{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:52:49Z","timestamp":1790898769051,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012554","name":"Hubei Provincial Department of Education","doi-asserted-by":"publisher","award":["B2018437"],"award-info":[{"award-number":["B2018437"]}],"id":[{"id":"10.13039\/100012554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study is to investigate the effect of irisin on leukemia inhibitory factor (LIF) and integrin \u03b1v\u03b23 in implantation failure uterus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Early pregnant rats were randomly divided into normal group (N), mifepristone treated group (M), irisin group (I) and progestin group (P). The implantation failure model was established using mifepristone. Second, we evaluated the average number of embryos and detected the expression of LIF and integrin \u03b1v\u03b23 protein and mRNA in endometrium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with group M, the average number of embryos was significantly higher in group N, P and I, the expression of LIF and integrin \u03b1v\u03b23 in endometrium was significantly higher in group N, P and I.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Irisin could improve the poor receptive state of endometrium by promoting LIF and integrin \u03b1v\u03b23 secretion to improve blastocyst implantation in rats of implantation failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12958-021-00700-9","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T02:03:27Z","timestamp":1612317807000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of Irisin on LIF and integrin \u03b1v\u03b23 in rats of implantation failure"],"prefix":"10.1186","volume":"19","author":[{"given":"Li","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0862-7970","authenticated-orcid":false,"given":"Chenggang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangshu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,3]]},"reference":[{"key":"700_CR1","first-page":"689","volume":"20","author":"K Panati","year":"2016","unstructured":"Panati K, Suneetha Y, Narala VR. Irisin\/FNDC5--an updated review. Eur Rev Med Pharmacol Sci. 2016;20:689\u201397.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"700_CR2","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s12902-016-0123-9","volume":"16","author":"X Shi","year":"2016","unstructured":"Shi X, Lin M, Liu C, et al. Elevated circulating irisin is associated with lower risk of insulin resistance: association and path analyses of obese Chinese adults. BMC Endocr Disord. 2016;16:44.","journal-title":"BMC Endocr Disord"},{"key":"700_CR3","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nature10777","volume":"481","author":"P Bostrom","year":"2012","unstructured":"Bostrom P, Wu J, Jedrychowski MP, et al. A PGC1- alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481:463\u20138.","journal-title":"Nature."},{"key":"700_CR4","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1007\/s12020-017-1476-1","volume":"59","author":"SA Polyzos","year":"2018","unstructured":"Polyzos SA, Anastasilakis AD, Efstathiadou ZA, et al. Irisin in metabolic diseases. Endocrine. 2018;59:260\u201374.","journal-title":"Endocrine."},{"key":"700_CR5","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1097\/MED.0b013e3282f1d6cb","volume":"14","author":"R Pasquali","year":"2007","unstructured":"Pasquali R, Patton L, Gambineri A. Obesity and infertility. Curr Opin Endocrinol Diabetes Obes. 2007;14:482\u20137.","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"700_CR6","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1051\/rnd:2006018","volume":"46","author":"JA Abecia","year":"2006","unstructured":"Abecia JA, Sosa C, Forcada F, et al. The effect of undernutrition on the establishment of pregnancy in the ewe. Reprod Nutr Dev. 2006;46:367\u201378.","journal-title":"Reprod Nutr Dev"},{"key":"700_CR7","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.metabol.2017.11.006","volume":"86","author":"H Mathew","year":"2018","unstructured":"Mathew H, Castracane VD, Mantzoros C. Adipose tissue and reproductive health. Metabolism. 2018;86:18\u201332.","journal-title":"Metabolism."