{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:12:27Z","timestamp":1780528347739,"version":"3.54.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871212"],"award-info":[{"award-number":["81871212"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key R&D Program of China","award":["2017YFC1002004"],"award-info":[{"award-number":["2017YFC1002004"]}]},{"DOI":"10.13039\/501100018543","name":"Natural Science Foundation of Tibet","doi-asserted-by":"crossref","award":["XZ2017ZR-028"],"award-info":[{"award-number":["XZ2017ZR-028"]}],"id":[{"id":"10.13039\/501100018543","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Recent studies have revealed that women with infertility have a higher risk of thyroid cancer (TC) than fertile women. However, studies on whether a history of thyroid cancer affects clinical outcomes in women who conceive using in vitro fertilization\/intracytoplasmic sperm injection (IVF\/ICSI) are scarce. We investigate whether a history of thyroid cancer (TC) affects the in vitro fertilization\/intracytoplasmic sperm injection (IVF\/ICSI) outcomes and increases the risk of adverse obstetric outcomes in women with infertility.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This retrospective study enrolled 384 women with infertility who underwent their first IVF\/ICSI treatment at the Peking University Third Hospital between 2010 and 2019. Participants were divided into the TC (64 women with TC history) and control (320 women matched from 85,272 women without thyroid diseases) groups. Controls were individually matched to the TC group according to age, body mass index, concomitant infertility factors, first IVF\/ICSI dates, and controlled ovarian stimulation and embryo transfer procedure protocols. IVF\/ICSI outcomes, including the numbers of retrieved oocytes and high-grade embryos, clinical pregnancy, miscarriage, preterm delivery, and live birth rates, and adverse obstetric outcome risk were assessed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The TC group had significantly higher thyroid hormone and lower thyroid-stimulating hormone (TSH) levels than the control group. Despite similar gonadotropin treatment dosage, the TC group had a significantly lower numbers of retrieved oocytes and high-grade embryos than the control group. The occurrence rates of clinical pregnancy, miscarriage, preterm delivery, live births, and adverse obstetric outcomes, including multiple gestation, preterm delivery, gestational diabetes mellitus, gestational hypertension, low birth weight, and large-for-gestational-age infants, were not significantly different between the two groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>TC history did not affect the pregnancy outcomes or increase the risk of adverse obstetric outcomes after the first IVF\/ICSI, but it may decrease the number of retrieved oocytes and high-grade embryos.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12958-021-00763-8","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T07:03:42Z","timestamp":1622790222000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Analysis of in vitro fertilization\/intracytoplasmic sperm injection outcomes in infertile women with a history of thyroid cancer: a retrospective study"],"prefix":"10.1186","volume":"19","author":[{"given":"Ning","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6074-0663","authenticated-orcid":false,"given":"Hongbin","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,4]]},"reference":[{"issue":"10061","key":"763_CR1","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1016\/S0140-6736(16)30172-6","volume":"388","author":"ME Cabanillas","year":"2016","unstructured":"Cabanillas ME, McFadden DG, Durante C. Thyroid cancer. Lancet. 2016;388(10061):2783\u201395. https:\/\/doi.org\/10.1016\/S0140-6736(16)30172-6.","journal-title":"Lancet"},{"issue":"5","key":"763_CR2","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1002\/ijc.29067","volume":"136","author":"R Zamora-Ros","year":"2015","unstructured":"Zamora-Ros R, Rinaldi S, Biessy C, Tj\u00f8nneland A, Halkjaer J, Fournier A, et al. Reproductive and menstrual factors and risk of differentiated thyroid carcinoma: the EPIC study. Int J Cancer. 2015;136(5):1218\u201327. https:\/\/doi.org\/10.1002\/ijc.29067.","journal-title":"Int J Cancer"},{"issue":"10","key":"763_CR3","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1002\/cncr.31964","volume":"125","author":"DC Ding","year":"2019","unstructured":"Ding DC, Chen W, Wang JH, Lin SZ, Sung FC. Thyroid cancer risk in women with infertility and association with fertility medications in Taiwan. Cancer. 2019;125(10):1701\u20138. https:\/\/doi.org\/10.1002\/cncr.31964.","journal-title":"Cancer"},{"issue":"3","key":"763_CR4","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1089\/thy.2016.0457","volume":"27","author":"EK Alexander","year":"2017","unstructured":"Alexander EK, Pearce EN, Brent GA, Brown RS, Chen H, Dosiou C, et al. 2017 guidelines of the American Thyroid Association for the diagnosis and Management of Thyroid Disease during Pregnancy and the postpartum. Thyroid. 2017;27(3):315\u201389. https:\/\/doi.org\/10.1089\/thy.2016.0457.","journal-title":"Thyroid"},{"issue":"4","key":"763_CR5","first-page":"327","volume":"32","author":"E Veiga","year":"2019","unstructured":"Veiga E, Trevi\u00f1o M, RomayAB ND, Trastoy R, Mac\u00eda M. Prevalence of genital Mycoplasma and response to eradication treatment in patients undergoing assisted reproductive techniques. 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Approval for a waiver for written consent was obtained from Peking University Third Hospital Medical Science Research Ethics Committee due to the retrospective nature of this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"This manuscript has not been published or presented elsewhere and is not under consideration by another journal. All study participants provided informed consent and approved it for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"82"}}