{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:11:05Z","timestamp":1790878265053,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020YQ58"],"award-info":[{"award-number":["ZR2020YQ58"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81972489"],"award-info":[{"award-number":["81972489"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Endometriosis is a chronic hormonal inflammatory disease characterized by the presence of endometrial tissue outside the uterus. Endometriosis often causes infertility, which brings physical and mental pain to patients and their families.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We examined the functions of heat shock factor 1 (HSF1) in endometriosis development through cell count assay, cell-scratch assay and clone formation experiments. We used quantitative real-time PCR (qRT-PCR) and Western blot (WB) to detect HSF1 expression. Glucose and lactate levels were determined using a glucose (GO) assay kit and a lactate assay kit. Furthermore, we used a HSF1 inhibitor-KRIBB11 to establish a mouse model of endometriosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Our data demonstrated that HSF1 promoted endometriosis development. Interestingly, HSF1 enhanced glycolysis via up-regulating PFKFB3 expression in endometriosis cells, which was a key glycolysis enzyme. Consistently, the HSF1 inhibitor KRIBB11 could abrogate endometriosis progression in vivo and in vitro.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Findings indicate that HSF1 plays an important role in endometriosis development, which might become a new target for the treatment of endometriosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Electronic supplementary material<\/jats:title>\n                <jats:p>Supplementary data are available.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12958-021-00770-9","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T06:18:37Z","timestamp":1623219517000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["HSF1 promotes endometriosis development and glycolysis by up-regulating PFKFB3 expression"],"prefix":"10.1186","volume":"19","author":[{"given":"Yixin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chune","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8928-6890","authenticated-orcid":false,"given":"Zhenhai","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"issue":"3","key":"770_CR1","first-page":"349","volume":"7","author":"C Mehedintu","year":"2014","unstructured":"Mehedintu C, Plotogea MN, Ionescu S, Antonovici M. Endometriosis still a challenge. J Med Life. 2014;7(3):349\u201357.","journal-title":"J Med Life"},{"issue":"25","key":"770_CR2","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1056\/NEJMcp1000274","volume":"362","author":"LC Giudice","year":"2010","unstructured":"Giudice LC. Clinical practice. Endometriosis. N Engl J Med. 2010;362(25):2389\u201398. https:\/\/doi.org\/10.1056\/NEJMcp1000274.","journal-title":"N Engl J Med"},{"issue":"3","key":"770_CR3","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1093\/humupd\/dmaa002","volume":"26","author":"K Olsarova","year":"2020","unstructured":"Olsarova K, Mishra GD. Early life factors for endometriosis: a systematic review. Hum Reprod Update. 2020;26(3):412\u201322. https:\/\/doi.org\/10.1093\/humupd\/dmaa002.","journal-title":"Hum Reprod Update"},{"key":"770_CR4","doi-asserted-by":"publisher","unstructured":"Chen H, Malentacchi F, Fambrini M, Harrath AH, Huang H, Petraglia F. Epigenetics of estrogen and progesterone receptors in endometriosis. Reprod Sci. 2020;27(11):1967\u201374. https:\/\/doi.org\/10.1007\/s43032-020-00226-2.","DOI":"10.1007\/s43032-020-00226-2"},{"issue":"5","key":"770_CR5","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/nrendo.2013.255","volume":"10","author":"P Vercellini","year":"2014","unstructured":"Vercellini P, Vigan\u00f2 P, Somigliana E, Fedele L. Endometriosis: pathogenesis and treatment. Nat Rev Endocrinol. 