{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:36:30Z","timestamp":1787502990035,"version":"build-2736575974"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004608","name":"natural science foundation of jiangsu province","doi-asserted-by":"publisher","award":["BK20201158"],"award-info":[{"award-number":["BK20201158"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"name":"qingmiao talents training program of changzhou health commission","award":["CZQM2020095"],"award-info":[{"award-number":["CZQM2020095"]}]},{"name":"qingmiao talents training program of changzhou health commission","award":["CZQM2020103"],"award-info":[{"award-number":["CZQM2020103"]}]},{"name":"great science and technology project of changzhou municipal health commission","award":["ZD201921"],"award-info":[{"award-number":["ZD201921"]}]},{"name":"great science and technology project of changzhou municipal health commission","award":["ZD202016"],"award-info":[{"award-number":["ZD202016"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Recurrent implantation failure (RIF) is a major limitation of assisted reproductive technology, which is associated with impaired endometrial receptivity. Although N\n                      <jats:sup>6<\/jats:sup>\n                      -methyladenosine (m\n                      <jats:sup>6<\/jats:sup>\n                      A) has been demonstrated to be involved in various biological processes, its potential role in the endometrium of women with RIF has been poorly studied.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Global m\n                      <jats:sup>6<\/jats:sup>\n                      A levels and major m\n                      <jats:sup>6<\/jats:sup>\n                      A methyltransferases\/demethylases mRNA levels in mid-secretory endometrium from normal and RIF women were examined by colorimetric m\n                      <jats:sup>6<\/jats:sup>\n                      A quantification strategy and quantitative real-time PCR, respectively. The effects of METTL3-mediated m\n                      <jats:sup>6<\/jats:sup>\n                      A modification on embryo attachment were evaluated by an vitro model of a confluent monolayer of Ishikawa cells co-cultured with BeWo spheroids, and the expression levels of homeo box A10 (HOXA10, a well-characterized marker of endometrial receptivity) and its downstream targets were evaluated by quantitative real-time PCR and Western blotting in METTL3-overexpressing Ishikawa cells. The molecular mechanism for METTL3 regulating HOXA10 expression was determined by methylated RNA immunoprecipitation assay and transcription inhibition assay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Global m\n                      <jats:sup>6<\/jats:sup>\n                      A methylation and METTL3 expression were significantly increased in the endometrial tissues from women with RIF compared with the controls. Overexpression of METTL3 in Ishikawa cells significantly decreased the ration of BeWo spheroid attachment, and inhibited HOXA10 expression with downstream decreased \u03b23-integrin and increased empty spiracles homeobox 2 expression. METTL3 catalyzed the m\n                      <jats:sup>6<\/jats:sup>\n                      A methylation of HOXA10 mRNA and contributed to its decay with shortened half-life. Enforced expression of HOXA10 in Ishikawa cells effectively rescued the impairment of METTL3 on the embryo attachment\n                      <jats:bold>\n                        <jats:italic>in vitro<\/jats:italic>\n                      <\/jats:bold>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Increased METTL3-mediated m\n                      <jats:sup>6<\/jats:sup>\n                      A modification represents an adverse impact on embryo implantation by inhibiting HOXA10 expression, contributing to the pathogenesis of RIF.