{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:38:55Z","timestamp":1790815135825,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T00:00:00Z","timestamp":1633737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T00:00:00Z","timestamp":1633737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["31970799"],"award-info":[{"award-number":["31970799"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>To investigate whether the endometrial thickness change ratio from the progesterone administration day to the blastocyst transfer day is associated with pregnancy outcomes in a single frozen-thawed euploid blastocyst transfer cycle.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>All patients used natural cycles with luteal support for endometrial preparation and selected a single euploid blastocyst for transfer after a biopsy for preimplantation genetic testing. The endometrial thickness was measured by transvaginal ultrasound on the progesterone administration day and the transfer day, the change in endometrial thickness was measured, and the endometrial thickness change ratio was calculated. According to the change rate of endometrial thickness, the patients were divided into three groups: the endometrial thickness compaction group, endometrial thickness non-change group and endometrial thickness expansion group. Among them, the endometrial thickness non-change and expansion groups were combined into the endometrial thickness noncompaction group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Ultrasound images of the endometrium in 219 frozen-thawed euploid blastocyst transfer cycles were evaluated. The clinical pregnancy rate increased with the increase in endometrial thickness change ratio, while the miscarriage rate and live birth rate were comparable among the groups. The multiple logistic regression results showed that in the fully adjusted model a higher endometrial thickness change ratio (per 10%) was associated with a higher clinical pregnancy rate (adjusted odds ratio [aOR] 1.29; 95% confidence interval [CI], 1.01\u20131.64; <jats:italic>P<\/jats:italic>\u2009=\u2009.040). Similarly, when the patients were divided into three groups according to the change rate of endometrial thickness, the endometrial thickness noncompaction group had a significant positive effect on the clinical pregnancy rate compared with the endometrial thickness compaction group after adjusting for all covariates.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In frozen-thawed euploid blastocyst transfer cycles in which the endometrium was prepared by natural cycles with luteal support, the clinical pregnancy rate was higher in cycles without endometrial compaction after progesterone administration.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12958-021-00841-x","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T19:18:54Z","timestamp":1633893534000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effect of endometrial thickness changes on clinical pregnancy rates after progesterone administration in a single frozen-thawed euploid blastocyst transfer cycle using natural cycles with luteal support for PGT-SR- and PGT-M-assisted reproduction: a retrospective cohort study"],"prefix":"10.1186","volume":"19","author":[{"given":"Ziqi","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingdi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EnTong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqin","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YiLe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,9]]},"reference":[{"key":"841_CR1","doi-asserted-by":"publisher","first-page":"121","DOI":"10.4103\/0974-1208.165153","volume":"8","author":"N Mahajan","year":"2015","unstructured":"Mahajan N. Endometrial receptivity array: clinical application. J Hum Reprod Sci. 2015;8:121\u20139.","journal-title":"J Hum Reprod Sci"},{"key":"841_CR2","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1080\/14737159.2017.1394186","volume":"17","author":"A Kuliev","year":"2017","unstructured":"Kuliev A, Rechitsky S. Preimplantation genetic testing: current challenges and future prospects. Expert Rev Mol Diagn. 