi.org\/10.1016\/j.patol.2024.05.005.","journal-title":"Rev Esp Patol"},{"issue":"4","key":"4379_CR28","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1309\/02w2-ke50-pkef-g2g4","volume":"113","author":"A de la Taille","year":"2000","unstructured":"dela Taille A, Katz AE, Bagiella E, Buttyan R, Sharir S, Olsson CA, et al. Microvessel density as a predictor of PSA recurrence after radical prostatectomy. A comparison of CD34 and CD31. Am J Clin Pathol. 2000;113(4):555\u201362. https:\/\/doi.org\/10.1309\/02w2-ke50-pkef-g2g4.","journal-title":"Am J Clin Pathol"},{"issue":"1","key":"4379_CR29","doi-asserted-by":"publisher","first-page":"89","DOI":"10.12865\/chsj.47.01.14","volume":"47","author":"A P\u0103nu\u015f","year":"2021","unstructured":"P\u0103nu\u015f A, Simionescu CE, Dr\u0103goescu PO, Stepan AE. VEGF immunoexpression in prostate adenocarcinoma. Curr Health Sci J. 2021;47(1):89\u201395. https:\/\/doi.org\/10.12865\/chsj.47.01.14.","journal-title":"Curr Health Sci J"},{"issue":"3","key":"4379_CR30","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/s41588-021-00791-5","volume":"53","author":"AP Heath","year":"2021","unstructured":"Heath AP, Ferretti V, Agrawal S, An M, Angelakos JC, Arya R, et al. The NCI Genomic Data Commons. Nat Genet. 2021;53(3):257\u201362. https:\/\/doi.org\/10.1038\/s41588-021-00791-5.","journal-title":"Nat Genet"},{"issue":"12","key":"4379_CR31","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550. https:\/\/doi.org\/10.1186\/s13059-014-0550-8.","journal-title":"Genome Biol"},{"issue":"1","key":"4379_CR32","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 2008;9(1):559. https:\/\/doi.org\/10.1186\/1471-2105-9-559","journal-title":"BMC Bioinformatics"},{"issue":"D1","key":"4379_CR33","doi-asserted-by":"publisher","first-page":"D672","DOI":"10.1093\/nar\/gkae909","volume":"53","author":"M Kanehisa","year":"2024","unstructured":"Kanehisa M, Furumichi M, Sato Y, Matsuura Y, Ishiguro-Watanabe M. KEGG: biological systems database as a model of the real world. Nucleic Acids Res. 2024;53(D1):D672\u20137. https:\/\/doi.org\/10.1093\/nar\/gkae909.","journal-title":"Nucleic Acids Res"},{"key":"4379_CR34","doi-asserted-by":"publisher","unstructured":"Consortium TGO, Aleksander SA, Balhoff J, Carbon S, Cherry JM, Drabkin HJ et al. The Gene Ontology knowledgebase in 2023. Genetics. 2023;224(1):iyad031. https:\/\/doi.org\/10.1093\/genetics\/iyad031.","DOI":"10.1093\/genetics\/iyad031"},{"issue":"7","key":"4379_CR35","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47-e. https:\/\/doi.org\/10.1093\/nar\/gkv007.","journal-title":"Nucleic Acids Res"},{"issue":"43","key":"4379_CR36","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005;102(43):15545\u201350. https:\/\/doi.org\/10.1073\/pnas.0506580102.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"4379_CR37","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1080\/15366367.2019.1565254","volume":"17","author":"RAM Villanueva","year":"2019","unstructured":"Villanueva RAM, Chen ZJ. ggplot2: elegant graphics for data analysis (2nd ed.). Meas Interdiscip Res Perspect. 2019;17(3):160\u20137. https:\/\/doi.org\/10.1080\/15366367.2019.1565254.","journal-title":"Meas Interdiscip Res Perspect"},{"issue":"3","key":"4379_CR38","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s00441-013-1779-3","volume":"355","author":"JR Privratsky","year":"2014","unstructured":"Privratsky JR, Newman PJ. PECAM-1: regulator of endothelial junctional integrity. Cell Tissue Res. 2014;355(3):607\u201319. https:\/\/doi.org\/10.1007\/s00441-013-1779-3.","journal-title":"Cell Tissue Res"},{"key":"4379_CR39","doi-asserted-by":"publisher","unstructured":"Grizzi F, Hegazi M, Zanoni M, Vota P, Toia G, Clementi MC et al. Prostate Cancer Microvascular Routes: Explor Meas Strategies Life (Basel). 