2014;10(5):261\u201375. https:\/\/doi.org\/10.1038\/nrendo.2013.255.","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"770_CR6","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1146\/annurev-pathmechdis-012419-032654","volume":"15","author":"Y Wang","year":"2020","unstructured":"Wang Y, Nicholes K, Shih IM. The origin and pathogenesis of endometriosis. Annu Rev Pathol. 2020;15(1):71\u201395. https:\/\/doi.org\/10.1146\/annurev-pathmechdis-012419-032654.","journal-title":"Annu Rev Pathol"},{"issue":"12","key":"770_CR7","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.tips.2019.10.008","volume":"40","author":"B Dong","year":"2019","unstructured":"Dong B, Jaeger AM, Thiele DJ. Inhibiting heat shock factor 1 in Cancer: a unique therapeutic opportunity. Trends Pharmacol Sci. 2019;40(12):986\u20131005. https:\/\/doi.org\/10.1016\/j.tips.2019.10.008.","journal-title":"Trends Pharmacol Sci"},{"key":"770_CR8","doi-asserted-by":"publisher","unstructured":"Kov\u00e1cs D, Sigmond T, Hotzi B, Boh\u00e1r B, Fazekas D, De\u00e1k V, et al. HSF1Base: a comprehensive database of HSF1 (Heat Shock Factor 1) target genes. Int J Mol Sci. 2019;20(22):5815. https:\/\/doi.org\/10.3390\/ijms20225815.","DOI":"10.3390\/ijms20225815"},{"key":"770_CR9","first-page":"188390","volume":"2020","author":"G Wang","year":"1874","unstructured":"Wang G, Cao P, Fan Y, Tan K. Emerging roles of HSF1 in cancer: cellular and molecular episodes. Biochim Biophys Acta Rev Cancer. 1874;2020:188390.","journal-title":"Biochim Biophys Acta Rev Cancer"},{"issue":"1","key":"770_CR10","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.tcb.2015.10.011","volume":"26","author":"C Dai","year":"2016","unstructured":"Dai C, Sampson SB. HSF1: Guardian of Proteostasis in Cancer. Trends Cell Biol. 2016;26(1):17\u201328. https:\/\/doi.org\/10.1016\/j.tcb.2015.10.011.","journal-title":"Trends Cell Biol"},{"issue":"3","key":"770_CR11","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/S0002-9440(10)64954-1","volume":"156","author":"AT Hoang","year":"2000","unstructured":"Hoang AT, Huang J, Rudra-Ganguly N, Zheng J, Powell WC, Rabindran SK, et al. A novel association between the human heat shock transcription factor 1 (HSF1) and prostate adenocarcinoma. Am J Pathol. 2000;156(3):857\u201364. https:\/\/doi.org\/10.1016\/S0002-9440(10)64954-1.","journal-title":"Am J Pathol"},{"key":"770_CR12","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/978-3-030-40204-4_7","volume":"1243","author":"N Grunberg","year":"2020","unstructured":"Grunberg N, Levi-Galibov O, Scherz-Shouval R. The role of HSF1 and the chaperone network in the tumor microenvironment. Adv Exp Med Biol. 2020;1243:101\u201311. https:\/\/doi.org\/10.1007\/978-3-030-40204-4_7.","journal-title":"Adv Exp Med Biol"},{"issue":"6","key":"770_CR13","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.rbmo.2014.09.004","volume":"29","author":"X Qi","year":"2014","unstructured":"Qi X, Zhang Y, Ji H, Wu X, Wang F, Xie M, et al. Knockdown of prohibitin expression promotes glucose metabolism in eutopic endometrial stromal cells from women with endometriosis. Reprod BioMed Online. 2014;29(6):761\u201370. https:\/\/doi.org\/10.1016\/j.rbmo.2014.09.004.","journal-title":"Reprod BioMed Online"},{"issue":"3191","key":"770_CR14","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1126\/science.123.3191.309","volume":"123","author":"O Warburg","year":"1956","unstructured":"Warburg O. On the origin of cancer cells. Science. 