{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:30:03Z","timestamp":1786681803013,"version":"build-2736575974"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":65,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"DOI":"10.1186\/s12957-026-04451-y","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T03:34:29Z","timestamp":1781062469000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The evolving landscape of colorectal liver metastasis management: from resection to transplantation \u2013 a narrative review"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6610-4094","authenticated-orcid":false,"given":"Francesco Saverio","family":"Papadia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"di Domenico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Santoliquido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"De Cian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"issue":"3","key":"4451_CR1","first-page":"209","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209\u201349.","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"4451_CR2","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12885-017-3925-x","volume":"18","author":"J Engstrand","year":"2018","unstructured":"Engstrand J, Nilsson H, Str\u00f6mberg C, Jonas E, Freedman J. Colorectal cancer liver metastases - a population-based study on incidence, management and survival. BMC Cancer. 2018;18(1):78.","journal-title":"BMC Cancer"},{"issue":"1","key":"4451_CR3","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/j.1463-1318.2010.02539.x","volume":"14","author":"AE van der Pool","year":"2012","unstructured":"van der Pool AE, Damhuis RA, Ijzermans JN, de Wilt JH, Eggermont AM, Krause R, et al. Trends in incidence, treatment and survival of patients with stage IV colorectal cancer: a population-based series. Colorectal Dis. 2012;14(1):56\u201361.","journal-title":"Colorectal Dis"},{"issue":"10458","key":"4451_CR4","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1016\/S0140-6736(24)01595-2","volume":"404","author":"R Adam","year":"2024","unstructured":"Adam R, Piedvache C, Chiche L, Adam JP, Salame E, Buc E, et al. Liver transplantation plus chemotherapy versus chemotherapy alone in patients with permanently unresectable colorectal liver metastases (TransMet): results from a multicentre, open-label, prospective, randomised controlled trial. Lancet. 2024;404(10458):1107\u201318.","journal-title":"Lancet"},{"issue":"8","key":"4451_CR5","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1093\/annonc\/mdw235","volume":"27","author":"E Van Cutsem","year":"2016","unstructured":"Van Cutsem E, Cervantes A, Adam R, Sobrero A, Van Krieken JH, Aderka D, et al. ESMO consensus guidelines for the management of patients with metastatic colorectal cancer. Ann Oncol. 2016;27(8):1386\u2013422.","journal-title":"Ann Oncol"},{"issue":"6","key":"4451_CR6","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1016\/j.surg.2018.01.004","volume":"163","author":"JM Creasy","year":"2018","unstructured":"Creasy JM, Sadot E, Koerkamp BG, Chou JF, Gonen M, Kemeny NE, et al. Actual 10-year survival after hepatic resection of colorectal liver metastases: what factors preclude cure? Surgery. 2018;163(6):1238\u201344.","journal-title":"Surgery"},{"issue":"29","key":"4451_CR7","doi-asserted-by":"publisher","first-page":"4575","DOI":"10.1200\/JCO.2007.11.0833","volume":"25","author":"JS Tomlinson","year":"2007","unstructured":"Tomlinson JS, Jarnagin WR, DeMatteo RP, Fong Y, Kornprat P, Gonen M, et al. Actual 10-Year Survival After Resection of Colorectal Liver Metastases Defines Cure. J Clin Oncol. 2007;25(29):4575\u201380.","journal-title":"J Clin Oncol"},{"key":"4451_CR8","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-024-16336-z","author":"AM De Rose","year":"2025","unstructured":"De Rose AM, Panettieri E, Lendoire M, Ferracci F, Cucchetti A, Majno P, et al. Short- and Long-Term Outcomes After Hepatectomy in Patients Receiving Triplet Versus Doublet Preoperative Chemotherapy for Colorectal Liver Metastases. Ann Surg Oncol. 