},{"key":"700_CR8","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1093\/molehr\/gav025","volume":"21","author":"JF Kawwass","year":"2015","unstructured":"Kawwass JF, Summer R, Kallen CB. Direct effects of leptin and adiponectin on peripheral reproductive tissues: a critical review. Mol Hum Reprod. 2015;21:617\u201332.","journal-title":"Mol Hum Reprod"},{"key":"700_CR9","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1080\/10520295.2017.1303194","volume":"92","author":"FM G\u00fcr","year":"2017","unstructured":"G\u00fcr FM, Timurkaan S, Yalcin MH, et al. Immunohistochemical localization of irisin in mole rats (Spalax leucodon). Biotech Histochem. 2017;92:245\u201351.","journal-title":"Biotech Histochem"},{"key":"700_CR10","volume-title":"Correlation between irisin in serum and endometrium and polycystic ovary syndrome","author":"Y Guo","year":"2016","unstructured":"Guo Y. Correlation between irisin in serum and endometrium and polycystic ovary syndrome. Shijiazhuang: Hebei Medical University; 2016."},{"key":"700_CR11","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1476-511X-14-2","volume":"14","author":"JQ Chen","year":"2015","unstructured":"Chen JQ, Huang YY, Gusdon AM, et al. Irisin:a new molecular marker and target in metabolic disorder. Lipids Health Dis. 2015;14:2.","journal-title":"Lipids Health Dis"},{"key":"700_CR12","doi-asserted-by":"publisher","first-page":"351","DOI":"10.12717\/DR.2017.21.4.351","volume":"21","author":"SM Kim","year":"2017","unstructured":"Kim SM, Kim JS. A review of mechanisms of implantation. Dev Reprod. 2017;21:351\u20139.","journal-title":"Dev Reprod"},{"key":"700_CR13","first-page":"1011","volume":"12","author":"SL Shang","year":"2006","unstructured":"Shang SL. The clinical application of mifepristone in the birth control. Med Recapitulate. 2006;12:1011\u20133.","journal-title":"Med Recapitulate"},{"key":"700_CR14","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1016\/j.fertnstert.2003.05.001","volume":"80","author":"X Sun","year":"2003","unstructured":"Sun X, Qiu X, Gemzell-Danielsson K. Effects of mifepristone on expression of endothelial nitric oxide synthase in human endometrium during the implantation phase. Fertil Steril. 2003;80:1454\u201360.","journal-title":"Fertil Steril"},{"key":"700_CR15","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1093\/humrep\/dey086","volume":"33","author":"LM Russo","year":"2018","unstructured":"Russo LM, Whitcomb BW, Mumford SL, et al. A prospective study of physical activity and fecundability in women with a history of pregnancy loss. Hum Reprod. 2018;33:1291\u20138.","journal-title":"Hum Reprod"},{"key":"700_CR16","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1016\/j.fertnstert.2009.07.1005","volume":"93","author":"DA Deugarte","year":"2010","unstructured":"Deugarte DA, DeUgarte CM, Sahakian V. Surrogate obesity negatively impacts pregnancy rates in third-party reproduction. Fertil Steril. 2010;93:1008\u201310.","journal-title":"Fertil Steril"},{"key":"700_CR17","doi-asserted-by":"publisher","first-page":"3082","DOI":"10.1093\/humrep\/dep303","volume":"24","author":"L Dessolle","year":"2009","unstructured":"Dessolle L, Darai E, Cornet D, et al. Determinants of pregnancy rate in the donor oocyte model: a multivariate analysis of 450 frozen-thawed embryo transfers. Hum Reprod. 2009;24:3082\u20139.","journal-title":"Hum Reprod"},{"key":"700_CR18","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.fertnstert.2008.12.032","volume":"93","author":"J Bellver","year":"2010","unstructured":"Bellver J, Ayllon Y, Ferrando M, et al. Female obesity impairs in vitro fertilization outcome without affecting embryo quality. Fertil Steril. 2010;93:447\u201354.","journal-title":"Fertil Steril"},{"key":"700_CR19","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.fertnstert.2013.06.001","volume":"100","author":"J Bellver","year":"2013","unstructured":"Bellver J, Pellicer A, Garcia-Velasco JA, et al. Obesity reduces uterine receptivity: clinical experience from 9587 first cycles of ovum donation with normal weight donors. Fertil Steril. 