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12958-021-00872-4","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T02:09:02Z","timestamp":1639447742000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Increased METTL3-mediated m6A methylation inhibits embryo implantation by repressing HOXA10 expression in recurrent implantation failure"],"prefix":"10.1186","volume":"19","author":[{"given":"Pingping","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianya","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcai","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,14]]},"reference":[{"key":"872_CR1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1055\/s-2007-1016233","volume":"17","author":"AT Fazleabas","year":"1999","unstructured":"Fazleabas AT, Kim JJ, Srinivasan S, Donnelly KM, Brudney A, Jaffe RC. Implantation in the baboon: endometrial responses. Semin Reprod Endocrinol. 1999;17:257\u201365.","journal-title":"Semin Reprod Endocrinol."},{"key":"872_CR2","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jri.2009.08.011","volume":"83","author":"S Nimbkar-Joshi","year":"2009","unstructured":"Nimbkar-Joshi S, Rosario G, Katkam RR, Manjramkar DD, Metkari SM, Puri CP, et al. Embryo-induced alterations in the molecular phenotype of primate endometrium. J Reprod Immunol. 2009;83:65\u201371.","journal-title":"J Reprod Immunol."},{"key":"872_CR3","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1053\/beog.2000.0121","volume":"14","author":"C Sim\u00f3n","year":"2000","unstructured":"Sim\u00f3n C, Mart\u00edn JC, Pellicer A. Paracrine regulators of implantation. Baillieres Best Pract Res Clin Obstet Gynaecol. 2000;14:815\u201326.","journal-title":"Baillieres Best Pract Res Clin Obstet Gynaecol."},{"key":"872_CR4","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/S0015-0282(16)55259-5","volume":"58","author":"PA Bergh","year":"1992","unstructured":"Bergh PA, Navot D. The impact of embryonic development and endometrial maturity on the timing of implantation. Fertil Steril. 1992;58:537\u201342.","journal-title":"Fertil Steril."},{"key":"872_CR5","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1093\/humupd\/dml033","volume":"12","author":"T Strowitzki","year":"2006","unstructured":"Strowitzki T, Germeyer A, Popovici R, von Wolff M. The human endometrium as a fertility-determining factor. Hum Reprod Update. 2006;12:617\u201330.","journal-title":"Hum Reprod Update."},{"key":"872_CR6","doi-asserted-by":"crossref","unstructured":"Moustafa S, Young SL. Diagnostic and therapeutic options in recurrent implantation failure. F1000Res. 2020;9:F1000 Faculty Rev-208.","DOI":"10.12688\/f1000research.22403.1"},{"key":"872_CR7","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1210\/er.2003-0020","volume":"25","author":"SK Dey","year":"2004","unstructured":"Dey SK, Lim H, Das SK, Reese J, Paria BC, Daikoku T, et al. Molecular cues to implantation. Endocr Rev. 2004;25:341\u201373.","journal-title":"Endocr Rev."},{"key":"872_CR8","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1172\/JCI1597","volume":"101","author":"HS Taylor","year":"1998","unstructured":"Taylor HS, Arici A, Olive D, Igarashi P. HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium. J Clin Invest. 1998;101:1379\u201384.","journal-title":"J Clin Invest."},{"key":"872_CR9","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1093\/humrep\/14.5.1328","volume":"14","author":"HS Taylor","year":"1999","unstructured":"Taylor HS, Bagot C, Kardana A, Olive D, Arici A. HOX gene expression is altered in the endometrium of women with endometriosis. Hum Reprod. 1999;14:1328\u201331.","journal-title":"Hum Reprod."},{"key":"872_CR10","first-page":"571","volume":"16","author":"GS Daftary","year":"2002","unstructured":"Daftary GS, Troy PJ, Bagot CN, Young SL, Taylor HS. Direct regulation of beta3-integrin subunit gene expression by HOXA10 in endometrial cells. Mol Endocrinol. 2002;16:571\u20139.","journal-title":"Mol Endocrinol."},{"key":"872_CR11","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1093\/molehr\/gam005","volume":"13","author":"JJ Kim","year":"2007","unstructured":"Kim JJ, Taylor HS, Lu Z, Ladhani O, Hastings JM, Jackson KS, et al. Altered expression of HOXA10 in endometriosis: potential role in decidualization. Mol Hum Reprod. 2007;13:323\u201332.","journal-title":"Mol Hum Reprod."