{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:33:51Z","timestamp":1768822431337,"version":"3.49.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T00:00:00Z","timestamp":1527552000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12958-018-0367-5","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T12:56:27Z","timestamp":1527598587000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The VEGF and PEDF levels in the follicular fluid of patients co- treated with LETROZOLE and gonadotropins during the stimulation cycle"],"prefix":"10.1186","volume":"16","author":[{"given":"Jigal","family":"Haas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rawad","family":"Bassil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noa","family":"Gonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim","family":"Meriano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Jurisicova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert F.","family":"Casper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,5,29]]},"reference":[{"key":"367_CR1","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1080\/09513590.2016.1177013","volume":"32","author":"N Pereira","year":"2016","unstructured":"Pereira N, Hancock K, Cordeiro CN, Lekovich JP, Schattman GL, Rosenwaks Z. Comparison of ovarian stimulation response in patients with breast cancer undergoing ovarian stimulation with letrozole and gonadotropins to patients undergoing ovarian stimulation with gonadotropins alone for elective cryopreservation of oocytesdagger. Gynecol Endocrinol. 2016;32:823\u20136.","journal-title":"Gynecol Endocrinol"},{"key":"367_CR2","doi-asserted-by":"crossref","unstructured":"Quinn MM, Cakmak H, Letourneau JM, Cedars MI, Rosen MP: Response to ovarian stimulation is not impacted by a breast cancer diagnosis. Hum Reprod. 2017;32(3):568-74.","DOI":"10.1093\/humrep\/dew355"},{"key":"367_CR3","doi-asserted-by":"publisher","first-page":"42 e41","DOI":"10.1016\/j.ajog.2016.08.018","volume":"216","author":"Q Mai","year":"2017","unstructured":"Mai Q, Hu X, Yang G, Luo Y, Huang K, Yuan Y, Zhou C. Effect of letrozole on moderate and severe early-onset ovarian hyperstimulation syndrome in high-risk women: a prospective randomized trial. Am J Obstet Gynecol. 2017;216:42 e41\u201310.","journal-title":"Am J Obstet Gynecol"},{"key":"367_CR4","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1007\/s00404-015-3987-4","volume":"293","author":"N Sahin","year":"2016","unstructured":"Sahin N, Apaydin N, Toz E, Sivrikoz ON, Genc M, Turan GA, Cengiz H, Eskicioglu F. Comparison of the effects of letrozole and cabergoline on vascular permeability, ovarian diameter, ovarian tissue VEGF levels, and blood PEDF levels, in a rat model of ovarian hyperstimulation syndrome. Arch Gynecol Obstet. 2016;293:1101\u20136.","journal-title":"Arch Gynecol Obstet"},{"key":"367_CR5","doi-asserted-by":"publisher","first-page":"E258","DOI":"10.1210\/jc.2012-3037","volume":"98","author":"D Chuderland","year":"2013","unstructured":"Chuderland D, Ben-Ami I, Kaplan-Kraicer R, Grossman H, Ron-El R, Shalgi R. The role of pigment epithelium-derived factor in the pathophysiology and treatment of ovarian hyperstimulation syndrome in mice. J Clin Endocrinol Metab. 2013;98:E258\u201366.","journal-title":"J Clin Endocrinol Metab"},{"key":"367_CR6","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1080\/09513590601137137","volume":"23","author":"R Orvieto","year":"2007","unstructured":"Orvieto R, Zohav E, Scharf S, Rabinson J, Meltcer S, Anteby EY, Homburg R. The influence of estradiol\/follicle and estradiol\/oocyte ratios on the outcome of controlled ovarian stimulation for in vitro fertilization. Gynecol Endocrinol. 2007;23:72\u20135.","journal-title":"Gynecol Endocrinol"},{"key":"367_CR7","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s10815-013-0117-8","volume":"31","author":"AN Imudia","year":"2014","unstructured":"Imudia AN, Goldman RH, Awonuga AO, Wright DL, Styer AK, Toth TL. The impact of supraphysiologic serum estradiol levels on peri-implantation embryo development and early pregnancy outcome following in vitro fertilization cycles. J Assist Reprod Genet. 2014;31:65\u201371.","journal-title":"J Assist Reprod Genet"},{"key":"367_CR8","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.fertnstert.2013.09.025","volume":"101","author":"O Ishihara","year":"2014","unstructured":"Ishihara O, Araki R, Kuwahara A, Itakura A, Saito H, Adamson GD. Impact of frozen-thawed single-blastocyst transfer on maternal and neonatal outcome: an analysis of 277,042 single-embryo transfer cycles from 2008 to 2010 in Japan. Fertil Steril. 