2013;100:1050\u20138.","journal-title":"Fertil Steril"},{"key":"700_CR20","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1016\/j.fertnstert.2011.03.021","volume":"95","author":"J Bellver","year":"2011","unstructured":"Bellver J, Martinez-Conejero JA, Labarta E, et al. Endometrial gene expression in the window of implantation is altered in obese women especially in association with polycystic ovary syndrome. Fertil Steril. 2011;95:2335\u2013541.","journal-title":"Fertil Steril"},{"key":"700_CR21","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1093\/humrep\/dew048","volume":"31","author":"JS Rhee","year":"2016","unstructured":"Rhee JS, Saben JL, Mayer AL, et al. Diet-induced obesity impairs endometrial stromal cell decidualization: a potential role for impaired autophagy. Hum Reprod. 2016;31:1315\u201326.","journal-title":"Hum Reprod"},{"key":"700_CR22","first-page":"155","volume":"22","author":"CY Wang","year":"2012","unstructured":"Wang CY, CFi D. Research progress of insulin resistance and endometrial receptivity in patients with polycystic ovary syndrome. Zhejiang Integr Med. 2012;22:155\u20138.","journal-title":"Zhejiang Integr Med"},{"key":"700_CR23","volume-title":"Effect of insulin resistance on reproductive function in patients with polycystic ovary syndrome","author":"XL Sun","year":"2013","unstructured":"Sun XL. Effect of insulin resistance on reproductive function in patients with polycystic ovary syndrome. Shanghai: Fudan University; 2013."},{"key":"700_CR24","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.jri.2011.02.005","volume":"89","author":"GJ Burtona","year":"2011","unstructured":"Burtona GJ, Sciosciab M, Rademacherc TW. Endometrial secretions: creating a stimulatory microenvironment within the human early placenta and implications for the aetiopathogenesis of preeclampsia. J Reprod Immunol. 2011;89:118\u201325.","journal-title":"J Reprod Immunol"},{"key":"700_CR25","doi-asserted-by":"publisher","first-page":"S64","DOI":"10.1016\/j.placenta.2007.01.007","volume":"28","author":"GJ Burton","year":"2007","unstructured":"Burton GJ, Jauniaux E, Charnock-Jones DS. Human early placental development: potential roles of the endometrial glands. Placenta. 2007;28:S64\u20139.","journal-title":"Placenta."},{"key":"700_CR26","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1038\/s41467-018-04848-8","volume":"22","author":"AM Kelleher","year":"2018","unstructured":"Kelleher AM, Milano-Foster J, Behura SK, et al. Uterine glands coordinate on-time embryo implantation and impact endometrial decidualization for pregnancy success. Nat Commun. 2018;22:2435.","journal-title":"Nat Commun"},{"key":"700_CR27","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.anireprosci.2005.05.019","volume":"92","author":"YJ Yang","year":"2006","unstructured":"Yang YJ, Cao YJ, Bo SM, et al. Leptin-directed embryo implantation: Leptin regulates adhesion and outgrowth of mouse blastocysts and receptivity of endometrial epithelial cells. Anim Reprod Sci. 2006;92:155\u201367.","journal-title":"Anim Reprod Sci"}],"container-title":["Reproductive Biology and Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-021-00700-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12958-021-00700-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-021-00700-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T02:03:37Z","timestamp":1612317817000},"score":1,"resource":{"primary":{"URL":"https:\/\/rbej.biomedcentral.com\/articles\/10.1186\/s12958-021-00700-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,3]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["700"],"URL":"https:\/\/doi.org\/10.1186\/s12958-021-00700-9","relation":{},"ISSN":["1477-7827"],"issn-type":[{"value":"1477-7827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,3]]},"assertion":[{"value":"26 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Animal Research Ethics Committee of Hubei Medical College approved the study protocol (Approval No.2018\u201387). We state that the \u201cPrinciples of Laboratory Animal Care\u201d (NIH publication No. 86\u201323, revised 1985) were followed as well as specific national laws where applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that no competing financial.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"18"}}