},{"key":"872_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/MCB.23.1.1-13.2003","volume":"23","author":"PJ Troy","year":"2003","unstructured":"Troy PJ, Daftary GS, Bagot CN, Taylor HS. Transcriptional repression of peri-implantation EMX2 expression in mammalian reproduction by HOXA10. Mol Cell Biol. 2003;23:1\u201313.","journal-title":"Mol Cell Biol."},{"key":"872_CR13","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/1477-7827-12-53","volume":"12","author":"A Germeyer","year":"2014","unstructured":"Germeyer A, Savaris RF, Jauckus J, Lessey B. Endometrial beta3 integrin profile reflects endometrial receptivity defects in women with unexplained recurrent pregnancy loss. Reprod Biol Endocrinol. 2014;12:53.","journal-title":"Reprod Biol Endocrinol."},{"issue":"1","key":"872_CR14","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.ejogrb.2013.06.019","volume":"170","author":"N Liu","year":"2013","unstructured":"Liu N, Zhou C, Chen Y, Zhao J. The involvement of osteopontin and \u03b23 integrin in implantation and endometrial receptivity in an early mouse pregnancy model. Eur J Obstet Gynecol Reprod Biol. 2013;170(1):171\u20136.","journal-title":"Eur J Obstet Gynecol Reprod Biol."},{"issue":"2","key":"872_CR15","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.rbmo.2019.03.211","volume":"39","author":"K Marron","year":"2019","unstructured":"Marron K, Harrity C, Dunne H, Shkrobot L, Kennedy J. Cytometric assessment of uterine receptivity via epithelial \u03b23 integrin expression. Reprod Biomed Online. 2019;39(2):294\u2013303.","journal-title":"Reprod Biomed Online."},{"issue":"5","key":"872_CR16","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.1210\/jc.2003-031389","volume":"89","author":"GS Daftary","year":"2004","unstructured":"Daftary GS, Taylor HS. EMX2 gene expression in the female reproductive tract and aberrant expression in the endometrium of patients with endometriosis. J Clin Endocrinol Metab. 2004;89(5):2390\u20136.","journal-title":"J Clin Endocrinol Metab."},{"issue":"4","key":"872_CR17","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.rbmo.2016.01.005","volume":"32","author":"Y Zhu","year":"2016","unstructured":"Zhu Y, Luo M, Huang H, Du X, Chen D, Xing Q, et al. HOXA10, EMX2 and TENM1 expression in the mid-secretory endometrium of infertile women with a M\u00fcllerian duct anomaly. Reprod Biomed Online. 2016;32(4):388\u201393.","journal-title":"Reprod Biomed Online."},{"key":"872_CR18","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1038\/sj.gt.3301245","volume":"7","author":"CN Bagot","year":"2000","unstructured":"Bagot CN, Troy PJ, Taylor HS. Alteration of maternal Hoxa10 expression by in vivo gene transfection affects implantation. Gene Ther. 2000;7:1378\u201384.","journal-title":"Gene Ther."},{"key":"872_CR19","doi-asserted-by":"publisher","first-page":"17057","DOI":"10.1038\/cddiscovery.2017.57","volume":"3","author":"R Jiang","year":"2017","unstructured":"Jiang R, Ding L, Zhou J, Huang C, Zhang Q, Jiang Y, et al. Enhanced HOXA10 sumoylation inhibits embryo implantation in women with recurrent implantation failure. Cell Death Discov. 2017;3:17057.","journal-title":"Cell Death Discov."},{"key":"872_CR20","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/s41419-018-0317-3","volume":"9","author":"Q Yan","year":"2018","unstructured":"Yan Q, Huang C, Jiang Y, Shan H, Jiang R, Wang J, et al. Calpain7 impairs embryo implantation by downregulating \u03b23-integrin expression via degradation of HOXA10. Cell Death Dis. 2018;9:291.","journal-title":"Cell Death Dis."},{"key":"872_CR21","doi-asserted-by":"publisher","first-page":"4417","DOI":"10.1210\/jc.2013-1429","volume":"98","author":"LH Zhu","year":"2013","unstructured":"Zhu LH, Sun LH, Hu YL, Jiang Y, Liu HY, Shen XY, et al. PCAF impairs endometrial receptivity and embryo implantation by down-regulating \u03b23-integrin expression via HOXA10 acetylation. J Clin Endocrinol Metab. 2013;98:4417\u201328.","journal-title":"J Clin Endocrinol Metab."},{"key":"872_CR22","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12943-021-01356-0","volume":"20","author":"MB Uddin","year":"2021","unstructured":"Uddin MB, Wang Z, Yang C. The m6A RNA methylation regulates oncogenic signaling pathways driving cell malignant transformation and carcinogenesis. Mol Cancer. 