{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:27:05Z","timestamp":1762900025157},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n              <jats:p>Affecting basic tenets of human existence such as health, economic as well as personal security and, of course, reproduction, the COVID-19 pandemic transcended medical specialties and professional disciplines. Yet, six months into the pandemic, there still exists no consensus on how to combat the virus in absence of a vaccine. Facing unprecedented circumstances, and in absence of real evidence on how to proceed, our organization early in the pandemic decided to act independently from often seemingly irrational guidance and, instead, to carefully follow a quickly evolving COVID-19 literature. Here described is the, likely, unique journey of a fertility center that maintained services during peaks of COVID-19 and political unrest that followed. Closely following publicly available data, we recognized relatively early that New York City and other East Coast regions, which during the initial COVID-19 wave between March and May represented the hardest-hit areas in the country, during the second wave, beginning in June and still in progress, remained almost completely unaffected. In contrast, south western regions, almost completely unaffected by the initial wave, were severely affected in the second wave. These two distinctively different infectious phenotypes suggested two likely explanations: The country was witnessing infections with two different SARS-CoV-2 viruses and NYC (along with the East Coast) acquired during the first wave much better immunity to the virus than south western regions. Both hypotheses since have been confirmed: East and West Coasts, indeed, were initially infected by two distinctively different lineages of the virus, with the East Coast lineage being 10-times more infectious. In addition, immunologists discovered an up to this point unknown long-term anti-viral innate (cellular) immune response which offers additional and much broader anti-viral immunity than the classical adaptive immunity via immobilizing antibodies that has been known for decades. Consequently, we predict that in the U.S., even in absence of an available vaccine, COVID-19, by September\u2013October, will be at similarly low levels as are currently seen in NYC and other East Coast regions (generally\u2009&lt;\u20091% test-positivity). We, furthermore, predict that, if current mitigation measures are maintained and no newly aggressive mutation of the virus enters the country, a significant fall-wave of COVID-19, in combination with the usual fall wave of influenza, appears unlikely. To continue serving patients uninterrupted throughout the pandemic, turned for all of our center\u2019s staff into a highly rewarding experience, garnered respect and appreciation from patients, and turned into an absolutely unique learning experience.<\/jats:p>","DOI":"10.1186\/s12958-020-00663-3","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T07:02:46Z","timestamp":1604473366000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The COVID-19 pandemic through eyes of a NYC fertility center: a unique learning experience with often unexpected results"],"prefix":"10.1186","volume":"18","author":[{"given":"Norbert","family":"Gleicher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,11,4]]},"reference":[{"issue":"6","key":"663_CR1","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.3201\/eid2606.200320","volume":"26","author":"N Wilson","year":"2020","unstructured":"Wilson N, Kvalsvig A, Elfar Barnard L, Baker MG. Case fatality risk estimates for CVID-19 calculated by using a lag time for fatality. Emerg Infect Dis. 2020;26(6):1339\u2013441.","journal-title":"Emerg Infect Dis"},{"key":"663_CR2","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1038\/s41591-020-0820-9","volume":"26","author":"KG Anderson","year":"2020","unstructured":"Anderson KG, Rambaut A, Ian Lipkin W, Holmes EC, Garry RF. The proximal origin of SARS-CoV-2. Nat Med. 2020;26:450.","journal-title":"Nat Med"},{"issue":"6503","key":"663_CR3","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1126\/science.abc6156","volume":"369","author":"NJ Matheson","year":"2020","unstructured":"Matheson NJ, Lehner PJ. How does SARS-CoV-2 cause COVID-19? Science. 