2025. https:\/\/doi.org\/10.1245\/s10434-024-16336-z.","journal-title":"Ann Surg Oncol"},{"issue":"7","key":"4451_CR9","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/S1470-2045(23)00219-X","volume":"24","author":"MJG Bond","year":"2023","unstructured":"Bond MJG, Bolhuis K, Loosveld OJL, de Groot JWB, Droogendijk H, Helgason HH, et al. First-line systemic treatment strategies in patients with initially unresectable colorectal cancer liver metastases (CAIRO5): an open-label, multicentre, randomised, controlled, phase 3 study from the Dutch Colorectal Cancer Group. Lancet Oncol. 2023;24(7):757\u201371.","journal-title":"Lancet Oncol"},{"issue":"1","key":"4451_CR10","doi-asserted-by":"publisher","first-page":"e2250030","DOI":"10.1001\/jamanetworkopen.2022.50030","volume":"6","author":"SM Koroukian","year":"2023","unstructured":"Koroukian SM, Booker BD, Vu L, Schiltz NK, Owusu C, Cooper GS, et al. Receipt of Targeted Therapy and Survival Outcomes in Patients With Metastatic Colorectal Cancer. JAMA Netw Open. 2023;6(1):e2250030.","journal-title":"JAMA Netw Open"},{"issue":"3","key":"4451_CR11","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/s41416-020-01140-9","volume":"124","author":"V Heinemann","year":"2021","unstructured":"Heinemann V, von Weikersthal LF, Decker T, Kiani A, Kaiser F, Al-Batran SE, et al. FOLFIRI plus cetuximab or bevacizumab for advanced colorectal cancer: final survival and per-protocol analysis of FIRE-3, a randomised clinical trial. Br J Cancer. 2021;124(3):587\u201394.","journal-title":"Br J Cancer"},{"issue":"3","key":"4451_CR12","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1097\/SLA.0b013e31824856f5","volume":"255","author":"AA Schnitzbauer","year":"2012","unstructured":"Schnitzbauer AA, Lang SA, Goessmann H, Nadalin S, Baumgart J, Farkas SA, et al. Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings. Ann Surg. 2012;255(3):405\u201314.","journal-title":"Ann Surg"},{"issue":"6","key":"4451_CR13","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1097\/00000658-200012000-00006","volume":"232","author":"R Adam","year":"2000","unstructured":"Adam R, Laurent A, Azoulay D, Castaing D, Bismuth H. Two-stage hepatectomy: A planned strategy to treat irresectable liver tumors. Ann Surg. 2000;232(6):777\u201385.","journal-title":"Ann Surg"},{"key":"4451_CR14","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006859","author":"T Boerner","year":"2025","unstructured":"Boerner T, Gagni\u00e8re J, Margonis GA, Srouji R, Gonen M, Kemeny NE, et al. Long-Term Outcomes of Patients Undergoing Two-Stage Hepatectomy For Extensive Colorectal Liver Metastasis Treated With Perioperative Hepatic Artery and Systemic Chemotherapy. Ann Surg. 2025. https:\/\/doi.org\/10.1097\/SLA.0000000000006859.","journal-title":"Ann Surg"},{"issue":"2","key":"4451_CR15","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S1470-2045(24)00660-0","volume":"26","author":"S van der Lei","year":"2025","unstructured":"van der Lei S, Puijk RS, Dijkstra M, Schulz HH, Vos DJW, De Vries JJJ, et al. Thermal ablation versus surgical resection of small-size colorectal liver metastases (COLLISION): an international, randomised, controlled, phase 3 non-inferiority trial. Lancet Oncol. 2025;26(2):187\u201399.","journal-title":"Lancet Oncol"},{"issue":"6","key":"4451_CR16","first-page":"1647","volume":"172","author":"T Horie","year":"2022","unstructured":"Horie T, Kanemitsu Y, Takamizawa Y, Hamaguchi T, Shida D, Tsukamoto S, et al. Prognostic differences between oligometastatic and polymetastatic disease after resection in patients with colorectal cancer and hepatic or lung metastases: Retrospective analysis of a large cohort at a single institution. Surgery. 