2021;20:61.","journal-title":"Mol Cancer."},{"key":"872_CR23","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/s41556-018-0045-z","volume":"20","author":"H Huang","year":"2018","unstructured":"Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, et al. Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat Cell Biol. 2018;20:285\u201395.","journal-title":"Nat Cell Biol."},{"key":"872_CR24","doi-asserted-by":"publisher","first-page":"3816","DOI":"10.1093\/nar\/gkaa048","volume":"48","author":"T Liu","year":"2020","unstructured":"Liu T, Wei Q, Jin J, Luo Q, Liu Y, Yang Y, , et al. The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation. Nucleic Acids Res. 2020;48:3816-3831.","journal-title":"Nucleic Acids Res."},{"key":"872_CR25","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nature12730","volume":"505","author":"X Wang","year":"2014","unstructured":"Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, et al. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014;505:117\u201320.","journal-title":"Nature."},{"key":"872_CR26","doi-asserted-by":"crossref","first-page":"E2047","DOI":"10.1073\/pnas.1521518113","volume":"113","author":"C Zhang","year":"2016","unstructured":"Zhang C, Samanta D, Lu H, Bullen JW, Zhang H, Chen I, et al. Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA. Proc Natl Acad Sci U S A. 2016;113:E2047\u201356.","journal-title":"Proc Natl Acad Sci U S A."},{"key":"872_CR27","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/nature18298","volume":"534","author":"X Wang","year":"2016","unstructured":"Wang X, Feng J, Xue Y, Guan Z, Zhang D, Liu Z, et al. Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex. Nature. 2016;534:575\u20138.","journal-title":"Nature."},{"key":"872_CR28","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.molcel.2016.03.021","volume":"62","author":"S Lin","year":"2016","unstructured":"Lin S, Choe J, Du P, Triboulet R, Gregory RI. The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. Mol Cell. 2016;62:335\u201345.","journal-title":"Mol Cell."},{"key":"872_CR29","doi-asserted-by":"publisher","first-page":"C762","DOI":"10.1152\/ajpcell.00212.2019","volume":"317","author":"Y Liu","year":"2019","unstructured":"Liu Y, Liu Z, Tang H, Shen Y, Gong Z, Xie N, et al. The N6-methyladenosine (m6A)-forming enzyme METTL3 facilitates M1 macrophage polarization through the methylation of STAT1 mRNA. Am J Physiol Cell Physiol. 2019;317:C762\u201375.","journal-title":"Am J Physiol Cell Physiol."},{"key":"872_CR30","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1038\/s41467-019-09903-6","volume":"10","author":"H Wang","year":"2019","unstructured":"Wang H, Hu X, Huang M, Liu J, Gu Y, Ma L, et al. Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation. Nat Commun. 2019;10:1898.","journal-title":"Nat Commun."},{"key":"872_CR31","doi-asserted-by":"publisher","first-page":"9143","DOI":"10.2147\/OTT.S226796","volume":"12","author":"J Cai","year":"2019","unstructured":"Cai J, Yang F, Zhan H, Situ J, Li W, Mao Y, et al. RNA m6A Methyltransferase METTL3 Promotes The Growth Of Prostate Cancer By Regulating Hedgehog Pathway. Onco Targets Ther. 2019;12:9143\u201352.","journal-title":"Onco Targets Ther."},{"key":"872_CR32","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/s12943-019-1053-8","volume":"18","author":"Y Chen","year":"2019","unstructured":"Chen Y, Peng C, Chen J, Chen D, Yang B, He B, et al. WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1. Mol Cancer. 2019;18:127.","journal-title":"Mol Cancer."},{"key":"872_CR33","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25:402\u20138.","journal-title":"Methods."},{"key":"872_CR34","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.molimm.2019.12.018","volume":"118","author":"P Xue","year":"2020","unstructured":"Xue P, Fan W, Diao Z, Li Y, Kong C, Dai X, et al. Up-regulation of PTEN via LPS\/AP-1\/NF-\u03baB pathway inhibits trophoblast invasion contributing to preeclampsia. Mol Immunol. 2020;118:182\u201390.","journal-title":"Mol Immunol."