2014;101:128\u201333.","journal-title":"Fertil Steril"},{"key":"367_CR9","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1093\/humrep\/det272","volume":"28","author":"UB Wennerholm","year":"2013","unstructured":"Wennerholm UB, Henningsen AK, Romundstad LB, Bergh C, Pinborg A, Skjaerven R, Forman J, Gissler M, Nygren KG, Tiitinen A. Perinatal outcomes of children born after frozen-thawed embryo transfer: a Nordic cohort study from the CoNARTaS group. Hum Reprod. 2013;28:2545\u201353.","journal-title":"Hum Reprod"},{"key":"367_CR10","doi-asserted-by":"publisher","first-page":"2951","DOI":"10.1210\/jcem.84.8.5929","volume":"84","author":"S Weil","year":"1999","unstructured":"Weil S, Vendola K, Zhou J, Bondy CA. Androgen and follicle-stimulating hormone interactions in primate ovarian follicle development. J Clin Endocrinol Metab. 1999;84:2951\u20136.","journal-title":"J Clin Endocrinol Metab"},{"key":"367_CR11","doi-asserted-by":"publisher","first-page":"355","DOI":"10.3109\/19396368.2014.957879","volume":"60","author":"Q He","year":"2014","unstructured":"He Q, Liang L, Zhang C, Li H, Ge Z, Wang L, Cui S. Effects of different doses of letrozole on the incidence of early-onset ovarian hyperstimulation syndrome after oocyte retrieval. Syst Biol Reprod Med. 2014;60:355\u201360.","journal-title":"Syst Biol Reprod Med"},{"key":"367_CR12","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/S1043-2760(02)00567-2","volume":"13","author":"A Kamat","year":"2002","unstructured":"Kamat A, Hinshelwood MM, Murry BA, Mendelson CR. Mechanisms in tissue-specific regulation of estrogen biosynthesis in humans. Trends Endocrinol Metab. 2002;13:122\u20138.","journal-title":"Trends Endocrinol Metab"},{"key":"367_CR13","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/0022-4731(88)90093-3","volume":"30","author":"F Naftolin","year":"1988","unstructured":"Naftolin F, MacLusky NJ, Leranth CZ, Sakamoto HS, Garcia-Segura LM. The cellular effects of estrogens on neuroendocrine tissues. J Steroid Biochem. 1988;30:195\u2013207.","journal-title":"J Steroid Biochem"},{"key":"367_CR14","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0016-5085(84)90171-9","volume":"87","author":"F Naftolin","year":"1984","unstructured":"Naftolin F, Romero R. H2-receptor antagonists and sexual differentiation. Gastroenterology. 1984;87:248\u20139.","journal-title":"Gastroenterology"},{"key":"367_CR15","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1210\/en.2016-1538","volume":"158","author":"M Laird","year":"2017","unstructured":"Laird M, Thomson K, Fenwick M, Mora J, Franks S, Hardy K. Androgen stimulates growth of mouse Preantral follicles in vitro: interaction with follicle-stimulating hormone and with growth factors of the TGFbeta superfamily. Endocrinology. 2017;158:920\u201335.","journal-title":"Endocrinology"},{"key":"367_CR16","doi-asserted-by":"publisher","first-page":"818010","DOI":"10.1155\/2014\/818010","volume":"2014","author":"CG Gervasio","year":"2014","unstructured":"Gervasio CG, Bernuci MP, Silva-de-Sa MF, Rosa ESAC. The role of androgen hormones in early follicular development. ISRN Obstet Gynecol. 2014;2014:818010.","journal-title":"ISRN Obstet Gynecol"},{"key":"367_CR17","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1093\/molehr\/gaq073","volume":"17","author":"ME Nielsen","year":"2011","unstructured":"Nielsen ME, Rasmussen IA, Kristensen SG, Christensen ST, Mollgard K, Wreford Andersen E, Byskov AG, Yding Andersen C. In human granulosa cells from small antral follicles, androgen receptor mRNA and androgen levels in follicular fluid correlate with FSH receptor mRNA. Mol Hum Reprod. 2011;17:63\u201370.","journal-title":"Mol Hum Reprod"},{"key":"367_CR18","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/S0015-0282(98)00301-X","volume":"70","author":"CI Friedman","year":"1998","unstructured":"Friedman CI, Seifer DB, Kennard EA, Arbogast L, Alak B, Danforth DR. Elevated level of follicular fluid vascular endothelial growth factor is a marker of diminished pregnancy potential. Fertil Steril. 