1956;123(3191):309\u201314. https:\/\/doi.org\/10.1126\/science.123.3191.309.","journal-title":"Science"},{"key":"770_CR15","doi-asserted-by":"publisher","unstructured":"Ghashghaeinia M, K\u00f6berle M, Mrowietz U, Bernhardt I. Proliferating tumor cells mimick glucose metabolism of mature human erythrocytes. Cell Cycle. 2019;18(12):1316\u201334. https:\/\/doi.org\/10.1080\/15384101.2019.1618125.","DOI":"10.1080\/15384101.2019.1618125"},{"key":"770_CR16","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.3389\/fonc.2019.01143","volume":"9","author":"KG de la Cruz-L\u00f3pez","year":"2019","unstructured":"de la Cruz-L\u00f3pez KG, Castro-Mu\u00f1oz LJ, Reyes-Hern\u00e1ndez DO, Garc\u00eda-Carranc\u00e1 A, Manzo-Merino J. Lactate in the regulation of tumor microenvironment and therapeutic approaches. Front Oncol. 2019;9:1143. https:\/\/doi.org\/10.3389\/fonc.2019.01143.","journal-title":"Front Oncol"},{"key":"770_CR17","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.ejogrb.2020.12.044","volume":"258","author":"H Kobayashi","year":"2021","unstructured":"Kobayashi H, Kimura M, Maruyama S, Nagayasu M, Imanaka S. Revisiting estrogen-dependent signaling pathways in endometriosis: potential targets for non-hormonal therapeutics. Eur J Obstet Gynecol Reprod Biol. 2021;258:103\u201310. https:\/\/doi.org\/10.1016\/j.ejogrb.2020.12.044.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"1","key":"770_CR18","doi-asserted-by":"publisher","first-page":"17044","DOI":"10.1038\/sigtrans.2017.44","volume":"2","author":"L Shi","year":"2017","unstructured":"Shi L, Pan H, Liu Z, Xie J, Han W. Roles of PFKFB3 in cancer. Signal Transduct Target Ther. 2017;2(1):17044. https:\/\/doi.org\/10.1038\/sigtrans.2017.44.","journal-title":"Signal Transduct Target Ther"},{"key":"770_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molmet.2018.11.013","volume":"20","author":"M Yi","year":"2019","unstructured":"Yi M, Ban Y, Tan Y, Xiong W, Li G, Xiang B. 6-Phosphofructo-2-kinase\/fructose-2,6-biphosphatase 3 and 4: a pair of valves for fine-tuning of glucose metabolism in human cancer. Mol Metab. 2019;20:1\u201313. https:\/\/doi.org\/10.1016\/j.molmet.2018.11.013.","journal-title":"Mol Metab"},{"issue":"3","key":"770_CR20","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.cell.2013.06.037","volume":"154","author":"K De Bock","year":"2013","unstructured":"De Bock K, Georgiadou M, Schoors S, Kuchnio A, Wong BW, Cantelmo AR, et al. Role of PFKFB3-driven glycolysis in vessel sprouting. Cell. 2013;154(3):651\u201363. https:\/\/doi.org\/10.1016\/j.cell.2013.06.037.","journal-title":"Cell"},{"key":"770_CR21","volume":"11","author":"C Lu","year":"2021","unstructured":"Lu C, Qiao P, Sun Y, Ren C, Yu Z. Positive regulation of PFKFB3 by PIM2 promotes glycolysis and paclitaxel resistance in breast cancer. Clin Transl Med. 2021;11:e400.","journal-title":"Clin Transl Med"},{"key":"770_CR22","doi-asserted-by":"publisher","first-page":"112612","DOI":"10.1016\/j.ejmech.2020.112612","volume":"203","author":"Y Wang","year":"2020","unstructured":"Wang Y, Qu C, Liu T, Wang C. PFKFB3 inhibitors as potential anticancer agents: mechanisms of action, current developments, and structure-activity relationships. Eur J Med Chem. 2020;203:112612. https:\/\/doi.org\/10.1016\/j.ejmech.2020.112612.","journal-title":"Eur J Med Chem"},{"issue":"5","key":"770_CR23","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1021\/pr901131p","volume":"9","author":"AN Stephens","year":"2010","unstructured":"Stephens AN, Hannan NJ, Rainczuk A, Meehan KL, Chen J, Nicholls PK, et al. Post-translational modifications and protein-specific isoforms in endometriosis revealed by 2D DIGE. J Proteome Res. 2010;9(5):2438\u201349. https:\/\/doi.org\/10.1021\/pr901131p.","journal-title":"J Proteome Res"},{"issue":"2","key":"770_CR24","first-page":"461","volume":"150","author":"R Gaetje","year":"1997","unstructured":"Gaetje R, Kotzian S, Herrmann G, Baumann R, Starzinski-Powitz A. Nonmalignant epithelial cells, potentially invasive in human endometriosis, lack the tumor suppressor molecule E-cadherin. Am J Pathol. 