2020;369(6503):510\u20131.","journal-title":"Science"},{"issue":"6503","key":"663_CR4","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1126\/science.abb9263","volume":"369","author":"X Deng","year":"2020","unstructured":"Deng X, Gu W, Federman S, du Plessis L, Pybus OG, et al. Genomic surveillance reveals multiple introductions of SARS-CoV-2 into northern California. Science. 2020;369(6503):582\u20137.","journal-title":"Science"},{"issue":"10","key":"663_CR5","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1056\/NEJMoa2001191","volume":"382","author":"ML Holshue","year":"2020","unstructured":"Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, Spitters C, Ericson K, Wikerson S, Tural A, Diaz G, Cohn A, Fox L, Patel A, Gerber SI, Kim L, Tong S, Lu X, Lindstrom S, Pallansch MA, Weldon WC, Biggs HM, Uyeki TM, Pillai SK. Washington state 2019-nCoV case investigation team. N Engl J Med. 2020;382(10):929\u201336.","journal-title":"N Engl J Med"},{"key":"663_CR6","unstructured":"Goldstein J, McKinley J. Coronavius in N.Y.: Manhattan woman is first confirmed case in state. The New York Times, \n                  https:\/\/www.nytimes.com\/2020\/03\/01\/nyregion\/new-york-coronvirus-confirmed.html\n                  \n                ; Updated March 5, 2020."},{"key":"663_CR7","doi-asserted-by":"publisher","unstructured":"Gonzalez-Reiche AS, Hernandez MM, Sullivan MJ, Ciferri B, Alshammary H, Obla A, Fabre S, Kleiner G, Polanco J, Khan Z, Alburquerque B, van de Guchte A, Dutta J, Francoeur N, Melo BS, Oussenko I, Deikus G, Soto J, Sridhar SH, Wang YC, Twyman K, Kasarskis A, Altman DR, Smith M, Sebra R, Aberg J, Krammer F, Garc\u00eda-Sastre A, Luksza M, Patel G, Paniz-Mondolfi A, Gitman M, Sordillo EM, Simon V, van Bakel H. Introduction and early spread of SARS-CoV-2 in the New York City area. Science. 2020. \n                  https:\/\/doi.org\/10.1126\/science.abc1917\n                  \n                .","DOI":"10.1126\/science.abc1917"},{"key":"663_CR8","unstructured":"Berman R. Facing a COVID-19 resurgence and unable to act. The Atlantic, \n                  https:\/\/www.theatlantic.com\/politics\/archive\/2020\/06\/covid-resurgence-governors\/613171\/\n                  \n                , June 18, 2020."},{"key":"663_CR9","unstructured":"Terry M. Mutated COVID-19 viral strain in U.S. and Europe 10 times more contagious than original strain. BioSpace, \n                  https:\/\/www.biospace.com\/article\/mutated-covid-19-viral-strain-in-us-and-europe-much-more-contagious\/\n                  \n                , June 30, 2020."},{"key":"663_CR10","unstructured":"The Editorial Board. The Swedish economic model. The Wall Street Journal, August 6, 2020; file:\/\/\/Users\/ng\/Dropbox%20(CHR)\/iMac\/Desktop\/The%20Swedish%20Economic%20Model%20-%20WSJ.webarchive."},{"key":"663_CR11","doi-asserted-by":"publisher","unstructured":"Jung F, Krieger V, Hufert FT, K\u00fcpper J-H. Herd immunity or suppression strategy to combat COVID-19. Clin Hemorrheol Microcirc. 2020. \n                  https:\/\/doi.org\/10.3233\/CH-209006\n                  \n                .","DOI":"10.3233\/CH-209006"},{"key":"663_CR12","unstructured":"Staff. Only 5% of Spain\u2019s population has coronavirus antibodies, despite severe outbreak. Reuters, \n                  https:\/\/globalnews.ca\/news\/7144280\/spain-immunity-study-coronavirus\/\n                  \n                , Updated July 6, 2020."},{"key":"663_CR13","unstructured":"Ahlander J, Pollard N. Swedish antibody study shows long road to immunity as COVID-19 toll mounts. \n                  https:\/\/www.reuters.com\/article\/us-health-coronavirus-sweden-strategy\/swedish-antibody-study-shows-long-road-to-immunity-as-covid-19-toll-mounts-idUSKBN22W2YC\n                  \n                . Accessed 26 July 2020."},{"key":"663_CR14","unstructured":"Fox J. When New York City got Covid-19. \n                  https:\/\/www.bloomberg.com\/opinion\/articles\/2020-07-23\/new-york-city-s-covid-19-peak-likely-occurred-in-march-not-april\n                  \n                . Accessed 28 July 2020."},{"key":"663_CR15","unstructured":"Goldstein J. 68% have antibodies in this clinic. Can a neighborhood beat a next wave? The New York Times; \n                  https:\/\/www.nytimes.com\/2020\/07\/09\/nyregion\/nyc-coronavirus-antibodies.html\n                  \n                ; Updated July 10, 2020."},{"key":"663_CR16","unstructured":"Gallo R. The case for a stopgap vaccine. The New York Times. \n                  https:\/\/www.nytimes.com\/2020\/06\/25\/opinion\/letters\/coronavirus-vaccine-gallo.html\n                  \n                , June 25, 2020."