2017;17:1071\u201388.","journal-title":"Expert Rev Mol Diagn"},{"key":"841_CR3","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s12958-018-0414-2","volume":"16","author":"A Bashiri","year":"2018","unstructured":"Bashiri A, Halper KI, Orvieto R. Recurrent implantation failure-update overview on etiology, diagnosis, treatment and future directions. Reprod Biol Endocrinol. 2018;16:121.","journal-title":"Reprod Biol Endocrinol"},{"key":"841_CR4","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1111\/aji.12226","volume":"72","author":"C von Grothusen","year":"2014","unstructured":"von Grothusen C, Lalitkumar S, Boggavarapu NR, Gemzell-Danielsson K, Lalitkumar PG. Recent advances in understanding endometrial receptivity: molecular basis and clinical applications. Am J Reprod Immunol. 2014;72:148\u201357.","journal-title":"Am J Reprod Immunol"},{"key":"841_CR5","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.rbmo.2016.05.002","volume":"33","author":"X Yuan","year":"2016","unstructured":"Yuan X, Saravelos SH, Wang Q, Xu Y, Li TC, Zhou C. Endometrial thickness as a predictor of pregnancy outcomes in 10787 fresh IVF-ICSI cycles. Reprod BioMed Online. 2016;33:197\u2013205.","journal-title":"Reprod BioMed Online"},{"key":"841_CR6","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.fertnstert.2004.09.020","volume":"83","author":"X Zhang","year":"2005","unstructured":"Zhang X, Chen CH, Confino E, Barnes R, Milad M, Kazer RR. Increased endometrial thickness is associated with improved treatment outcome for selected patients undergoing in vitro fertilization-embryo transfer. Fertil Steril. 2005;83:336\u201340.","journal-title":"Fertil Steril"},{"key":"841_CR7","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.rbmo.2018.08.025","volume":"37","author":"ID Gallos","year":"2018","unstructured":"Gallos ID, Khairy M, Chu J, Rajkhowa M, Tobias A, Campbell A, et al. Optimal endometrial thickness to maximize live births and minimize pregnancy losses: analysis of 25,767 fresh embryo transfers. Reprod BioMed Online. 2018;37:542\u20138.","journal-title":"Reprod BioMed Online"},{"key":"841_CR8","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1016\/j.fertnstert.2003.08.004","volume":"80","author":"U Zollner","year":"2003","unstructured":"Zollner U, Zollner KP, Specketer MT, Blissing S, Muller T, Steck T, et al. Endometrial volume as assessed by three-dimensional ultrasound is a predictor of pregnancy outcome after in vitro fertilization and embryo transfer. Fertil Steril. 2003;80:1515\u20137.","journal-title":"Fertil Steril"},{"key":"841_CR9","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.fertnstert.2015.05.036","volume":"104","author":"JA Gingold","year":"2015","unstructured":"Gingold JA, Lee JA, Rodriguez-Purata J, Whitehouse MC, Sandler B, Grunfeld L, et al. Endometrial pattern, but not endometrial thickness, affects implantation rates in euploid embryo transfers. Fertil Steril. 2015;104:620\u20138 e5.","journal-title":"Fertil Steril"},{"key":"841_CR10","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.rbmo.2014.05.011","volume":"29","author":"J Zhao","year":"2014","unstructured":"Zhao J, Zhang Q, Wang Y, Li Y. Endometrial pattern, thickness and growth in predicting pregnancy outcome following 3319 IVF cycle. Reprod BioMed Online. 2014;29:291\u20138.","journal-title":"Reprod BioMed Online"},{"key":"841_CR11","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.fertnstert.2007.02.029","volume":"89","author":"LT Merce","year":"2008","unstructured":"Merce LT, Barco MJ, Bau S, Troyano J. Are endometrial parameters by three-dimensional ultrasound and power Doppler angiography related to in vitro fertilization\/embryo transfer outcome? Fertil Steril. 2008;89:111\u20137.","journal-title":"Fertil Steril"},{"key":"841_CR12","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/1477-7827-8-122","volume":"8","author":"L Wang","year":"2010","unstructured":"Wang L, Qiao J, Li R, Zhen X, Liu Z. Role of endometrial blood flow assessment with color Doppler energy in predicting pregnancy outcome of IVF-ET cycles. Reprod Biol Endocrinol. 