2022;172(6):1647\u201353.","journal-title":"Surgery"},{"issue":"12","key":"4451_CR17","first-page":"1","volume":"24","author":"L Depauw","year":"2024","unstructured":"Depauw L, Townsend A, Karapetis C, Becke D, Price T. Role of locoregional therapy including liver transplantation in liver-only metastatic colorectal cancer: a review Paper. Expert Rev Anticancer Ther. 2024;24(12):1\u201318.","journal-title":"Expert Rev Anticancer Ther"},{"issue":"5","key":"4451_CR18","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.ciresp.2023.11.012","volume":"102","author":"K Mils","year":"2024","unstructured":"Mils K, Llad\u00f3 L, L\u00f3pez-Dom\u00ednguez J, Barrios O, Leiva D, Santos C, et al. Have we improved postoperative and long-term outcomes of liver surgery for colorectal cancer metastasis? Analysis of 1736 hepatectomies performed over 3 decades in a single center. Cir Esp (Engl Ed). 2024;102(5):243\u201351.","journal-title":"Cir Esp (Engl Ed)"},{"issue":"1","key":"4451_CR19","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41698-023-00353-4","volume":"7","author":"FA Zeineddine","year":"2023","unstructured":"Zeineddine FA, Zeineddine MA, Yousef A, Gu Y, Chowdhury S, Abdelhakeem A, et al. Survival improvement for patients with metastatic colorectal cancer over twenty years. NPJ Precis Oncol. 2023;7(1):16.","journal-title":"NPJ Precis Oncol"},{"issue":"3","key":"4451_CR20","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/SLA.0b013e3181f1fd44","volume":"252","author":"R Adam","year":"2010","unstructured":"Adam R, Kitano Y. Post-recurrence survival after resection of colorectal liver metastases: a 25-year experience. Ann Surg. 2010;252(3):499\u2013508.","journal-title":"Ann Surg"},{"issue":"12","key":"4451_CR21","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1016\/S1470-2045(13)70447-9","volume":"14","author":"B Nordlinger","year":"2013","unstructured":"Nordlinger B, Sorbye H, Glimelius B, Poston GJ, Schlag PM, Rougier P, et al. Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial. Lancet Oncol. 2013;14(12):1208\u201315.","journal-title":"Lancet Oncol"},{"key":"4451_CR22","doi-asserted-by":"publisher","DOI":"10.1200\/JCO-25-01231","author":"Y Kanemitsu","year":"2026","unstructured":"Kanemitsu Y, Shimizu Y, Mizusawa J, Inaba Y, Tsukamoto S, Takashima A, et al. Randomized Phase II\/III Trial Comparing Hepatectomy Followed by mFOLFOX6 With Hepatectomy Alone for Liver Metastasis From Colorectal Cancer: Long-Term Results of JCOG0603. J Clin Oncol. 2026. https:\/\/doi.org\/10.1200\/JCO-25-01231.","journal-title":"J Clin Oncol"},{"issue":"2","key":"4451_CR23","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1097\/SLA.0000000000003404","volume":"271","author":"S Dueland","year":"2020","unstructured":"Dueland S, Syversveen T, Solheim JM, Solberg S, Grut H, Bj\u00f8rnbeth BA, et al. Survival Following Liver Transplantation for Patients With Nonresectable Liver-only Colorectal Metastases. Ann Surg. 2020;271(2):212\u20138.","journal-title":"Ann Surg"},{"issue":"13","key":"4451_CR24","doi-asserted-by":"publisher","first-page":"7986","DOI":"10.1245\/s10434-023-14302-9","volume":"30","author":"J Sarkar","year":"2023","unstructured":"Sarkar J, Attwood K, Schwarz RE. Perioperative Chemotherapy is Associated with Superior Overall Survival in Patients with Synchronous Colorectal Liver Metastases. Ann Surg Oncol. 2023;30(13):7986\u201395.","journal-title":"Ann Surg Oncol"},{"issue":"3","key":"4451_CR25","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/S1470-2045(19)30798-3","volume":"21","author":"JA Bridgewater","year":"2020","unstructured":"Bridgewater JA, Pugh SA, Maishman T, Eminton Z, Mellor J, Whitehead A, et al. Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis (New EPOC): long-term results of a multicentre, randomised, controlled, phase 3 trial. Lancet Oncol. 