2023;13(10):2034. https:\/\/doi.org\/10.3390\/life13102034.","DOI":"10.3390\/life13102034"},{"issue":"2","key":"4379_CR40","doi-asserted-by":"publisher","first-page":"389","DOI":"10.3892\/or.2011.1539","volume":"27","author":"I Steiner","year":"2012","unstructured":"Steiner I, Jung K, Miller K, Stephan C, Erbersdobler A. Expression of endothelial factors in prostate cancer: a possible role of caveolin-1 for tumour progression. Oncol Rep. 2012;27(2):389\u201395. https:\/\/doi.org\/10.3892\/or.2011.1539.","journal-title":"Oncol Rep"},{"key":"4379_CR41","doi-asserted-by":"publisher","unstructured":"Melegh Z, Oltean S. Targeting Angiogenesis in Prostate Cancer. Int J Mol Sci. 2019;20(11):2676. https:\/\/doi.org\/10.3390\/ijms20112676.","DOI":"10.3390\/ijms20112676"},{"issue":"5","key":"4379_CR42","doi-asserted-by":"publisher","first-page":"311","DOI":"10.7150\/jca.8716","volume":"5","author":"M Senchukova","year":"2014","unstructured":"Senchukova M, Kiselevsky MV. The \u201ccavitary\u201d type of angiogenesis by gastric cancer. Morphological characteristics and prognostic value. J Cancer. 2014;5(5):311\u20139. https:\/\/doi.org\/10.7150\/jca.8716.","journal-title":"J Cancer"},{"issue":"2","key":"4379_CR43","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s10549-023-06974-4","volume":"200","author":"V Milosevic","year":"2023","unstructured":"Milosevic V, Edelmann RJ, Winge I, Strell C, Mezheyeuski A, Knutsvik G, et al. Vessel size as a marker of survival in estrogen receptor positive breast cancer. Breast Cancer Res Treat. 2023;200(2):293\u2013304. https:\/\/doi.org\/10.1007\/s10549-023-06974-4.","journal-title":"Breast Cancer Res Treat"},{"key":"4379_CR44","doi-asserted-by":"publisher","first-page":"155239","DOI":"10.1016\/j.prp.2024.155239","volume":"256","author":"FG De La Vega","year":"2024","unstructured":"De La Vega FG, Duenweg C, Jain S, Rubenstein P, Bobholz SI, Barrett S. Morphologic features of prostate cancer-encased native vessels: An image analysis study. Pathol Res Pract. 2024;256:155239. https:\/\/doi.org\/10.1016\/j.prp.2024.155239.","journal-title":"Pathol Res Pract"},{"issue":"12","key":"4379_CR45","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1038\/nrc3627","volume":"13","author":"HL Goel","year":"2013","unstructured":"Goel HL, Mercurio AM. VEGF targets the tumour cell. Nat Rev Cancer. 2013;13(12):871\u201382. https:\/\/doi.org\/10.1038\/nrc3627.","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"4379_CR46","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.3892\/ol.2017.7374","volume":"15","author":"J Rivera\u2011P\u00e9rez","year":"2018","unstructured":"Rivera\u2011P\u00e9rez J, Monter\u2011Vera M, Barrientos\u2011Alvarado C, Toscano\u2011Garibay JD, Cuesta\u2011Mej\u00edas T, Flores\u2011Estrada J. Evaluation of VEGF and PEDF in prostate cancer: a preliminary study in serum and biopsies. Oncol Lett. 2018;15(1):1072\u20138. https:\/\/doi.org\/10.3892\/ol.2017.7374.","journal-title":"Oncol Lett"},{"key":"4379_CR47","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17132189","author":"FP Bizzarri","year":"2025","unstructured":"Bizzarri FP, Campetella M, Russo P, Palermo G, Moosavi SK, Rossi F, et al. Prognostic value of PLR, SIRI, PIV, SII, and NLR in non-muscle invasive bladder cancer: can inflammatory factors influence pathogenesis and outcomes? Cancers (Basel). 2025;17(13):2189. https:\/\/doi.org\/10.3390\/cancers17132189.","journal-title":"Cancers (Basel)"}],"container-title":["World Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12957-026-04379-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-026-04379-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-026-04379-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:47:32Z","timestamp":1780966052000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12957-026-04379-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,25]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4379"],"URL":"https:\/\/doi.org\/10.1186\/s12957-026-04379-3","relation":{},"ISSN":["1477-7819"],"issn-type":[{"value":"1477-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,25]]},"assertion":[{"value":"22 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by the Ethics Committee of Shahed University (IR.SHAHED.REC.1403.101). All patients in the study had written informed consent in their files for using their file information and tissue samples for research purposes.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to participate"}},{"value":"Signed written informed consent was obtained from the patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors confirm that there are no known conflicts of interest associated with this publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"246"}}