2010;8:122.","journal-title":"Reprod Biol Endocrinol"},{"key":"841_CR13","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1093\/humupd\/dmy044","volume":"25","author":"L Craciunas","year":"2019","unstructured":"Craciunas L, Gallos I, Chu J, Bourne T, Quenby S, Brosens JJ, et al. Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis. Hum Reprod Update. 2019;25:202\u201323.","journal-title":"Hum Reprod Update"},{"key":"841_CR14","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1023\/B:JARG.0000025937.43936.73","volume":"21","author":"C Laasch","year":"2004","unstructured":"Laasch C, Puscheck E. Cumulative embryo score, not endometrial thickness, is best for pregnancy prediction in IVF. J Assist Reprod Genet. 2004;21:47\u201350.","journal-title":"J Assist Reprod Genet"},{"key":"841_CR15","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s10815-009-9312-z","volume":"26","author":"MA Barker","year":"2009","unstructured":"Barker MA, Boehnlein LM, Kovacs P, Lindheim SR. Follicular and luteal phase endometrial thickness and echogenic pattern and pregnancy outcome in oocyte donation cycles. J Assist Reprod Genet. 2009;26:243\u20139.","journal-title":"J Assist Reprod Genet"},{"key":"841_CR16","doi-asserted-by":"publisher","first-page":"e9689","DOI":"10.1097\/MD.0000000000009689","volume":"97","author":"T Zhang","year":"2018","unstructured":"Zhang T, Li Z, Ren X, Huang B, Zhu G, Yang W, et al. Endometrial thickness as a predictor of the reproductive outcomes in fresh and frozen embryo transfer cycles: A retrospective cohort study of 1512 IVF cycles with morphologically good-quality blastocyst. Medicine. 2018;97:e9689.","journal-title":"Medicine."},{"key":"841_CR17","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1093\/humrep\/dey281","volume":"33","author":"KE Liu","year":"2018","unstructured":"Liu KE, Hartman M, Hartman A, Luo ZC, Mahutte N. The impact of a thin endometrial lining on fresh and frozen-thaw IVF outcomes: an analysis of over 40 000 embryo transfers. Hum Reprod. 2018;33:1883\u20138.","journal-title":"Hum Reprod"},{"key":"841_CR18","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1093\/humupd\/dmu011","volume":"20","author":"A Kasius","year":"2014","unstructured":"Kasius A, Smit JG, Torrance HL, Eijkemans MJ, Mol BW, Opmeer BC, et al. Endometrial thickness and pregnancy rates after IVF: a systematic review and meta-analysis. Hum Reprod Update. 2014;20:530\u201341.","journal-title":"Hum Reprod Update"},{"key":"841_CR19","doi-asserted-by":"publisher","first-page":"hox031","DOI":"10.1093\/hropen\/hox031","volume":"2018","author":"G Griesinger","year":"2018","unstructured":"Griesinger G, Trevisan S, Cometti B. Endometrial thickness on the day of embryo transfer is a poor predictor of IVF treatment outcome. Hum Reprod Open. 2018;2018:hox031.","journal-title":"Hum Reprod Open."},{"key":"841_CR20","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/j.fertnstert.2019.12.030","volume":"113","author":"E Zilberberg","year":"2020","unstructured":"Zilberberg E, Smith R, Nayot D, Haas J, Meriano J, Barzilay E, et al. Endometrial compaction before frozen euploid embryo transfer improves ongoing pregnancy rates. Fertil Steril. 2020;113:990\u20135.","journal-title":"Fertil Steril"},{"key":"841_CR21","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.fertnstert.2019.05.001","volume":"112","author":"J Haas","year":"2019","unstructured":"Haas J, Smith R, Zilberberg E, Nayot D, Meriano J, Barzilay E, et al. Endometrial compaction (decreased thickness) in response to progesterone results in optimal pregnancy outcome in frozen-thawed embryo transfers. Fertil Steril. 2019;112:503\u20139 e1.","journal-title":"Fertil Steril"},{"key":"841_CR22","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s10815-020-02043-7","volume":"38","author":"C Riestenberg","year":"2021","unstructured":"Riestenberg C, Quinn M, Akopians A, Danzer H, Surrey M, Ghadir S, et al. Endometrial compaction does not predict live birth rate in single euploid frozen embryo transfer cycles. J Assist Reprod Genet. 