},{"key":"663_CR17","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.puhe.2020.05.042","volume":"185","author":"M Madan","year":"2020","unstructured":"Madan M, Pahuja S, Mohan A, Pandey RM, Madan K, Hadda V, Tiwari P, Guleria R, Mittal S. TB infections and BCG vaccination: are we protected from COVID-19? Public Health. 2020;185:91\u20132.","journal-title":"Public Health"},{"key":"663_CR18","doi-asserted-by":"publisher","unstructured":"Mateeus J, Grifoni A, Tarke A, Sidney J, Ramirez SI, et al. Selective and cross-reactive SARS-CoV-2T cell epitopes in unexposed humans. Science. 2020. \n                  https:\/\/doi.org\/10.1126\/science.abd3871\n                  \n                .","DOI":"10.1126\/science.abd3871"},{"issue":"7","key":"663_CR19","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1016\/j.cell.2020.05.015","volume":"181","author":"A Grifoni","year":"2020","unstructured":"Grifoni A, Weiskopf D, Ramirez SI, Mateus J, Dan JM, Rydyznski Moderbacher C, Rawlins SA, Sutherland A, Premkumar L, Jadi RS, Merrama D, de Silva AM, Frazier A, Carlin AF, Greenbaum JA, Peters B, Krammer F, Smith DM, Crotty S, Sette A. Targets of T cell responses to SARS-C0V-2 coronavirus in humans with COVID-19 disease and unexposed individuals. Cell. 2020;181(7):1489\u2013501 e15.","journal-title":"Cell"},{"key":"663_CR20","doi-asserted-by":"publisher","unstructured":"Sekine T, Perez-Potti A, Rivera-Ballestro O, Str\u00e5lin K, Gorin J-B, et al. Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19. \n                  https:\/\/doi.org\/10.1101\/2020.06.29.174888\n                  \n                .","DOI":"10.1101\/2020.06.29.174888"},{"key":"663_CR21","first-page":"1","volume":"12","author":"RD Collins","year":"2020","unstructured":"Collins RD, Gaiha GD, Walker BD. CD8+ T cells in HIV control, cure and prevention. Nat Rev Immunol. 2020;12:1\u201312.","journal-title":"Nat Rev Immunol"},{"key":"663_CR22","doi-asserted-by":"publisher","unstructured":"Britton T, Ball F, Trapman P. A mathematical model reveals the influence of population heterogeneity on herd immunity to SARS-CoV-2. Science. 2020. \n                  https:\/\/doi.org\/10.1126\/science.abc681\n                  \n                .","DOI":"10.1126\/science.abc681"},{"key":"663_CR23","unstructured":"Cuomo AM, Zucker HA, Dreslin S. Health Advisory: Sexual and Reproductive Health Services During the COVID-19 Public Health Emergency. \n                  https:\/\/coronavirus.health.ny.gov\/system\/files\/documents\/2020\/04\/doh_covid19_sexualreproductivehealthadvisory_040820-technical-correction.pdf\n                  \n                . Accessed 5 Aug 2020."},{"key":"663_CR24","unstructured":"Finley A. The bearer of good Coronavirus news. Wall Street Journal., April 24, 2020. \n                  https:\/\/www.wsj.com\/articles\/the-bearer-of-good-coronavirus-news-11587746176\n                  \n                ."},{"key":"663_CR25","unstructured":"Landler M, Castle S. Ehind the virus report that jarred the U.S. and the U.K. to action. The New York Times. \n                  https:\/\/www.nytimes.com\/2020\/03\/17\/world\/europe\/coronavirus-imperial-college-johnson.html\n                  \n                . Accessed 5 Aug 2020."},{"key":"663_CR26","volume-title":"Trust in experts: why and why not?","author":"M Baghramian","year":"2020","unstructured":"Baghramian M. Trust in experts: why and why not? 2020; \n                  https:\/\/jerichochambers.com\/trust-in-experts-why-and-why-not\/\n                  \n                ."},{"key":"663_CR27","unstructured":"The New York Times. More than 40% of U.S. Coronavirus deaths are linked to nursing homes. \n                  https:\/\/www.nytimes.com\/interactive\/2020\/us\/coronavirus-nursing-homes.html\n                  \n                ; Updated July 30, 2020."},{"key":"663_CR28","unstructured":"Finley A. The lockdown skeptic they couldn\u2019t silence. Wall Street Journal. \n                  https:\/\/www.wsj.com\/articles\/the-lockdown-skeptic-they-couldnt-silence-11589566245\n                  \n                ; Updated May 15, 2020."},{"issue":"12","key":"663_CR29","doi-asserted-by":"publisher","first-page":"E1152","DOI":"10.1001\/amajethics.2018.1152","volume":"20","author":"IG Isogna","year":"2018","unstructured":"Isogna IG, Ginsburg ES. Infertility inequality, and how lack of insurance coverage compromises reproductive autonomy. AMA J Ethics. 