},{"key":"872_CR35","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1038\/s41467-021-21594-6","volume":"12","author":"Y Yao","year":"2021","unstructured":"Yao Y, Yang Y, Guo W, Xu L, You M, Zhang YC, et al. METTL3-dependent m6A modification programs T follicular helper cell differentiation. Nat Commun. 2021;12:1333.","journal-title":"Nat Commun."},{"key":"872_CR36","doi-asserted-by":"publisher","first-page":"25916","DOI":"10.18632\/aging.202163","volume":"12","author":"L Jiang","year":"2020","unstructured":"Jiang L, Zhang M, Wu J, Wang S, Yang X, Yi M, et al. Exploring diagnostic m6A regulators in endometriosis. Aging (Albany NY). 2020;12:25916\u201338.","journal-title":"Aging (Albany NY)."},{"key":"872_CR37","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1038\/s41556-018-0174-4","volume":"20","author":"J Liu","year":"2018","unstructured":"Liu J, Eckert MA, Harada BT, Liu SM, Lu Z, Yu K, et al. m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018;20:1074\u201383.","journal-title":"Nat Cell Biol."},{"key":"872_CR38","doi-asserted-by":"publisher","first-page":"716","DOI":"10.3389\/fgene.2020.00716","volume":"11","author":"J Zhai","year":"2020","unstructured":"Zhai J, Li S, Sen S, Opoku-Anane J, Du Y, Chen ZJ, et al. m6A RNA Methylation Regulators Contribute to Eutopic Endometrium and Myometrium Dysfunction in Adenomyosis. Front Genet. 2020;11:716.","journal-title":"Front Genet."},{"key":"872_CR39","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/j.fertnstert.2010.09.060","volume":"95","author":"CP Fischer","year":"2011","unstructured":"Fischer CP, Kayisili U, Taylor HS. HOXA10 expression is decreased in endometrium of women with adenomyosis. Fertil Steril. 2011;95:1133\u20136.","journal-title":"Fertil Steril."},{"key":"872_CR40","doi-asserted-by":"publisher","first-page":"2549789","DOI":"10.1155\/2018\/2549789","volume":"2018","author":"J Wang","year":"2018","unstructured":"Wang J, Huang C, Jiang R, Du Y, Zhou J, Jiang Y, et al. Decreased Endometrial IL-10 Impairs Endometrial Receptivity by Downregulating HOXA10 Expression in Women with Adenomyosis. Biomed Res Int. 2018;2018:2549789.","journal-title":"Biomed Res Int."},{"key":"872_CR41","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1210\/jc.2015-1588","volume":"101","author":"C Kong","year":"2016","unstructured":"Kong C, Sun L, Zhang M, Ding L, Zhang Q, Cheng X, et al. miR-133b Reverses the Hydrosalpinx-induced Impairment of Embryo Attachment Through Down-regulation of SGK1. J Clin Endocrinol Metab. 2016;101:1478\u201389.","journal-title":"J Clin Endocrinol Metab."},{"key":"872_CR42","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/374460a0","volume":"374","author":"I Satokata","year":"1995","unstructured":"Satokata I, Benson G, Maas R. Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice. Nature. 1995;374:460\u20133.","journal-title":"Nature."}],"container-title":["Reproductive Biology and Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-021-00872-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12958-021-00872-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12958-021-00872-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T23:40:39Z","timestamp":1666741239000},"score":1,"resource":{"primary":{"URL":"https:\/\/rbej.biomedcentral.com\/articles\/10.1186\/s12958-021-00872-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,14]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["872"],"URL":"https:\/\/doi.org\/10.1186\/s12958-021-00872-4","relation":{},"ISSN":["1477-7827"],"issn-type":[{"value":"1477-7827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,14]]},"assertion":[{"value":"16 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the endometrial samples were collected with written informed consent of the patients who were recruited from in vitro fertilization unit of Reproductive Medicine Center of the Affiliated Changzhou Maternity and Child Health Care Hospital of Nanjing Medical University, and approval was obtained from the Scientific Research Ethics Committee of Changzhou Maternity and Child Health Care Hospital for this study (2020103).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"187"}}