2021;38:407\u201312.","journal-title":"J Assist Reprod Genet"},{"key":"841_CR23","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s12958-019-0545-0","volume":"17","author":"Z Bu","year":"2019","unstructured":"Bu Z, Yang X, Song L, Kang B, Sun Y. The impact of endometrial thickness change after progesterone administration on pregnancy outcome in patients transferred with single frozen-thawed blastocyst. Reprod Biol Endocrinol. 2019;17:99.","journal-title":"Reprod Biol Endocrinol"},{"key":"841_CR24","doi-asserted-by":"publisher","first-page":"546232","DOI":"10.3389\/fendo.2020.546232","volume":"11","author":"J Ye","year":"2020","unstructured":"Ye J, Zhang J, Gao H, Zhu Y, Wang Y, Cai R, et al. Effect of endometrial thickness change in response to progesterone administration on pregnancy outcomes in Frozen-Thawed embryo transfer: analysis of 4465 cycles. Front Endocrinol. 2020;11:546232.","journal-title":"Front Endocrinol."},{"key":"841_CR25","doi-asserted-by":"publisher","first-page":"424","DOI":"10.3389\/fendo.2020.00424","volume":"11","author":"G Li","year":"2020","unstructured":"Li G, Wu Y, Niu W, Xu J, Hu L, Shi H, et al. Analysis of the number of euploid embryos in preimplantation genetic testing cycles with early-follicular phase long-acting gonadotropin-releasing hormone agonist long protocol. Front Endocrinol. 2020;11:424.","journal-title":"Front Endocrinol."},{"key":"841_CR26","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/s10815-020-01718-5","volume":"37","author":"D Shi","year":"2020","unstructured":"Shi D, Xu J, Niu W, Liu Y, Shi H, Yao G, et al. Live births following preimplantation genetic testing for dynamic mutation diseases by karyomapping: a report of three cases. J Assist Reprod Genet. 2020;37:539\u201348.","journal-title":"J Assist Reprod Genet"},{"key":"841_CR27","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.fertnstert.2017.06.005","volume":"108","author":"F Zegers-Hochschild","year":"2017","unstructured":"Zegers-Hochschild F, Adamson GD, Dyer S, Racowsky C, de Mouzon J, Sokol R, et al. The international glossary on infertility and fertility care, 2017. Fertil Steril. 2017;108:393\u2013406.","journal-title":"Fertil Steril"},{"key":"841_CR28","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/S2213-8587(15)00255-7","volume":"3","author":"D Farrar","year":"2015","unstructured":"Farrar D, Fairley L, Santorelli G, Tuffnell D, Sheldon TA, Wright J, et al. Association between hyperglycaemia and adverse perinatal outcomes in south Asian and white British women: analysis of data from the born in Bradford cohort. Lancet Diabetes Endocrinol. 2015;3:795\u2013804.","journal-title":"Lancet Diabetes Endocrinol"},{"key":"841_CR29","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/1477-7827-4-56","volume":"4","author":"JL Alcazar","year":"2006","unstructured":"Alcazar JL. Three-dimensional ultrasound assessment of endometrial receptivity: a review. Reprod Biol Endocrinol. 2006;4:56.","journal-title":"Reprod Biol Endocrinol"}],"container-title":["Reproductive Biology and Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-021-00841-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12958-021-00841-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-021-00841-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T20:58:25Z","timestamp":1633899505000},"score":1,"resource":{"primary":{"URL":"https:\/\/rbej.biomedcentral.com\/articles\/10.1186\/s12958-021-00841-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,9]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["841"],"URL":"https:\/\/doi.org\/10.1186\/s12958-021-00841-x","relation":{},"ISSN":["1477-7827"],"issn-type":[{"value":"1477-7827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,9]]},"assertion":[{"value":"23 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study has received approval and was carried out in accordance with the approved guidelines from the Zhengzhou University Research Ethics Board.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"154"}}