2018;20(12):E1152\u20139.","journal-title":"AMA J Ethics"},{"issue":"14","key":"663_CR30","first-page":"e211150","volume":"24","author":"BCJM Fauser","year":"2019","unstructured":"Fauser BCJM, Boivin J, Barri PN, Tarlatzis BC, Schmidt L, Levy-Toledano R. Beliefs, attitudes and funding of assisted reproductive technology: public perception of over 6,000 respondnets from 6 European countries. PLoS One. 2019;24(14):e211150.","journal-title":"PLoS One"},{"key":"663_CR31","unstructured":"World Health Organization. Zika virus, July 20, 2018, \n                  https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/zika-virus\n                  \n                ."},{"issue":"4","key":"663_CR32","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.vaccine.2016.12.012","volume":"35","author":"D Mertz","year":"2018","unstructured":"Mertz D, Geraci J, Winkup J, Gessner BD, Ortiz JR, Loeb M. Pregnancy as a risk factor for severe outcomes from influenza virus infection: a systematic review and meta-analysis of observational studies. Vaccine. 2018;35(4):521\u20138.","journal-title":"Vaccine"},{"issue":"2","key":"663_CR33","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1097\/AOG.0000000000004011","volume":"136","author":"RR Galang","year":"2020","unstructured":"Galang RR, Chang K, Strid P, Snead MC, Woodwortt KR, et al. Severe Corona infections in pregnancy: a systematic review. Obstet Gynecol. 2020;136(2):262\u201372.","journal-title":"Obstet Gynecol"},{"key":"663_CR34","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1186\/s12884-020-03026-3","volume":"20","author":"L Zhang","year":"2020","unstructured":"Zhang L, Dong L, Ming L, Wei M, Li J, et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during late pregnancy: a report of 18 patients from Wuhan, China. BMC Pregnancy Childbirth. 2020;20:394.","journal-title":"BMC Pregnancy Childbirth"},{"key":"663_CR35","volume-title":"Characteristics of women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status \u2013 United States, january22-June 7, MMMWR 69(25)","author":"S Ellington","year":"2020","unstructured":"Ellington S, Strid P, Tong VT, Woodworth K, Galang RR, et al. Characteristics of women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status \u2013 United States, january22-June 7, MMMWR 69(25), 2020."},{"issue":"2","key":"663_CR36","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1097\/AOG.0000000000004025","volume":"136","author":"R Khoury","year":"2020","unstructured":"Khoury R, Bernstein PS, Debolt C, Stone J, Sutton DM, et al. Characteristics and outcome of 241 births to women with severe acute repiratory syndrome coronavirus 2 (SARS-CoV-2) infection at five New York City medical centers. Obestet Gynecol. 2020;136(2):273\u201382.","journal-title":"Obestet Gynecol"},{"key":"663_CR37","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1097\/AOG.0000000000004005","volume":"136","author":"I Telefus Goldfarb","year":"2020","unstructured":"Telefus Goldfarb I, Vlapp MA, Soffer MD, Shook LL, Rushfirth K, et al. Prevalence and severity of coronavirus disease 2019 (COVID-19) illness in symptomatic pregnant and postpartum women stratified by Hispanic ethnicity. Obstet Gynecol. 2020;136:300\u20132.","journal-title":"Obstet Gynecol"},{"key":"663_CR38","unstructured":"Bowen A. Of the COVID-19 pregnancy cases reported in Illinois, black and Latina women make up over 70%. Chicago Tribune; \n                  https:\/\/www.chicagotribune.com\/coronavirus\/ct-life-coronavirus-hispanic-black-moms-pregnant-women-covid-20200702-opoekt3avvbqvfkf3caxtvrnkm-story.html\n                  \n                ."},{"key":"663_CR39","doi-asserted-by":"crossref","unstructured":"Huntley BJF, Huntley ES, Di Mascio D, Chen T, Berghella V. Chauhan sp. rates of maternal and perinatal mortality and vertical transmission in pregnanciescomplicated by severe acute respiratory syndrome coronavirus (SARS-co-V-2) infection: a systemic review. Obstet Gynecol. 2020;136(2):303\u201312.","DOI":"10.1097\/AOG.0000000000004010"},{"issue":"8","key":"663_CR40","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1055\/s-0040-1710050","volume":"37","author":"MC Alzamora","year":"2020","unstructured":"Alzamora MC, Paredes T, Caceres D, Webb CM, Valdez LM, La Rosa M. Severe COVID-19 during pregnancy and possible vertical transmission. Am J Perinatol. 