1998;70:836\u20139.","journal-title":"Fertil Steril"},{"key":"367_CR19","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.ejogrb.2004.01.034","volume":"115","author":"P Ocal","year":"2004","unstructured":"Ocal P, Aydin S, Cepni I, Idil S, Idil M, Uzun H, Benian A. Follicular fluid concentrations of vascular endothelial growth factor, inhibin a and inhibin B in IVF cycles: are they markers for ovarian response and pregnancy outcome? Eur J Obstet Gynecol Reprod Biol. 2004;115:194\u20139.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"367_CR20","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/S0015-0282(97)00278-1","volume":"68","author":"CI Friedman","year":"1997","unstructured":"Friedman CI, Danforth DR, Herbosa-Encarnacion C, Arbogast L, Alak BM, Seifer DB. Follicular fluid vascular endothelial growth factor concentrations are elevated in women of advanced reproductive age undergoing ovulation induction. Fertil Steril. 1997;68:607\u201312.","journal-title":"Fertil Steril"},{"key":"367_CR21","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s12958-017-0288-8","volume":"15","author":"J Haas","year":"2017","unstructured":"Haas J, Bassil R, Meriano J, Samara N, Barzilay E, Gonen N, Casper RF. Does daily co-administration of letrozole and gonadotropins during ovarian stimulation improve IVF outcome? Reprod Biol Endocrinol. 2017;15:70.","journal-title":"Reprod Biol Endocrinol"},{"key":"367_CR22","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1161\/CIRCRESAHA.110.239665","volume":"108","author":"S Sela","year":"2011","unstructured":"Sela S, Natanson-Yaron S, Zcharia E, Vlodavsky I, Yagel S, Keshet E. Local retention versus systemic release of soluble VEGF receptor-1 are mediated by heparin-binding and regulated by heparanase. Circ Res. 2011;108:1063\u201370.","journal-title":"Circ Res"},{"key":"367_CR23","first-page":"477","volume":"68","author":"AJ Jakimiuk","year":"2017","unstructured":"Jakimiuk AJ, Nowicka MA, Zagozda M, Koziol K, Lewandowski P, Issat T. High levels of soluble vascular endothelial growth factor receptor 1\/sFlt1 and low levels of vascular endothelial growth factor in follicular fluid on the day of oocyte retrieval correlate with ovarian hyperstimulation syndrom regardless of the stimulation protocol. J Physiol Pharmacol. 2017;68:477\u201384.","journal-title":"J Physiol Pharmacol"},{"key":"367_CR24","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1016\/j.fertnstert.2010.02.009","volume":"94","author":"A Tropea","year":"2010","unstructured":"Tropea A, Lanzone A, Tiberi F, Romani F, Catino S, Apa R. Estrogens and androgens affect human luteal cell function. Fertil Steril. 2010;94:2257\u201363.","journal-title":"Fertil Steril"},{"key":"367_CR25","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1093\/humrep\/deu044","volume":"29","author":"M von Wolff","year":"2014","unstructured":"von Wolff M, Kollmann Z, Fluck CE, Stute P, Marti U, Weiss B, Bersinger NA. Gonadotrophin stimulation for in vitro fertilization significantly alters the hormone milieu in follicular fluid: a comparative study between natural cycle IVF and conventional IVF. Hum Reprod. 2014;29:1049\u201357.","journal-title":"Hum Reprod"},{"key":"367_CR26","first-page":"434","volume":"46","author":"JH Yang","year":"2001","unstructured":"Yang JH, Chen HF, Lien YR, Chen SU, Ho HN, Yang YS. Elevated E2: oocyte ratio in women undergoing IVF and tubal ET. Correlation with a decrease in the implantation rate. J Reprod Med. 2001;46:434\u20138.","journal-title":"J Reprod Med"}],"container-title":["Reproductive Biology and Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-018-0367-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12958-018-0367-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-018-0367-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T23:14:07Z","timestamp":1559085247000},"score":1,"resource":{"primary":{"URL":"https:\/\/rbej.biomedcentral.com\/articles\/10.1186\/s12958-018-0367-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,29]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["367"],"URL":"https:\/\/doi.org\/10.1186\/s12958-018-0367-5","relation":{},"ISSN":["1477-7827"],"issn-type":[{"value":"1477-7827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,29]]},"assertion":[{"value":"28 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}},{"value":"The study was approved by the Research Ethics Board at Mount Sinai Hospital in Toronto.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All the patients signed a consent form prior recruited for this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"54"}}