2020;21(3):398\u2013411.","journal-title":"Lancet Oncol"},{"issue":"23","key":"4451_CR26","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1056\/NEJMoa2017699","volume":"383","author":"T Andr\u00e9","year":"2020","unstructured":"Andr\u00e9 T, Shiu KK, Kim TW, Jensen BV, Jensen LH, Punt CJA, et al. Pembrolizumab versus chemotherapy for microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer (KEYNOTE-177): final analysis of a randomised, open-label, phase 3 study. N Engl J Med. 2020;383(23):2207\u201318.","journal-title":"N Engl J Med"},{"issue":"2","key":"4451_CR27","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S1470-2045(24)00734-4","volume":"26","author":"L St\u00f6ffler","year":"2025","unstructured":"St\u00f6ffler L, Modest DP, Pratschke J, Haber PK. Solidifying local ablation in the treatment of small-size colorectal liver metastasis. Lancet Oncol. 2025;26(2):149\u201350.","journal-title":"Lancet Oncol"},{"key":"4451_CR28","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ejca.2023.03.038","volume":"187","author":"P Tinguely","year":"2023","unstructured":"Tinguely P, Ruiter SJS, Engstrand J, de Haas RJ, Nilsson H, Candinas D, et al. A prospective multicentre trial on survival after microwave ablation versus resection for resectable colorectal liver metastases (MAVERRIC). Eur J Cancer. 2023;187:65\u201376.","journal-title":"Eur J Cancer"},{"issue":"6","key":"4451_CR29","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1200\/JCO.1984.2.6.595","volume":"2","author":"N Kemeny","year":"1984","unstructured":"Kemeny N, Daly J, Oderman P, Shike M, Chun H, Petroni G, et al. Hepatic artery pump infusion: toxicity and results in patients with metastatic colorectal carcinoma. J Clin Oncol. 1984;2(6):595\u2013600.","journal-title":"J Clin Oncol"},{"issue":"4","key":"4451_CR30","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1002\/jso.24898","volume":"117","author":"LM Pak","year":"2018","unstructured":"Pak LM, Kemeny NE, Capanu M, Chou JF, Boucher T, Cercek A, et al. Prospective phase II trial of combination hepatic artery infusion and systemic chemotherapy for unresectable colorectal liver metastases: long term results and curative potential. J Surg Oncol. 2018;117(4):634\u201343.","journal-title":"J Surg Oncol"},{"issue":"5","key":"4451_CR31","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1097\/SLA.0000000000000786","volume":"261","author":"S Dueland","year":"2015","unstructured":"Dueland S, Guren TK, Hagness M, Glimelius B, Line PD, Pfeiffer P, et al. Chemotherapy or liver transplantation for nonresectable liver metastases from colorectal cancer? Ann Surg. 2015;261(5):956\u201360.","journal-title":"Ann Surg"},{"issue":"2","key":"4451_CR32","doi-asserted-by":"publisher","first-page":"5155","DOI":"10.1097\/JS9.0000000000004018","volume":"112","author":"AF Sayed Ahmed","year":"2026","unstructured":"Sayed Ahmed AF, Wehrle CJ, Ring T Jr, Wu J, Hong H, Nadeem MA, et al. Liver transplantation for colorectal metastasis - selection criteria, outcomes, and management recurrence: a systematic review and meta-analysis. Int J Surg. 2026;112(2):5155\u201371.","journal-title":"Int J Surg"},{"issue":"8","key":"4451_CR33","first-page":"2481","volume":"20","author":"JB Ammori","year":"2013","unstructured":"Ammori JB, Kemeny NE, Fong Y, Cercek A, Dematteo RP, Allen PJ, et al. Conversion to complete resection and\/or ablation using hepatic artery infusion chemotherapy in patients with unresectable liver metastases from colorectal cancer. Ann Surg Oncol. 