1997;150(2):461\u20137.","journal-title":"Am J Pathol"},{"issue":"5","key":"770_CR25","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1210\/en.2003-1606","volume":"145","author":"G Krikun","year":"2004","unstructured":"Krikun G, Mor G, Alvero A, Guller S, Schatz F, Sapi E, et al. A novel immortalized human endometrial stromal cell line with normal progestational response. Endocrinology. 2004;145(5):2291\u20136. https:\/\/doi.org\/10.1210\/en.2003-1606.","journal-title":"Endocrinology"},{"issue":"20","key":"770_CR26","doi-asserted-by":"publisher","first-page":"5233","DOI":"10.1158\/0008-5472.CAN-19-0063","volume":"79","author":"T Yang","year":"2019","unstructured":"Yang T, Ren C, Lu C, Qiao P, Han X, Wang L, et al. Phosphorylation of HSF1 by PIM2 induces PD-L1 expression and promotes tumor growth in breast Cancer. Cancer Res. 2019;79(20):5233\u201344. https:\/\/doi.org\/10.1158\/0008-5472.CAN-19-0063.","journal-title":"Cancer Res"},{"issue":"5","key":"770_CR27","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1002\/1878-0261.12192","volume":"12","author":"C Ren","year":"2018","unstructured":"Ren C, Yang T, Qiao P, Wang L, Han X, Lv S, et al. PIM2 interacts with tristetraprolin and promotes breast cancer tumorigenesis. Mol Oncol. 2018;12(5):690\u2013704. https:\/\/doi.org\/10.1002\/1878-0261.12192.","journal-title":"Mol Oncol"},{"issue":"45","key":"770_CR28","doi-asserted-by":"publisher","first-page":"5997","DOI":"10.1038\/s41388-018-0386-x","volume":"37","author":"T Yang","year":"2018","unstructured":"Yang T, Ren C, Qiao P, Han X, Wang L, Lv S, et al. PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer. Oncogene. 2018;37(45):5997\u20136009. https:\/\/doi.org\/10.1038\/s41388-018-0386-x.","journal-title":"Oncogene"},{"issue":"5","key":"770_CR29","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1158\/1541-7786.MCR-19-0842","volume":"18","author":"C Lu","year":"2020","unstructured":"Lu C, Ren C, Yang T, Sun Y, Qiao P, Wang D, et al. A noncanonical role of Fructose-1, 6-Bisphosphatase 1 is essential for inhibition of Notch1 in breast Cancer. Mol Cancer Res. 2020;18(5):787\u201396. https:\/\/doi.org\/10.1158\/1541-7786.MCR-19-0842.","journal-title":"Mol Cancer Res"},{"issue":"38","key":"770_CR30","doi-asserted-by":"publisher","first-page":"6537","DOI":"10.1038\/s41388-019-0898-z","volume":"38","author":"X Han","year":"2019","unstructured":"Han X, Ren C, Yang T, Qiao P, Wang L, Jiang A, et al. Negative regulation of AMPKalpha1 by PIM2 promotes aerobic glycolysis and tumorigenesis in endometrial cancer. Oncogene. 2019;38(38):6537\u201349. https:\/\/doi.org\/10.1038\/s41388-019-0898-z.","journal-title":"Oncogene"},{"issue":"19","key":"770_CR31","doi-asserted-by":"publisher","first-page":"8606","DOI":"10.7150\/thno.46861","volume":"10","author":"C Lu","year":"2020","unstructured":"Lu C, Ren C, Yang T, Sun Y, Qiao P, Han X, et al. Fructose-1, 6-bisphosphatase 1 interacts with NF-kappaB p65 to regulate breast tumorigenesis via PIM2 induced phosphorylation. Theranostics. 