2020;37(8):861\u2013965.","journal-title":"Am J Perinatol"},{"key":"663_CR41","doi-asserted-by":"publisher","first-page":"104447","DOI":"10.1016\/j.jcv.2020.104447","volume":"128","author":"C Egloff","year":"2020","unstructured":"Egloff C, Vauloup-Fellous C, Picone O, Mandelbrot L, Roques P. Evidence fand possible mechanisms of rare maternal fetal-transmission of SARS-C0V-2. J Clin Virol. 2020;128:104447.","journal-title":"J Clin Virol"},{"key":"663_CR42","unstructured":"Bredderman W, Messer O. Modelers warn Baltimore, Boston, and Chicago could be next COVID-19 hot-spots. The Daily Beast August. 2020. p. 12. \n                  https:\/\/www.thedailybeast.com\/baltimore-boston-and-chicago-could-be-next-coronavirus-hot-spots-modelers-warn?ref=home\n                  \n                ."},{"key":"663_CR43","unstructured":"ASRM, ESHRE and IFFS. COVID-19 and Human Reproduction Joint Statement:ASRM\/ESHRE\/IFFS. \n                  https:\/\/www.asrm.org\/globalassets\/asrm\/asrm-content\/news-and-publications\/covid-19\/asrm-eshre-iffs-joint-statement.pdf\n                  \n                . Accessed 5 Aug 2020."},{"key":"663_CR44","doi-asserted-by":"crossref","unstructured":"Lindberg LD, VandeVusse A, Mueller J,Kirstein M. Early impacts of the COVID-19 pandemic: Findings from the 2020 Guttmacher Survey of Reproductive Health Experiences. \n                  https:\/\/www.guttmacher.org\/report\/early-impacts-covid-19-pandemic-findings-2020-guttmacher-survey-reproductive-health\n                  \n                . Accessed 5 Aug 2020.","DOI":"10.1363\/2020.31482"},{"key":"663_CR45","unstructured":"Crudele J. Declining IVF rates might signal the next recession. New York Post, Dece,ber 16, 2016; \n                  https:\/\/nypost.com\/2015\/12\/14\/can-less-baby-making-mean-bad-news-for-us-economy\/\n                  \n                ."},{"key":"663_CR46","volume-title":"Fertility Inc.: inside the big business of babymaking. Forbes","author":"B Kowitt","year":"2020","unstructured":"Kowitt B. Fertility Inc.: inside the big business of babymaking. Forbes 2020; \n                  https:\/\/fortune.com\/longform\/fertility-business-femtech-investing-ivf\/\n                  \n                ."},{"key":"663_CR47","unstructured":"Bloomberg Law News. Embryo and egg freezer IntegraMed America files for liquidation. May 22, 2020; \n                  https:\/\/news.bloomberglaw.com\/bankruptcy-law\/embryo-and-egg-freezer-integramed-america-files-for-liquidation\n                  \n                ."},{"key":"663_CR48","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12958-020-00605-z","volume":"18","author":"C Alviggi","year":"2020","unstructured":"Alviggi C, Esteves SC, Orvieto R, Conforti A, La Marca A, et al. COVID-19 and assisted reproductive technology services: repercussions for patients and proposal for individualized clinical management. Reprod Biol Endocrinol. 2020;18:45.","journal-title":"Reprod Biol Endocrinol"},{"key":"663_CR49","doi-asserted-by":"publisher","unstructured":"Korber B, Fischer WM, Gnanakaran S, Yoon H, Theiler J, et al. Tracking changes in SARS-CoV-2 spike: evidence that D614G increases infectivity of the COVID-19 virus. Cell2020.06.043. doi: \n                  https:\/\/doi.org\/10.1016\/j.cell.2020.06.043\n                  \n                .","DOI":"10.1016\/j.cell.2020.06.043"},{"key":"663_CR50","doi-asserted-by":"publisher","unstructured":"Grubaugh ND, Hanage WP, Rasmussen AL. Making sense of mutation: What D614G menas for the COVID-19 pandemic remains unclear. Cell. 2020:06.040. \n                  https:\/\/doi.org\/10.1016\/j.cell.2020.06.040\n                  \n                .","DOI":"10.1016\/j.cell.2020.06.040"}],"container-title":["Reproductive Biology and Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-020-00663-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12958-020-00663-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-020-00663-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T23:02:54Z","timestamp":1604530974000},"score":1,"resource":{"primary":{"URL":"https:\/\/rbej.biomedcentral.com\/articles\/10.1186\/s12958-020-00663-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,4]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["663"],"URL":"https:\/\/doi.org\/10.1186\/s12958-020-00663-3","relation":{},"ISSN":["1477-7827"],"issn-type":[{"value":"1477-7827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,4]]},"assertion":[{"value":"27 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The author has no competing interest to report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"105"}}