2013;20(8):2481\u20137.","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"4451_CR34","doi-asserted-by":"publisher","first-page":"znae089","DOI":"10.1093\/bjs\/znae089","volume":"111","author":"MF Krul","year":"2024","unstructured":"Krul MF, Kok NFM, Osmani H, van Lienden KP, Grootscholten C, Groot Koerkamp B, et al. Hepatic arterial infusion pump chemotherapy combined with systemic chemotherapy for borderline resectable and unresectable colorectal liver metastases: phase II feasibility study. Br J Surg. 2024;111(4):znae089.","journal-title":"Br J Surg"},{"issue":"8","key":"4451_CR35","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1093\/annonc\/mdx175","volume":"28","author":"D Arnold","year":"2017","unstructured":"Arnold D, Lueza B, Douillard JY, Peeters M, Lenz HJ, Venook A, et al. Prognostic and predictive value of primary tumour side in patients with RAS wild-type metastatic colorectal cancer treated with chemotherapy and EGFR directed antibodies in six randomized trials. Ann Oncol. 2017;28(8):1713\u201329.","journal-title":"Ann Oncol"},{"issue":"15suppl","key":"4451_CR36","first-page":"3521","volume":"35","author":"S Tejpar","year":"2017","unstructured":"Tejpar S, Stintzing S, Ciardiello F, Tabernero J, Van Cutsem E, Beier F, et al. Prognostic and predictive relevance of primary tumor location in patients with RAS wild-type metastatic colorectal cancer: retrospective analyses of the CRYSTAL and FIRE-3 trials. J Clin Oncol. 2017;35(15suppl):3521.","journal-title":"J Clin Oncol"},{"issue":"5","key":"4451_CR37","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1097\/SLA.0b013e3182823957","volume":"257","author":"M Hagness","year":"2013","unstructured":"Hagness M, Foss A, Line PD, Scholz T, J\u00f8rgensen PF, Fosby B, et al. Liver transplantation for nonresectable liver metastases from colorectal cancer. Ann Surg. 2013;257(5):800\u20136.","journal-title":"Ann Surg"},{"issue":"12","key":"4451_CR38","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1111\/j.1432-2277.2008.00735.x","volume":"21","author":"E Hoti","year":"2008","unstructured":"Hoti E, Adam R. Liver transplantation for primary and metastatic liver cancers. Transpl Int. 2008;21(12):1107\u201317.","journal-title":"Transpl Int"},{"issue":"12","key":"4451_CR39","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1007\/s12149-022-01796-8","volume":"36","author":"H Grut","year":"2022","unstructured":"Grut H, Line PD, Syversveen T, Dueland S. Metabolic tumor volume predicts long-term survival after transplantation for unresectable colorectal liver metastases: 15 years of experience from the SECA study. Ann Nucl Med. 2022;36(12):1073\u201381.","journal-title":"Ann Nucl Med"},{"issue":"11","key":"4451_CR40","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/S2468-1253(21)00219-3","volume":"6","author":"GK Bonney","year":"2021","unstructured":"Bonney GK, Chew CA, Lodge P, Hubscher S, Neil D, Mirza D, et al. Liver transplantation for non-resectable colorectal liver metastases: the International Hepato-Pancreato-Biliary Association consensus guidelines. Lancet Gastroenterol Hepatol. 2021;6(11):933\u201346.","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"3","key":"4451_CR41","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1097\/SLA.0000000000006904","volume":"283","author":"Y Nakao","year":"2026","unstructured":"Nakao Y, Adam R, Nasser AH, Imai K, Golse N, Pietrasz D, et al. Two-stage Hepatectomy Versus Liver Transplantation for Patients With Marginally Resectable Extensive Bilobar Colorectal Liver Metastases. Ann Surg. 2026;283(3):365\u201374.","journal-title":"Ann Surg"},{"issue":"3","key":"4451_CR42","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1097\/SLA.0000000000006899","volume":"283","author":"M Serenari","year":"2026","unstructured":"Serenari M, Lanari J, Dueland S, Ettorre GM, Aldrighetti L, Vivarelli M, et al. Liver Transplantation Versus ALPPS for Colorectal Liver Metastases: An Entropy Balanced Retrospective Analysis. Ann Surg. 2026;283(3):357\u201364.","journal-title":"Ann Surg"},{"issue":"3","key":"4451_CR43","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1097\/SLA.0000000000006969","volume":"283","author":"M Pfister","year":"2026","unstructured":"Pfister M, Clavien PA. Liver Transplantation Versus Staged Hepatectomy (ALPPS) for Colorectal Liver Metastases: Are We Ready for a Paradigm Shift? Ann Surg. 