2020;10(19):8606\u201318. https:\/\/doi.org\/10.7150\/thno.46861.","journal-title":"Theranostics"},{"issue":"4","key":"770_CR32","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.cell.2015.10.034","volume":"163","author":"SJ Han","year":"2015","unstructured":"Han SJ, Jung SY, Wu SP, Hawkins SM, Park MJ, Kyo S, et al. Estrogen receptor beta modulates apoptosis complexes and the Inflammasome to drive the pathogenesis of endometriosis. Cell. 2015;163(4):960\u201374. https:\/\/doi.org\/10.1016\/j.cell.2015.10.034.","journal-title":"Cell"},{"issue":"3","key":"770_CR33","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1074\/jbc.M110.179440","volume":"286","author":"YJ Yoon","year":"2011","unstructured":"Yoon YJ, Kim JA, Shin KD, Shin DS, Han YM, Lee YJ, et al. KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. J Biol Chem. 2011;286(3):1737\u201347. https:\/\/doi.org\/10.1074\/jbc.M110.179440.","journal-title":"J Biol Chem"},{"issue":"1","key":"770_CR34","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1186\/s12967-020-02471-0","volume":"18","author":"H Malvezzi","year":"2020","unstructured":"Malvezzi H, Marengo EB, Podgaec S, Piccinato CA. Endometriosis: current challenges in modeling a multifactorial disease of unknown etiology. J Transl Med. 2020;18(1):311. https:\/\/doi.org\/10.1186\/s12967-020-02471-0.","journal-title":"J Transl Med"},{"issue":"20","key":"770_CR35","doi-asserted-by":"publisher","first-page":"4140","DOI":"10.1111\/j.1742-4658.2010.07829.x","volume":"277","author":"H Sakurai","year":"2010","unstructured":"Sakurai H, Enoki Y. Novel aspects of heat shock factors: DNA recognition, chromatin modulation and gene expression. FEBS J. 2010;277(20):4140\u20139. https:\/\/doi.org\/10.1111\/j.1742-4658.2010.07829.x.","journal-title":"FEBS J"},{"key":"770_CR36","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.ejphar.2018.01.005","volume":"822","author":"C Huang","year":"2018","unstructured":"Huang C, Wu J, Xu L, Wang J, Chen Z, Yang R. Regulation of HSF1 protein stabilization: an updated review. Eur J Pharmacol. 2018;822:69\u201377. https:\/\/doi.org\/10.1016\/j.ejphar.2018.01.005.","journal-title":"Eur J Pharmacol"},{"issue":"7","key":"770_CR37","doi-asserted-by":"publisher","first-page":"515","DOI":"10.2174\/1568009618666181018162117","volume":"19","author":"RL Carpenter","year":"2019","unstructured":"Carpenter RL, G\u00f6kmen-Polar Y. HSF1 as a Cancer biomarker and therapeutic target. Curr Cancer Drug Targets. 2019;19(7):515\u201324. https:\/\/doi.org\/10.2174\/1568009618666181018162117.","journal-title":"Curr Cancer Drug Targets"},{"key":"770_CR38","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/978-3-030-40204-4_3","volume":"1243","author":"D Pincus","year":"2020","unstructured":"Pincus D. Regulation of Hsf1 and the heat shock response. Adv Exp Med Biol. 2020;1243:41\u201350. https:\/\/doi.org\/10.1007\/978-3-030-40204-4_3.","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"770_CR39","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/bjc.2014.262","volume":"111","author":"H Engerud","year":"2014","unstructured":"Engerud H, Tangen IL, Berg A, Kusonmano K, Halle MK, Oyan AM, et al. High level of HSF1 associates with aggressive endometrial carcinoma and suggests potential for HSP90 inhibitors. Br J Cancer. 2014;111(1):78\u201384. https:\/\/doi.org\/10.1038\/bjc.2014.262.","journal-title":"Br J Cancer"},{"key":"770_CR40","doi-asserted-by":"publisher","unstructured":"Chantalat E, Valera MC, Vaysse C, Noirrit E, Rusidze M, Weyl A, et al. Estrogen Receptors and Endometriosis. Int J Mol Sci. 2020;21(8):2815. https:\/\/doi.org\/10.3390\/ijms21082815.","DOI":"10.3390\/ijms21082815"},{"key":"770_CR41","doi-asserted-by":"publisher","unstructured":"Murgia F, Angioni S, D'Alterio MN, Pirarba S, Noto A, Santoru ML, et al. Metabolic profile of patients with severe endometriosis: a prospective experimental study. Reprod Sci. 2021;28(3):728-35. https:\/\/doi.org\/10.1007\/s43032-020-00370-9.","DOI":"10.1007\/s43032-020-00370-9"},{"issue":"7","key":"770_CR42","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1016\/j.fertnstert.2009.08.043","volume":"93","author":"AS Melo","year":"2010","unstructured":"Melo AS, Rosa-e-Silva JC, Rosa-e-Silva AC, Poli-Neto OB, Ferriani RA, Vieira CS. Unfavorable lipid profile in women with endometriosis. Fertil Steril. 