2026;283(3):375\u20137.","journal-title":"Ann Surg"},{"issue":"5","key":"4451_CR44","first-page":"565","volume":"44","author":"H Meidell Sjule","year":"2024","unstructured":"Meidell Sjule H, Vinter CN, Dueland S, Line PD, Aas E. The Spillover Effects of Extending Liver Transplantation to Patients with Colorectal Liver Metastases: A Discrete Event Simulation Analysis. Med Decis Mak. 2024;44(5):565\u201378.","journal-title":"Med Decis Mak"},{"key":"4451_CR45","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.ijsu.2020.03.078","volume":"82S","author":"S Nadalin","year":"2020","unstructured":"Nadalin S, Settmacher U, Rauchfuss F, Balci D, Koenigrainer A, Line PD, et al. RAPID procedure for colorectal cancer liver metastasis. Int J Surg. 2020;82S:93\u20136.","journal-title":"Int J Surg"},{"issue":"2","key":"4451_CR46","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1245\/s10434-023-14611-z","volume":"31","author":"CJ Wehrle","year":"2024","unstructured":"Wehrle CJ, Fujiki M, Schlegel A, Whitsett Linganna M, Khalil M, Pita A, et al. Update to \u2018A Contemporary Systematic Review on Liver Transplantation for Unresectable Liver Metastasis of Colorectal Cancer\u2019. Ann Surg Oncol. 2024;31(2):697\u2013700.","journal-title":"Ann Surg Oncol"},{"issue":"8","key":"4451_CR47","doi-asserted-by":"publisher","first-page":"3345","DOI":"10.1007\/s00423-022-02707-1","volume":"407","author":"S Hajibandeh","year":"2022","unstructured":"Hajibandeh S, Mowbray NG, Chin C, Hakeem A, Reddy S, Rowe I, et al. Cohort study of long-term survival and recurrence patterns following operative management of colorectal liver metastasis - is follow-up beyond 5 years warranted? Langenbecks Arch Surg. 2022;407(8):3345\u201353.","journal-title":"Langenbecks Arch Surg"},{"issue":"1","key":"4451_CR48","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.annonc.2022.10.003","volume":"34","author":"A Cervantes","year":"2023","unstructured":"Cervantes A, Adam R, Rosell\u00f3 S, Arnold D, Normanno N, Ta\u00efeb J, et al. Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol. 2023;34(1):10\u201332.","journal-title":"Ann Oncol"},{"key":"4451_CR49","first-page":"e2300111","volume":"7","author":"CJ Wehrle","year":"2023","unstructured":"Wehrle CJ, Raj R, Aykun N, Jiao C, Orabi D, Esteban J, et al. Circulating Tumor DNA in Colorectal Cancer Liver Metastasis: Analysis of Patients Receiving Liver Resection and Transplant. JCO Clin Cancer Inf. 2023;7:e2300111.","journal-title":"JCO Clin Cancer Inf"},{"issue":"4","key":"4451_CR50","first-page":"315","volume":"23","author":"F Salv\u00e0","year":"2024","unstructured":"Salv\u00e0 F, Saoudi N, Rodr\u00edguez M, Nuciforo P, Hernando J, Blanco G, et al. Determinants of Metastatic Colorectal Cancer With Permanent Liver-Limited Disease. Clin Colorectal Cancer. 2024;23(4):315\u2013e3223.","journal-title":"Clin Colorectal Cancer"}],"container-title":["World Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12957-026-04451-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-026-04451-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12957-026-04451-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:13:45Z","timestamp":1786680825000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12957-026-04451-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,10]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4451"],"URL":"https:\/\/doi.org\/10.1186\/s12957-026-04451-y","relation":{},"ISSN":["1477-7819"],"issn-type":[{"value":"1477-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,10]]},"assertion":[{"value":"17 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable. This is a review article and does not report on or involve the use of any animal or human data or tissue.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. This manuscript does not contain data from any individual person.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"338"}}