2010;93(7):2433\u20136. https:\/\/doi.org\/10.1016\/j.fertnstert.2009.08.043.","journal-title":"Fertil Steril"},{"issue":"1","key":"770_CR43","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s12958-019-0513-8","volume":"17","author":"HM Atkins","year":"2019","unstructured":"Atkins HM, Bharadwaj MS, O'Brien Cox A, Furdui CM, Appt SE, Caudell DL. Endometrium and endometriosis tissue mitochondrial energy metabolism in a nonhuman primate model. Reprod Biol Endocrinol. 2019;17(1):70. https:\/\/doi.org\/10.1186\/s12958-019-0513-8.","journal-title":"Reprod Biol Endocrinol"},{"key":"770_CR44","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3389\/fphys.2018.00014","volume":"9","author":"J Li","year":"2018","unstructured":"Li J, Gao Y, Guan L, Zhang H, Sun J, Gong X, et al. Discovery of phosphatidic acid, phosphatidylcholine, and phosphatidylserine as biomarkers for early diagnosis of endometriosis. Front Physiol. 2018;9:14. https:\/\/doi.org\/10.3389\/fphys.2018.00014.","journal-title":"Front Physiol"},{"issue":"11","key":"770_CR45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047374","volume":"7","author":"HS Wang","year":"2012","unstructured":"Wang HS, Wu HM, Cheng BH, Yen CF, Chang PY, Chao A, et al. Functional analyses of endometriosis-related polymorphisms in the estrogen synthesis and metabolism-related genes. PLoS One. 2012;7(11):e47374. https:\/\/doi.org\/10.1371\/journal.pone.0047374.","journal-title":"PLoS One"},{"key":"770_CR46","doi-asserted-by":"publisher","first-page":"329058","DOI":"10.1155\/2013\/329058","volume":"2013","author":"SK Jana","year":"2013","unstructured":"Jana SK, Dutta M, Joshi M, Srivastava S, Chakravarty B, Chaudhury K. 1H NMR based targeted metabolite profiling for understanding the complex relationship connecting oxidative stress with endometriosis. Biomed Res Int. 2013;2013:329058.","journal-title":"Biomed Res Int"},{"issue":"9","key":"770_CR47","doi-asserted-by":"publisher","first-page":"3450","DOI":"10.1210\/jc.2014-1026","volume":"99","author":"VJ Young","year":"2014","unstructured":"Young VJ, Brown JK, Maybin J, Saunders PT, Duncan WC, Horne AW. Transforming growth factor-\u03b2 induced Warburg-like metabolic reprogramming may underpin the development of peritoneal endometriosis. J Clin Endocrinol Metab. 2014;99(9):3450\u20139. https:\/\/doi.org\/10.1210\/jc.2014-1026.","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Reproductive Biology and Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-021-00770-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12958-021-00770-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-021-00770-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T06:20:38Z","timestamp":1623219638000},"score":1,"resource":{"primary":{"URL":"https:\/\/rbej.biomedcentral.com\/articles\/10.1186\/s12958-021-00770-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,9]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["770"],"URL":"https:\/\/doi.org\/10.1186\/s12958-021-00770-9","relation":{},"ISSN":["1477-7827"],"issn-type":[{"value":"1477-7827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,9]]},"assertion":[{"value":"18 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in this study involving were in accordance with the ethical standards of the institutional research committee of Weifang medical university.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"86"}}